Zhuang Ding


Affiliation: Jilin University
Country: China


  1. Zhang W, Zhang N, Xie X, Guo J, Jin X, Xue F, et al. Toll-Like Receptor 2 Agonist Pam3CSK4 Alleviates the Pathology of Leptospirosis in Hamster. Infect Immun. 2016;84:3350-3357 pubmed
    ..Our data demonstrate that coinjection of leptospires and Pam3CSK4 alleviates the pathology of leptospirosis in hamsters; this effect may result from the enhanced expression of TLR2-dependent IL-10. ..
  2. Xu X, Ding Z, Yuan Q, Ding J, Li J, Wang W, et al. A genotype VII Newcastle disease virus-like particles confer full protection with reduced virus load and decreased virus shedding. Vaccine. 2019;37:444-451 pubmed publisher
    ..These results proposed the potential role of NDV VLPs as an alternative to current live genotype unmatched vaccine for the control and eliminate NDV in the avian flocks. ..
  3. Xu X, Xue C, Liu X, Li J, Fei Y, Liu Z, et al. A novel recombinant attenuated Newcastle disease virus expressing H9 subtype hemagglutinin protected chickens from challenge by genotype VII virulent Newcastle disease virus and H9N2 avian influenza virus. Vet Microbiol. 2019;228:173-180 pubmed publisher
    ..Therefore, the recombinant rmNA-H9F is a promising bivalent vaccine candidate against NDV and H9 subtype AIV in chickens. ..
  4. Xu X, Qian J, Ding J, Li J, Nan F, Wang W, et al. Detection of viral components in exosomes derived from NDV-infected DF-1 cells and their promoting ability in virus replication. Microb Pathog. 2018;: pubmed publisher
    ..Therefore, NDV infection produces exosomes, which transfer viral NP protein and promote NDV infection, emphasizing the importance of exosomes in an NDV infection. ..
  5. Sun Y, Qian J, Xu X, Tang Y, Xu W, Yang W, et al. Dendritic cell-targeted recombinantLactobacilli induce DC activation and elicit specific immune responses against G57 genotype of avian H9N2 influenza virus infection. Vet Microbiol. 2018;223:9-20 pubmed publisher
  6. Liu W, Qiu X, Song C, Sun Y, Meng C, Liao Y, et al. Deep Sequencing-Based Transcriptome Profiling Reveals Avian Interferon-Stimulated Genes and Provides Comprehensive Insight into Newcastle Disease Virus-Induced Host Responses. Viruses. 2018;10: pubmed publisher
  7. Rehman Z, Qiu X, Sun Y, Liao Y, Tan L, Song C, et al. Vitamin E Supplementation Ameliorates Newcastle Disease Virus-Induced Oxidative Stress and Alleviates Tissue Damage in the Brains of Chickens. Viruses. 2018;10: pubmed publisher
    ..These findings also demonstrate that supplementing vitamin E ameliorates these pathologies in chickens and proposes its supplementation for NDV-induced stresses. ..
  8. Wang J, Cong Y, Yin R, Feng N, Yang S, Xia X, et al. Generation and evaluation of a recombinant genotype VII Newcastle disease virus expressing VP3 protein of Goose parvovirus as a bivalent vaccine in goslings. Virus Res. 2015;203:77-83 pubmed publisher
    ..This is the first study demonstrating that recombinant NDV has the potential to serve as bivalent live vaccine against Goose parvovirus and Newcastle disease virus infection in birds. ..
  9. Zhang W, Zhang N, Wang W, Wang F, Gong Y, Jiang H, et al. Efficacy of cefepime, ertapenem and norfloxacin against leptospirosis and for the clearance of pathogens in a hamster model. Microb Pathog. 2014;77:78-83 pubmed publisher
    ..We conclude that all of the antibiotics tested in vivo produce a statistically significant survival advantage, alleviate tissue injury and decrease the abundance of leptospira in target organs. ..

More Information


  1. Yin R, Liu X, Zhang P, Chen Y, Xie G, Ai L, et al. A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus. Antiviral Res. 2016;133:140-4 pubmed publisher
    ..Thus, we conclude that the Raf kinase inhibitor compound RKIV, by inhibiting the host cellular target Raf kinase, might be very promising as a new class of antivirals against the enzootic virulent NDV infection. ..
  2. Xue C, Cong Y, Yin R, Sun Y, Ding C, Yu S, et al. Genetic diversity of the genotype VII Newcastle disease virus: identification of a novel VIIj sub-genotype. Virus Genes. 2017;53:63-70 pubmed publisher
    ..It is worthy of note that the isolation rate of VIIj is increasing recently. It emphasizes the necessity to pay close attention to the epidemiological dynamic of genotype VII NDV and highlights the importance of vaccination program. ..
  3. Qian J, Ding J, Yin R, Sun Y, Xue C, Xu X, et al. Newcastle disease virus-like particles induce dendritic cell maturation and enhance viral-specific immune response. Virus Genes. 2017;53:555-564 pubmed publisher
    ..These data indicate that NDV VLPs can be a valuable candidate for NDV vaccine development. ..
  4. Xue C, Xu X, Yin R, Qian J, Sun Y, Wang C, et al. Identification and pathotypical analysis of a novel VIk sub-genotype Newcastle disease virus obtained from pigeon in China. Virus Res. 2017;238:1-7 pubmed publisher
    ..The emergence and spread of the sub-genotype VIk viruses illustrated that the genotype VI NDV was undergoing evolutionary changes. It is necessary to pay close attention and carry out epidemiological surveillance in pigeons. ..
  5. Qian J, Xu X, Ding J, Yin R, Sun Y, Xue C, et al. Newcastle disease virus-like particles induce DC maturation through TLR4/NF-κB pathway and facilitate DC migration by CCR7-CCL19/CCL21 axis. Vet Microbiol. 2017;203:158-166 pubmed publisher
    ..Together, these results present new insights for NDV VLPs induced DC maturation and migration, providing a better understanding of VLP-triggered innate immune responses. ..
  6. Zhou Y, Ren Y, Cong Y, Mu Y, Yin R, Ding Z. Autophagy induced by bovine viral diarrhea virus infection counteracts apoptosis and innate immune activation. Arch Virol. 2017;162:3103-3118 pubmed publisher
    ..These findings might help to illustrate the pathogenesis of persistent infection caused by BVDV. ..