Hong Jiang

Summary

Country: China

Publications

  1. pmc A rare Von Hippel-Lindau disease that mimics acute myelitis: case report and review of the literature
    Hong Jiang
    Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People s Republic of China
    Neurol Sci 32:305-7. 2011
  2. pmc Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4
    Jiping Yi
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
    PLoS ONE 8:e54792. 2013
  3. doi [MicroRNAs and polyglutamine diseases]
    Li Zhang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30:683-6. 2013
  4. doi [Cloning and localization of A3IP -a novel protein that interacts with ataxin-3]
    Feng zhen Huang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30:394-8. 2013
  5. doi [Spinal muscular atrophy mimicking myotonic dystrophy: a case report and clinical, pathological and genetic analysis]
    Li Xia Luo
    Department of Neurology, Central South University, Changsha, Hunan, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:455-8. 2012
  6. doi [Histone deacetylase inhibitors as therapeutic agents for polyglutamine disorders]
    Hong Jiang
    Department of Neurology, Xiangya Hospital Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, 410008 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:52-5. 2010
  7. ncbi [Clinical and pathologic analysis of an autosomal recessive kindred with nemaline myopathy]
    Hong Jiang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Yi Xue Za Zhi 89:3316-9. 2009
  8. doi Analysis of SCA2 and SCA3/MJD repeats in Parkinson's disease in mainland China: genetic, clinical, and positron emission tomography findings
    Jun ling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People s Republic of China
    Mov Disord 24:2007-11. 2009
  9. ncbi [Mutation analysis of DJ1 gene in patients with autosomal recessive early-onset Parkinsonism]
    Ji Feng Guo
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:641-3. 2005
  10. doi Expansion of the phenotypic spectrum of SPG6 caused by mutation in NIPA1
    Juan Du
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    Clin Neurol Neurosurg 113:480-2. 2011

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. pmc A rare Von Hippel-Lindau disease that mimics acute myelitis: case report and review of the literature
    Hong Jiang
    Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People s Republic of China
    Neurol Sci 32:305-7. 2011
    ..This study further confirmed that VHL is of highly clinical, imaging, and pathological heterogeneity. Diagnosis for VHL should be based on combination of clinical, radiological, pathological, and genetic data...
  2. pmc Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4
    Jiping Yi
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
    PLoS ONE 8:e54792. 2013
    ..These results collectively support the premise that VPA is a promising therapeutic agent for the treatment of SCA3 and other polyQ diseases...
  3. doi [MicroRNAs and polyglutamine diseases]
    Li Zhang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30:683-6. 2013
    ..This review will focus on the roles of microRNAs in the pathogenesis of PolyQ diseases and their potential use for therapy. ..
  4. doi [Cloning and localization of A3IP -a novel protein that interacts with ataxin-3]
    Feng zhen Huang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30:394-8. 2013
    ..To clone an A3IP gene and investigate its cellular and histological localization based on previous research which has identified part of A3IP sequence interacting with carboxyl-terminal of ataxin-3...
  5. doi [Spinal muscular atrophy mimicking myotonic dystrophy: a case report and clinical, pathological and genetic analysis]
    Li Xia Luo
    Department of Neurology, Central South University, Changsha, Hunan, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:455-8. 2012
    ..To investigate a patient featuring a complex neuromuscular disease phenotype...
  6. doi [Histone deacetylase inhibitors as therapeutic agents for polyglutamine disorders]
    Hong Jiang
    Department of Neurology, Xiangya Hospital Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, 410008 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:52-5. 2010
    ....
  7. ncbi [Clinical and pathologic analysis of an autosomal recessive kindred with nemaline myopathy]
    Hong Jiang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Yi Xue Za Zhi 89:3316-9. 2009
    ..To investigate the clinical, pathological and ultrastructural features of nemaline myopathy (NM)...
  8. doi Analysis of SCA2 and SCA3/MJD repeats in Parkinson's disease in mainland China: genetic, clinical, and positron emission tomography findings
    Jun ling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People s Republic of China
    Mov Disord 24:2007-11. 2009
    ..8%) in the MJD1 locus. [(11)C]-CFT PET in detected members in SCA2 and SCA3/MJD families showed decrements of (11)C-CFT uptake. These findings suggest that a mutation in SCA2 or SCA3/MJD may be one of the genetic causes of PD...
