Yong Zhao

Summary

Affiliation: Institute of Zoology
Country: China

Publications

  1. ncbi The characteristics of Th1/Th2 cytokine receptors on monocytes in untreated patients of long term nonprogressor or chronic HIV infection
    C Sun
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Curr Mol Med 12:1028-39. 2012
  2. ncbi MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
    Ping Jiang
    Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China
    Radiat Oncol 5:100. 2010
  3. ncbi The biological effect of 125I seed continuous low dose rate irradiation in CL187 cells
    Hong Qing Zhuang
    Cancer Center, Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, PR China
    J Exp Clin Cancer Res 28:12. 2009
  4. ncbi The radiosensitization effects of Endostar on human lung squamous cancer cells H-520
    Zhen Y You
    Cancer Center, Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China
    Cancer Cell Int 10:17. 2010
  5. ncbi EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells
    Yingdong Zhang
    Department of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing, P, R, China 100191
    Cancer Cell Int 10:39. 2010
  6. ncbi Specific immune tolerance of antigen-presenting cells: Hypothesis and significance
    Yong Zhao
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing 100080, China
    Med Hypotheses 68:404-6. 2007
  7. ncbi The two simultaneously occurring processes in one immune response: the positive immune reaction and immune tolerance
    Yong Zhao
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing 100080, China
    Med Hypotheses 67:1384-5. 2006
  8. ncbi A novel approach to generate host antitumor T cells: adoptive immunotherapy by T cells maturing in xenogeneic thymus
    Yong Zhao
    Transplantation Biology Research Division, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
    J Immunother 30:83-8. 2007
  9. ncbi Cross-immune tolerance: conception and its potential significance on transplantation tolerance
    Yong Zhao
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Mol Immunol 7:20-5. 2010
  10. ncbi The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term
    Chenming Sun
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    J Cell Physiol 227:1670-9. 2012

Collaborators

Detail Information

Publications88

  1. ncbi The characteristics of Th1/Th2 cytokine receptors on monocytes in untreated patients of long term nonprogressor or chronic HIV infection
    C Sun
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Curr Mol Med 12:1028-39. 2012
    ..Therefore, our present study offered the basic information for the Th1/Th2 cytokine receptor expression and function on monocyte subsets in untreated HIV-infected individuals...
  2. ncbi MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
    Ping Jiang
    Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China
    Radiat Oncol 5:100. 2010
    ....
  3. ncbi The biological effect of 125I seed continuous low dose rate irradiation in CL187 cells
    Hong Qing Zhuang
    Cancer Center, Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, PR China
    J Exp Clin Cancer Res 28:12. 2009
    ..To investigate the effectiveness and mechanism of 125I seed continuous low-dose-rate irradiation on colonic cell line CL187 in vitro...
  4. ncbi The radiosensitization effects of Endostar on human lung squamous cancer cells H-520
    Zhen Y You
    Cancer Center, Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China
    Cancer Cell Int 10:17. 2010
    ..The present study mainly aimed to investigate the direct effects of Endostar (ES) on the proliferation and radiosensitivity of human lung squamous cancer cell line H-520...
  5. ncbi EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells
    Yingdong Zhang
    Department of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing, P, R, China 100191
    Cancer Cell Int 10:39. 2010
    ..953 Gy/min) in the presence or absence of C225. The cellular proliferation, colony forming capacity, apoptosis, the cell cycle distribution as well as caspase-3 were analyzed in vitro...
  6. ncbi Specific immune tolerance of antigen-presenting cells: Hypothesis and significance
    Yong Zhao
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing 100080, China
    Med Hypotheses 68:404-6. 2007
    ..We believe that, with the proving by the coming evidences, the impacts of the present hypothesis on basic and clinical immunology would be significant...
  7. ncbi The two simultaneously occurring processes in one immune response: the positive immune reaction and immune tolerance
    Yong Zhao
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing 100080, China
    Med Hypotheses 67:1384-5. 2006
    ..On the other hand, it will impact the immunotherapy for tumors and the development of vaccines...
