Tao Jiang

Summary

Country: China

Publications

  1. pmc High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
    Chunzhi Zhang
    Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China
    J Transl Med 10:119. 2012
  2. pmc Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma
    Jun Xia Zhang
    Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, China
    Neuro Oncol 15:279-89. 2013
  3. ncbi Prevalence estimates for primary brain tumors in China: a multi-center cross-sectional study
    Tao Jiang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 124:2578-83. 2011
  4. doi Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer 119:814-24. 2013
  5. doi The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, China
    Carcinogenesis 33:2276-82. 2012
  6. pmc Glioblastoma with an oligodendroglioma component: distinct clinical behavior, genetic alterations, and outcome
    Yongzhi Wang
    Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China
    Neuro Oncol 14:518-25. 2012
  7. doi miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2
    Lingchao Chen
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
    Eur J Cancer 48:3104-11. 2012
  8. doi Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas
    Tao Tao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Eur J Cancer 49:3055-63. 2013
  9. pmc Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Neuro Oncol 14:1432-40. 2012
  10. pmc Significance of miR-196b in tumor-related epilepsy of patients with gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e46218. 2012

Collaborators

Detail Information

Publications86

  1. pmc High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
    Chunzhi Zhang
    Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China
    J Transl Med 10:119. 2012
    ..MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression and apoptosis, respectively. However, the association of miR-221/222 with glioma cell invasion and survival remains unknown...
  2. pmc Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma
    Jun Xia Zhang
    Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, China
    Neuro Oncol 15:279-89. 2013
    ..New molecular classification of GBM was proposed and validated in Western and Asian populations...
  3. ncbi Prevalence estimates for primary brain tumors in China: a multi-center cross-sectional study
    Tao Jiang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 124:2578-83. 2011
    ..This study aimed to report a comprehensive assessment on the prevalence of PBT...
  4. doi Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer 119:814-24. 2013
    ..The objective of this study was to identify a microRNA expression signature to improve outcome prediction for patients with primary GBM...
  5. doi The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, China
    Carcinogenesis 33:2276-82. 2012
    ..Thus, we have identified that miR-524-5p behaves as a tumor suppressor by negatively targeting Jagged-1 and Hes-1 and provides an additional option to inhibit this oncogene in gliomas...
  6. pmc Glioblastoma with an oligodendroglioma component: distinct clinical behavior, genetic alterations, and outcome
    Yongzhi Wang
    Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China
    Neuro Oncol 14:518-25. 2012
    ..Presence of an oligodendroglial component may therefore be a useful classification and stratification variable in therapeutic trials of GBMs...
  7. doi miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2
    Lingchao Chen
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
    Eur J Cancer 48:3104-11. 2012
    ..In conclusion, our study demonstrates that miR-137 deregulation is common in glioma, and restoration of its function inhibits cell proliferation and invasion, suggesting that miR-137 may act as a tumour suppressor...
  8. doi Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas
    Tao Tao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Eur J Cancer 49:3055-63. 2013
    ....
  9. pmc Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Neuro Oncol 14:1432-40. 2012
    ..Our classification scheme may reflect the clinical and genetic alterations more clearly. Classical subtype-associated gene signature was not found in our dataset...
  10. pmc Significance of miR-196b in tumor-related epilepsy of patients with gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e46218. 2012
    ..The authors set out to correlate miR-196b expression in low-grade glioma patients with pre-operative seizures and post-operative seizure control...
  11. doi Clinical correlation of MGMT protein expression and promoter methylation in Chinese glioblastoma patients
    Kai Tang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili 100050, Dongcheng District, Beijing, China
    Med Oncol 29:1292-6. 2012
    ....
  12. pmc Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China
    Wei Yan
    Department of Neurosurgery, Capital Medical University, Beijing Tiantan Hospital, Beijing, China
    PLoS ONE 7:e30339. 2012
    ....
  13. pmc miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression
    Wei Zhang
    Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China
    Neuro Oncol 14:712-9. 2012
    ..Together, these results suggest that miR-181d is a predictive biomarker for TMZ response and that its role is mediated, in part, by posttranscriptional regulation of MGMT...
  14. pmc VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1α/VEGF and β-catenin/Tcf-4 signaling
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, China
    Neuro Oncol 14:1026-36. 2012
    ..Therefore, we demonstrated that downregulation of miR-23b suppressed tumor survival through targeting VHL, leading to the inhibition of β-catenin/Tcf-4 and HIF-1α/VEGF signaling pathways...