  9. ncbi [Mutation analysis of DJ1 gene in patients with autosomal recessive early-onset Parkinsonism]
    Ji Feng Guo
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:641-3. 2005
    ..To investigate the mutation characteristics of DJ1 gene in Chinese patients with autosomal recessive early-onset Parkinsonism (AR-EP)...
  10. doi Expansion of the phenotypic spectrum of SPG6 caused by mutation in NIPA1
    Juan Du
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    Clin Neurol Neurosurg 113:480-2. 2011
    ..Hereditary spastic paraplegia type 6 (SPG6) is caused by mutations in the NIPA1 gene, this is a rare cause of HSP, until now, all the affected individuals reported displayed "pure" spastic paraplegia...
  11. ncbi Research on screening and identification of proteins interacting with ataxin-3
    Lu Shen
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:242-7. 2005
    ....
  12. ncbi [Mutation analysis of small heat shock protein 27 gene in Chinese patients with Charcot-Marie-Tooth disease]
    Xiao Min Liu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:510-3. 2005
    ..To investigate the features of small heat shock protein 27 (HSP27) gene mutation in Chinese patients with Charcot-Marie-Tooth disease (CMT)...
  13. doi A spinocerebellar ataxia family with expanded alleles in the TATA-binding protein gene and ataxin-3 gene
    Qian Xu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
    Int J Neurosci 120:159-61. 2010
    ..The study also provides us a novel conception that mutations from two pathogenetic genes may coexist in one patient and SCA-affected patients with intermediate allele need to be further excluded for other SCA subtypes...
  14. ncbi Lithium chloride alleviates neurodegeneration partly by inhibiting activity of GSK3β in a SCA3 Drosophila model
    Dan dan Jia
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
    Cerebellum 12:892-901. 2013
    ..Taken together, our findings suggest that lithium is a promising therapeutic agent for the treatment of SCA3 and other PolyQ diseases. ..
  15. ncbi Mutation analysis of the small heat shock protein 27 gene in chinese patients with Charcot-Marie-Tooth disease
    Beisha Tang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, People s Republic of China
    Arch Neurol 62:1201-7. 2005
    ..Recently, mutations in small heat shock protein 27 (Hsp27) were reported to cause CMT disease type 2F and distal hereditary motor neuropathy...
  16. pmc SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity
    Ya fang Zhou
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
    PLoS ONE 8:e54214. 2013
    ..Our findings revealed the role of ataxin-3 SUMOylation in SCA3/MJD pathogenesis...
  17. doi Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population
    Lei Wang
    Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China
    J Clin Neurosci 18:541-4. 2011
    ....
  18. doi Spinocerebellar ataxia type 11 in the Chinese Han population
    Qian Xu
    Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, China
    Neurol Sci 31:107-9. 2010
    ..All analyzed samples displayed the normal elution profile, which denoted that no disease-related mutation was identified. We provided the evidence that SCA11 is a rare form of ataxia in China...
  19. doi TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing
    Jun ling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China
    Brain 133:3510-8. 2010
    ....
  20. ncbi Mutation analysis of PRRT2 in two Chinese BFIS families and nomenclature of PRRT2 related paroxysmal diseases
    Jun ling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China
    Neurosci Lett 552:40-5. 2013
    ....
  21. ncbi Mutation analysis of the ATM gene in two Chinese patients with ataxia telangiectasia
    Hong Jiang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    J Neurol Sci 241:1-6. 2006
    ..To our knowledge, this is the first report of ATM mutations in Mainland China, in which the transversions 1346G>C (Gly449Ala) and 610G>T (Gly204Stop) are two novel, disease-causing mutations...
  22. ncbi [Mutation analysis of GCH1 gene in Chinese patients with dopa responsive dystonia]
    Jing Li
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:302-4. 2007
    ..To detect mutations of guanosine triphosphate cyclohydrolase I (GCH1) gene in Chinese patients with dopa responsive dystonia (DRD)...
  23. ncbi [Detection of the CAG trinucleotide repeats of MJD1 gene by recombinant DNA technology]
    Shen Zhang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:406-9. 2009
    ..To establish a stable, accurate and intuitive method for detecting the CAG trinucleotide repeats of MJD1 gene...
  24. ncbi [Frequency of different subtypes of spinocerebellar ataxia in the Han nationality of Hunan province in China]
    Xing wang Song
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:702-5. 2006
    ..To determine the frequency of different subtypes of spinocerebellar ataxias (SCAs) in the Han nationality of Hunan province in China...
