Research Topics
Genomes and GenesSpecies | Wei Hua JiaSummaryCountry: China Publications
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Publications
Sequencing of DC-SIGN promoter indicates an association between promoter variation and risk of nasopharyngeal carcinoma in cantoneseYa Fei Xu
State Key Laboratory of Oncology in South China, 651 Dongfeng Road East, Guangzhou 510060, China
BMC Med Genet 11:161. 2010..The aim of this study is to ascertain the potential involvement of DC-SIGN promoter single nucleotide polymorphisms (SNPs) in NPC susceptibility...- Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese populationJun Fang He
State Key Laboratory of Oncology in Southern China
BMC Cancer 7:194. 2007..Toll-like receptor 3 (TLR3) plays an important role in the antivirus response. Therefore, we examined the association between TLR3 gene polymorphisms and NPC susceptibility... - Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern ChinaWei Hua Jia
Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, State Key Laboratory of Oncology in Southern China, China
BMC Cancer 6:178. 2006.... 
[Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]Qin Fan
Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, P R China
Ai Zheng 24:915-8. 2005..Therefore, it is an ideal candidate gene for research on genetic susceptibility of nasopharyngeal carcinoma (NPC). This study was designed to explore correlation of pIgR gene polymorphisms to genetic susceptibility of NPC...
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility lociJin Xin Bei
State Key Laboratory of Oncology in Southern China, Guangzhou, China
Nat Genet 42:599-603. 2010..61) and rs28421666 (Pcombined=2.49x10(-18), OR=0.67). Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules...- Elevated Epstein-Barr virus seroreactivity among unaffected members of families with nasopharyngeal carcinomaHai De Qin
State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, China
J Med Virol 83:1792-8. 2011..0146). In conclusion, EBV seropositivity rates were elevated among unaffected family members in both multiplex and sporadic families with NPC... - Antibodies against Epstein-Barr virus gp78 antigen: a novel marker for serological diagnosis of nasopharyngeal carcinoma detected by xMAP technologyAi Di Gu
State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
J Gen Virol 89:1152-8. 2008..Thus, simultaneous detection of these EBV serological markers could improve the predictive values of NPC using xMAP technology... - Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy CantoneseGuo Ping Shen
State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
Int J Cancer 129:1459-66. 2011..0085 to 0.00027). Our study provides evidence that genetic variation within the HRR might affect an individual's propensity for EBV seropositive status of anti-VCA IgA antibody... - [Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms]Ya Fei Xu
Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, China
Zhonghua Yu Fang Yi Xue Za Zhi 43:586-90. 2009..To investigate the association between CYP1A1 gene polymorphisms and susceptibility of nasopharyngeal carcinoma in Cantonese nuclear families through family-based association study... - Pretreatment lifestyle behaviors as survival predictors for patients with nasopharyngeal carcinomaGuo Ping Shen
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
PLoS ONE 7:e36515. 2012..However, the relationship between pretreatment lifestyle behaviors and survival among patients with nasopharyngeal carcinoma (NPC) is unclear... - Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma riskXin Xi Zhou
Sun Yat Sen University, Cancer Center, 651 Dong Feng Road East, 510060 Guangzhou, China
Cancer Epidemiol Biomarkers Prev 15:862-6. 2006..It is possible that this is not a causal haplotype for NPC; rather, it is in strong linkage disequilibrium with a causal single nucleotide polymorphism in close proximity... - Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, ChinaWei Hua Jia
State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China
BMC Cancer 10:446. 2010.... - Evaluation of a multianalyte profiling assay and an enzyme-linked immunosorbent assay for serological examination of Epstein-Barr virus-specific antibody responses in diagnosis of nasopharyngeal carcinomaAi Di Gu
State Key Laboratory of Oncology in South China, Sun Yat Sen University, Guangzhou, China
Clin Vaccine Immunol 15:1684-8. 2008..798, respectively. The concordances of the two methods for NPC discrimination were good (79 to 88%). Our results suggest that both the xMAP assay and ELISA are satisfactory for EBV antibody evaluation when multiple antigens are included... - Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinomaHai De Qin
State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, China
Cancer Res 71:3000-8. 2011..Our findings support the notion that DNA repair genes, in particular RAD51L1, play a role in NPC etiology and development... - [Study on genetic polymorphisms of CYP2F1 gene in Guangdong population of China]Ju hong Jiang
Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080 P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:383-7. 2006.... - [Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]Ju hong Jiang
Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, PR China
Ai Zheng 23:672-7. 2004..We performed a preliminary investigation on the xenobiotics metabolism of human nasopharynx by determining the expression of CYP450 genes in NPC and non-cancerous nasopharynx tissues... - Alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in Guangdong, ChinaHong Lian Ruan
State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China
Front Med China 4:448-56. 2010..Specifically, moderate consumption of alcohol was associated with decreased risk of NPC, while overuse, especially strong distillate spirits, appeared to be a risk factor... - An in situ molecular signature to predict early recurrence in hepatitis B virus-related hepatocellular carcinomaJing Xu
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen Zhongshan University, Guangzhou, PR China
J Hepatol 57:313-21. 2012..To develop an in situ molecular signature to predict postsurgical recurrence in hepatocellular carcinoma (HCC) patients... - Clinical values of multiple Epstein-Barr virus (EBV) serological biomarkers detected by xMAP technologyAi Di Gu
