Wei Hua Jia

Summary

Country: China

Publications

  1. pmc Sequencing of DC-SIGN promoter indicates an association between promoter variation and risk of nasopharyngeal carcinoma in cantonese
    Ya Fei Xu
    State Key Laboratory of Oncology in South China, 651 Dongfeng Road East, Guangzhou 510060, China
    BMC Med Genet 11:161. 2010
  2. pmc Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population
    Jun Fang He
    State Key Laboratory of Oncology in Southern China
    BMC Cancer 7:194. 2007
  3. pmc Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, State Key Laboratory of Oncology in Southern China, China
    BMC Cancer 6:178. 2006
  4. doi request reprint Antibodies against Epstein-Barr virus gp78 antigen: a novel marker for serological diagnosis of nasopharyngeal carcinoma detected by xMAP technology
    Ai Di Gu
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
    J Gen Virol 89:1152-8. 2008
  5. ncbi request reprint Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4
    Bing Jian Feng
    Cancer Institute, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Nat Genet 31:395-9. 2002
  6. doi request reprint A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
  7. doi request reprint Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese
    Guo Ping Shen
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    Int J Cancer 129:1459-66. 2011
  8. ncbi request reprint [Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]
    Qin Fan
    Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, P R China
    Ai Zheng 24:915-8. 2005
  9. ncbi request reprint Complex segregation analysis of nasopharyngeal carcinoma in Guangdong, China: evidence for a multifactorial mode of inheritance (complex segregation analysis of NPC in China)
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Eur J Hum Genet 13:248-52. 2005
  10. ncbi request reprint [Epidemiological study of nasopharyngeal carcinoma risk in relatives of high-risk families in Guangdong]
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, 510060, P R China
    Ai Zheng 23:767-70. 2004