  25. doi Spinocerebellar ataxia type 27 (SCA27) is an uncommon cause of dominant ataxia among Chinese Han population
    Zhao Chen
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 520:16-9. 2012
    ..10delC) characterized by different clinical features, which is probably a novel insertion/deletion (I/D) polymorphism in the 5'UTR region of the exon 1b. It suggests that SCA27 is a rare subtype in China...
  26. ncbi Spinocerebellar ataxia type 6 in Mainland China: molecular and clinical features in four families
    Hong Jiang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    J Neurol Sci 236:25-9. 2005
    ..In the 4 families with SCA6, we found significant anticipation in the absence of genetic instability on transmission. This is the first report of geographic cluster of families with SCA6 subtype in Mainland China...
  27. doi Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism
    Ji Feng Guo
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People s Republic of China
    Mov Disord 23:2074-9. 2008
    ..Mutations of DJ-1 and PINK1 gene are also found in Chinese families with AREP. Mutations in ATP13A2 gene may be rare in Chinese families with AREP...
  28. doi Spinocerebellar ataxias in mainland China: an updated genetic analysis among a large cohort of familial and sporadic cases
    Junling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:482-9. 2011
    ..To undertake an updated genetic spectrum analysis in patients with hereditary spinocerebellar ataxia (SCA) in mainland China...
  29. doi Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population
    Xing Zuo
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 481:69-72. 2010
    ..We concluded that the two markers rs9652490 and rs11856808 were not strongly related to the development of ET or late onset SPD, but the rs9652490G allele might be a protective factor for EOPD in Chinese population...
  30. doi Transglutaminase 6 interacts with polyQ proteins and promotes the formation of polyQ aggregates
    Wen Juan Guan
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
    Biochem Biophys Res Commun 437:94-100. 2013
    ..These data suggest that transglutaminase 6 could be involved in polyQ diseases and there may exist a common pathological link between polyQ associated SCA and SCA35. ..
  31. ncbi [Mutation detection of parkin gene by denaturing high performance liquid chromatography]
    Jing Li
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:449-52. 2007
    ..To detect parkin gene mutation of early-onset parkinsonism (EOP) by denaturing high performance liquid chromatography (DHPLC)...
  32. doi [Studies on the CAG repeat expansion in patients with hereditary spinocerebellar ataxia from Chinese Han]
    Junling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:620-5. 2009
    ..To investigate the CAG trinucleotide repeat expansion in spinocerebellar ataxia (SCA) types 1, 2, 3, 6, 7, 12, and 17 from Chinese Han...
  33. doi Mutation detection in candidate genes for benign familial infantile seizures on a novel locus
    Nan Li
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Int J Neurosci 120:217-21. 2010
    ..The analyses suggest those candidate genes that were detected might not be involved in the epileptogenesis of pure BFIS, at least in the Chinese family we studied...
  34. doi Spinocerebellar ataxia type 23 is an uncommon SCA subtype in the Chinese Han population
    Yu tao Liu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People s Republic of China
    Neurosci Lett 528:51-4. 2012
    ..Although no SCA23 mutation was identified, one novel single nucleotide polymorphism (c.255G>A, p.Lys85Lys) in exon 4 of the PDYN gene was found. This suggests that SCA23 is a rare form of dominant ataxia in the Chinese Han population...
  35. ncbi [Exon rearrangement analysis of parkin gene in patients with isolated early-onset parkinsonism using semi-quantitative PCR]
    Ji Feng Guo
    Department of Neurology, Xiangya Hospital, Central South University, Chansha 410008, China
    Zhonghua Yi Xue Za Zhi 86:1447-9. 2006
    ..To investigate the value of fluorescence semi-quantitative PCR in analysis of the exon rearrangement of parkin gene in Chinese patients with isolated early-onset parkinsonism (EOP)...
  36. doi Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase 6 mutants sensitize cells to apoptosis
    Wen Juan Guan
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
    Biochem Biophys Res Commun 430:780-6. 2013
    ..Furthermore, overexpressing the TG6 mutants sensitized cells to staurosporine-induced apoptosis by increasing the activity of caspases. We propose that the pro-apoptotic role of these mutants might underlie the pathogenesis of SCA35...