State Key Laboratory of Oncology in Southern China, Guangzhou, PR China
J Transl Med 7:73. 2009..Serological examination of Epstein-Barr virus (EBV) antibodies has been performed for screening nasopharyngeal carcinoma (NPC) and other EBV-associated diseases... - Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinomaJian Rong He
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China School of Public Health, Sun Yat Sen University, Guangzhou, China Guangzhou Women and Children s Medical Center, Guangzhou Medical College, Guangzhou, China
Head Neck 34:1769-76. 2012..The purpose of this study was to evaluate the counts and percentages of differential leukocytes as prognostic indicators in patients with nasopharyngeal carcinoma (NPC)... - Fluctuations of epstein-barr virus serological antibodies and risk for nasopharyngeal carcinoma: a prospective screening study with a 20-year follow-upSu Mei Cao
State Key Laboratory of Oncology in Southern China, Department of Epidemiology, Clinical Trial Study Center, Cancer Center, Sun Yat Sen University, Guangzhou, China
PLoS ONE 6:e19100. 2011..We analyzed the fluctuations of antibodies against EBV before histopathological diagnosis to assess the risk of NPC and aimed to provide a reliable basis for screening in high risk populations... - Familial nasopharyngeal carcinomaYi Xin Zeng
Cancer Center, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou 510060, China
Semin Cancer Biol 12:443-50. 2002..The major findings in this field were summarized. Furthermore, future directions leading to understanding the genetic mechanism of the familial form of NPC was also discussed... - [Family-based association study of XRCC1 gene polymorphisms in nasopharyngeal carcinoma]Qing hua Pan
Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
Zhonghua Yu Fang Yi Xue Za Zhi 41:12-6. 2007..To test the association between XRCC1 gene polymorphisms and susceptibility of nasopharyngeal carcinoma in Cantonese nuclear families through a family-based association study... - Characterization of a novel mechanism of genomic instability involving the SEI1/SET/NM23H1 pathway in esophageal cancersYan Li
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Cancer Res 70:5695-705. 2010..Taken together, these findings define a novel mechanism of genomic instability and malignant progression in esophageal cancers, a deadly disease of increasing incidence in developed countries... - Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosisLi He
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
PLoS ONE 7:e42992. 2012..The aim of this study was to identify a biomarker useful in the diagnosis and therapy of ovarian malignant germ cell tumor (OMGCT)... - High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapyLi Ru He
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Int J Cancer 127:138-47. 2010..Evaluation of EZH2 expressions might be useful for predicting tumor response to CRT and prognosis for patients with ESCC... - [Comparative study on risk factors and family history of familial and sporadic nasopharyngeal carcinoma patients]Xiang Yu Luo
Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
Zhonghua Yu Fang Yi Xue Za Zhi 43:293-8. 2009.... - Identification of a gene-expression signature for predicting lymph node metastasis in patients with early stage cervical carcinomaLong Huang
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, People s Republic of China
Cancer 117:3363-73. 2011..Pelvic lymph node metastasis (PLNM) is an important prognostic factor for patients with cervical carcinoma. The objective of this study was to identify a gene-expression signature that could predict PLNM in cervical carcinoma... - Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, ChinaWei-Hua Jia
Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China
Cancer 101:363-9. 2004..CONCLUSIONS: NPC tends to aggregate in Cantonese families in Guangdong Province, and the malignancies in these families appear to be site specific, with no excess of any other malignancy... - Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4Bing-Jian Feng
Cancer Institute, Cancer Center, Sun Yat-sen University, Guangzhou, China
Nat Genet 31:395-9. 2002..70 (P = 2.0 x 10(-5)) and 5.36 (P = 4.36 x 10(-6)) for D4S405 and D4S3002, respectively. Our findings provide evidence of a major susceptibility locus for NPC on chromosome 4 in a subset of families... - [Epidemiological study of nasopharyngeal carcinoma risk in relatives of high-risk families in Guangdong]Wei-Hua Jia
Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China
Ai Zheng 23:767-70. 2004..55; in addition, SIRs were 50.72, 79.64, 7.12, and 33.58 in their brothers, sisters, fathers, and mothers respectively. CONCLUSION: NPC risk of relatives in familial NPC pedigrees elevates 7.12 to 79.64 times in high-risk families... - Complex segregation analysis of nasopharyngeal carcinoma in Guangdong, China: evidence for a multifactorial mode of inheritance (complex segregation analysis of NPC in China)Wei-Hua Jia
Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
Eur J Hum Genet 13:248-52. 2005..The current results do not provide evidence for a major gene and the observed data are best explained by a multifactorial mode of inheritance for NPC... - A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinomaRi Cheng Jiang
State Key Laboratory of Oncology in Southern China Departments of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, China
Cancer Res 66:693-700. 2006..Collectively, these results provide evidence that the -32A variant is a functional sequence change and may be related to nasopharyngeal carcinoma susceptibility in the families studied... - The 30-bp deletion variant: a polymorphism of latent membrane protein 1 prevalent in endemic and non-endemic areas of nasopharyngeal carcinomas in ChinaXiao-Shi Zhang
Cancer Institute, Cancer Center, Sun Yat-sen University of Medical Sciences, 651 Dongfeng East Road, Guangzhou 510060, People's Republic of China
Cancer Lett 176:65-73. 2002..These results indicate that del-LMP1 represents a geographic or race-associated polymorphism rather than an NPC disease phenotype-associated polymorphism...