  8. ncbi A novel approach to generate host antitumor T cells: adoptive immunotherapy by T cells maturing in xenogeneic thymus
    Yong Zhao
    Transplantation Biology Research Division, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
    J Immunother 30:83-8. 2007
    ..This study may offer a novel resource to produce host antitumor T cells for adoptive immunotherapy of tumor patients...
  9. ncbi Cross-immune tolerance: conception and its potential significance on transplantation tolerance
    Yong Zhao
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Mol Immunol 7:20-5. 2010
    ..The definition and significance of this concept were discussed in details...
  10. ncbi The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term
    Chenming Sun
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    J Cell Physiol 227:1670-9. 2012
    ..To further identify different components of diabetes on the dysfunction of macrophages is important for efficient prevention of diabetic complications...
  11. ncbi The influence of cyclosporin A on lymphocyte attenuator expression
    Chun Zeng
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    J Autoimmun 28:234-44. 2007
    ....
  12. ncbi The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice
    Aqeel Javeed
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transpl Immunol 20:253-60. 2009
    ..This study may have potential impacts in the clinical application of ASA...
  13. ncbi The immunity of splenic and peritoneal F4/80(+) resident macrophages in mouse mixed allogeneic chimeras
    Guangwei Liu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing, 100080, China
    J Mol Med (Berl) 85:1125-35. 2007
    ..The present study also, for the first time, offered basic information for macrophages maturing in heterogeneous environments...
  14. ncbi Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo
    Tingting Wu
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transpl Immunol 27:30-8. 2012
    ..The stronger inhibiting effects of MMF, LEF, CsA and Cy on CD4(+)CD25(+)Foxp3(+) Tregs than on T effectors may block the host immune tolerance potentiality...
  15. ncbi Development of mouse CD4(+)CD25(+)Foxp3(+) regulatory T cells in xenogeneic pig thymic grafts
    Baojun Zhang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transpl Immunol 20:180-5. 2009
    ..Therefore, the present data provides direct evidence for the ability of xenogeneic porcine thymus grafts to support the development of mouse naturally occurring CD4(+)CD25(+)Foxp3(+) Treg cells...
  16. ncbi Deficiency of mouse CD4+CD25+Foxp3+ regulatory T cells in xenogeneic pig thymus-grafted nude mice suffering from autoimmune diseases
    Baojun Zhang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Mol Immunol 5:325-32. 2008
    ..Thus, the decreased frequency, altered phenotype and functional deficiency of mouse CD4+CD25+ Treg cells in pig thymus-grafted nude mice may contribute to the development of AID in this model...
  17. ncbi Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes
    Yu Zhen
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beichen Xi Road 1 5, Beijing, China
    Cell Mol Immunol 9:75-85. 2012
    ..Our data show that hyperglycemia may alter the frequency of CD4+CD25+Foxp3+ Tregs in mice, which may result in late-state immune dysfunction in patients with diabetes...
  18. ncbi Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice
    Liang Zhao
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing, China 100080
    J Leukoc Biol 81:1386-94. 2007
    ..The functional defects of CD4(+)CD25(+) Treg cells may shed light on the role of CD4(+)CD25(+) Treg cells in the increased sensitivity to autoimmune diseases of aged populations...
  19. ncbi Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term
    Haixia Ma
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang, Beijing 100101, China
    J Mol Med (Berl) 86:391-400. 2008
    ....
  20. ncbi An instructive role of donor macrophages in mixed chimeras in the induction of recipient CD4(+)Foxp3(+) Treg cells
    Guangwei Liu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Immunol Cell Biol 89:827-35. 2011
    ..Whether this approach is involved in transplant immune tolerance needs to be determined...
  21. ncbi Immunotoxic effects of perfluorononanoic acid on BALB/c mice
    Xuemei Fang
    Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China
    Toxicol Sci 105:312-21. 2008
    ..Interestingly, at the transcriptional level, the nuclear factor-kappa B signaling pathway appears to be uninvolved in the immunotoxic potential of PFNA...
  22. ncbi The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications
    Chun Zeng
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beichen Xi Road 1 5, 100101 Beijing, China
    J Mol Med (Berl) 90:175-86. 2012
    ..These results opened an alternative explanation for the substantial activation of immune cells as well as the development of T2D and complications, which may have significant impacts on the prevention and treatment of T2D patients...
