Dan Zhang

Summary

Affiliation: Institute of Materia Medica
Country: China

Publications

  1. pmc Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
    Dan Zhang
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 8:3. 2011
  2. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
  3. pmc Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    J Neuroimmune Pharmacol 7:187-201. 2012
  4. doi request reprint Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
  5. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
  6. pmc Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 181:7194-204. 2008
  7. pmc Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
    Hui Zhou
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:303-13. 2012
  8. pmc Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:64-70. 2009
  9. pmc Astrogliosis in CNS pathologies: is there a role for microglia?
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA
    Mol Neurobiol 41:232-41. 2010
  10. ncbi request reprint Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Glia 55:1178-88. 2007

Collaborators

Detail Information

Publications11

  1. pmc Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
    Dan Zhang
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 8:3. 2011
    ..However, the upstream signaling pathway of superoxide production remains unclear...
  2. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
    ..Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases...
  3. pmc Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    J Neuroimmune Pharmacol 7:187-201. 2012
    ....
  4. doi request reprint Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
    ..Taken together, our study implicated that curcumin might be a potential preventive and therapeutic strategy for inflammation-related neurodegenerative diseases...
  5. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
    ..Microglial activation is important in the pathogenesis of PD...
  6. pmc Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 181:7194-204. 2008
    ....
  7. pmc Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
    Hui Zhou
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:303-13. 2012
    ..In conclusion, rotenone directly interacted with gp91(phox); such an interaction triggered membrane translocation of p67(phox), leading to PHOX activation and superoxide production...
  8. pmc Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:64-70. 2009
    ..These findings are important in elucidating the role of activated microglia and PGE(2) in astrocyte proliferation and in suggesting a potential avenue in the use of anti-inflammatory agents for the therapy of astroglioma...
  9. pmc Astrogliosis in CNS pathologies: is there a role for microglia?
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA
    Mol Neurobiol 41:232-41. 2010
    ..Development of targeted anti-microglial activation therapies might slow or halt the progression of astrogliosis and, therefore, help achieve a more beneficial environment in various CNS pathologies...
  10. ncbi request reprint Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Glia 55:1178-88. 2007
    ..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...
  11. doi request reprint Anti-inflammatory activity of methyl salicylate glycosides isolated from Gaultheria yunnanensis (Franch.) Rehder
    Dan Zhang
    National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Molecules 16:3875-84. 2011
    ..These results showed that the isolated compounds possess anti-inflammatory properties through inhibition the production pro-inflammatory cytokines, NO, and ROS...