  37. doi Spinocerebellar ataxia type 28 (SCA28) is an uncommon cause of dominant ataxia among Chinese kindreds
    Dandan Jia
    Department of Neurology, Xiangya Hospital, Central South University Changsha, Hunan, China
    Int J Neurosci 122:560-2. 2012
    ..At last, we did not find AFG3L2 gene mutation, except for three known single nucleotide polymorphisms (SNP)s. It suggests that SCA28 subtype is very rare in Chinese mainland...
  38. ncbi Mutation screening of Cx32 in Han Chinese patients with Charcot-Marie-Tooth disease
    Ru xu Zhang
    Department of Neurology, Xiangya Hospital, Changsha 410008, China
    Beijing Da Xue Xue Bao 37:68-71. 2005
    ..To investigate the Cx32 mutation features and the clinical manifestations of Chinese patients with Charcot-Marie-Tooth disease(CMT)...
  39. ncbi Frequency analysis of autosomal dominant spinocerebellar ataxias in mainland Chinese patients and clinical and molecular characterization of spinocerebellar ataxia type 6
    Hong Jiang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Chin Med J (Engl) 118:837-43. 2005
    ....
  40. doi Six cases of SCA3/MJD patients that mimic hereditary spastic paraplegia in clinic
    Yin guang Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    J Neurol Sci 285:121-4. 2009
    ..But the data in China is still absent...
  41. doi Using next-generation sequencing as a genetic diagnostic tool in rare autosomal recessive neurologic Mendelian disorders
    Zhao Chen
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Neurobiol Aging 34:2442.e11-7. 2013
    ....
  42. doi A deletion mutation of the VHL gene associated with a patient with sporadic von Hippel-Lindau disease
    Dandan Jia
    Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China
    J Clin Neurosci 20:842-7. 2013
    ..Phe76del) of the VHL protein in a patient with sporadic VHL with a benign prognosis. The mutation involved may be de novo or the seemingly unaffected parent may be mosaic for the disease...
  43. ncbi A novel candidate locus on chromosome 11p14.1-p11.2 for autosomal dominant hereditary spastic paraplegia
    Guo Hua Zhao
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
    Chin Med J (Engl) 121:430-4. 2008
    ..Thirteen loci for autosomal dominant HSP have been mapped...
  44. ncbi [Genotype and phenotype analyses of three families with autosomal recessive juvenile parkinsonism]
    Ji Feng Guo
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:70-3. 2006
    ..To investigate the gene mutations and the clinical features of Chinese patients with autosomal recessive juvenile parkinsonism(AR-JP)...
  45. doi A novel mutation of KCNQ3 gene in a Chinese family with benign familial neonatal convulsions
    Haiyan Li
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Epilepsy Res 79:1-5. 2008
    ..To our knowledge, this is the first report of KCNQ3 mutation in Chinese family with BFNC...
  46. doi Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat
    Yuan Xue
    Department of Neurology, Qilu Hospital, Shandong University, 44, Wenhua Xi Road, Jinan 250012, China
    Neurosci Lett 495:130-4. 2011
    ..DZ could reduce oxidative injury induced by seizures by suppressing the activity of MDA and increasing the level of SOD in part by the PI3K/Akt pathway...
  47. ncbi [Studies on the CTA/CTG trinucleotide repeats of ATXN8OS gene in Chinese Hans]
    Junling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:511-4. 2008
    ..To study the normal range of (CTA/CTG)n repeats of ATXN8OS gene in Chinese Hans, and the frequency of ATXN8OS (CTA/CTG)n repeat expansion in spinocerebellar ataxia(SCA) patients in Mainland China...
  48. doi [Polynucleotide repeat expansion of nine spinocerebellar ataxia subtypes and dentatorubral-pallidoluysian atrophy in healthy Chinese Han population]
    Jun ling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:501-5. 2010
    ....
  49. doi Novel mutations of the SPG11 gene in hereditary spastic paraplegia with thin corpus callosum
    Shu sheng Liao
    Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, China
    J Neurol Sci 275:92-9. 2008
    ..Recently pathogenic mutations in the KIAA1840 (now named SPG11) for SPG11, the major HSP-TCC locus, were identified; at least 42 different mutations have been detected...
  50. ncbi Gluten ataxia of sporadic and hereditary cerebellar ataxia in patients from mainland China
    Wen Juan Guan
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    Neurol India 61:226-30. 2013
    ..Gluten sensitivity (GS) is a spectrum of disorders with diverse manifestations. Recent evidence suggests that ataxia may be the only manifestation of GS and that it may be one of the causes of sporadic ataxia...