  23. ncbi Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells
    Kaizhong Duan
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transpl Immunol 25:173-9. 2011
    ..Thus, this humanized animal model is suitable for examining development and function of human CD4(+)CD25(+) regulatory T cells in vivo...
  24. ncbi The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice
    Yanyan Qu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing, 100080, China
    Transpl Immunol 17:153-61. 2007
    ..The different effects of rapa on CD4(+)CD25(+)Treg and T effector cells make rapa to be a favorable choice for inducing immune tolerance to self-, allo-, or xeno-antigens...
  25. ncbi B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation
    Ting He Wu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Immunol Cell Biol 85:590-5. 2007
    ..These results suggest that BTLA functions to regulate T-cell signaling by controlling the phosphorylated form of TCRzeta accumulation in the lipid raft...
  26. ncbi Gamma-ray resistance of regulatory CD4+CD25+Foxp3+ T cells in mice
    Yanyan Qu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Radiat Res 173:148-57. 2010
    ..These results indicate that mouse CD4(+)CD25(+) Treg cells and CD4(+)CD25(-) T effector cells have different sensitivities to gamma radiation in mice...
  27. ncbi Dendritic cells induced in the presence of GM-CSF and IL-5
    Huanfa Yi
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cytokine 37:35-43. 2007
    ..Together, these data suggest that IL-5 could partially inhibit GM-CSF-induced DC differentiation which could be reversed by IL-4 in vitro...
  28. ncbi Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: influence on regulatory CD4+CD25+Foxp3+ T cells in mice
    Huanfa Yi
    Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transplantation 85:1167-74. 2008
    ..The effects of depleting anti-CD4 monoclonal antibody (GK1.5), which was used in transplant tolerance induction, on CD4(+)CD25(+) Treg cells have not been investigated...
  29. ncbi Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway
    Tingting Wu
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    J Immunol 189:4989-5000. 2012
    ..Thus, this study identifies Smad3 as an intrinsic negative regulator that critically inhibits the differentiation and function of immunosuppressive CD11b(+)Gr1(+) myeloid-derived suppressor cells...
  30. ncbi Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice
    Guangwei Liu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Immunol Cell Biol 89:130-42. 2011
    ..CD4(+)CD25(+) Treg cells efficiently induced M2 macrophage differentiation in mice, offering the in vivo evidence to support the role of CD4(+)CD25(+) Treg cells in regulating innate immunity...
  31. ncbi Allograft inflammatory factor-1 and its immune regulation
    Guangwei Liu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing 100080, China
    Autoimmunity 40:95-102. 2007
    ..In the present manuscript, the genomic and functional characteristics of AIF-1 family proteins as well as their immune regulatory effects are reviewed...
  32. ncbi 2-Gy whole-body irradiation significantly alters the balance of CD4+ CD25- T effector cells and CD4+ CD25+ Foxp3+ T regulatory cells in mice
    Yanyan Qu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Mol Immunol 7:419-27. 2010
    ..The enhanced proportion of CD4(+)CD25(+)Foxp3(+) Treg cells in the periphery by a low dose of WBI may make hosts more susceptible to immune tolerance induction...
  33. ncbi TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice
    Lianjun Zhang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e30592. 2012
    ..Collectively, our study suggests that TSC1 plays an essential role in regulating peripheral naïve CD8(+) T cell homeostasis, possible via an mTOR-Akt-FoxO-Bim signaling pathway...
  34. ncbi The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation
    Di Jin
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Inflamm Res 61:53-60. 2012
    ..The effect of LEF on CD4(+)CD25(+)T regulatory cells (Treg) was determined in a mouse model of allogeneic bone marrow transplantation...
  35. ncbi The biological role of dectin-1 in immune response
    Lina Sun
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datui Road Yi 5, Beijing 100101, China
    Int Rev Immunol 26:349-64. 2007
    ..In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. In this paper, we will mainly focus on the characteristics of dectin-1 and its biological role in immune response...
