Dan Zhang

Summary

Affiliation: Institute of Materia Medica
Country: China

Publications

  1. pmc FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation
    Xiu Qi Bao
    State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 8:e78033. 2013
  2. pmc Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
    Dan Zhang
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 8:3. 2011
  3. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
  4. doi request reprint Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
  5. doi request reprint Sesquiterpenes and alkaloids from the roots of Alangium chinense
    Yan Zhang
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    J Nat Prod 76:1058-63. 2013
  6. pmc Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    J Neuroimmune Pharmacol 7:187-201. 2012
  7. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
  8. doi request reprint A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages
    Tiantai Zhang
    State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No 1 Xiannongtan Street, Xicheng District, Beijing 100050, PR China
    Mol Pharm 9:671-7. 2012
  9. pmc Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 181:7194-204. 2008
  10. pmc Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
    Hui Zhou
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:303-13. 2012

Collaborators

Detail Information

Publications40

  1. pmc FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation
    Xiu Qi Bao
    State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 8:e78033. 2013
    ..These results suggested FLZ might be a potential anti-AD drug as it not only reduced Aβ production via inhibition amyloidogenic APP processing pathway, but also attenuated tau hyperphosphoylation mediated by Akt/GSK3β. ..
  2. pmc Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
    Dan Zhang
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 8:3. 2011
    ..However, the upstream signaling pathway of superoxide production remains unclear...
  3. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
    ..Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases...
  4. doi request reprint Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
    ..Taken together, our study implicated that curcumin might be a potential preventive and therapeutic strategy for inflammation-related neurodegenerative diseases...
  5. doi request reprint Sesquiterpenes and alkaloids from the roots of Alangium chinense
    Yan Zhang
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    J Nat Prod 76:1058-63. 2013
    ..7 μM. None of the compounds exhibited detectable cytotoxic activity toward any of five tumor cell lines (A549, Be-17402, BGC-823, HCT-8, and A2780) in the MTT assay. ..
  6. pmc Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    J Neuroimmune Pharmacol 7:187-201. 2012
    ....
  7. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
    ..Microglial activation is important in the pathogenesis of PD...
  8. doi request reprint A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages
    Tiantai Zhang
    State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No 1 Xiannongtan Street, Xicheng District, Beijing 100050, PR China
    Mol Pharm 9:671-7. 2012
    ..Therefore, DL0309 may have therapeutic potential for treating inflammatory diseases by regulating the NF-κB pathway and pro-inflammatory cytokine production...
  9. pmc Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 181:7194-204. 2008
    ....
  10. pmc Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
    Hui Zhou
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:303-13. 2012
    ..In conclusion, rotenone directly interacted with gp91(phox); such an interaction triggered membrane translocation of p67(phox), leading to PHOX activation and superoxide production...
  11. doi request reprint Lycojaponicumins A-C, three alkaloids with an unprecedented skeleton from Lycopodium japonicum
    Xiao Jing Wang
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Org Lett 14:2614-7. 2012
    ..2.1]heptane moiety. These structures were elucidated by spectroscopic methods and X-ray diffraction analysis. A plausible biogenetic pathway was proposed. ..
  12. doi request reprint Prenylated C6-C3 compounds from the roots of Illicium henryi
    Peng Yu Zhuang
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    Phytochemistry 86:176-83. 2013
    ..Compound 4 exhibited strong antioxidant activity with an IC(50) value of 2.97±1.30 μM, whereas compounds 3 and 8 showed antioxidant activities with IC(50) values of 44.36±0.30 and 48.00±2.01 μM, respectively...
  13. ncbi request reprint Bisindole alkaloids with neural anti-inflammatory activity from Gelsemium elegans
    Jing Qu
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    J Nat Prod 76:2203-9. 2013
    ..2 μM. These findings confirm the importance of bioactive trace components in medicinal plant research. ..
  14. pmc Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:64-70. 2009
    ..These findings are important in elucidating the role of activated microglia and PGE(2) in astrocyte proliferation and in suggesting a potential avenue in the use of anti-inflammatory agents for the therapy of astroglioma...