Collaborators

Detail Information

Publications43

  1. pmc Sequencing of DC-SIGN promoter indicates an association between promoter variation and risk of nasopharyngeal carcinoma in cantonese
    Ya Fei Xu
    State Key Laboratory of Oncology in South China, 651 Dongfeng Road East, Guangzhou 510060, China
    BMC Med Genet 11:161. 2010
    ..The aim of this study is to ascertain the potential involvement of DC-SIGN promoter single nucleotide polymorphisms (SNPs) in NPC susceptibility...
  2. pmc Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population
    Jun Fang He
    State Key Laboratory of Oncology in Southern China
    BMC Cancer 7:194. 2007
    ..Toll-like receptor 3 (TLR3) plays an important role in the antivirus response. Therefore, we examined the association between TLR3 gene polymorphisms and NPC susceptibility...
  3. pmc Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, State Key Laboratory of Oncology in Southern China, China
    BMC Cancer 6:178. 2006
    ....
  4. doi request reprint Antibodies against Epstein-Barr virus gp78 antigen: a novel marker for serological diagnosis of nasopharyngeal carcinoma detected by xMAP technology
    Ai Di Gu
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
    J Gen Virol 89:1152-8. 2008
    ..Thus, simultaneous detection of these EBV serological markers could improve the predictive values of NPC using xMAP technology...
  5. ncbi request reprint Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4
    Bing Jian Feng
    Cancer Institute, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Nat Genet 31:395-9. 2002
    ..70 (P = 2.0 x 10(-5)) and 5.36 (P = 4.36 x 10(-6)) for D4S405 and D4S3002, respectively. Our findings provide evidence of a major susceptibility locus for NPC on chromosome 4 in a subset of families...
  6. doi request reprint A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
    ..61) and rs28421666 (Pcombined=2.49x10(-18), OR=0.67). Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules...
  7. doi request reprint Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese
    Guo Ping Shen
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    Int J Cancer 129:1459-66. 2011
    ..0085 to 0.00027). Our study provides evidence that genetic variation within the HRR might affect an individual's propensity for EBV seropositive status of anti-VCA IgA antibody...
  8. ncbi request reprint [Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]
    Qin Fan
    Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, P R China
    Ai Zheng 24:915-8. 2005
    ..Therefore, it is an ideal candidate gene for research on genetic susceptibility of nasopharyngeal carcinoma (NPC). This study was designed to explore correlation of pIgR gene polymorphisms to genetic susceptibility of NPC...
  9. ncbi request reprint Complex segregation analysis of nasopharyngeal carcinoma in Guangdong, China: evidence for a multifactorial mode of inheritance (complex segregation analysis of NPC in China)
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Eur J Hum Genet 13:248-52. 2005
    ..The current results do not provide evidence for a major gene and the observed data are best explained by a multifactorial mode of inheritance for NPC...
  10. ncbi request reprint [Epidemiological study of nasopharyngeal carcinoma risk in relatives of high-risk families in Guangdong]
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, 510060, P R China
    Ai Zheng 23:767-70. 2004
    ..The purpose of the study was to estimate NPC risk among relatives of high-risk pedigrees in Guangong province, so as to provide information for genetic epidemiology and clinical genetic consultation...
  11. doi request reprint Elevated Epstein-Barr virus seroreactivity among unaffected members of families with nasopharyngeal carcinoma
    Hai De Qin
    State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, China
    J Med Virol 83:1792-8. 2011
    ..0146). In conclusion, EBV seropositivity rates were elevated among unaffected family members in both multiplex and sporadic families with NPC...
  12. ncbi request reprint [Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms]
    Ya Fei Xu
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Zhonghua Yu Fang Yi Xue Za Zhi 43:586-90. 2009
    ..To investigate the association between CYP1A1 gene polymorphisms and susceptibility of nasopharyngeal carcinoma in Cantonese nuclear families through family-based association study...
  13. pmc Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinoma
    Hai De Qin
    State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Res 71:3000-8. 2011
    ..Our findings support the notion that DNA repair genes, in particular RAD51L1, play a role in NPC etiology and development...
  14. pmc Pretreatment lifestyle behaviors as survival predictors for patients with nasopharyngeal carcinoma
    Guo Ping Shen
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e36515. 2012
    ..However, the relationship between pretreatment lifestyle behaviors and survival among patients with nasopharyngeal carcinoma (NPC) is unclear...
  15. pmc Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, China
    Wei Hua Jia
    State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China
    BMC Cancer 10:446. 2010
    ....
  16. ncbi request reprint Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk
    Xin Xi Zhou
    Sun Yat Sen University, Cancer Center, 651 Dong Feng Road East, 510060 Guangzhou, China
    Cancer Epidemiol Biomarkers Prev 15:862-6. 2006
