Zhong Mei Zou

Summary

Affiliation: Institute of Medicinal Plant Development
Country: China

Publications

  1. pmc Salvianolic Acid B reducing portal hypertension depends on macrophages in isolated portal perfused rat livers with chronic hepatitis
    Xin Zhao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Evid Based Complement Alternat Med 2012:786365. 2012
  2. pmc Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San
    Hongmei Jia
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Evid Based Complement Alternat Med 2013:487158. 2013
  3. doi request reprint Hippocampus and serum metabolomic studies to explore the regulation of Chaihu-Shu-Gan-San on metabolic network disturbances of rats exposed to chronic variable stress
    Zhi Heng Su
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, P R China
    Mol Biosyst 10:549-61. 2014
  4. doi request reprint The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics
    Yue Tao Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, P R China
    Mol Biosyst 9:2823-34. 2013
  5. ncbi request reprint [Two new triterpenoid saponins from Lysimachia capillipes Hemsl]
    Jing Kui Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Yao Xue Xue Bao 39:722-5. 2004
  6. pmc Integration of ¹H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress
    Hong Mei Jia
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    PLoS ONE 8:e63624. 2013
  7. doi request reprint Laevigatbenzoate from Croton laevigatus Vahl
    Guo An Zou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People s Republic of China
    J Nat Med 65:391-4. 2011
  8. ncbi request reprint Cytotoxic germacranolide sesquiterpene from Inula cappa
    Hong Gang Xie
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chem Pharm Bull (Tokyo) 55:1258-60. 2007
  9. ncbi request reprint Two new triterpene saponins from Lysimachia davurica
    Jing Kui Tian
    Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    J Asian Nat Prod Res 7:601-6. 2005
  10. doi request reprint A new dihydroagarofuranoid sesquiterpene from the roots of Tripterygium hypoglaucum
    Zhen Zhen Liu
    a Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100193, China
    J Asian Nat Prod Res 16:327-31. 2014