  15. doi request reprint FLZ, a novel HSP27 and HSP70 inducer, protects SH-SY5Y cells from apoptosis caused by MPP(+)
    Xiang Chen Kong
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China
    Brain Res 1383:99-107. 2011
    ..These results provide new evidence for elucidating the mechanism of the neuroprotective effect of FLZ against PD...
  16. ncbi request reprint Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Glia 55:1178-88. 2007
    ..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...
  17. doi request reprint Lycojaponicumins D and E: two new alkaloids from Lycopodium japonicum
    Xiao Jing Wang
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Org Lett 14:5688-91. 2012
    ..Lycojaponicumin D (1) possesses an unprecedented 5/7/6/6 tetracyclic skeleton formed by an unusual C3-C13 linkage, which is first reported in Lycopodium alkaloids. The plausible biogenetic pathway of 1 is proposed...
  18. pmc Astrogliosis in CNS pathologies: is there a role for microglia?
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA
    Mol Neurobiol 41:232-41. 2010
    ..Development of targeted anti-microglial activation therapies might slow or halt the progression of astrogliosis and, therefore, help achieve a more beneficial environment in various CNS pathologies...
  19. ncbi request reprint [Research progress of the relationship between microglia and cerebral ischemia]
    Wen Jiao Tai
    State Key Laboratory of Natural Products and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 47:346-53. 2012
    ..This paper is a review of microglial activation and regulation during cerebral ischemia as well as related therapeutic methods...
  20. ncbi request reprint A,D-seco-limonoids from the stems of Clausena emarginata
    Hong Min Xia
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    J Nat Prod 77:784-91. 2014
    ..The absolute configurations of 1 and 5 were confirmed by X-ray crystallography and ECD spectroscopy, respectively. Compounds 1, 2, 8-10, and 13 showed moderate inhibitory effects on LPS-induced NO production (IC50 values<10 μM)...
  21. ncbi request reprint The novel squamosamide derivative FLZ protects against 6-hydroxydopamine-induced apoptosis through inhibition of related signal transduction in SH-SY5Y cells
    Dan Zhang
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Eur J Pharmacol 561:1-6. 2007
    ..The results suggested that FLZ has potential neuroprotective effect on 6-OHDA-induced apoptosis of SH-SY5Y cells through regulating related signal-transduction...
  22. doi request reprint Pharmacokinetics of methyl salicylate-2-O-β-D-lactoside, a novel salicylic acid analog isolated from Gaultheria yunnanensis ,in dogs
    Dan Zhang
    Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China
    Biomed Chromatogr 27:1680-4. 2013
    ..These results will aid in understanding the pharmacological significance of MSL. The developed method was successfully used for evaluation of the oral and intravenous pharmacokinetic profile of MSL in dogs...
  23. doi request reprint FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells
    Xuan Ye
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, People s Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 387:75-85. 2014
    ..We propose that FLZ is a potential anti-AD drug candidate, and its mechanism may be improving mitochondrial function by reducing the Aβ burden in mitochondria. ..
  24. doi request reprint Antioxidant phenolic glycosides from the roots of Illicium dunnianum
    Jian Bai
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    Carbohydr Res 361:206-11. 2012
    ..Compounds 1-5, 7, and 9 exhibited potent antioxidant activities against Fe(2+)-cystine-induced rat liver microsomal lipid peroxidation, with IC(50) values ranging from 3.8 ± 0.6 to 23.0 ± 2.2 μM...
  25. ncbi request reprint Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice
    Wenyu Xin
    State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Key Laboratory of Molecular Pharmacology and Drug Evaluation Ministry of Education of China, School of Pharmacy, Yantai University, Yantai, China Binzhou Medical University, Yantai, China
    Br J Pharmacol 171:3526-38. 2014
    ..The aim of this study was to investigate the therapeutic effect of MSL in mice with collagen-induced arthritis (CIA) and explore its underlying mechanism...
  26. ncbi request reprint [Therapeutic effect of a natural squamosamide derivative FLZ on Parkinson's disease model mice induced by LPS plus MPTP]
    Ling Hong Yu
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 48:1557-62. 2013
    ..This study showed FLZ has significant therapeutic effect on LPS plus MPTP induced chronic PD model, which indicates its potential as a new candidate drug to treat PD...
  27. pmc A comparison of E15.5 fetus and newborn rat serum proteomes
    Lilong Wei
    Department of Physiology and Pathophysiology, National Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China
    Proteome Sci 10:64. 2012
    ..abstract:..
  28. doi request reprint Lupane triterpenoids from the stems of Euonymus carnosus
    Jian Zhou
