Tao Jiang

Summary

Country: China

Publications

  1. pmc Significance of miR-196b in tumor-related epilepsy of patients with gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e46218. 2012
  2. pmc Circulating microRNAs in cancer: origin, function and application
    Ruimin Ma
    Laboratory Diagnosis Center, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
    J Exp Clin Cancer Res 31:38. 2012
  3. doi The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, China
    Carcinogenesis 33:2276-82. 2012
  4. doi Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer 119:814-24. 2013
  5. pmc HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma
    Jun Xia Zhang
    Corresponding Authors Yong Ping You, PhD, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China Tao Jiang, PhD, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Chun Sheng Kang, PhD, Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
    Neuro Oncol 15:1595-603. 2013
  6. pmc Glioblastoma with an oligodendroglioma component: distinct clinical behavior, genetic alterations, and outcome
    Yongzhi Wang
    Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China
    Neuro Oncol 14:518-25. 2012
  7. doi miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2
    Lingchao Chen
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
    Eur J Cancer 48:3104-11. 2012
  8. doi Clinical correlation of MGMT protein expression and promoter methylation in Chinese glioblastoma patients
    Kai Tang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili 100050, Dongcheng District, Beijing, China
    Med Oncol 29:1292-6. 2012
  9. doi Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas
    Tao Tao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Eur J Cancer 49:3055-63. 2013
  10. pmc Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Neuro Oncol 14:1432-40. 2012

Collaborators

Detail Information

Publications99

  1. pmc Significance of miR-196b in tumor-related epilepsy of patients with gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e46218. 2012
    ..The authors set out to correlate miR-196b expression in low-grade glioma patients with pre-operative seizures and post-operative seizure control...
  2. pmc Circulating microRNAs in cancer: origin, function and application
    Ruimin Ma
    Laboratory Diagnosis Center, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
    J Exp Clin Cancer Res 31:38. 2012
    ..Although several challenges remain to be concerned, circulating miRNAs could be useful, non-invasive biomarkers for cancer diagnosis...
  3. doi The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, China
    Carcinogenesis 33:2276-82. 2012
    ..Thus, we have identified that miR-524-5p behaves as a tumor suppressor by negatively targeting Jagged-1 and Hes-1 and provides an additional option to inhibit this oncogene in gliomas...
  4. doi Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer 119:814-24. 2013
    ..The objective of this study was to identify a microRNA expression signature to improve outcome prediction for patients with primary GBM...
  5. pmc HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma
    Jun Xia Zhang
    Corresponding Authors Yong Ping You, PhD, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China Tao Jiang, PhD, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Chun Sheng Kang, PhD, Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
    Neuro Oncol 15:1595-603. 2013
    ..Long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) has been characterized as a negative prognostic factor in breast and colon cancer patients. The clinical significance and function of HOTAIR in glioma remains unclear...
  6. pmc Glioblastoma with an oligodendroglioma component: distinct clinical behavior, genetic alterations, and outcome
    Yongzhi Wang
    Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China
    Neuro Oncol 14:518-25. 2012
    ..Presence of an oligodendroglial component may therefore be a useful classification and stratification variable in therapeutic trials of GBMs...
  7. doi miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2
    Lingchao Chen
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
    Eur J Cancer 48:3104-11. 2012
    ..In conclusion, our study demonstrates that miR-137 deregulation is common in glioma, and restoration of its function inhibits cell proliferation and invasion, suggesting that miR-137 may act as a tumour suppressor...
  8. doi Clinical correlation of MGMT protein expression and promoter methylation in Chinese glioblastoma patients
    Kai Tang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili 100050, Dongcheng District, Beijing, China
    Med Oncol 29:1292-6. 2012
    ....
  9. doi Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas
    Tao Tao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Eur J Cancer 49:3055-63. 2013
    ....
  10. pmc Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Neuro Oncol 14:1432-40. 2012
    ..Our classification scheme may reflect the clinical and genetic alterations more clearly. Classical subtype-associated gene signature was not found in our dataset...
