Yong Chang Chen

Summary

Affiliation: Jiangsu University
Country: China

Publications

  1. ncbi request reprint H pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade
    Yong Chang Chen
    School of Medicine, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
    World J Gastroenterol 12:5972-7. 2006
  2. ncbi request reprint Analysis on the mechanism of Helicobacter pylori-induced apoptosis in gastric cancer cell line BGC-823
    Yongchang Chen
    Department of Physiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province 212001, PR China
    Int J Mol Med 16:741-5. 2005
  3. ncbi request reprint The cross talk between protein kinase A- and RhoA-mediated signaling in cancer cells
    Yongchang Chen
    School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, Jiangsu 212001, China
    Exp Biol Med (Maywood) 230:731-41. 2005
  4. doi request reprint Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823
    Yong Chang Chen
    School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu 212013, P R China
    Mol Med Report 3:361-6. 2010
  5. ncbi request reprint Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells
    Chongxu Han
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, 112 Ninghai Road, Nanjing, Jiangsu, 210097, China
    Int J Mol Med 16:205-13. 2005
  6. pmc Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901
    Yan Tao
    School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu Province, China
    World J Gastroenterol 14:1175-81. 2008
  7. ncbi request reprint Phosphorylated vasodilator-stimulated phosphoprotein is localized on mitotic spindles of the gastric cancer cell line SGC-7901
    Yan Tao
    School of Medicine, Jiangsu University, No 2 Dongwu Road, Zhenjiang 212001, Jiangsu Province, China
    World J Gastroenterol 12:7478-81. 2006
  8. ncbi request reprint Human mesenchymal stem cells isolated from the umbilical cord
    Chun Qiao
    School of Medical Technology, Centre for Clinical Laboratory Medicine of Affiliated Hospital, Jiangsu University, Zhenjiang Key Institute of Clinical Laboratory Medicine, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China
    Cell Biol Int 32:8-15. 2008
  9. ncbi request reprint Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo
    Wei Zhu
    School of Medical Technology, Jiangsu University, Zhenjiang, Jiangsu 212001, China
    Exp Mol Pathol 80:267-74. 2006
  10. ncbi request reprint Effect of nitric oxide on the proliferation of AGS gastric cancer cells
    Jian Rong Sang
    Department of Physiology, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China
    Chin J Cancer 29:158-62. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint H pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade
    Yong Chang Chen
    School of Medicine, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
    World J Gastroenterol 12:5972-7. 2006
    ..To explore the mechanism by which H pylori causes activation of gastric epithelial cells...
  2. ncbi request reprint Analysis on the mechanism of Helicobacter pylori-induced apoptosis in gastric cancer cell line BGC-823
    Yongchang Chen
    Department of Physiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province 212001, PR China
    Int J Mol Med 16:741-5. 2005
    ..The results suggested that Hp extract initiated apoptosis in BGC-823 cells through activating tyrosine kinase, caspase-1, -3, and DFF...
  3. ncbi request reprint The cross talk between protein kinase A- and RhoA-mediated signaling in cancer cells
    Yongchang Chen
    School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, Jiangsu 212001, China
    Exp Biol Med (Maywood) 230:731-41. 2005
    ..The results may be helpful in implementing novel therapeutic strategies for invasive and metastatic prostate and gastric cancers...
  4. doi request reprint Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823
    Yong Chang Chen
    School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu 212013, P R China
    Mol Med Report 3:361-6. 2010
    ..These data indicate that the activation of PKG II by 8-pCPT-cGMP inhibits the proliferation of human gastric cancer cells...
  5. ncbi request reprint Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells
    Chongxu Han
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, 112 Ninghai Road, Nanjing, Jiangsu, 210097, China
    Int J Mol Med 16:205-13. 2005
    ..These results implied that nucleostemin may play an important role in both tumorigenesis and transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells...
  6. pmc Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901
    Yan Tao
    School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu Province, China
    World J Gastroenterol 14:1175-81. 2008
    ..To elucidate the localization of RhoA in gastric SGC-7901 cancer cells and its translocation by lysophosphatidic acid (LPA) and/or 8-chlorophenylthio-cAMP (CPT-cAMP)...
  7. ncbi request reprint Phosphorylated vasodilator-stimulated phosphoprotein is localized on mitotic spindles of the gastric cancer cell line SGC-7901
    Yan Tao
    School of Medicine, Jiangsu University, No 2 Dongwu Road, Zhenjiang 212001, Jiangsu Province, China
    World J Gastroenterol 12:7478-81. 2006
    ..To elucidate the localization of vasodilator stimulated phosphoprotein (VASP), a cytoskeletal organizing protein and a substrate of protein kinases A and G in mitotic gastric cancer cells...
  8. ncbi request reprint Human mesenchymal stem cells isolated from the umbilical cord