  15. doi MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1
    Yanwei Liu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China
    Oncol Rep 28:1013-21. 2012
    ....
  16. doi MiR-24 regulates the proliferation and invasion of glioma by ST7L via β-catenin/Tcf-4 signaling
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300060, China
    Cancer Lett 329:174-80. 2013
    ..In conclusion, our study demonstrates that miR-24 upregulation is common in glioma and that suppression of miR-24 expression inhibits cell proliferation and invasion, suggesting that miR-24 may act as an oncogene in glioma...
  17. doi Management and survival rates in patients with glioma in China (2004-2010): a retrospective study from a single-institution
    Pei Yang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China
    J Neurooncol 113:259-66. 2013
    ..Age, preoperative KPS, tumor grades, radiotherapy, chemotherapy and Ki-67 expression were significantly associated with clinical prognosis...
  18. pmc Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility
    Peng Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    BMC Cancer 13:234. 2013
    ..We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development...
  19. pmc High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression
    Junxia Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, China
    Neuro Oncol 13:600-9. 2011
    ..Taken together, we have demonstrated that Tcf-4 is associated with glioma progression and that AKT2 is a new member of the genes that are regulated by β-catenin/Tcf-4...
  20. pmc Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study
    Peng Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    BMC Cancer 12:617. 2012
    ..Potential links between polymorphisms of antioxidant genes and glioma risk are currently unknown. We therefore investigated the association between polymorphisms in antioxidant genes and glioma risk...
  21. doi Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer Lett 328:120-5. 2013
    ..Taken together, our results defined prognosis-related methylation signatures systematically for the first time in G-CIMP- primary GBMs. ALDH1A3 promoter methylation conferred a favorable prognosis in G-CIMP- primary GBMs...
  22. ncbi [Correlation between loss of heterozygosity on chromosome 1p and 19q and expression of MGMT, p53 and Ki-67 proteins in gliomas]
    Lei Huang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Zhonghua Zhong Liu Za Zhi 33:752-8. 2011
    ..To study the correlation of loss of heterozygosity (LOH) on chromosome 1p and 19q with the expression of MGMT, p53 and Ki-67 proteins in gliomas...
  23. pmc BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas
    Zhaoshi Bao
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    J Transl Med 11:100. 2013
    ..However, the prognostic and molecular features of gliomas with BMP4 expression is still unclear...
  24. doi Identifying Ki-67 specific miRNA-mRNA interactions in malignant astrocytomas
    Yanwei Liu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Neurosci Lett 546:36-41. 2013
    ..Conclusions: Ki-67 protein may be regulated by specific miRNA-mRNA interactions which may contribute to the proliferation of glioma cells...
  25. pmc Molecular prognostic factors of anaplastic oligodendroglial tumors and its relationship: a single institutional review of 77 patients from China
    Shouwei Li
    Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, China
    Neuro Oncol 14:109-16. 2012
    ..Inter-relationship between LOH 1p, LOH 19q, IDH1 mutation, MGMT promoter methylation, and MGMT expression level were also revealed. Future clinical trials for AO and AOA should consider the molecular alterations of patients...
  26. pmc Complete genome sequence of dengue virus serotype 2 Cosmopolitan genotype strain in Guangdong, China
    Hui Zhao
    Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 86:13808-9. 2012
    ..The reemergence of the Cosmopolitan genotype of DENV-2 in China deserves further investigation...
  27. pmc Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype
    Ruimin Ma
    Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e38096. 2012
    ..To explore the expression pattern, prognostic value and functional role of miR-196b in glioblastoma (GBM) patients using large cohorts...
  28. doi Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways
    Yongzhi Wang
    Glioma Center, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China
    Oncol Rep 26:1173-80. 2011
    ..These findings strongly support the hypothesis that STAT3 inhibition significantly improves the clinical efficacy of alkylating agents...
  29. doi Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, No 6 Tiantan Xili, Dongcheng District, Beijing 100050, China
    Brain Res 1411:108-15. 2011
    ..To our knowledge, this is the first study to identify the MMP-9 specific microRNA signature which may provide potential targets for anti-invasion therapy in GBM...