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    J Nat Prod 77:276-84. 2014
    ..39, 7.48, 7.80, 3.48, 2.54, and 6.09 μM, respectively. ..
  29. doi request reprint Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models
    Xiu Qi Bao
    State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China Electronic address
    Brain Res 1547:49-57. 2014
    ..The data also provided evidence that FLZ had potent neuroprotecive effects and might become a new promising agent for PD treatment. ..
  30. doi request reprint Anti-inflammatory activity of methyl salicylate glycosides isolated from Gaultheria yunnanensis (Franch.) Rehder
    Dan Zhang
    National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Molecules 16:3875-84. 2011
    ..These results showed that the isolated compounds possess anti-inflammatory properties through inhibition the production pro-inflammatory cytokines, NO, and ROS...
  31. ncbi request reprint The novel squamosamide derivative (compound FLZ) attenuated 1-methyl, 4-phenyl-pyridinium ion (MPP+)-induced apoptosis and alternations of related signal transduction in SH-SY5Y cells
    Dan Zhang
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Neuropharmacology 52:423-9. 2007
    ..The results suggest that cFLZ possesses potent neuroprotective activity and may be a potential anti-Parkinson's disease drug worthy for further study...
  32. doi request reprint Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models
    Wenjiao Tai
    State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Neuropharmacology 75:201-12. 2013
    ..Furthermore, this study defines a critical role of Src tyrosine kinase in neuroinflammation, and suggests that particular tyrosine kinase inhibition may be a potential anti-inflammatory approach for PD treatment. ..
  33. doi request reprint Asymmetric dimethylarginine confers the communication between endothelial and smooth muscle cells and leads to VSMC migration through p38 and ERK1/2 signaling cascade
    Lan Sun
    National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    FEBS Lett 585:2727-34. 2011
    ..Investigations to identify the factors regulating VSMC migration may provide novel insights into atherosclerosis and its complications...
  34. pmc Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy
    Long Ze Sha
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 7:e39152. 2012
    ..Taken together, our results indicate that mTOR activation is most prominent in reactive astrocytes in both an animal model of TLE and the sclerotic hippocampus from patients with drug resistant TLE...
  35. doi request reprint Pharmacokinetic study of baicalein after oral administration in monkeys
    Shuo Tian
    National Centre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Fitoterapia 83:532-40. 2012
    ..The analytes were stable during samples storage and handling, and no matrix effects were observed. The method we developed in this study was sensitive, precise, stable and producible...
  36. ncbi request reprint Dactylorhin B reduces toxic effects of beta-amyloid fragment (25-35) on neuron cells and isolated rat brain mitochondria
    Dan Zhang
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Naunyn Schmiedebergs Arch Pharmacol 374:117-25. 2006
    ..Co-incubation of DHB attenuated Abeta(25-35)-induced pathological changes. The significance of DHB in the management of mitochondria-related disorders is discussed...
  37. pmc Novel nonphosphorylated peptides with conserved sequences selectively bind to Grb7 SH2 domain with affinity comparable to its phosphorylated ligand
    Dan Zhang
    National Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences School of Basic Medicine, Peking Union Medical College, Beijing, China
    PLoS ONE 7:e29902. 2012
    ..Such nonphosphorylated peptides may be useful for rational design of drugs targeted against cancers that express high levels of Grb7 protein...
  38. doi request reprint Spoken sentences decoding based on intracranial high gamma response using dynamic time warping
    Dan Zhang
    Department of Biomedical Engineering, Tsinghua University, Beijing, China
    Conf Proc IEEE Eng Med Biol Soc 2012:3292-5. 2012
    ..Our preliminary results shed light on the construction of cortical speech brain-computer interfaces on the sentence level...
  39. doi request reprint The early events of Alzheimer's disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits
    Xuan Ye
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Neurobiol Aging 33:1122.e1-10. 2012
    ..The modification of the origin in this pathway may contribute to slow down the disease progression of AD...
  40. doi request reprint Neolignans and sesquiterpenes from cell cultures of Stellera chamaejasme
    Li Rui Qiao
    State Key Laboratory of Bioactive Substances and Function of Natural Medicines and Key Laboratory of Biosynthesis of Natural Products, Ministry of Health, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Planta Med 78:711-9. 2012
    ..49 % at 10 µM. These compounds have not been isolated from plant material, which implies that in vitro plant cell cultures may offer alternative and effective sources of bioactive natural compounds...