  36. ncbi Achievement of cellular immunity and discordant xenogeneic tolerance in mice by porcine thymus grafts
    Yong Zhao
    Transplantation Biology Research Division, State Key Lab of Membrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Cell Mol Immunol 1:173-9. 2004
    ..Xenogeneic thymic replacement might have a potential role in the reconstitution of cellular immunity in patients with AIDS or other immunodeficiencies caused by thymus dysfunction...
  37. ncbi Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice
    Aqeel Javeed
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Beijing, 100101, China
    Inflamm Res 60:389-98. 2011
    ..The effect of acetylsalicyclic acid (ASA) on the phagocytosis and immunogenicity of macrophages remains to be determined...
  38. ncbi A potential side effect of cyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice
    Hongjun Wang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transplantation 82:1484-92. 2006
    ..The present studies suggest that CsA may block the potential induction of immune tolerance and increase the susceptibility to develop autoimmune diseases while preventing graft rejection...
  39. ncbi Platelet aggregation and thrombosis in xenotransplantation between pigs and humans
    Baojun Zhang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datun Road 5, Beijing, China, 100101, China
    Thromb Res 121:433-41. 2008
    ..Here we reviewed platelet incompatibility between pigs and humans related to thrombosis after xenotransplantation, and contribution of immunosuppressive agents to minimizing thrombosis and rejection...
  40. ncbi Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells
    Guangwei Liu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Immunology 122:149-56. 2007
    ..This immunomodulation pathway may therefore have potential applications in the treatment of graft rejection, autoimmune diseases, infection diseases and cancers...
  41. ncbi The effects of antibody treatment on regulatory CD4(+)CD25(+) T cells
    Huanfa Yi
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transpl Immunol 19:37-44. 2008
    ..In this manuscript, we review the recent progress on the effects of therapeutic antibodies on the development, phenotypic changes and functions of CD4(+)CD25(+) Tregs...
  42. ncbi The inflammatory Th 17 subset in immunity against self and non-self antigens
    Di Jin
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China
    Autoimmunity 41:154-62. 2008
    ....
  43. ncbi Regulatory CD4(+)CD25(+) T-cells are controlled by multiple pathways at multiple levels
    Yanyan Qu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Int Rev Immunol 26:145-60. 2007
    ....
  44. ncbi The nonopsonic allogeneic cell phagocytosis of macrophages detected by flow cytometry and two photon fluorescence microscope
    Guang-Wei Liu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transpl Immunol 16:220-6. 2006
    ..Our present data indicated that the FCM and TPM combined method is a practical approach to detect macrophage nonopsonic phagocytosis of allogeneic lymphocytes and to identify the phenotype alteration of macrophages after phagocytosis...
  45. ncbi Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice
    Qanhui Zheng
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang, Beijing, China 100101
    J Mol Med (Berl) 87:1191-205. 2009
    ....
  46. ncbi Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4(+)CD25(+) regulatory T cells
    Xuelian Hu
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Mol Immunol 9:464-72. 2012
    ..We have provided in vivo evidence to support the unknown pathways by which allogeneic donor CD4(+)CD25(+) Tregs regulate innate immunity in recipient mice by promoting the differentiation of M2 macrophages...
  47. ncbi Transforming growth factor-beta: an important role in CD4+CD25+ regulatory T cells and immune tolerance
    Lianjun Zhang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China
    Autoimmunity 39:269-76. 2006
    ..We will, herein, focus on the crucial role of TGF-beta signaling in Treg cell biology and summarize the current studies regarding TGF-beta in the generation and function of CD4+CD25+Treg cells both in vivo and in vitro...
  48. ncbi The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells
    Huanfa Yi
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Mol Immunol 3:189-95. 2006
    ....
  49. ncbi Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1
    Guangwei Liu
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Blood 121:519-29. 2013
    ..Thus, our findings identify a previously unrecognized p53-independent function of Wip1 as a cell type-specific negative regulator of neutrophil generation and homeostasis through limiting the p38 MAPK-STAT1 pathway...
  50. ncbi Molecular cloning and characterization of a novel mouse actin-binding protein Zfp185
    Na Wang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Beijing 100101, China
    J Mol Histol 39:295-302. 2008
    ..Thus, our data offered evidence for the association of mouse Zfp185 with F-actin, which supports the potential role of Zfp185 in cell fundamental activity...