Collaborators

Detail Information

Publications43

  1. pmc Salvianolic Acid B reducing portal hypertension depends on macrophages in isolated portal perfused rat livers with chronic hepatitis
    Xin Zhao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Evid Based Complement Alternat Med 2012:786365. 2012
    ..Sal B reduces PH in IPPRL with chronic hepatitis, via promoting portal relaxation due to macrophage-originated NO or CO in portal triads, partly at least...
  2. pmc Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San
    Hongmei Jia
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Evid Based Complement Alternat Med 2013:487158. 2013
    ..The integration of metabonomics and chemical profile was proved to be a useful strategy for uncovering what the active chemical constituents in TCM formula are and how they make contributions for the efficacy of the formula...
  3. doi request reprint Hippocampus and serum metabolomic studies to explore the regulation of Chaihu-Shu-Gan-San on metabolic network disturbances of rats exposed to chronic variable stress
    Zhi Heng Su
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, P R China
    Mol Biosyst 10:549-61. 2014
    ..The results showed that CSGS reversed disruptions of BDNF, ERK1/2 and pERK1/2 in CVS rats, which provides the first evidence that the ERK signal system may be one of the targets related to the antidepressant action of CSGS. ..
  4. doi request reprint The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics
    Yue Tao Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, P R China
    Mol Biosyst 9:2823-34. 2013
    ..These findings provided a unique perspective on localized metabolic information of ISO induced-MI, which gave us new insights into the pathogenesis of MI, discovery of targets for clinical diagnosis and treatment...
  5. ncbi request reprint [Two new triterpenoid saponins from Lysimachia capillipes Hemsl]
    Jing Kui Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Yao Xue Xue Bao 39:722-5. 2004
    ..To study the triterpenoid saponins in the whole plants of Lysimachia capillipes Hemsl....
  6. pmc Integration of ¹H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress
    Hong Mei Jia
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    PLoS ONE 8:e63624. 2013
    ....
  7. doi request reprint Laevigatbenzoate from Croton laevigatus Vahl
    Guo An Zou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People s Republic of China
    J Nat Med 65:391-4. 2011
    ..This compound showed weak cytotoxicity against HeLa cells, with an IC(50) value of 45.4 μM...
  8. ncbi request reprint Cytotoxic germacranolide sesquiterpene from Inula cappa
    Hong Gang Xie
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chem Pharm Bull (Tokyo) 55:1258-60. 2007
    ..In vitro, it showed antiproliferative effects against human cervical cancer HeLa, human leukemia K562 and human nasopharyngeal carcinoma KB cell lines with IC(50) values of 1.2 microM, 3.8 microM and 5.3 microM, respectively...
  9. ncbi request reprint Two new triterpene saponins from Lysimachia davurica
    Jing Kui Tian
    Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    J Asian Nat Prod Res 7:601-6. 2005
    ..Two new saponins, named davuricoside L (1) and davuricoside O (2), have been isolated from the whole plants of Lysimachia davurica. Their structures were determined by 1D and 2D NMR, FAB-MS techniques, and chemical methods...
  10. doi request reprint A new dihydroagarofuranoid sesquiterpene from the roots of Tripterygium hypoglaucum
    Zhen Zhen Liu
    a Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100193, China
    J Asian Nat Prod Res 16:327-31. 2014
    ..Compound 1 exhibited weak cytotoxicity against HeLa cells, with an IC₅₀ value of 30.2 μM...
  11. pmc Chronic unpredictive mild stress leads to altered hepatic metabolic profile and gene expression
    Hong Mei Jia
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No 151 Malianwa North Road, Haidian District, Beijing 100193, China
    Sci Rep 6:23441. 2016
    ..Results of liver-targeted metabonomics and mRNA expression demonstrated that CUMS-induced depression leads to variations in hepatic metabolic profile and gene expression, and ultimately results in liver injury. ..
  12. ncbi request reprint A new glycoside from Alpinia officinarum
    Ning An
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
    Yao Xue Xue Bao 41:233-5. 2006
    ..To investigate the glycosidic constituents in the rhizomes of Alpinia officinarum Hance...
  13. doi request reprint Lactones from Angiopteris caudatiformis
    Yong Ming Yu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People s Republic of China
    J Nat Prod 72:921-4. 2009
    ..Compound 1 was slightly cytotoxic against HeLa cells, with an IC(50) value of 68.8 microM, and compounds 3 and 4 showed moderate insect antifeeding activity against Plutella xylostella and Heliothis virescens...
  14. doi request reprint Norcyperone, a novel skeleton norsesquiterpene from Cyperus rotundus L
