Yongguo Cao


Affiliation: Jilin University
Country: China


  1. Zhang Z, Shen P, Xie W, Cao H, Liu J, Cao Y, et al. Pingwei San ameliorates dextran sulfate sodium-induced chronic colitis in mice. J Ethnopharmacol. 2019;: pubmed publisher
    ..Our data also indicated that PWS could inhibit NLRP3 inflammasome activation. PWS treatment alleviated the degree of colitis caused by DSS, suggesting that PWS might be a novel agent for the treatment of chronic colitis. ..
  2. Zhang Z, Li S, Cao H, Shen P, Liu J, Fu Y, et al. The protective role of phloretin against dextran sulfate sodium-induced ulcerative colitis in mice. Food Funct. 2019;10:422-431 pubmed publisher
    ..Escherichia coli (E. coli) and Lactobacillus levels were also re-balanced after phloretin treatment. These results indicate that phloretin might be a new dietary strategy for the treatment of UC. ..
  3. Shen P, Zhang Z, Zhu K, Cao H, Liu J, Lu X, et al. Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome. Biomed Pharmacother. 2019;110:786-795 pubmed publisher
    ..These findings suggested that EVO may have a potential protective effect on DSS-induced colitis and may be useful for the prevention and treatment of UC. ..
  4. Wang W, Gao X, Guo M, Zhang W, Song X, Wang T, et al. Leptospira interrogans induces uterine inflammatory responses and abnormal expression of extracellular matrix proteins in dogs. Microb Pathog. 2014;75:1-6 pubmed publisher
    ..These data indicated that strongly inflammatory responses, and abnormal regulation of ECM might contribute to the proliferation of dogs infected by L. interrogans. ..
  5. Zhang W, Zhang N, Wang W, Wang F, Gong Y, Jiang H, et al. Efficacy of cefepime, ertapenem and norfloxacin against leptospirosis and for the clearance of pathogens in a hamster model. Microb Pathog. 2014;77:78-83 pubmed publisher
    ..We conclude that all of the antibiotics tested in vivo produce a statistically significant survival advantage, alleviate tissue injury and decrease the abundance of leptospira in target organs. ..
  6. Hu X, Tian Y, Wang T, Zhang W, Wang W, Gao X, et al. TRAM-Derived Decoy Peptides inhibits the inflammatory response in mouse mammary epithelial cells and a mastitis model in mice. Eur J Pharmacol. 2015;764:607-12 pubmed publisher
    ..In conclusion, this study demonstrated that TM6 had protective effects on LPS-mastitis and may be a promising therapeutic reagent for mastitis treatment. ..
  7. Hu X, Fu Y, Tian Y, Zhang Z, Zhang W, Gao X, et al. The anti-inflammatory effect of TR6 on LPS-induced mastitis in mice. Int Immunopharmacol. 2016;30:150-156 pubmed publisher
    ..TR6 may be a promising therapeutic reagent for mastitis treatment. ..
  8. Zhang Z, Gao X, Guo M, Jiang H, Cao Y, Zhang N. The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice. Biol Trace Elem Res. 2017;175:129-135 pubmed publisher
    ..In addition, baicalin enhanced the Bcl-2/Bax ratio associated with apoptosis in the kidney. These data indicated that further investigation of the use of baicalin as a new natural chemopreventive agent against Pd poisoning is warranted. ..
  9. Shen P, Zhang Z, He Y, Gu C, Zhu K, Li S, et al. Magnolol treatment attenuates dextran sulphate sodium-induced murine experimental colitis by regulating inflammation and mucosal damage. Life Sci. 2018;196:69-76 pubmed publisher
    ..These results showed that magnolol played protective effects on DSS-induced colitis and may be an alternative therapeutic reagent for colitis treatment. ..

More Information


  1. Wu D, Zhang W, Wang T, Lin T, Jin X, Xie X, et al. Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. Microb Pathog. 2017;102:36-41 pubmed publisher
    ..The delayed induction of IL-1? and TNF-? was found in tissues of norfloxacin group. Our study indicates an increased risk associated with low-dose norfloxacin and ciprofloxacin in leptospirosis. ..
  2. Zhang W, Lu X, Wang W, Ding Z, Fu Y, Zhou X, et al. Inhibitory Effects of Emodin, Thymol, and Astragalin on Leptospira interrogans-Induced Inflammatory Response in the Uterine and Endometrium Epithelial Cells of Mice. Inflammation. 2017;40:666-675 pubmed publisher