  51. ncbi Thymic epithelial progenitor cells and thymus regeneration: an update
    Lianjun Zhang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Cell Res 17:50-5. 2007
    ..Great progress has been made to characterize the common TEC progenitor cells in recent years. We herein discuss the sole origin paradigm with regard to TEC differentiation as well as these progenitor cells in thymus regeneration...
  52. ncbi The direct biologic effects of radioactive 125I seeds on pancreatic cancer cells PANC-1, at continuous low-dose rates
    Jidong Wang
    Department of Radiation Oncology, Cancer Center, Peking University Third Hospital, Beijing, China
    Cancer Biother Radiopharm 24:409-16. 2009
    ..Interestingly, CLDR irradiation by 125I seeds can cause PANC-1cell-cycle arrest at the G2=M phase and induce apoptosis, which may be an important mechanism underlying 125Iseed-induced PANC-1 cell inhibition...
  53. ncbi The macrophage heterogeneity: difference between mouse peritoneal exudate and splenic F4/80+ macrophages
    Guangwei Liu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    J Cell Physiol 209:341-52. 2006
    ....
  54. ncbi Mouse models with human immunity and their application in biomedical research
    Baojun Zhang
    Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    J Cell Mol Med 13:1043-58. 2009
    ..The applications of the humanized mice to study the development and response of human immune cells, human autoimmune diseases, virus infections, transplantation biology and tumour biology are reviewed as well...
  55. ncbi The effects of immunosuppression on regulatory CD4(+)CD25(+) T cells: impact on immunosuppression selection in transplantation
    Aqeel Javeed
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Mol Diagn Ther 12:171-81. 2008
    ..In this review we summarize the effects of immunosuppressive reagents on CD4(+)CD25(+) T(reg) cells in order to bring attention to this issue, which may affect the choice of immunosuppressive regimen in the clinical setting...
  56. ncbi Toll-like receptors and graft rejection
    Guangwei Liu
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Transpl Immunol 16:25-31. 2006
    ..Clinical and laboratory studies have shown that TLRs may participate in organ graft rejection and transplant immune tolerance, which are briefly reviewed in the present manuscript...
  57. ncbi Compatibility of porcine and human interleukin 2: implications for xenotransplantation
    Baojun Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Transplantation Biology Research Division, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Xenotransplantation 13:423-32. 2006
    ..Our data suggested an additional potential advantage for the mixed xenogeneic chimeras...
  58. ncbi The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road
    Lianjun Zhang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    J Cell Physiol 211:590-7. 2007
    ....
  59. ncbi Radiosensitivity of prostate cancer cells is enhanced by EGFR inhibitor C225
    Feng Liu
    Cancer Center, Peking University Third Hospital, Beijing, China
    Urol Oncol 28:59-66. 2010
    ..To determine the direct effects of the epidermal growth factor receptor (EGFR) inhibitor C225 on the radiosensitivity of human prostate cancer cells...
  60. ncbi The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein-protein interaction
    Quanhui Zheng
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Biol Cell 99:489-502. 2007
    ..LIM domain proteins are distributed in both the nucleus and the cytoplasm, and they exert their functions through interactions with various protein partners...
  61. ncbi Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells
    Feng Wang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Proc Natl Acad Sci U S A 109:20413-8. 2012
    ..Thus, hnRNP A2* plays a positive role in unfolding telomere G-quadruplexes and in enhancing telomere extension by telomerase...
  62. ncbi Combination of amlodipine plus angiotensin receptor blocker or diuretics in high-risk hypertensive patients: a 96-week efficacy and safety study
    Liyuan Ma
    Department of Evidence Based Medicine, Cardiovascular Institute, Beijing, China
    Am J Cardiovasc Drugs 12:137-42. 2012
    ....
  63. ncbi [Cancer stem cells play an important role in resistance of laryngeal squamous cancer to irradiation mediated by hypoxia]
    Mao Xin Wang
    Department of Otorhinolaryngology, Head and Neck Surgery, Chinese People Liberation Army General Hospital, Beijing, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 46:1024-9. 2011
    ..To study whether laryngeal cancer stem cells in hypoxia have the characteristic of resistance to irradiation and underlying mechanism...