    Yan Xu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    Molecules 13:2474-81. 2008
    ..This is the first report of a 8,11,11-trimethyl- bicyclo[5.3.1]undecane-3-one type norsesquiterpene with a tetrahydrofuran ring at C-5 and C-8...
  15. doi request reprint Synthesis and Evaluation of New Podophyllotoxin Derivatives with in Vitro Anticancer Activity
    Wei Hua Cheng
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Molecules 20:12266-79. 2015
    ..93, 6.42, 6.89 μM, respectively. ..
  16. doi request reprint UPLC-Q/TOF MS standardized Chinese formula Xin-Ke-Shu for the treatment of atherosclerosis in a rabbit model
    Yue Tao Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    Phytomedicine 21:1364-72. 2014
    ..This study indicated that the UPLC-Q/TOF MS-based metabonomics not only gave a systematic view of the pathomechanism of AS, but also provided a powerful tool to study the efficacy and mechanism of complex TCM prescriptions. ..
  17. doi request reprint Stereochemical determination of new cytochalasans from the plant endophytic fungus Trichoderma gamsii
    Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China Electronic address
    Fitoterapia 96:115-22. 2014
    ..In addition, compounds 1-5, 7 and 8 were tested cytotoxic activities against several cancer cell lines. ..
  18. doi request reprint Metabolic pathways involved in Xin-Ke-Shu protecting against myocardial infarction in rats using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
    Yue Tao Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    J Pharm Biomed Anal 90:35-44. 2014
    ....
  19. doi request reprint Urinary metabonomics study of anti-depressive effect of Chaihu-Shu-Gan-San on an experimental model of depression induced by chronic variable stress in rats
    Zhi Heng Su
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    J Pharm Biomed Anal 55:533-9. 2011
    ..This study indicated that the rapid and noninvasive urinary metabonomics approach may be a powerful tool to study the efficacy and mechanism of complex TCM prescriptions...
  20. doi request reprint Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook
    Guo An Zou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Molecules 15:1097-102. 2010
    ..All compounds were isolated from and identified in this species for the first time and compounds 1-6 are new for the genus Croton...
  21. ncbi request reprint New polyoxygenated cyclohexenes from Uvaria kweichowensis and their antitumour activities
    Qiong Ming Xu
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China
    Chem Pharm Bull (Tokyo) 53:826-8. 2005
    ..The two new compounds showed some antitumour activity by MTT assay...
  22. ncbi request reprint [A new benzophenone from the root of Securidaca inappendiculata]
    Li Jie Zhang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Yao Xue Xue Bao 40:536-8. 2005
    ..To study the benzophenones in the roots of Securidaca inappendiculata Hassk...
  23. doi request reprint Trichalasins C and D from the plant endophytic fungus Trichoderma gamsii
    Gang Ding
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    Fitoterapia 83:541-4. 2012
    ..Compound 3 displaying inhibitory activity with EC₅₀ value 5.72 μM, whereas the EC₅₀ values for compounds 1, 2 and 4, 5 are more than 40 μM...
  24. ncbi request reprint [Quinic acid esters from herba of Siphonostegia chinensis]
    Hong Liang Jiang
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 27:923-6. 2002
    ..To study the bioactive constituents, quinic acid esters, from Siphonostegia chinensis...
  25. ncbi request reprint [Pharmacokinetics of patchouli alcohol and patchouli alcohol in patchouli oil after iv administrated to rats]
    Fu chuan Yang
    Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Yao Xue Xue Bao 39:726-9. 2004
    ..To develop a capillary gas chromatographic method for the determination and pharmacokinetic study of patchouli alcohol in rat plasma after iv administration...
  26. doi request reprint Qualitative and quantitative characterization of chemical constituents in Xin-Ke-Shu preparations by liquid chromatography coupled with a LTQ Orbitrap mass spectrometer
    Jing Bo Peng
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, No 151 Malianwa North Road, Haidian District, Beijing 100193, PR China
    J Pharm Biomed Anal 55:984-95. 2011
    ..The results suggested that the established methods would be a powerful and reliable analytical tool for the characterization of multi-constituent in complex chemical system and quality control of TCM preparations...
  27. doi request reprint Aberrant purine metabolism in allergic asthma revealed by plasma metabolomics
    Meng Yu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    J Pharm Biomed Anal 120:181-9. 2016
    ....
  28. ncbi request reprint [Two new triterpenoid saponins from Lysimachia davurica]
    Jing Kui Tian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    Yao Xue Xue Bao 39:194-7. 2004
    ..To study the triterpenoid saponins in the whole plant of Lysimachia davurica Ledeb...