  51. ncbi A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family
    Beisha Tang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    J Neurol Sci 221:31-4. 2004
    ..An unusual clinical feature of this family is that the seizures of every patient did not remit until 12 to 18 months. This is the first report of KCNQ2 gene mutation in China...
  52. pmc Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias
    Jun ling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China
    Brain 134:3493-3501. 2011
    ..Thus, we have identified PRRT2 as the first causative gene of paroxysmal kinesigenic dyskinesias, warranting further investigations to understand the pathogenesis of this disorder...
  53. ncbi [Study on the single-nucleotide substitution (c.-16C to T) of the PURATROPHIN-1 gene in Chinese patients with spinocerebellar ataxia]
    Yafang Zhou
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:646-8. 2008
    ..To study the single-nucleotide substitution (c.-16C to T) of the PURATROPHIN-1 gene in spinocerebellar ataxia (SCA) patients in China...
  54. doi Magnetic resonance spectroscopy of the cerebellum in patients with spinocerebellar ataxia type 3/Machado-Joseph disease
    Lifang Lei
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:511-9. 2011
    ....
  55. ncbi Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity
    Hong Jiang
    Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, People s Republic of China
    Biol Pharm Bull 34:1194-7. 2011
    ....
  56. doi Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures
    Yuan Xue
    Department of Neurology, Qilu Hospital, Shandong University, 44, Wenhua Xi Road, Jinan 250012, China
    Brain Res 1383:135-40. 2011
    ..DZ could reduce neuronal death induced by seizures in hippocampus by suppressing the translocation of AIF, CytC release and the activation of caspase-3 via the PI3K/Akt pathway...
  57. doi Mitochondrial transcription factor A (TFAM) polymorphisms and risk of late-onset Alzheimer's disease in Han Chinese
    Qun Zhang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, China
    Brain Res 1368:355-60. 2011
    ..Haplotype analysis identified the haplotype CC as a protective factor of LOAD (P=0.038, OR=0.76). This study provides the evidence that variations in TFAM are involved in the pathogenesis of sporadic LOAD in the Han Chinese population...
  58. ncbi [The advances in research on phosphorylation of polyglutamine disease]
    Ya fang Zhou
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:414-7. 2008
    ....
  59. doi The correlation between magnetic resonance imaging features of the brainstem and cerebellum and clinical features of spinocerebellar ataxia 3/Machado-Joseph disease
    Xiaochun Liang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410 078, Hunan, P R China
    Neurol India 57:578-83. 2009
    ..However, the correlation between brainstem and cerebellar atrophy and the clinical features has not been well studied...
  60. ncbi [Construction of the eukaryotic expression vector of MJD1 and its expression in SH-SY5Y cells]
    Jian guang Tang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:640-4. 2005
    ....
  61. ncbi [Clinical characteristics and molecular biology of hereditary spinocerebellar ataxia type 7: study of 3 Chinese families]
    Xing wang Song
    Department of Neurology, Xiangya Hospital of Central South University, Changsha 410008, China
    Zhonghua Yi Xue Za Zhi 86:1755-8. 2006
    ..To study the clinical characteristics and molecular biology of hereditary spinocerebellar ataxia type 7 (SCA7)...
  62. ncbi The APOE ε2 allele may decrease the age at onset in patients with spinocerebellar ataxia type 3 or Machado-Joseph disease from the Chinese Han population
    Huirong Peng
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P R China
    Neurobiol Aging 35:2179.e15-8. 2014
    ..This study may also reconfirm the effect of the APOE gene on SCA3 or MJD patients from different races and indicated that certain APOE alleles might be genetic modifiers for AO in SCA3 or MJD. ..
  63. doi [Research progress in roles of microRNA in polyglutamine diseases]
    Yu ting Shi
    Department of Neurology, Xiangya Hospital, Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, 410008 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:406-9. 2010
    ..This review is focused on research progress in roles of miRNA in the pathogenesis of PolyQ diseases...
  64. ncbi A new locus for autosomal dominant Charcot-Marie-Tooth disease type 2 (CMT2L) maps to chromosome 12q24
    Bei sha Tang
    National Laboratory of Medical Genetics of China, Central South University, 410078 Changsha, Hunan, People s Republic of China
    Hum Genet 114:527-33. 2004
    ..08 for marker D12S76 at a recombination fraction (theta) of 0 strongly supported linkage to this locus. Thus, CMT2 neuropathy in this family represents a novel genetic entity that we have designated as CMT2L...