  11. pmc VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1α/VEGF and β-catenin/Tcf-4 signaling
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, China
    Neuro Oncol 14:1026-36. 2012
    ..Therefore, we demonstrated that downregulation of miR-23b suppressed tumor survival through targeting VHL, leading to the inhibition of β-catenin/Tcf-4 and HIF-1α/VEGF signaling pathways...
  12. pmc Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China
    Wei Yan
    Department of Neurosurgery, Capital Medical University, Beijing Tiantan Hospital, Beijing, China
    PLoS ONE 7:e30339. 2012
    ....
  13. doi MiR-24 regulates the proliferation and invasion of glioma by ST7L via β-catenin/Tcf-4 signaling
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300060, China
    Cancer Lett 329:174-80. 2013
    ..In conclusion, our study demonstrates that miR-24 upregulation is common in glioma and that suppression of miR-24 expression inhibits cell proliferation and invasion, suggesting that miR-24 may act as an oncogene in glioma...
  14. pmc miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression
    Wei Zhang
    Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China
    Neuro Oncol 14:712-9. 2012
    ..Together, these results suggest that miR-181d is a predictive biomarker for TMZ response and that its role is mediated, in part, by posttranscriptional regulation of MGMT...
  15. doi MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1
    Yanwei Liu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China
    Oncol Rep 28:1013-21. 2012
    ....
  16. doi Management and survival rates in patients with glioma in China (2004-2010): a retrospective study from a single-institution
    Pei Yang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China
    J Neurooncol 113:259-66. 2013
    ..Age, preoperative KPS, tumor grades, radiotherapy, chemotherapy and Ki-67 expression were significantly associated with clinical prognosis...
  17. doi Prognostic and predictive value of p53 in low MGMT expressing glioblastoma treated with surgery, radiation and adjuvant temozolomide chemotherapy
    Shouwei Li
    Glioma Treatment Center, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China
    Neurol Res 32:690-4. 2010
    ..To assess the prognostic and predictive significance of p53 protein expression in low O6-methylguanine-DNA methyltransferase (MGMT) expressing glioblastoma multiform (GBM) treated with combined therapy...
  18. ncbi [Correlation between loss of heterozygosity on chromosome 1p and 19q and expression of MGMT, p53 and Ki-67 proteins in gliomas]
    Lei Huang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Zhonghua Zhong Liu Za Zhi 33:752-8. 2011
    ..To study the correlation of loss of heterozygosity (LOH) on chromosome 1p and 19q with the expression of MGMT, p53 and Ki-67 proteins in gliomas...
  19. pmc High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression
    Junxia Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, China
    Neuro Oncol 13:600-9. 2011
    ..Taken together, we have demonstrated that Tcf-4 is associated with glioma progression and that AKT2 is a new member of the genes that are regulated by β-catenin/Tcf-4...
  20. doi Identifying Ki-67 specific miRNA-mRNA interactions in malignant astrocytomas
    Yanwei Liu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Neurosci Lett 546:36-41. 2013
    ..Conclusions: Ki-67 protein may be regulated by specific miRNA-mRNA interactions which may contribute to the proliferation of glioma cells...
  21. pmc Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility
    Peng Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    BMC Cancer 13:234. 2013
    ..We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development...
  22. pmc Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN
    Xi Rui Wang
    Corresponding Authors Yong Ping You, PhD, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Ning Liu, PhD, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029 China
    Neuro Oncol 15:1491-501. 2013
    ..The goal of this study was to investigate the function of lethal (let)-7a miRNA in glioma cell lines with different PTEN phenotypes...
  23. ncbi BCL2A1 is a potential biomarker for postoperative seizure control in patients with low-grade gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    CNS Neurosci Ther 19:882-8. 2013
    ..To identify molecular genetic factors that influence preoperative seizure occurrence and postoperative seizure control in patients with low-grade gliomas (LGGs)...
