Yong Q Zhang
Affiliation: Institute of Genetics and Developmental Biology
Mao C, Wen X, Jin S, Zhang Y. Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila. Dis Model Mech. 2017;10:1245-1252 pubmed publisher
..Overall, our results indicate that increasing MT acetylation by either genetic manipulations or drugs might be used as potential strategies for intervention in tauopathies. ..
Metwally E, Zhao G, Li W, Wang Q, Zhang Y. Calcium-Activated Calpain Specifically Cleaves Glutamate Receptor IIA But Not IIB at the Drosophila Neuromuscular Junction. J Neurosci. 2019;39:2776-2791 pubmed publisher
..Different calpains constitute an active protease complex to cleave its target. This study reveals a critical role of calpains during development to specifically cleave GluRIIA at synapses and consequently regulate synaptic function. ..
Jia M, Meng D, Chen M, Li T, Zhang Y, Yao A. Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation. J Genet Genomics. 2019;46:5-17 pubmed publisher
..As Drosophila Acsl and human ACSL4 are functionally conserved, our findings provide novel insights into a critical and previously unappreciated role of Acsl in neurogenesis and the pathogenesis of ACSL4-related ID. ..
Jiang F, Lu F, Li P, Liu W, Zhao L, Wang Q, et al
. Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi. J Genet Genomics. 2016;43:11-24 pubmed publisher
..Taken together, we propose that dFMRP cooperates with Piwi in maintaining genome integrity by regulating heterochromatic silencing in somatic cells and suppressing transposon activity via the piRNA pathway in germlines. ..
Huang Y, Huang S, Lam S, Liu Z, Shui G, Zhang Y. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. J Cell Sci. 2016;129:4034-4045 pubmed
..These findings suggest that Acsl inhibits NMJ growth by stimulating C16:1 fatty acyl production and concomitantly suppressing raft-associated lipid levels. ..