  64. ncbi Chemokines, chemokine receptors and CD4(+)CD25(+) regulatory T cells
    Huanfa Yi
    Chinese Academy of Sciences, Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Beijing, China
    Expert Rev Clin Immunol 3:343-9. 2007
    ....
  65. ncbi Molecular diversity and functional evolution of scorpion potassium channel toxins
    Shunyi Zhu
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Mol Cell Proteomics 10:M110.002832. 2011
    ..Our results demonstrate that accelerated evolution drives affinity variations of orthologous α-KTxs on Kv channels and indicate that MeuTXKα1 is a promising candidate to develop an immune modulation agent for human autoimmune diseases...
  66. ncbi BTLA, a new inhibitory B7 family receptor with a TNFR family ligand
    Chun Zeng
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Cell Mol Immunol 2:427-32. 2005
    ..The exploration of the biological mechanisms and regulation of BTLA will open possibilities on novel therapeutic strategies in immune-related diseases...
  67. ncbi Functional expression of cystic fibrosis transmembrane conductance regulator in mouse chondrocytes
    Haitao Liang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Clin Exp Pharmacol Physiol 37:506-8. 2010
    ..3. Thus, the results of the present study demonstrate that functional CFTR is expressed in mouse chondrocytes, which offers essential evidence for the potential direct role of CFTR in physiological and pathological processes of bone...
  68. ncbi Murine CD4 T cells selected in a highly disparate xenogeneic porcine thymus graft do not show rapid decay in the absence of selecting MHC in the periphery
    Jose-Ignacio Rodriguez-Barbosa
    Transplantation Biology Research Center, Bone Marrow Transplantation Section, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    J Immunol 169:6697-710. 2002
    ..Our results support the interpretation that xenogeneic thymic transplantation is a feasible strategy to reconstitute CD4 T cells and render recipients tolerant of a xenogeneic donor...
  69. ncbi Pre-transplant analysis of accommodation in donor pigs
    William E Beschorner
    Ximerex, Inc, Omaha, NE 68116 2461, USA
    Xenotransplantation 10:66-71. 2003
    ..Acute vascular rejection was not observed in the heterotopic heart transplants from six donors with PBL accommodation. Only one incident of moderate diffuse cellular rejection (grade 3) was observed...
  70. ncbi Fetal porcine thymus engraftment, survival and CD4 reconstitution in alphaGal-KO mice is impaired in the presence of high levels of antibodies against alphaGal
    Jose-Ignacio Rodriguez-Barbosa
    Transplantation Biology Research Center, Bone Marrow Transplantation Section, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 10:24-40. 2003
    ....
  71. ncbi The different effects of indirubin on effector and CD4+CD25+ regulatory T cells in mice: potential implication for the treatment of autoimmune diseases
    Aijun Zhang
    Hematology Oncology Center, Qilu Hospital, Shandong University, Jinan 250012, China
    J Mol Med (Berl) 85:1263-70. 2007
    ..The selectively enhanced CD4(+)CD25(+)Treg cell levels by indirubin made host to be more favorable for immune tolerance induction, which opened one possibility for indirubin to treat autoimmune diseases...
  72. ncbi Xenogeneic skin graft rejection in M-CSF/macrophage deficient osteopetrotic mice
    Yong Zhao
    Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, Omaha, NE 68198 7690, USA
    Xenotransplantation 10:232-9. 2003
    ..The cellular infiltrate in xenografts suggests that macrophages may be involved in xenograft rejection. However, the precise role of macrophages in xenograft rejection has not yet been fully addressed...
  73. ncbi NK cell tolerance in mixed allogeneic chimeras
    Yong Zhao
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    J Immunol 170:5398-405. 2003
    ..Thus, the present studies demonstrate that NK cells in mixed chimeras are stably tolerant to both donor and host Ags, by mechanisms that are as yet unexplained...
  74. ncbi Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity
    Yong Zhao
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    Transplantation 75:1832-40. 2003
    ....