  24. doi Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, No 6 Tiantan Xili, Dongcheng District, Beijing 100050, China
    Brain Res 1411:108-15. 2011
    ..To our knowledge, this is the first study to identify the MMP-9 specific microRNA signature which may provide potential targets for anti-invasion therapy in GBM...
  25. pmc Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype
    Ruimin Ma
    Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e38096. 2012
    ..To explore the expression pattern, prognostic value and functional role of miR-196b in glioblastoma (GBM) patients using large cohorts...
  26. pmc Molecular prognostic factors of anaplastic oligodendroglial tumors and its relationship: a single institutional review of 77 patients from China
    Shouwei Li
    Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, China
    Neuro Oncol 14:109-16. 2012
    ..Inter-relationship between LOH 1p, LOH 19q, IDH1 mutation, MGMT promoter methylation, and MGMT expression level were also revealed. Future clinical trials for AO and AOA should consider the molecular alterations of patients...
  27. pmc Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study
    Peng Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    BMC Cancer 12:617. 2012
    ..Potential links between polymorphisms of antioxidant genes and glioma risk are currently unknown. We therefore investigated the association between polymorphisms in antioxidant genes and glioma risk...
  28. pmc A chimeric dengue virus vaccine using Japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates
    Xiao Feng Li
    Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 87:13694-705. 2013
    ....
  29. doi Recurrent glioblastoma of childhood treated with bevacizumab: case report and molecular features
    Wei Zhang
    Glioma Therapy Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
    Childs Nerv Syst 26:137-43. 2010
    ..Childhood glioblastoma multiforme (GBM) is uncommon, accounting for 7.2% of the central nervous system tumors in childhood. Their clinical behaviors are almost as aggressive as those in adults, and the 5-year overall survival rate is poor...
  30. doi Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China
    Chuan bao Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
    J Cancer Res Clin Oncol 140:45-51. 2014
    ..We aimed to identify the mutation frequency of IDH genes in Chinese anaplastic glioma patients, the association of IDH gene mutation with other clinical and molecular pathological features and the prognostic value of it...
  31. doi Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer Lett 328:120-5. 2013
    ..Taken together, our results defined prognosis-related methylation signatures systematically for the first time in G-CIMP- primary GBMs. ALDH1A3 promoter methylation conferred a favorable prognosis in G-CIMP- primary GBMs...
  32. doi Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways
    Yongzhi Wang
    Glioma Center, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China
    Oncol Rep 26:1173-80. 2011
    ..These findings strongly support the hypothesis that STAT3 inhibition significantly improves the clinical efficacy of alkylating agents...
  33. pmc Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression
    Yongsheng Li
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150080, China, Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing 100050, China, College of Fundamental Medical Sciences, Harbin Medical University, Harbin 150080, China and Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin 300052, China
    Nucleic Acids Res 41:e203. 2013
    ..Therefore, network-based biomarkers are expected to be more effective and provide deep insights into the molecular mechanism of glioma malignant progression. ..
  34. pmc Complete genome sequence of dengue virus serotype 2 Cosmopolitan genotype strain in Guangdong, China
    Hui Zhao
    Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 86:13808-9. 2012
    ..The reemergence of the Cosmopolitan genotype of DENV-2 in China deserves further investigation...
  35. pmc BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas
    Zhaoshi Bao
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    J Transl Med 11:100. 2013
    ..However, the prognostic and molecular features of gliomas with BMP4 expression is still unclear...
  36. pmc Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    World J Surg Oncol 9:97. 2011
    ..To date, only a few such cases with tumor-like IACNS have been reported...
  37. pmc Novel cis-acting element within the capsid-coding region enhances flavivirus viral-RNA replication by regulating genome cyclization
    Zhong Yu Liu
    Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 87:6804-18. 2013
    ....
  38. pmc ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples samples
    Jinquan Cai
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Oncotarget 5:2551-61. 2014
    ..The molecular stratification in astrocytic tumors may aid in treatment strategy selection, therapeutic trial design, and clinical prognosis evaluation. ..