  29. ncbi request reprint [Research on the technology of soaking under pressure and cutting process of Radix Curcumae]
    Wen Hua Huang
    Institute of Medicinal Plant Development, Chinese Academy of Medica Sciences and Chinese Peking Union Medica College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 30:498-500. 2005
    ..To determine the best processing technology parameters...
  30. doi request reprint Online identification of the antioxidant constituents of traditional Chinese medicine formula Chaihu-Shu-Gan-San by LC-LTQ-Orbitrap mass spectrometry and microplate spectrophotometer
    Zhi Heng Su
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    J Pharm Biomed Anal 53:454-61. 2010
    ....
  31. doi request reprint Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung
    Ling ling Yu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People s Republic of China
    J Nat Prod 74:1009-14. 2011
    ..Compounds 1-4 exhibited strong inhibitory effects not only on the mushroom tyrosinase activity in vitro but also on melanogenesis in cells...
  32. ncbi request reprint [Studies on chemical constituents in herba of Lysimachia davurica]
    Jing Kui Tian
    Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 27:283-4. 2002
    ..To study the chemical constituents from the whole plant of Lysimachia davurica...
  33. ncbi request reprint Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity
    Ning An
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Fitoterapia 79:27-31. 2008
    ..Compound 4 showed moderate cytotoxicity against human tumor cell lines, HepG2, MCF-7 and SF-268, while no significant effect were found for compounds 1-3...
  34. doi request reprint Inositol angelates from the whole herb of Inula cappa
    Zhong Mei Zou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Fitoterapia 79:393-4. 2008
    ....
  35. pmc Identification of candidate diagnostic biomarkers for adolescent idiopathic scoliosis using UPLC/QTOF-MS analysis: a first report of lipid metabolism profiles
    Zhi Jian Sun
    Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng District Shuaifuyuan No 1, Beijing 100730, China
    Sci Rep 6:22274. 2016
    ..Our findings suggest that differential metabolites discovered in AIS could be used as potential diagnostic biomarkers and that lipid metabolism plays a role in the pathogenesis of AIS. ..
  36. doi request reprint Synthesis and evaluation of novel podophyllotoxin derivatives as potential antitumor agents
    Wei Hua Cheng
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    Eur J Med Chem 85:498-507. 2014
    ..Furthermore, preliminary investigation suggested that 5p inhibited the expression of MDR-1 in K562/A02 cells more effectively than etoposide. ..
  37. doi request reprint Protoberberine isoquinoline alkaloids from Arcangelisia gusanlung
    Ling ling Yu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China
    Molecules 19:13332-41. 2014
    ..Gusanlung E (1) expressed weak cytotoxic activity against the SGC 7901 cell line with an IC50 value of 85.1 µM. ..
  38. ncbi request reprint [Studies on chemical constituents of rhizomes of Smilax china]
    Yan Xu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 33:2497-9. 2008
    ..To study the chemical constituents of the rhizomes of Smilax china...
  39. pmc Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC Strategy
    Chao Yuan
    Institute of Medicinal Plant Development Yunnan Branch, Chinese Academy of Medical Sciences and Peking Union Medical College, Jinghong, P R China
    Sci Rep 6:19350. 2016
    ..From the view of biosynthetic pathway, all four compounds 1-4 might be originated from Non-Reduced Polyketide synthase (NR-PKS). ..
  40. doi request reprint Lactonecembranoids from Croton laevigatus
    Guo An Zou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People s Republic of China
    J Nat Prod 73:792-5. 2010
    ..Their structures were elucidated on the basis of spectroscopic analysis, and that of 1 was confirmed by X-ray crystallography. Compound 2 exhibited modest cytotoxicity against HeLa cells, with an IC(50) value of 38.4 microM...
  41. doi request reprint Complete assignments of (1)H and (13)C NMR data for two new sesquiterpenes from Cyperus rotundus L
    Yan Xu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, PR China
    Magn Reson Chem 47:527-31. 2009
    ....
  42. doi request reprint Antihypertensive effect of total flavone extracts from Puerariae Radix
    Run Lan Cai
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, PR China
    J Ethnopharmacol 133:177-83. 2011
    ..To evaluate the antihypertensive effect of total flavone extracts from Puerariae Radix (FEPR). To explore the hemodynamic profiles and pertinent mechanism of the extracts...
  43. ncbi request reprint [Studies on lignan constituents of Clematis parviloba]
    Li Hua Yan
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:1839-43. 2008
    ..To study the chemical constituents of the stems of Clematis parviloba...