Zhiheng Xu


Affiliation: Institute of Genetics and Developmental Biology
Country: China


  1. Wang S, Tan N, Zhu X, Yao M, Wang Y, Zhang X, et al. Sh3rf2 Haploinsufficiency Leads to Unilateral Neuronal Development Deficits and Autistic-Like Behaviors in Mice. Cell Rep. 2018;25:2963-2971.e6 pubmed publisher
    ..Our results support a notion that Sh3rf2 haploinsufficiency is a highly penetrant risk factor for ASD, with disease pathogenesis most likely resulting from deficits in synaptic function in the left hemisphere of the brain. ..
  2. Zhang F, Wang Y, Wang T, Yao L, Lam S, Huang X, et al. cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. Proc Natl Acad Sci U S A. 2018;115:E9449-E9458 pubmed publisher
    ..Because mutations in cTAGE5/MEA6 have been found in patients with Fahr's disease, our study potentially also provides insight into the pathogenesis of this disorder. ..
  3. Zhu X, Li C, Afridi S, Zu S, Xu J, Quanquin N, et al. E90 subunit vaccine protects mice from Zika virus infection and microcephaly. Acta Neuropathol Commun. 2018;6:77 pubmed publisher
    ..It also supports the further development of the E90 subunit vaccine towards clinical trials. ..
  4. Li C, Gao F, Yu L, Wang R, Jiang Y, Shi X, et al. A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos. Cell Rep. 2018;23:1424-1434 pubmed publisher
    ..Thus, ZK2B10 is a promising candidate for the development of antibody-based interventions and informs the rational design of ZIKV vaccine. ..
  5. Li C, Xu D, Ye Q, Hong S, Jiang Y, Liu X, et al. Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell. 2016;19:120-6 pubmed publisher
  6. Li C, Deng Y, Wang S, Ma F, Aliyari R, Huang X, et al. 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. Immunity. 2017;46:446-456 pubmed publisher
    ..Our findings highlight the protective role of CH25H during ZIKV infection and the potential use of 25HC as a natural antiviral agent to combat ZIKV infection and prevent ZIKV-associated outcomes, such as microcephaly. ..
  7. request reprint
    Xu Z, Sproul A, Wang W, Kukekov N, Greene L. Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis. J Biol Chem. 2006;281:303-12 pubmed
    ..These findings thus reveal a "loop" mechanism in which the JNK pathway promotes SIAH1 stabilization and in which SIAH1 in turn activates the JNK pathway and, ultimately, contributes to cell death. ..
  8. Xu D, Zhang F, Wang Y, Sun Y, Xu Z. Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Rep. 2014;6:104-16 pubmed publisher
    ..Thus, our findings indicate that WDR62 is required for proper neurogenesis via JNK1 and provide an insight into the molecular mechanisms underlying MCPH pathogenesis. ..
  9. Zhang F, Yu J, Yang T, Xu D, Chi Z, Xia Y, et al. A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. J Biol Chem. 2016;291:11466-75 pubmed publisher
    ..We suggest that unique JNK protein complexes are involved in the diversified biological and pathological functions during brain development and pathogenesis of diseases. ..

More Information


  1. Li C, Zhu X, Ji X, Quanquin N, Deng Y, Tian M, et al. Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice. EBioMedicine. 2017;24:189-194 pubmed publisher
    ..Selecting drugs that were previously FDA-approved, such as CQ, also improves the likelihood that they may more quickly reach stages of clinical testing and use by the public. ..
  2. Zhang F, Wang H, Wang Q, Liu Z, Yuan L, Huang X, et al. American Strain of Zika Virus Causes More Severe Microcephaly Than an Old Asian Strain in Neonatal Mice. EBioMedicine. 2017;25:95-105 pubmed publisher
  3. Fan J, Wang Y, Liu L, Zhang H, Zhang F, Shi L, et al. cTAGE5 deletion in pancreatic ? cells impairs proinsulin trafficking and insulin biogenesis in mice. J Cell Biol. 2017;216:4153-4164 pubmed publisher
    ..Together our data provide more insight into the underlying mechanism of the proinsulin trafficking pathway. ..
  4. Deng Y, Zhang N, Li X, Wang Y, Tian M, Qiu Y, et al. Intranasal infection and contact transmission of Zika virus in guinea pigs. Nat Commun. 2017;8:1648 pubmed publisher
    ..These collective results from animal models highlight the risk of exposure to ZIKV contaminants and raise the possibility of close contact transmission of ZIKV in humans. ..