  39. doi Prognostic value of a nine-gene signature in glioma patients based on mRNA expression profiling
    Zhao Shi Bao
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    CNS Neurosci Ther 20:112-8. 2014
    ..Gliomas are the most common primary brain tumors in adults and a significant cause of cancer-related mortality. A 9-gene signature was identified as a novel prognostic model reflecting survival situation obviously in gliomas...
  40. pmc Global transcriptomic analysis of human neuroblastoma cells in response to enterovirus type 71 infection
    Li Juan Xu
    Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 8:e65948. 2013
    ..Overall, our results provided fundamental information regarding the host response to EV71 infection in human neuroblastoma cells, and this finding will help explain the pathogenesis of EV71 infection and virus-host interaction. ..
  41. doi MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma
    Rui Yan Li
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    CNS Neurosci Ther 19:477-83. 2013
    ..The mechanisms underlying its dysregulation have not been clarified. In this study, we explored the involvement of micro-RNAs that acted as endogenous sequence-specific suppressors of gene expression...
  42. pmc Development and characterization of the replicon system of Japanese encephalitis live vaccine virus SA14-14-2
    Shi Hua Li
    Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
    Virol J 10:64. 2013
    ..Many kinds of flavivirus replicons have been developed with broad applications...
  43. doi MicroRNA-21 expression is regulated by β-catenin/STAT3 pathway and promotes glioma cell invasion by direct targeting RECK
    Lei Han
    Department of Neurosurgery, Tianjin Medical University General Hospital, China
    CNS Neurosci Ther 18:573-83. 2012
    ..Recent studies report that miR-21 regulates cell invasion by targeting RECK, however, the underlying transcriptional regulation of miR-21 in glioma cells remains elusive...
  44. ncbi Relationship between magnetic resonance imaging features and miRNA gene expression in patients with glioblastoma multiforme
    Wen Bin Li
    Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    Chin Med J (Engl) 126:2881-5. 2013
    ..This study aimed to investigate the relationship between MRI features and miRNA gene expression in patients with glioblastoma multiforme...
  45. pmc Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of low-grade gliomas: a clinicopathological study
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Neuro Oncol 14:230-41. 2012
    ..These factors may provide insight into developing effective treatment strategies aimed at prolonging patients' survival...
  46. pmc In vitro characterization of human adenovirus type 55 in comparison with its parental adenoviruses, types 11 and 14
    Juan Liu
    Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China Department of Transfusion Medicine, General Hospital of PLA Air Force, Beijing, China
    PLoS ONE 9:e100665. 2014
    ..Together, the findings described here expand current knowledge about this re-emerging recombinant HAdV, shedding light on the pathogenesis of HAdV-B55. ..
  47. doi Correlation between tumor-related seizures and molecular genetic profile in 103 Chinese patients with low-grade gliomas: a preliminary study
    Lei Huang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    J Neurol Sci 302:63-7. 2011
    ....
  48. pmc Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression
    Li Juan Xu
    Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China PLA 404 Hospital, Weihai, Shandong, China
    PLoS ONE 9:e95272. 2014
    ..These findings provide new information on the miRNA and mRNA profiles of HEV71-infected neuroblastoma cells. The biological significance of miR-1246 and DLG3 during the course of HEV71 infection deserves further investigation. ..
  49. pmc Induction of neutralizing antibodies against four serotypes of dengue viruses by MixBiEDIII, a tetravalent dengue vaccine
    Hui Zhao
    Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 9:e86573. 2014
    ..Our data demonstrated that MixBiEDIII, as a novel form of subunit vaccine candidates, might have the potential to be further developed as a tetravalent dengue vaccine in the near future. ..
  50. pmc Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas
    Yi Lin
    LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    Neuro Oncol 11:468-76. 2009
    ..Longitudinal studies with a larger study population are needed to confirm these findings...
  51. ncbi Gene expression profiling reveals Ki-67 associated proliferation signature in human glioblastoma
    Qiang Jin
    Glioma Treatment Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 124:2584-8. 2011
    ..However, the driver genes or core pathways for cellular proliferation in GBM have not been elucidated systematically...