  30. pmc HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma
    Jun Xia Zhang
    Corresponding Authors Yong Ping You, PhD, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China Tao Jiang, PhD, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Chun Sheng Kang, PhD, Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
    Neuro Oncol 15:1595-603. 2013
    ..Long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) has been characterized as a negative prognostic factor in breast and colon cancer patients. The clinical significance and function of HOTAIR in glioma remains unclear...
  31. doi Prognostic value of a nine-gene signature in glioma patients based on mRNA expression profiling
    Zhao Shi Bao
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    CNS Neurosci Ther 20:112-8. 2014
    ..Gliomas are the most common primary brain tumors in adults and a significant cause of cancer-related mortality. A 9-gene signature was identified as a novel prognostic model reflecting survival situation obviously in gliomas...
  32. doi MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma
    Rui Yan Li
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    CNS Neurosci Ther 19:477-83. 2013
    ..The mechanisms underlying its dysregulation have not been clarified. In this study, we explored the involvement of micro-RNAs that acted as endogenous sequence-specific suppressors of gene expression...
  33. pmc Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN
    Xi Rui Wang
    Corresponding Authors Yong Ping You, PhD, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Ning Liu, PhD, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029 China
    Neuro Oncol 15:1491-501. 2013
    ..The goal of this study was to investigate the function of lethal (let)-7a miRNA in glioma cell lines with different PTEN phenotypes...
  34. doi MicroRNA-21 expression is regulated by β-catenin/STAT3 pathway and promotes glioma cell invasion by direct targeting RECK
    Lei Han
    Department of Neurosurgery, Tianjin Medical University General Hospital, China
    CNS Neurosci Ther 18:573-83. 2012
    ..Recent studies report that miR-21 regulates cell invasion by targeting RECK, however, the underlying transcriptional regulation of miR-21 in glioma cells remains elusive...
  35. pmc Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of low-grade gliomas: a clinicopathological study
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Neuro Oncol 14:230-41. 2012
    ..These factors may provide insight into developing effective treatment strategies aimed at prolonging patients' survival...
  36. pmc Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    World J Surg Oncol 9:97. 2011
    ..To date, only a few such cases with tumor-like IACNS have been reported...
  37. doi BCL2A1 is a potential biomarker for postoperative seizure control in patients with low-grade gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    CNS Neurosci Ther 19:882-8. 2013
    ..To identify molecular genetic factors that influence preoperative seizure occurrence and postoperative seizure control in patients with low-grade gliomas (LGGs)...
  38. pmc Complete genome sequence of a dengue virus serotype 4 strain isolated in Guangdong, China
    Hui Zhao
    Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 86:7021-2. 2012
    ..The sequence information provided herein will help us to understand the molecular epidemiology of dengue virus and predict the risk of severe diseases in mainland China...
  39. doi Dissociation of subtraction and multiplication in the right parietal cortex: evidence from intraoperative cortical electrostimulation
    Xiaodan Yu
    National Key Laboratory of Cognitive Neuroscience and Learning, Institute of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    Neuropsychologia 49:2889-95. 2011
    ..This dissociation between subtraction and multiplication suggests that the right parietal cortex plays a more significant role in quantity processing (subtraction) than in verbal processing (multiplication) in numerical processing...
  40. pmc MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas
    Zhu Mei Shi
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
    RNA 19:552-60. 2013
    ..Taken together, our results indicate that miR-181b functions in gliomas to suppress growth by targeting the IGF-1R oncogene and that miR-181b may serve as a novel therapeutic target for gliomas...
  41. doi Prognostic and predictive value of p53 in low MGMT expressing glioblastoma treated with surgery, radiation and adjuvant temozolomide chemotherapy
    Shouwei Li
    Glioma Treatment Center, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China
    Neurol Res 32:690-4. 2010
    ..To assess the prognostic and predictive significance of p53 protein expression in low O6-methylguanine-DNA methyltransferase (MGMT) expressing glioblastoma multiform (GBM) treated with combined therapy...
  42. ncbi Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma
    Yi Lin
    Department of Neurosurgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
    Chin Med J (Engl) 124:3042-8. 2011
    ..To evaluate its potential as a surrogate biomarker for glioma, we measured plasma IgE levels in glioma patients and healthy controls, and correlated them with clinicopathological factors and the patients' outcome...
  43. doi Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China
    Chuan bao Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
    J Cancer Res Clin Oncol 140:45-51. 2014
    ..We aimed to identify the mutation frequency of IDH genes in Chinese anaplastic glioma patients, the association of IDH gene mutation with other clinical and molecular pathological features and the prognostic value of it...