  65. doi Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line
    Kun Hong
    Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
    Neurosci Lett 530:144-9. 2012
    ..These studies suggest that human TDP-43 and its C-terminal fragments may cause mitochondrial dysfunction and enhance mitophagy...
  66. doi [Roles of axonal transport affected by K141N mutant HSP22 in the pathogenesis of CMT2L]
    Fu feng Zhang
    Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China
    Zhonghua Yi Xue Za Zhi 92:496-8. 2012
    ..To compare the axonal transport of wild-type (WT) and K141N mutant HSP22 in transfected primary cultured cortical neurons...
  67. ncbi Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L
    Bei sha Tang
    National Laboratory of Medical Genetics of China, Central South University, 410078, Changsha, Hunan, People s Republic of China
    Hum Genet 116:222-4. 2005
    ..No disease-causing mutations have been identified in another 114 CMT families...
  68. ncbi [Screening for proteins interacting with ataxin-3, the gene product of SCA3/MJD]
    Lu Shen
    Department of Neurology, Xiangya Hospital, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:40-4. 2006
    ..To screen for proteins interacting with ataxin-3 by yeast two-hybrid system 3, and to discuss the function of ataxin-3 and pathogenesis of spinocerebellar ataxia type 3 and Machado-Joseph disease (SCA3/MJD)...
  69. doi [Direct interaction between BAG5 protein and Parkin protein]
    XueJing Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:1156-61. 2010
    ..To explore the interaction between BCL2-associated athanogene 5 (BAG5) and Parkin protein,and the regulatory mechanism of BAG5 protein on the level of Parkin protein...
  70. doi Related factors of ICARS and SARA scores on spinocerebellar ataxia type 3/Machado-Joseph disease
    Jie Zhou
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:498-503. 2011
    ..To investigate the related factors of international cooperative ataxia rating scale (ICARS) and scale for the assessment and rating of ataxia scores (SARA) in patients with spinocerebellar ataxia type 3/Machado-Joseph disease...
  71. doi Common variant in GAB2 is associated with late-onset Alzheimer's disease in Han Chinese
    Xiao ling Zhong
    Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Shandong Province, China
    Clin Chim Acta 412:446-9. 2011
    ..While there are no studies on the association of rs10793294 polymorphism with AD risk in the Chinese population...
  72. ncbi [The clinical and genetic characteristics of autosomal recessive juvenile Parkinsonism in a Chinese family]
    Ya wei Shen
    Department of Neurology, Xiangya Hospital of Central South University, Changsha 418000, China
    Zhonghua Nei Ke Za Zhi 44:360-2. 2005
    ..To understand clinic and genetic characteristics of Chinese AR-JP...
  73. ncbi [Recent advances in molecular genetics of spinocerebellar ataxia type 3/Machado-Joseph disease]
    Dandan Jia
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:660-2. 2008
    ..In this review, authors covered the recent advances in molecular genetic of SCA3/MJD...
  74. ncbi [Research on clinical characteristics and ATM gene mutations in Chinese patients with ataxia-telangiectasia]
    Hong Jiang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Yi Xue Za Zhi 85:1117-20. 2005
    ..To investigate the clinical manifestation and mutation characteristics of ATM gene in Chinese patients with ataxia-telangiectasia (AT)...
  75. ncbi Clinical features of hereditary spastic paraplegia with thin corpus callosum: report of 5 Chinese cases
    Bei sha Tang
    Department of Neurology, Xiangya Hospital, Central Southern University, Changsha 410008, China
    Chin Med J (Engl) 117:1002-5. 2004
    ..This study was conducted to investigate the clinical features of hereditary spastic paraplegia with thin corpus callosum (HSP-TCC)...
  76. doi A neuropathological study at autopsy of early onset spinocerebellar ataxia 6
    XueJing Wang
    Department of Neurology, Xiangya Hospital, Central South University, Xiangya Road, Changsha, Hunan 410008, PR China
    J Clin Neurosci 17:751-5. 2010
    ..Finally, our postmortem study confirms that SCA6 is not a simple "pure" cerebellar disease, but a complex neurodegenerative condition in which many extracerebellar structures are involved...