  52. pmc Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009
    Tao Jiang
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No 20 Dongda Street, Fengtai District, Beijing 100071, China
    Virol J 9:125. 2012
    ..Careful investigation and virological analysis should be warranted in the future...
  53. ncbi Dissociation of subtraction and multiplication in the right parietal cortex: evidence from intraoperative cortical electrostimulation
    Xiaodan Yu
    National Key Laboratory of Cognitive Neuroscience and Learning, Institute of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    Neuropsychologia 49:2889-95. 2011
    ..This dissociation between subtraction and multiplication suggests that the right parietal cortex plays a more significant role in quantity processing (subtraction) than in verbal processing (multiplication) in numerical processing...
  54. pmc Complete genome sequence of a dengue virus serotype 4 strain isolated in Guangdong, China
    Hui Zhao
    Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 86:7021-2. 2012
    ..The sequence information provided herein will help us to understand the molecular epidemiology of dengue virus and predict the risk of severe diseases in mainland China...
  55. doi Progress on molecular biomarkers and classification of malignant gliomas
    Chuanbao Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Front Med 7:150-6. 2013
    ..In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas...
  56. ncbi Preoperative 3T high field blood oxygen level dependent functional magnetic resonance imaging for glioma involving sensory cortical areas
    Shao wu Li
    Neuroimaging Center, Beijing Neurosurgical Institute, Capital Medical University, China
    Chin Med J (Engl) 123:1006-10. 2010
    ....
  57. doi Comparison of the clinical efficacy of temozolomide (TMZ) versus nimustine (ACNU)-based chemotherapy in newly diagnosed glioblastoma
    Yongzhi Wang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China
    Neurosurg Rev 37:73-8. 2014
    ..Our data suggest that the survival benefit of TMZ therapy is superior to that of an ACNU-based regimen in patients with extensive tumor resection, also shows greater tolerability. ..
  58. ncbi Antiangiogenic therapy with bevacizumab in recurrent malignant gliomas: analysis of the response and core pathway aberrations
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 122:1250-4. 2009
    ....
  59. doi Histone deacetylase 3 implicated in the pathogenesis of children glioma by promoting glioma cell proliferation and migration
    Jin Zhu
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Brain Res 1520:15-22. 2013
    ..The higher level of HDAC3 expression was associated with more advanced tumor grades and shorter survival. HDAC3 participated in the pathogenesis of children gliomas by promoting glioma cell proliferation and migration...
  60. doi Cortical areas involved in numerical processing: an intraoperative electrostimulation study
    Song Pu
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Stereotact Funct Neurosurg 89:42-7. 2011
    ..Numerical processing is important in our everyday lives. However, very few attempts have been made to map the numerical processing function areas during lesion surgery...
  61. pmc MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas
    Zhu Mei Shi
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
    RNA 19:552-60. 2013
    ..Taken together, our results indicate that miR-181b functions in gliomas to suppress growth by targeting the IGF-1R oncogene and that miR-181b may serve as a novel therapeutic target for gliomas...
  62. ncbi Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma
    Yi Lin
    Department of Neurosurgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
    Chin Med J (Engl) 124:3042-8. 2011
    ..To evaluate its potential as a surrogate biomarker for glioma, we measured plasma IgE levels in glioma patients and healthy controls, and correlated them with clinicopathological factors and the patients' outcome...
  63. pmc MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab
    Kai Liang Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital Laboratory of Neuro Oncology, Tianjin Neurological Institute Key Laboratory of Post trauma Neuro repair and Regeneration in Central Nervous System, Ministry of Education Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China
    Mol Cancer 13:63. 2014
    ..Whether microRNAs can impact the therapeutic effects of EGFR inhibitors in glioblastoma is unknown...
  64. ncbi Dynamic radiological change of gliomas located in the paralimbic system and its clinical significance
    Xu zhu Chen
    Department of Neuroimaging, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 121:713-5. 2008
    ..The purpose of this study was to identify the growth tendency of gliomas located in the paralimbic system and to obtain some suggestions for clinical treatment...