    ..It is possible that this is not a causal haplotype for NPC; rather, it is in strong linkage disequilibrium with a causal single nucleotide polymorphism in close proximity...
  17. ncbi request reprint Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer 101:363-9. 2004
    ..However, to date, few large-scale studies have been conducted on familial risk and clustering of NPC in a high-risk area of China...
  18. pmc Evaluation of a multianalyte profiling assay and an enzyme-linked immunosorbent assay for serological examination of Epstein-Barr virus-specific antibody responses in diagnosis of nasopharyngeal carcinoma
    Ai Di Gu
    State Key Laboratory of Oncology in South China, Sun Yat Sen University, Guangzhou, China
    Clin Vaccine Immunol 15:1684-8. 2008
    ..798, respectively. The concordances of the two methods for NPC discrimination were good (79 to 88%). Our results suggest that both the xMAP assay and ELISA are satisfactory for EBV antibody evaluation when multiple antigens are included...
  19. pmc Quantitative association of tobacco smoking with the risk of nasopharyngeal carcinoma: a comprehensive meta-analysis of studies conducted between 1979 and 2011
    Wen Qiong Xue
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou 510060, People s Republic of China
    Am J Epidemiol 178:325-38. 2013
    ..76 and 2.20, respectively, versus 1.29 and 1.27. In this comprehensive meta-analysis, well-established statistical evidence was provided about the role of tobacco smoking in the etiology of NPC. ..
  20. pmc Developing genetic epidemiological models to predict risk for nasopharyngeal carcinoma in high-risk population of China
    Hong Lian Ruan
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    PLoS ONE 8:e56128. 2013
    ..If these findings are confirmed in larger cohort and population-based case-control studies, use of the new models to analyse data from NPC-endemic areas could well lead to earlier detection of NPC...
  21. ncbi request reprint [Study on genetic polymorphisms of CYP2F1 gene in Guangdong population of China]
    Ju hong Jiang
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:383-7. 2006
    ....
  22. ncbi request reprint Complement receptor 1 expression in peripheral blood mononuclear cells and the association with clinicopathological features and prognosis of nasopharyngeal carcinoma
    Jian Rong He
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    Asian Pac J Cancer Prev 13:6527-31. 2012
    ..We conducted the present study to evaluate the association of CR1 expression with clinicopathological features and prognosis of NPC...
  23. pmc Fluctuations of epstein-barr virus serological antibodies and risk for nasopharyngeal carcinoma: a prospective screening study with a 20-year follow-up
    Su Mei Cao
    State Key Laboratory of Oncology in Southern China, Department of Epidemiology, Clinical Trial Study Center, Cancer Center, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e19100. 2011
    ..We analyzed the fluctuations of antibodies against EBV before histopathological diagnosis to assess the risk of NPC and aimed to provide a reliable basis for screening in high risk populations...
  24. doi request reprint Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma
    Jian Rong He
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Head Neck 34:1769-76. 2012
    ..The purpose of this study was to evaluate the counts and percentages of differential leukocytes as prognostic indicators in patients with nasopharyngeal carcinoma (NPC)...
  25. doi request reprint Alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in Guangdong, China
    Hong Lian Ruan
    State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China
    Front Med China 4:448-56. 2010
    ..Specifically, moderate consumption of alcohol was associated with decreased risk of NPC, while overuse, especially strong distillate spirits, appeared to be a risk factor...
  26. ncbi request reprint [Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]
    Ju hong Jiang
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 23:672-7. 2004
    ..We performed a preliminary investigation on the xenobiotics metabolism of human nasopharynx by determining the expression of CYP450 genes in NPC and non-cancerous nasopharynx tissues...
  27. pmc Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis
    Li He
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    PLoS ONE 7:e42992. 2012
    ..The aim of this study was to identify a biomarker useful in the diagnosis and therapy of ovarian malignant germ cell tumor (OMGCT)...
  28. doi request reprint An in situ molecular signature to predict early recurrence in hepatitis B virus-related hepatocellular carcinoma
    Jing Xu
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen Zhongshan University, Guangzhou, PR China
    J Hepatol 57:313-21. 2012
    ..To develop an in situ molecular signature to predict postsurgical recurrence in hepatocellular carcinoma (HCC) patients...
  29. pmc Clinical values of multiple Epstein-Barr virus (EBV) serological biomarkers detected by xMAP technology
    Ai Di Gu
    State Key Laboratory of Oncology in Southern China, Guangzhou, PR China
    J Transl Med 7:73. 2009
    ..Serological examination of Epstein-Barr virus (EBV) antibodies has been performed for screening nasopharyngeal carcinoma (NPC) and other EBV-associated diseases...
  30. doi request reprint Effects of passive smoking on breast cancer risk in pre/post-menopausal women as modified by polymorphisms of PARP1 and ESR1
    Lu ying Tang
    The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Gene 524:84-9. 2013
