Affiliation: Institute of Biophysics
Shang L, Zhang S, Yang X, Sun J, Li L, Cui Z, et al
. Biochemical characterization of recombinant Enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay. Antimicrob Agents Chemother. 2015;59:1827-36 pubmed publisher
..54 Â± 0.51 Î¼M; 50% cytotoxic concentration [CC50] > 100 Î¼M). This fast and efficient assay for lead discovery and optimization provides an ideal platform for anti-EV71 drug development targeting 3C protease. ..
Wang Y, Cao L, Zhai Y, Yin Z, Sun Y, Shang L. Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor. Antimicrob Agents Chemother. 2017;61: pubmed publisher
..Together with the results of our previous works, these in-depth results elucidate the inhibitory mechanism of PIs and shed light to develop PIs for the clinical treatment of infections caused by EV71 and other enteroviruses. ..
Shang L, Wang Y, Qing J, Shu B, Cao L, Lou Z, et al
. An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation. Antiviral Res. 2014;112:47-58 pubmed publisher
..A significant synergistic anti-EV71 effect of NITD008 with rupintrivir (AG7088) (a protease inhibitor) was documented, supporting the potential combination therapy of NITD008 with other inhibitors for the treatment of EV71 infections. ..
Qing J, Luo R, Wang Y, Nong J, Wu M, Shao Y, et al
. Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus. Antiviral Res. 2016;126:43-54 pubmed publisher
..These results verify that NITD008 is an effective analog inhibitor against hepatitis C virus and a good research tool as a supplement to other types of nucleoside analogs. ..
Wang Y, Cao L, Zhai Y, Ma J, Nie Q, Li T, et al
. Inhibition of enterovirus 71 replication by an Î±-hydroxy-nitrile derivative NK-1.9k. Antiviral Res. 2017;141:91-100 pubmed publisher
..The combination of NK-1.9k and EV71 polymerase or entry inhibitors produced strong synergistic antiviral effects. Collectively, our findings suggest our compounds can potentially be developed as drugs for the treatment of HFMD. ..