  65. pmc MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
    Chun zhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:229. 2010
    ..Recent studies have reported that miR-221/222 regulate cell growth and cell cycle progression by targeting p27 and p57. However the underlying mechanism involved in cell survival modulation of miR-221/222 remains elusive...
  66. doi Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts
    Aihua Gu
    Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China
    Toxicol Sci 128:357-64. 2012
    ..Further studies with a larger sample size and ethnically diverse populations are required to elucidate the potential biological mechanism for, as well as the impact of, the susceptibility to glioma due to genetic variants of AHR...
  67. doi Development of RT-LAMP and real-time RT-PCR assays for the rapid detection of the new duck Tembusu-like BYD virus
    Tao Jiang
    State Key Laboratory of Pathogen and Biosecurity, Department of Virology, Beijing Institute of Microbiology and Epidemiology, Fengtai District, 100071 Beijing, China
    Arch Virol 157:2273-80. 2012
    ..The TMUV-specific RT-LAMP and real-time RT-PCR assays will provide useful tools for the diagnosis and epidemiological surveillance of TMUV infection...
  68. pmc Complete genome sequence analysis of human echovirus type 30 isolated in China
    Jian Feng Han
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 86:13856-7. 2012
    ..Phylogenetic analysis showed that ECV30/GX10/05 was closely related to a Korean strain isolated in 2008. The sequence information will help in an understanding of the molecular epidemiology and evolution of echovirus...
  69. pmc Complete genome sequence of a chikungunya virus isolated in Guangdong, China
    Xiao Feng Li
    Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    J Virol 86:8904-5. 2012
    ..The sequence information is important for surveillance of this emerging arboviral infection in China...
  70. pmc High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
    Chunzhi Zhang
    Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China
    J Transl Med 10:119. 2012
    ..MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression and apoptosis, respectively. However, the association of miR-221/222 with glioma cell invasion and survival remains unknown...
  71. doi TLR9 expression is associated with prognosis in patients with glioblastoma multiforme
    Lige Leng
    Beijing Neurosurgical Institute, 6 Tiantan Xili Street, Beijing 100050, China Capital Medical University, Beijing, China
    J Clin Neurosci 19:75-80. 2012
    ..Because the CpG ODN is a TLR9 agonist, we recommend caution when using CpG ODN in immunotherapy...
  72. ncbi Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme
    Wen Bin Li
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 124:2589-92. 2011
    ..The diagnosis and treatment of GBM is largely guided by histopathology and immunohistochemistry. This study aimed to identify the relationship between magnetic resonance features and molecular pathology of GBM...
  73. ncbi Fractionated resection on low grade gliomas involving Broca's area and insights to brain plasticity
    Chen xing Wu
    Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 121:2026-30. 2008
    ..We report the first surgical series of planned fractionated resections on LGGs within Broca's area, focusing on language functional reshaping...
  74. ncbi Surgical strategies for glioma involving language areas
    Zhong Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Chin Med J (Engl) 121:1800-5. 2008
    ..The present study was performed to evaluate the procedure of language mapping via intraoperative direct cortical electrical stimulation under awake anaesthesia when performed prior to resective glioma surgery...
  75. ncbi Preoperative blood oxygen level-dependent functional magnetic resonance imaging in patients with gliomas involving the motor cortical areas
    Jian Xie
    Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 121:631-5. 2008
    ..This study aimed to assess the value of fMRI in presurgical planning and functional outcome of patients with gliomas in the motor cortical areas...
  76. ncbi Basic fibroblast growth factor inhibits radiation-induced apoptosis of HUVECs. I. The PI3K/AKT pathway and induction of phosphorylation of BAD
    Qingyang Gu
    Department of Pathology, Beijing Institute of Radiation Medicine, Beijing, China
    Radiat Res 161:692-702. 2004
    ..Activation of the PI3K/AKT pathway plays an important role in bFGF-induced endothelial cell survival in the treatment of radiation-induced skin ulcers...