    ..We aimed to explore the modification effects of PARP1 rs1136410 and ESR1 rs2234693 on the association between passive smoking and breast cancer risk among pre- and post-menopausal women...
  31. pmc Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer
    Wei Hua Jia
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Nat Genet 45:191-6. 2013
    ..This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC...
  32. ncbi request reprint [Family-based association study of XRCC1 gene polymorphisms in nasopharyngeal carcinoma]
    Qing hua Pan
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Zhonghua Yu Fang Yi Xue Za Zhi 41:12-6. 2007
    ..To test the association between XRCC1 gene polymorphisms and susceptibility of nasopharyngeal carcinoma in Cantonese nuclear families through a family-based association study...
  33. doi request reprint Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma
    Rongrong Wei
    State Key Laboratory of Oncology in South China, Department of Hepatobiliary Oncology, Sun Yat sen University Cancer Center, Guangzhou, China
    Clin Cancer Res 19:4780-91. 2013
    ..The aim of this study is to identify miRNA expression signatures in hepatocellular carcinoma and delineate their clinical significance for hepatocellular carcinoma...
  34. doi request reprint HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway
    Xiao song Ge
    Department of Experimental Research, State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Sci 104:1675-82. 2013
    ..This newly identified HOTAIR/WIF-1 axis clarified the molecular mechanism of ESCC cell metastasis and represented a novel therapeutic target in patients with ESCC. ..
  35. ncbi request reprint [Comparative study on risk factors and family history of familial and sporadic nasopharyngeal carcinoma patients]
    Xiang Yu Luo
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Zhonghua Yu Fang Yi Xue Za Zhi 43:293-8. 2009
    ....
  36. doi request reprint Characterization of a novel mechanism of genomic instability involving the SEI1/SET/NM23H1 pathway in esophageal cancers
    Yan Li
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 70:5695-705. 2010
    ..Taken together, these findings define a novel mechanism of genomic instability and malignant progression in esophageal cancers, a deadly disease of increasing incidence in developed countries...
  37. ncbi request reprint Low expression of tyrosine-protein phosphatase nonreceptor type 12 is associated with lymph node metastasis and poor prognosis in operable triple-negative breast cancer
    Min Qing Wu
    Department of Breast Oncology, Sun Yat sen University Cancer Center, Guangzhou, China
    Asian Pac J Cancer Prev 14:287-92. 2013
    ..Low tyrosine-protein phosphatase nonreceptor type 12 (PTPN12) expression may be associated with breast cancer growth, proliferation, and metastasis. However, the prognostic value of PTPN12 in breast cancer has not been clearly identified...
  38. ncbi request reprint Familial nasopharyngeal carcinoma
    Yi Xin Zeng
    Cancer Center, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou 510060, China
    Semin Cancer Biol 12:443-50. 2002
    ..The major findings in this field were summarized. Furthermore, future directions leading to understanding the genetic mechanism of the familial form of NPC was also discussed...
  39. doi request reprint High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy
    Li Ru He
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Int J Cancer 127:138-47. 2010
    ..Evaluation of EZH2 expressions might be useful for predicting tumor response to CRT and prognosis for patients with ESCC...
  40. doi request reprint MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42
    Ruizhi Wang
    Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat Sen University, Guangzhou, People s Republic of China
    Hepatology 58:642-53. 2013
    ..Conclusion: miR-195 deregulation contributes to angiogenesis and metastasis in HCC. The restoration of miR-195 expression may be a promising strategy for HCC therapy...
  41. doi request reprint Identification of a gene-expression signature for predicting lymph node metastasis in patients with early stage cervical carcinoma
    Long Huang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Cancer 117:3363-73. 2011
    ..Pelvic lymph node metastasis (PLNM) is an important prognostic factor for patients with cervical carcinoma. The objective of this study was to identify a gene-expression signature that could predict PLNM in cervical carcinoma...
  42. ncbi request reprint The 30-bp deletion variant: a polymorphism of latent membrane protein 1 prevalent in endemic and non-endemic areas of nasopharyngeal carcinomas in China
    Xiao Shi Zhang
    Cancer Institute, Cancer Center, Sun Yat Sen University of Medical Sciences, 651 Dongfeng East Road, Guangzhou 510060, People s Republic of China
    Cancer Lett 176:65-73. 2002
    ..These results indicate that del-LMP1 represents a geographic or race-associated polymorphism rather than an NPC disease phenotype-associated polymorphism...
  43. ncbi request reprint A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma
    Ri Cheng Jiang
    State Key Laboratory of Oncology in Southern China Departments of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, China
    Cancer Res 66:693-700. 2006
    ..Collectively, these results provide evidence that the -32A variant is a functional sequence change and may be related to nasopharyngeal carcinoma susceptibility in the families studied...