Affiliation: Jilin University
Xu X, Ding Z, Li J, Liang J, Bu Z, Ding J, et al
. Newcastle disease virus-like particles containing the Brucella BCSP31 protein induce dendritic cell activation and protect mice against virulent Brucella challenge. Vet Microbiol. 2019;229:39-47 pubmed publisher
..In summary, this study provides a new strategy for the development of a safe and effective vaccine candidate against virulent Brucella and further extends the application of NDV VLP-based vaccine platforms. ..
Gao C, Ding Z, Qian J, Liu X, Zhang X, Cong Y, et al
. The virulence of NDV NA-1 strain regulated by the 3' leader or 5' trailer sequences. Microb Pathog. 2019;126:109-115 pubmed publisher
..Therefore, our results suggest that the 3' and 5' terminal sequences of NDV genome could only influence the viral virulence when worked collaboratively, while separate replacement would not alter its biological characteristics. ..
Liu J, Cong Y, Yin R, Ding C, Yu S, Liu X, et al
. The deletion of an extra six nucleotides in the 5' -untranslated region of the nucleoprotein gene of Newcastle disease virus NA-1 decreases virulence. BMC Vet Res. 2014;10:964 pubmed publisher
..However, rNA-1(-) was more virulent in chickens than geese, as seen by the higher intracerebral pathogenicity index value. ..
Zhang P, Xie G, Liu X, Ai L, Chen Y, Meng X, et al
. High Genetic Diversity of Newcastle Disease Virus in Wild and Domestic Birds in Northeastern China from 2013 to 2015 Reveals Potential Epidemic Trends. Appl Environ Microbiol. 2015;82:1530-1536 pubmed publisher
..Our findings, together with recent prevalence trends of class I and virulent class II NDV in China, suggest possible virus transmission between wild and domestic birds and the potential for an NDV epidemic in the future. ..
Yin R, Liu X, Zhang P, Chen Y, Xie G, Ai L, et al
. A Raf kinase inhibitor demonstrates antiviral activities both inÂ vitro and inÂ vivo against different genotypes of virulent Newcastle disease virus. Antiviral Res. 2016;133:140-4 pubmed publisher
..Thus, we conclude that the Raf kinase inhibitor compound RKIV, by inhibiting the host cellular target Raf kinase, might be very promising as a new class of antivirals against the enzootic virulent NDV infection. ..
Zhou Y, Ren Y, Cong Y, Mu Y, Yin R, Ding Z. Autophagy induced by bovine viral diarrhea virus infection counteracts apoptosis and innate immune activation. Arch Virol. 2017;162:3103-3118 pubmed publisher
..These findings might help to illustrate the pathogenesis of persistent infection caused by BVDV. ..