  77. ncbi [Effects of three different etching methods on surface morphology and element of pure titanium]
    Tao Jiang
    School of Stomatology, Wuhan University, Wuhan 430079, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23:814-7. 2006
    ..The substances were TiO2, Ti2O3, TiO and metal Ti on the surface etched with HNO3 or hot H2SO4/H2O2. Only TiO2 was detected on the surface etched with hot H2SO4/HCl...
  78. pmc Preservation of non-heart-beating donor livers in extracorporeal liver perfusion and histidine-trytophan-ketoglutarate solution
    Jin Gong
    Department of Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China
    World J Gastroenterol 14:2338-42. 2008
    ..To compare the preservation of non-heart-beating donor (NHBD) livers in cold histidine-trytophan-ketoglutarate (HTK) solution and extracorporeal liver perfusion (ECLP)...
  79. ncbi Establishment and evaluation of the system of extracorporeal liver perfusion in pigs
    Jin Gong
    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hepatobiliary Pancreat Dis Int 4:94-7. 2005
    ..The purpose of this experiment was to detect the factors affecting the system of ECLP and to establish a stable and effective system of ECLP...
  80. ncbi [Association between genetic polymorphisms of ERCC1, XRCC1, GSTP1 and survival of advanced gastric cancer patients treated with oxaliplatin/5-Fu-based chemotherapy]
    Jun Liang
    Department of Oncology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China
    Zhonghua Zhong Liu Za Zhi 32:515-9. 2010
    ....
  81. ncbi [Surgical treatment for maxillary sinus benign diseases under nasal endoscopy]
    Wenzhong Wang
    Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 22:645-6. 2008
    ..To investigate the surgical methods to treat maxillary sinus benign diseases with nasal endoscopy...
  82. ncbi Significance of margin in nephron sparing surgery for renal cell carcinoma of 4 cm or less
    Quan lin Li
    Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China
    Chin Med J (Engl) 121:1662-5. 2008
    ..We explored whether margin size has significant impacts on clinical outcomes in nephron sparing surgery for renal cell carcinoma of 4 cm or less...
  83. pmc Silencing of heat shock protein 70 expression enhances radiotherapy efficacy and inhibits cell invasion in endometrial cancer cell line
    Xue lian Du
    Department of Gynecologic Oncology, Shandong Tumor Hospital, Shandong University, No 440, Jiyan Road, Jinan, China 250117
    Croat Med J 50:143-50. 2009
    ..To investigate the role of heat shock proteins 70 (HSP70) in radiosensitivity and invasiveness of endometrial cancer in vitro...
  84. ncbi [Applied anatomy study of optic canal by transnasal endoscopy]
    Jianyao Zhang
    Department of Otolaryngology, Yinzhou People s Hospital of Ningbo, Ningbo, 315040, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23:346-8. 2009
    ..To provide transnasal endoscopic optic canal decompression with the anatomic reference...
  85. pmc Oncogene addiction in gliomas: implications for molecular targeted therapy
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili, Dongcheng District, Beijing 100050, China
    J Exp Clin Cancer Res 30:58. 2011
    ..In addition, we discuss future direction for defining complex "oncogene addiction network" through the integrated analysis of multiple platforms in the flow of genetic information in gliomagenesis...
  86. pmc TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients
    Chao Wang
    Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, China
    BMC Cancer 10:415. 2010
    ....
  87. doi Complete genome sequence analysis of tick-borne encephalitis viruses isolated in northeastern China
    Bing yin Si
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No 20 Dongda Street, Fengtai District, Beijing, 100071, China
    Arch Virol 156:1485-8. 2011
    ..These findings provide insight into the evolutionary relationships among Chinese TBEV isolates and are useful for laboratory diagnosis and vaccine development for TBEV...
  88. ncbi Prognostic factors influencing clinical outcomes of glioblastoma multiforme
    Shou wei Li
    Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 122:1245-9. 2009
    ..In this retrospective study, we assessed the clinical, radiological, genetic molecular and treatment factors that influence clinical outcomes of patients with GBM...