  77. doi Novel GIGYF2 gene variants in patients with Parkinson's disease in Chinese population
    Lei Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 473:131-5. 2010
    ..Another variant Gln979stop encodes a truncated protein. In conclusion, we identified nine novel variants in GIGYF2 gene, which might be associated with PD in the Chinese population...
  78. doi A novel presenilin 1 mutation (Ser169del) in a Chinese family with early-onset Alzheimer's disease
    Jifeng Guo
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 468:34-7. 2010
    ..The amnestic presentation and absence of other features contrast with the other two mutations at codon 169 which have been associated with myoclonic jerks and seizures...
  79. doi Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese
    Nan Nan Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China
    Neurosci Lett 491:83-6. 2011
    ..78, P=0.037). This study provides the evidence that variations in the TTBK1 gene may play an important role in the pathogenesis of sporadic LOAD in a Han Chinese population...
  80. doi Serum concentrations of NSE and S100B in spinocerebellar ataxia type 3/Machado-Joseph disease
    Jie Zhou
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:504-10. 2011
    ....
  81. ncbi Identification of human fetal liver miRNAs by a novel method
    Hanjiang Fu
    Beijing Institute of Radiation Medicine, Department of Biochemistry and Molecular Biology, 27 Taiping Road, Beijing 100850, People s Republic of China
    FEBS Lett 579:3849-54. 2005
    ..These finding indicate that a large diverse population of miRNAs may function to regulate gene expression in hepatocyte...
  82. ncbi [Effects of simulated acid rain on Quercus glauca seedlings photosynthesis and chlorophyll fluorescence]
    Jia Li
    International Ecological Research Center of Zhejiang Forestry University, Hangzhou 311300, China
    Ying Yong Sheng Tai Xue Bao 20:2092-6. 2009
    ..5 and 4.0. All the results suggested that the photosynthesis and chlorophyll fluorescence of Q. glauca increased under the effects of acid rain with pH 2.5 and 4.0, and the acid rain with pH 2.5 had more obvious effects...
  83. ncbi Differences in the changing trends of monophasic action potential duration and effective refractory period of the ventricular myocardium after myocardial infarction in vivo
    Congxin Huang
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
    Circ J 68:1205-9. 2004
    ..The relationship between monophasic action potential duration (MAPD) and effective refractory period (ERP) is poorly understood after myocardial infarction (MI) in vivo...
  84. ncbi Time course of inflammatory response after renal artery stenting in patients with atherosclerotic renal stenosis
    Jian Jun Li
    Renmin Hospital, Wuhan University School of Medicine, Wuhan 430060, PR China
    Clin Chim Acta 350:115-21. 2004
    ..Such response following renal artery stenting has not yet been established, however, in patients with atherosclerotic renal artery stenosis...
  85. ncbi Increased C-reactive protein level after renal stent implantation in patients with atherosclerotic renal stenosis
    Jian Jun Li
    Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, People s Republic of China
    Angiology 55:479-84. 2004
    ....
  86. ncbi Ischemic preconditioning detected by treadmill exercise tests in patients with stable angina
    Jian Jun Li
    Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan, People s Republic of China
    Angiology 54:45-50. 2003
    ..In conclusion, the first ischemic event could induce the IP phenomenon and protect the heart from more serious damage at a 10-minute interval. However, this effect disappeared when the second test was done at a 60-minute interval...
  87. ncbi Differential densities of muscarinic acetylcholine receptor and I(K,ACh) in canine supraventricular tissues and the effect of amiodarone on cholinergic atrial fibrillation and I(K,ACh)
    Cong Xin Huang
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People s Republic of China
    Cardiology 106:36-43. 2006
    ....
  88. ncbi Quality of life and cost for patients with premature ventricular contractions by radiofrequency catheter ablation
    Cong Xin Huang
    Department of Cardiology, Renmin Hospital of Wuhan University, Hubei, China
    Pacing Clin Electrophysiol 29:343-50. 2006
    ..To evaluate the quality of life (QoL), health-care resource utilization, and cost for the patients with premature ventricular contractions (PVCs) by radiofrequency catheter ablation (RFCA)...
  89. ncbi Abnormal intracellular calcium handling underlying T-wave alternans and its hysteresis
    Mingwei Bao
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
    Cardiology 108:147-56. 2007
    ..To investigate the mechanism underlying T-wave alternans (TWA) and its hysteresis under ischemia conditions...