    Chun Qiao
    School of Medical Technology, Centre for Clinical Laboratory Medicine of Affiliated Hospital, Jiangsu University, Zhenjiang Key Institute of Clinical Laboratory Medicine, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China
    Cell Biol Int 32:8-15. 2008
    ..Here we show that umbilical cords may be a novel alternative source of human MSCs for experimental and clinical applications...
  9. ncbi request reprint Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo
    Wei Zhu
    School of Medical Technology, Jiangsu University, Zhenjiang, Jiangsu 212001, China
    Exp Mol Pathol 80:267-74. 2006
    ..These findings suggested that MSCs could favor tumor growth in vivo. It is necessary to carry out a study for assurance of the long-term safety before MSCs were used as a therapy tools in regenerative medicine and tissue engineering...
  10. ncbi request reprint Effect of nitric oxide on the proliferation of AGS gastric cancer cells
    Jian Rong Sang
    Department of Physiology, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China
    Chin J Cancer 29:158-62. 2010
    ..This study investigated the effect of NO donor sodium nitroprusside (SNP) on the growth and proliferation of gastric cancer cell line AGS...
  11. doi request reprint RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1
    Yan Wu
    Jiangsu University, Zhenjiang, Jiangsu 212013, People s Republic of China
    Mol Med Report 4:697-703. 2011
    ..These results reveal a previously unrecognized interaction between IQGAP1 and RhoC, and demonstrate that IQGAP1 is a downstream effector of RhoC in the regulation of the migration activity of gastric cancer cells...
  12. ncbi request reprint A novel tumor cell line cloned from mutated human embryonic bone marrow mesenchymal stem cells
    Wenrong Xu
    School of Medical Technology, Jiangsu University, Zhenjiang, Jiangsu 212001, P R China
    Oncol Rep 12:501-8. 2004
    ..These findings suggested that F6 may be a novel tumor cell line. It may provide evidence for the theory that cancer originates from stem cells, and may be useful for the investigation on safety of human MSCs in the clinical application...
  13. ncbi request reprint Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro
    Wenrong Xu
    School of Life Science, Nanjing Normal University, Nanjing, Jiangsu, 210097, China
    Exp Biol Med (Maywood) 229:623-31. 2004
    ..Cardiomyocytes cultured from bone marrow sources are potentially valuable for repairing injured myocardium...
  14. doi request reprint Phosphorylation of vasodilator stimulated phosphoprotein is correlated with cell cycle progression in HeLa cells
    Yan Tao
    School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu 212013, P R China
    Mol Med Report 3:657-62. 2010
    ..These results suggest that p-VASP S157 may play an important role in the G2/M transition and the completion of cytokinesis in HeLa cells...
  15. pmc LPS-induced nuclear translocation of RhoA is dependent on NF-κB in the human lung cancer cell line A549
    Yan Tao
    School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P R China
    Oncol Lett 3:1283-1287. 2012
    ..These results demonstrate that LPS is able to activate RhoA and trigger its nuclear translocation, which is dependent on NF-κB, and that RhoA plays a significant role in the LPS/NF-κB signaling pathway...
  16. ncbi request reprint Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells
    Hui Qian
    Zhenjiang Key Institute of Clinical Laboratory Medicine, School of Medical Technology, Jiangsu University, Zhenjiang 212013, P R China
    Int J Mol Med 22:325-32. 2008
    ..These results demonstrate that cell therapy has potential as a novel intervention in ARF...
  17. ncbi request reprint Localization of phosphorylated TrkA in carrier vesicles involved in its nuclear translocation in U251 cell line
    Aihua Gong
    School of Medicine, Jiangsu University, Zhenjiang 212013, China
    Sci China C Life Sci 50:141-6. 2007
    ..Accordingly, our results suggested that such a series of membrane compartments might be involved in the pathway of nuclear translocation of the transmembrane receptor TrkA...
  18. ncbi request reprint Histological type of oncogenity and expression of cell cycle genes in tumor cells from human mesenchymal stem cells
    Runqiu Jiang
    School of Medical Technology, Zhenjiang Key Institute of Clinical Laboratory Medicine, Jiangsu 212001, PR China
    Oncol Rep 16:1021-8. 2006
    ....
  19. ncbi request reprint Localization of NGF and TrkA at mitotic apparatus in human glioma cell line U251
    Zhijian Zhang
    School of Medicine, Jiangsu University, Jiangsu Zhenjiang 212001, China
    Biochem Biophys Res Commun 337:68-74. 2005
    ..The phosphorylated TrkA with the tyrosine kinase activity may phosphorylate the tubulin and promote the mitotic spindle assembly. By these mechanisms, NGF can modulate the mitosis of human glioma cells...
  20. ncbi request reprint Breviscapine, a traditional Chinese medicine, alleviates myocardial ischaemia reperfusion injury in diabetic rats
    Jun Hai Jia
    Institute of Life Science, Jiangsu University, Zhenjiang, Jiangsu, China
    Acta Cardiol 63:757-62. 2008
    ..The aim of this study was to explore the effects of breviscapine on the expressions of intercellular adhesion molecule-I (ICAM-I), ATPase activities and oxidative stress in ischaemia-reperfused (I/R) myocardium of diabetic rats...