  89. doi The diagnosis and treatment of subependymal giant cell astrocytoma combined with tuberous sclerosis
    Tao Jiang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People s Republic of China
    Childs Nerv Syst 27:55-62. 2011
    ..Subependymal giant cell astrocytoma develops in a small proportion of tuberous sclerosis patients. There are still several controversies on the early diagnosis of the tumor, treatment of hydrocephalus, and timing of operation, etc...
  90. doi Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription
    Lei Han
    Department of Neurosurgery, Laboratory of Neuro Oncology, Tianjin Medical University General Hospital, Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government 300052, China
    Brain Res 1366:9-17. 2010
    ..These results suggest that the PI3K/AKT signaling pathway regulates glioma cell proliferation, in part via repression of the Wnt/β-catenin pathway...
  91. doi The pathogenesis of tumor-related epilepsy and its implications for clinical treatment
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Seizure 21:153-9. 2012
    ..Knowledge of these mechanisms may provide guidance in the search for new strategies for the surgical and medical treatment of tumor-related epilepsy...
  92. doi Impact of p53 status to response of temozolomide in low MGMT expression glioblastomas: preliminary results
    Shouwei Li
    Department of Neurosurgery, No 1 Hospital of Harbin Medical University, Harbin 150001, China
    Neurol Res 30:567-70. 2008
    ..This study was designed to assess the clinical outcomes of MGMT low expression glioblastomas with different p53 statuses to the treatment of temozolomide capsule chemotherapy...
  93. pmc MicroRNA roles in beta-catenin pathway
    Kai Huang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:252. 2010
    ..Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment...
  94. ncbi Proton magnetic resonance spectroscopy predicts radiotherapy response and time-to-progression in high-grade gliomas after surgery
    Jin rong Qu
    Department of Neuroradiology, Capital Medical University, Beijing, China
    Chin Med J (Engl) 125:4334-7. 2012
    ....
  95. ncbi Prevalence estimates for primary brain tumors in China: a multi-center cross-sectional study
    Tao Jiang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Chin Med J (Engl) 124:2578-83. 2011
    ..This study aimed to report a comprehensive assessment on the prevalence of PBT...
  96. doi Retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 are induced but not essential for dengue virus induced type I interferon response
    Cheng feng Qin
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China
    Mol Biol Rep 38:3867-73. 2011
    ..These findings suggest that innate immune pathway are involved in the recognition of DENV by human non-immune cells, and provide insights for the understanding of the molecular mechanism for DENV-induced antiviral response...
  97. doi Supratentorial WHO grade II glioma invasion: a morphologic study using sequential conventional MRI
    Xuzhu Chen
    Department of Neuroimaging, Beijing Tiantan Hospital, Capital Medical University, Beijing, P R China
    Br J Neurosurg 24:196-201. 2010
    ..The growth of supratentorial WHO grade II glioma is a complicated process. The growth directionality may be determined by initial tumour location...
  98. ncbi [Function magnetic resonance imaging and diffusion tensor tractography in patients with brain gliomas involving motor areas: clinical application and outcome]
    Zi xiao Li
    Neuroradiology Center of the Capital University of Medical Sciences, Affiliated Beijing Neurosurgery Institute, Beijing 100050, China
    Zhonghua Wai Ke Za Zhi 44:1275-9. 2006
    ....
  99. ncbi [Effect of intraischemic mild hypothermia on interleukin-1beta and monocyte chemoattractant protein-1 contents in ischemic core of rat cortex after transient focal cerebral ischemia]
    Li Xian Li
    Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    Zhonghua Yi Xue Za Zhi 83:541-3. 2003
    ..To investigate the effect of intraischemic mild hypothermia on the protein levels of interleukin (IL)-1beta and monocyte chemoattractant protein (MCP)-1 in the ischemic core of rat cortex after transient focal cerebralischemia...