  90. ncbi [Usability of the laboratory report and knowledge of lipid-lowering in out-patients from dyslipidemia-related departments]
    Sheng kai Yan
    Department of Laboratory Medicine, China Japan Friendship Hospital, and Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100029, China
    Beijing Da Xue Xue Bao 42:675-80. 2010
    ..To investigate the usability of laboratory test report from the angle of patients and understand to what degree the patients master the knowledge of lipid-lowering...
  91. ncbi [Actinobacterial diversity of marine sediment samples from Chile]
    Hong Jiang
    Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou 350007, China
    Wei Sheng Wu Xue Bao 50:862-9. 2010
    ..The aim of this study was to investigate actinobacterial diversity in Chilean marine sediments...
  92. ncbi [Magnetic resonance imaging character in chronic injury of the elbows in athletes]
    Wei Zhang
    Department of Radiology, Wuhan Chinese and Western Medecine Hospital, Tongfi College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China
    Zhongguo Gu Shang 23:114-6. 2010
    ..To introduce the experiences of applying MR to diagnose the imaging characters in chronic injury of the elbows in athletes...
  93. doi Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome
    Yun Liu
    Center for Reproductive Medicine, Fuzhou General Hospital, Fuzhou, Fujian Province, China
    Reprod Fertil Dev 23:520-6. 2011
    ..These changes in UCP-2 and CYP11A1 expression may mediate follicle development in PCOS...
  94. ncbi Relationship between autonomic innervation in crista terminalis and atrial arrhythmia
    Qing Yan Zhao
    Cardiovascular Research Institute of Wuhan University, Renmin Hospital of Wuhan University, Wuhan City, China
    J Cardiovasc Electrophysiol 20:551-7. 2009
    ..This study sought to study the relation between autonomic innervation in CT and atrial arrhythmia...
  95. doi Paracrine action of HO-1-modified mesenchymal stem cells mediates cardiac protection and functional improvement
    Bin Zeng
    Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei, PR China
    Cell Biol Int 32:1256-64. 2008
    ..It can be concluded hHO-1-modified MSCs prevent myocardial cell injury via secretion of paracrine-acting mediators...
  96. ncbi M2 and M3-muscarinic acetylcholine receptors remodelling in patients with a dilated atrium
    Qingyan Zhao
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People s Republic of China
    Acta Cardiol 63:166-70. 2008
    ..We investigated the remodelling of muscarinic receptors in patients with dilated atrium and assessed the relationship between the muscarinic receptor remodelling and the dilated atrium...
  97. ncbi [Identification of a functional ITAM-like sequence within G1 cytoplasmic tail of Hantaan virus]
    Dan Lei Mou
    Center of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Bing Du Xue Bao 23:424-8. 2007
    ..These findings demonstrated that HTNV envelope glycoprotein G1 contains a functional ITAM-like sequence in its cytoplasmic tail, which can bind critical cellular kinases that regulate immune and endothelial cell functions...
  98. ncbi [Multi-center clinical trial on efficacy of national-made radiofrequency ablation catheter for the treatment of atrioventricular nodal reentrant tachycardia and atrioventricular reentrant tachycardia]
    Shu Lin Wu
    Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, China
    Zhonghua Xin Xue Guan Bing Za Zhi 38:35-8. 2010
    ..The aim of this trial is to compare the efficacy and safety between national-made and imported ablation catheters for the treatment of atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT)...
  99. doi MG132 enhances neurite outgrowth in neurons overexpressing mutant TAR DNA-binding protein-43 via increase of HO-1
    Weisong Duan
    Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, People s Republic of China
    Brain Res 1397:1-9. 2011
    ..It was well known that HO-1 was regulated by nuclear factor E2-related factor 2 (Nrf2). However, MG132 increased the expression of HO-1 independent of the Nrf2 pathway...
  100. ncbi Three novel mutations of the spastin gene in Chinese patients with hereditary spastic paraplegia
    Beisha Tang
    National Laboratory of Medical Genetics of China, and the Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People s Republic of China
    Arch Neurol 61:49-55. 2004
    ..The most common form of hereditary spastic paraplegia is caused by mutations in the spastin gene (SPG4), which encodes spastin, an adenosine triphosphatase associated with various cellular activities protein...
  101. doi [Fragile X-associated tremor/ataxia syndrome]
    Wei Wei Han
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:52-5. 2011
    ..In this paper, the research progress of clinical manifestatios, pathological characteristics, epidemiology and molecular mechanisms will be reviewed...