Affiliation: Institute of Materia Medica
Zhang Q, Heng Y, Chen Y, Luo P, Wen L, Zhang Z, et al
. A Novel Bibenzyl Compound (20C) Protects Mice from 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine/Probenecid Toxicity by Regulating the α-Synuclein-Related Inflammatory Response. J Pharmacol Exp Ther. 2017;363:284-292 pubmed publisher
Chen Y, Zhang Q, Shao Q, Wang S, Yuan Y, Chen N, et al
. NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP. Acta Pharmacol Sin. 2019;: pubmed publisher
..Our results demonstrate that MPTP/P-caused olfactory bulb damage might be related to NLRP3-mediated inflammation. ..
Wang S, Yuan Y, Chen N, Wang H. The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease. Int Immunopharmacol. 2019;67:458-464 pubmed publisher
..In addition, we focus on some inhibitors of NLRP3 inflammatory pathways to alleviate the progression of PD by inhibiting central inflammation and provide new therapeutic strategies for the treatment of PD. ..
Yan J, Yuan Y, Chu S, Li G, Chen N. E46K Mutant α-Synuclein Is Degraded by Both Proteasome and Macroautophagy Pathway. Molecules. 2018;23: pubmed publisher
..Our findings may verify the possible routes contributing to the degradation of the E46K mutant α-syn. ..
Shao Q, Yan W, Zhang Z, Ma K, Peng S, Cao Y, et al
. Nurr1: A vital participant in the TLR4-NF-κB signal pathway stimulated by α-synuclein in BV-2 cells. Neuropharmacology. 2019;144:388-399 pubmed publisher
..In conclusion, Nurr1 is a novel participant in the neuroinflammation stimulated by α-synuclein, thus the regulation of Nurr1 may be a novel neuroprotective target for PD treatment. ..
Shao Q, Zhang X, Chen Y, Zhu C, Shi J, Yuan Y, et al
. Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways. Mol Immunol. 2018;99:115-123 pubmed publisher
..These findings suggest that 20C has therapeutic potential for treating neurodegenerative diseases in the future. ..
Chen Y, Shao Q, Yuan Y, Chen N. Prion-like propagation of α-synuclein in the gut-brain axis. Brain Res Bull. 2018;140:341-346 pubmed publisher
..We then summarize the mechanism of the gut-brain axis and confirm α-synuclein as a potential target for drug design or new clinical treatment. ..
Heng Y, Zhang Q, Mu Z, Hu J, Yuan Y, Chen N. Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting Î±-synuclein abnormalities in the substantia nigra. Toxicol Lett. 2016;243:7-21 pubmed publisher
..In conclusion, Rg1 protects dopaminergic neurons, most likely by reducing aberrant Î±-synuclein-mediated neuroinflammation, and holds promise for PD therapeutics. ..
Wen L, Zhang Q, Heng Y, Chen Y, Wang S, Yuan Y, et al
. NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model. Toxicol Lett. 2018;288:1-8 pubmed publisher
..A disordered thymus might take part in the development of PD, and its enhanced immune response might promote the degenerative changes in the brain. ..