  44. doi Comparison of the clinical efficacy of temozolomide (TMZ) versus nimustine (ACNU)-based chemotherapy in newly diagnosed glioblastoma
    Yongzhi Wang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China
    Neurosurg Rev 37:73-8. 2014
    ..Our data suggest that the survival benefit of TMZ therapy is superior to that of an ACNU-based regimen in patients with extensive tumor resection, also shows greater tolerability. ..
  45. doi Cortical areas involved in numerical processing: an intraoperative electrostimulation study
    Song Pu
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Stereotact Funct Neurosurg 89:42-7. 2011
    ..Numerical processing is important in our everyday lives. However, very few attempts have been made to map the numerical processing function areas during lesion surgery...
  46. doi Correlation between tumor-related seizures and molecular genetic profile in 103 Chinese patients with low-grade gliomas: a preliminary study
    Lei Huang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    J Neurol Sci 302:63-7. 2011
    ....
  47. pmc Complete genome sequence of a chikungunya virus isolated in Guangdong, China
    Xiao Feng Li
    Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 86:8904-5. 2012
    ..The sequence information is important for surveillance of this emerging arboviral infection in China...
  48. pmc Complete genome sequence analysis of human echovirus type 30 isolated in China
    Jian Feng Han
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 86:13856-7. 2012
    ..Phylogenetic analysis showed that ECV30/GX10/05 was closely related to a Korean strain isolated in 2008. The sequence information will help in an understanding of the molecular epidemiology and evolution of echovirus...
  49. doi Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts
    Aihua Gu
    Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China
    Toxicol Sci 128:357-64. 2012
    ..Further studies with a larger sample size and ethnically diverse populations are required to elucidate the potential biological mechanism for, as well as the impact of, the susceptibility to glioma due to genetic variants of AHR...
  50. ncbi Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme
    Wen Bin Li
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 124:2589-92. 2011
    ..The diagnosis and treatment of GBM is largely guided by histopathology and immunohistochemistry. This study aimed to identify the relationship between magnetic resonance features and molecular pathology of GBM...
  51. pmc MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
    Chun zhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:229. 2010
    ..Recent studies have reported that miR-221/222 regulate cell growth and cell cycle progression by targeting p27 and p57. However the underlying mechanism involved in cell survival modulation of miR-221/222 remains elusive...
  52. ncbi Gene expression profiling reveals Ki-67 associated proliferation signature in human glioblastoma
    Qiang Jin
    Glioma Treatment Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 124:2584-8. 2011
    ..However, the driver genes or core pathways for cellular proliferation in GBM have not been elucidated systematically...
  53. ncbi Antiangiogenic therapy with bevacizumab in recurrent malignant gliomas: analysis of the response and core pathway aberrations
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 122:1250-4. 2009
    ....
  54. ncbi Relationship between magnetic resonance imaging features and miRNA gene expression in patients with glioblastoma multiforme
    Wen Bin Li
    Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    Chin Med J (Engl) 126:2881-5. 2013
    ..This study aimed to investigate the relationship between MRI features and miRNA gene expression in patients with glioblastoma multiforme...
  55. doi Understanding high grade glioma: molecular mechanism, therapy and comprehensive management
    Yongzhi Wang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Cancer Lett 331:139-46. 2013
    ....
  56. pmc MRI manifestions correlate with survival of glioblastoma multiforme patients
    Wen Bin Li
    Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    Cancer Biol Med 9:120-3. 2012
    ..To identify the correlation between magnetic resonance manifestation and survival of patients with glioblastoma multiforme (GBM)...
  57. ncbi [Whole-genome messenger RNA profiling reveals genes involved in malignant progression of glioma]
    Pei Yang
    Department of Neurosurgery, Capital Medical University, Beijing, China
    Zhonghua Yi Xue Za Zhi 93:5-7. 2013
    ..To employ whole-genome messenger RNA profiling to identify the genes involved in malignant progression in glioma...
  58. doi Nuclear translocation of β-catenin is essential for glioma cell survival
    Zhendong Shi
    Department of Neurosurgery, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Key Laboratory of Post trauma Neuro repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Medical University General Hospital, 152, Anshan Road, Heping, Tianjin, 300052, People s Republic of China
    J Neuroimmune Pharmacol 7:892-903. 2012
    ..Results from the present study provided evidence that nuclear accumulation of β-catenin participated in malignant progression of gliomas and implicated poor prognosis, highlighting it as a potential therapeutic target for gliomas...