  75. ncbi MOP3, a component of the molecular clock, regulates the development of B cells
    Yimin Sun
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Immunology 119:451-60. 2006
    ..This study also showed a connection between a master regular of circadian rhythm with B-cell development in mice...
  76. ncbi Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues
    Hua He
    State Key Laboratory of Genetic Engineering, Group of Liver Cancer Research, Institute of Genetics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Gene Expr 10:231-42. 2002
    ..The above findings could be valuable for understanding the vesicular transport system and elucidating the molecular basis of liver cancer carcinogenesis...
  77. ncbi Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
    G Matthew Longo
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 7690, USA
    J Clin Invest 110:625-32. 2002
    ..These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA...
  78. ncbi The role of cyclooxygenase-2/prostanoid pathway in visceral pain induced liver stress response in rats
    Donald Piston
    Department of Gastroenterological Surgery, Peking University People s Hospital, Beijing 100044, China
    Chin Med J (Engl) 120:1813-9. 2007
    ..But there was no report on visceral pain induced liver stress. This study was to investigate the role of the COX-2/prostanoid pathway in liver stress response in rat acute colitis visceral pain liver stress model...
  79. ncbi Effects of corticosterone, cAMP, cGMP, Ca2+, and protein kinase C on apoptosis of mouse thymocytes induced by X-ray irradiation
    Shou Liang Gong
    Key Laboralory of Radiobiology Unit, Ministry of Health, School of Public Health, Jilin University, Changchun 130021, Jilin, China
    Biomed Environ Sci 21:167-72. 2008
    ..To observe the effects of signal factors of corticosterone (CS), cAMP, cGMP, Ca2+ andprotein kinase C (PKC) on lymphocyte apoptosis in mouse thymus induced by X-rays of 4 Gy in vitro...
  80. ncbi Transplant tolerance: is it really free of concerns?
    Yong Zhao
    Trends Immunol 28:376-7. 2007
  81. ncbi A human peripheral blood monocyte-derived subset acts as pluripotent stem cells
    Yong Zhao
    Biochip Technology Center, Argonne National Laboratory, Argonne, IL 60439, USA
    Proc Natl Acad Sci U S A 100:2426-31. 2003
    ..The ability to store, expand, and differentiate these PSC from autologous peripheral blood should make them valuable candidates for transplantation therapy...
  82. ncbi Prolongation of allogeneic skin graft survival by injection of anti-Ly49A monoclonal antibody YE1/48
    Tian-Yu Yang
    Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, 987690 University of Nebraska Medical Center, Omaha, NE 68198-7690, USA
    Clin Immunol 106:148-54. 2003
    ..The presence of NK, NKT cells, and some cytotoxic T cells may be essential for YE1/48-mediated immunosuppression in vivo...
  83. ncbi Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow
    Jia Lin Zhang
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198-3285, USA
    Transplantation 80:362-9. 2005
    ....
  84. ncbi Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 172:2607-12. 2004
    ..This study has important implications for other degenerative diseases associated with matrix destruction...
  85. ncbi Altered allogeneic immune responses in middle-aged mice
    Yimin Sun
    Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, UNMC, Omaha, NE 68198-7690, USA
    Cell Mol Immunol 1:440-6. 2004
    ..Further studies on the characteristics of allogeneic immunity in aging individuals may help to determine the appropriated treatment for transplant aging individuals...
  86. ncbi Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
    Immunol Lett 108:78-87. 2007
    ..Our findings may advance our understanding of the immunobiology of stem cells and facilitate the therapeutic application of cord blood stem cells...
  87. ncbi The mortality of MOP3 deficient mice with a systemic functional failure
    Yimin Sun
    Department of Surgery, University of Nebrasaka Medical Center, Omaha, NE 68131 5805, USA
    J Biomed Sci 13:845-51. 2006
    ..This study may have significant clinical impacts on the consideration about the abnormality of circadian rhythms and sleeping disorders caused physical and metabolism dysfunctions as well as the mortality...
  88. ncbi Induction of regulatory T cells from mature T cells by allogeneic thymic epithelial cells in vitro
    Yimin Sun
    Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, Omaha, NE, USA
    Transpl Int 19:404-14. 2006
    ....