  59. doi TLR9 expression is associated with prognosis in patients with glioblastoma multiforme
    Lige Leng
    Beijing Neurosurgical Institute, 6 Tiantan Xili Street, Beijing 100050, China Capital Medical University, Beijing, China
    J Clin Neurosci 19:75-80. 2012
    ..Because the CpG ODN is a TLR9 agonist, we recommend caution when using CpG ODN in immunotherapy...
  60. pmc TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients
    Chao Wang
    Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, China
    BMC Cancer 10:415. 2010
    ....
  61. ncbi [Biomechanical evaluation of the valgus stability of elbow after reconstruction]
    Tao Jiang
    Department of Orthopaedic Surgery, the Third People s Hospital of Mianyang, Mianyang Sichuan, 621000, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 19:141-4. 2005
    ..To evaluate of the valgus stability of the elbow after excision of the radial head, release of the medial collateral ligament (MCL), radial head replacement, and medial collateral ligament reconstruction...
  62. ncbi Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine
    Ede Qin
    Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Fengtai District, Beijing, PR China
    Vaccine 24:1028-34. 2006
    ..In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys...
  63. ncbi Proton magnetic resonance spectroscopy predicts radiotherapy response and time-to-progression in high-grade gliomas after surgery
    Jin rong Qu
    Department of Neuroradiology, Capital Medical University, Beijing, China
    Chin Med J (Engl) 125:4334-7. 2012
    ....
  64. doi Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo
    Wen Zhong Du
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    CNS Neurosci Ther 19:926-36. 2013
    ..To study the role of curcumin on glioma cells via the SHH/GLI1 pathway in vitro and vivo...
  65. ncbi Effect of intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy on clinical outcomes in patients with glioblastoma multiforme
    Yi Dong Chen
    Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    Chin Med J (Engl) 126:2320-4. 2013
    ..This study aimed to determine whether IMRT improves clinical outcomes compared with 3D-CRT in patients with GBM...
  66. doi Progress on molecular biomarkers and classification of malignant gliomas
    Chuanbao Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Front Med 7:150-6. 2013
    ..In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas...
  67. doi Functional FEN1 genetic variants and haplotypes are associated with glioma risk
    Yi Dong Chen
    Department of Radiation Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
    J Neurooncol 111:145-51. 2013
    ..Additionally, the G(-69)G(4150) haplotype was also significantly associated with increased glioma risk compared with the A(-69)T(4150) haplotype. Our results suggest that FEN1 polymorphisms and haplotypes are associated with glioma risk...
  68. pmc Circulating microRNAs in cancer: origin, function and application
    Ruimin Ma
    Laboratory Diagnosis Center, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
    J Exp Clin Cancer Res 31:38. 2012
    ..Although several challenges remain to be concerned, circulating miRNAs could be useful, non-invasive biomarkers for cancer diagnosis...
  69. doi Complete genome sequence analysis of tick-borne encephalitis viruses isolated in northeastern China
    Bing yin Si
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No 20 Dongda Street, Fengtai District, Beijing, 100071, China
    Arch Virol 156:1485-8. 2011
    ..These findings provide insight into the evolutionary relationships among Chinese TBEV isolates and are useful for laboratory diagnosis and vaccine development for TBEV...
  70. ncbi Surgical strategies for glioma involving language areas
    Zhong Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Chin Med J (Engl) 121:1800-5. 2008
    ..The present study was performed to evaluate the procedure of language mapping via intraoperative direct cortical electrical stimulation under awake anaesthesia when performed prior to resective glioma surgery...
  71. pmc Oncogene addiction in gliomas: implications for molecular targeted therapy
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili, Dongcheng District, Beijing 100050, China
    J Exp Clin Cancer Res 30:58. 2011
    ..In addition, we discuss future direction for defining complex "oncogene addiction network" through the integrated analysis of multiple platforms in the flow of genetic information in gliomagenesis...
  72. pmc Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease
    Tianyu Wang
    National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China, Graduate School of Chinese Academy of Sciences, Beijing 100039, China and State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    Nucleic Acids Res 41:7556-65. 2013
    ..coli ExoX. The crystal structures also provide insight into the structural framework of the different substrate specificities of the DnaQ family members. ..
  73. doi Recurrent glioblastoma of childhood treated with bevacizumab: case report and molecular features
    Wei Zhang
    Glioma Therapy Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
    Childs Nerv Syst 26:137-43. 2010
    ..Childhood glioblastoma multiforme (GBM) is uncommon, accounting for 7.2% of the central nervous system tumors in childhood. Their clinical behaviors are almost as aggressive as those in adults, and the 5-year overall survival rate is poor...
  74. doi The diagnosis and treatment of subependymal giant cell astrocytoma combined with tuberous sclerosis
    Tao Jiang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People s Republic of China
    Childs Nerv Syst 27:55-62. 2011
    ..Subependymal giant cell astrocytoma develops in a small proportion of tuberous sclerosis patients. There are still several controversies on the early diagnosis of the tumor, treatment of hydrocephalus, and timing of operation, etc...
  75. pmc MicroRNA roles in beta-catenin pathway
    Kai Huang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:252. 2010
    ..Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment...
  76. doi The pathogenesis of tumor-related epilepsy and its implications for clinical treatment
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Seizure 21:153-9. 2012
    ..Knowledge of these mechanisms may provide guidance in the search for new strategies for the surgical and medical treatment of tumor-related epilepsy...
  77. doi Histone deacetylase 3 implicated in the pathogenesis of children glioma by promoting glioma cell proliferation and migration
    Jin Zhu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Brain Res 1520:15-22. 2013
    ..The higher level of HDAC3 expression was associated with more advanced tumor grades and shorter survival. HDAC3 participated in the pathogenesis of children gliomas by promoting glioma cell proliferation and migration...
  78. ncbi Preoperative 3T high field blood oxygen level dependent functional magnetic resonance imaging for glioma involving sensory cortical areas
    Shao wu Li
    Neuroimaging Center, Beijing Neurosurgical Institute, Capital Medical University, China
    Chin Med J (Engl) 123:1006-10. 2010
    ....
  79. ncbi Fractionated resection on low grade gliomas involving Broca's area and insights to brain plasticity
    Chen xing Wu
    Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 121:2026-30. 2008
    ..We report the first surgical series of planned fractionated resections on LGGs within Broca's area, focusing on language functional reshaping...
  80. doi Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription
    Lei Han
    Department of Neurosurgery, Laboratory of Neuro Oncology, Tianjin Medical University General Hospital, Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government 300052, China
    Brain Res 1366:9-17. 2010
    ..These results suggest that the PI3K/AKT signaling pathway regulates glioma cell proliferation, in part via repression of the Wnt/β-catenin pathway...
  81. doi Retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 are induced but not essential for dengue virus induced type I interferon response
    Cheng feng Qin
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
    Mol Biol Rep 38:3867-73. 2011
    ..These findings suggest that innate immune pathway are involved in the recognition of DENV by human non-immune cells, and provide insights for the understanding of the molecular mechanism for DENV-induced antiviral response...
  82. pmc Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas
    Yi Lin
    LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    Neuro Oncol 11:468-76. 2009
    ..Longitudinal studies with a larger study population are needed to confirm these findings...
  83. doi Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA
    Yong Gong
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Nat Struct Mol Biol 18:1297-9. 2011
    ..The bound DNA adopts a 5'-flap conformation that facilitates 5'-AMP access to the active site, where AMP cleavage occurs by a canonical catalytic mechanism...
  84. ncbi Prognostic factors influencing clinical outcomes of glioblastoma multiforme
    Shou wei Li
    Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 122:1245-9. 2009
    ..In this retrospective study, we assessed the clinical, radiological, genetic molecular and treatment factors that influence clinical outcomes of patients with GBM...
  85. doi Supratentorial WHO grade II glioma invasion: a morphologic study using sequential conventional MRI
    Xuzhu Chen
    Department of Neuroimaging, Beijing Tiantan Hospital, Capital Medical University, Beijing, P R China
    Br J Neurosurg 24:196-201. 2010
    ..The growth of supratentorial WHO grade II glioma is a complicated process. The growth directionality may be determined by initial tumour location...
  86. doi Impact of p53 status to response of temozolomide in low MGMT expression glioblastomas: preliminary results
    Shouwei Li
    Department of Neurosurgery, No 1 Hospital of Harbin Medical University, Harbin 150001, China
    Neurol Res 30:567-70. 2008
    ..This study was designed to assess the clinical outcomes of MGMT low expression glioblastomas with different p53 statuses to the treatment of temozolomide capsule chemotherapy...