Jian Gong Shi

Summary

Affiliation: Institute of Materia Medica
Country: China

Publications

  1. ncbi Cytotoxic triterpenoid glycosides from the roots of Gordonia chrysandra
    Lei Yu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Ministry of Education, Beijing 100050, People s Republic of China
    J Nat Prod 72:866-70. 2009
  2. ncbi Furostanol oligoglycosides from Asparagus cochinchinensis
    Jian Gong Shi
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100050, China
    J Asian Nat Prod Res 6:99-105. 2004
  3. ncbi Anti-apoptotic effect of esculin on dopamine-induced cytotoxicity in the human neuroblastoma SH-SY5Y cell line
    Da Long Zhao
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine affiliated Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, District Xuanwu, Beijing, China
    Neuropharmacology 53:724-32. 2007
  4. ncbi [Dihydroflavonol glycosides and flavan-3-ols from Bauhinia aurea]
    Xiao Ya Shang
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China
    Zhongguo Zhong Yao Za Zhi 32:815-8. 2007
  5. ncbi Butanolide derivatives from the bark of Machilus yaoshansis
    Ming tao Liu
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Asian Nat Prod Res 14:713-20. 2012
  6. ncbi Methoxylated fatty acids from the bark of Fraxinus sieboldiana
    Sheng Lin
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
    J Asian Nat Prod Res 14:235-43. 2012
  7. ncbi Chemical constituents of Bauhinia aurea
    Xiao Ya Shang
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, China
    J Asian Nat Prod Res 14:966-72. 2012
  8. ncbi [Chemical constituents from branch of Macaranga adenantha and their TNF-alpha inhibitory activity]
    Ming Ma
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China
    Zhongguo Zhong Yao Za Zhi 32:1175-9. 2007
  9. ncbi Two novel glycosidic triterpene alkaloids from the stem barks of Machilus yaoshansis
    Ming tao Liu
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, People s Republic of China
    Org Lett 9:129-32. 2007
  10. ncbi Triterpenoids from the roots of Pterospermum heterophyllum Hance
    Shuai Li
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Asian Nat Prod Res 11:652-7. 2009

Collaborators

Detail Information

Publications19

  1. ncbi Cytotoxic triterpenoid glycosides from the roots of Gordonia chrysandra
    Lei Yu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Ministry of Education, Beijing 100050, People s Republic of China
    J Nat Prod 72:866-70. 2009
    ..Among these substances, compounds 1, 3, 5, and 6 exhibited cytotoxic activity against several human cancer cell lines, with 3 being the most potent...
  2. ncbi Furostanol oligoglycosides from Asparagus cochinchinensis
    Jian Gong Shi
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100050, China
    J Asian Nat Prod Res 6:99-105. 2004
    ....
  3. ncbi Anti-apoptotic effect of esculin on dopamine-induced cytotoxicity in the human neuroblastoma SH-SY5Y cell line
    Da Long Zhao
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine affiliated Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, District Xuanwu, Beijing, China
    Neuropharmacology 53:724-32. 2007
    ..These data indicate that esculin may provide a useful therapeutic strategy for the treatment of progressive neurodegenerative diseases such as Parkinson's disease (PD)...
  4. ncbi [Dihydroflavonol glycosides and flavan-3-ols from Bauhinia aurea]
    Xiao Ya Shang
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China
    Zhongguo Zhong Yao Za Zhi 32:815-8. 2007
    ..To study the chemical constituents of Bauhinia aurea...
  5. ncbi Butanolide derivatives from the bark of Machilus yaoshansis
    Ming tao Liu
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Asian Nat Prod Res 14:713-20. 2012
    ..Their structures were elucidated by spectroscopic and chemical methods. All the isolates were evaluated for cytotoxic and anti-inflammatory activities...
  6. ncbi Methoxylated fatty acids from the bark of Fraxinus sieboldiana
    Sheng Lin
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
    J Asian Nat Prod Res 14:235-43. 2012
    ..Their structures were determined by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments. The 3- or 9-methoxylated fatty acids are reported for the first time in nature...
  7. ncbi Chemical constituents of Bauhinia aurea
    Xiao Ya Shang
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, China
    J Asian Nat Prod Res 14:966-72. 2012
    ..Their structures were determined by spectroscopic and chemical methods...
  8. ncbi [Chemical constituents from branch of Macaranga adenantha and their TNF-alpha inhibitory activity]
    Ming Ma
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China
    Zhongguo Zhong Yao Za Zhi 32:1175-9. 2007
    ..To investigate the chemical constituents of the brach of Macaranga adenantha, and evaluate their TNF-alpha inhibitory activity...
  9. ncbi Two novel glycosidic triterpene alkaloids from the stem barks of Machilus yaoshansis
    Ming tao Liu
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, People s Republic of China
    Org Lett 9:129-32. 2007
    ..1 and 2 showed nonselective cytotoxic activities against several human cancer cell lines as well as TNF-alpha secretion inhibitory activities...
  10. ncbi Triterpenoids from the roots of Pterospermum heterophyllum Hance
    Shuai Li
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Asian Nat Prod Res 11:652-7. 2009
    ..21, 0.55, 0.40, 0.59, and 0.34 microM, respectively. However, the other compounds were inactive (IC(50)>10 microM)...
  11. ncbi [Alkaloids from a Tibetan medicine Meconopsis quintuplinervia Regel]
    Xiao Ya Shang
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 38:276-8. 2003
    ..CONCLUSION: Norsanguinarine (I) was isolated from genus Meconopsis for the first time, and 6-methoxy-17-methyl-2,3-[methylenebis(oxy)]-morphin-5-en-7-one (III) is a new alkaloid named as meconoquintupline...
  12. ncbi Phenylpropene diglycosides from the bark of Machilus wangchiana
    Wei Cheng
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China
    J Asian Nat Prod Res 14:1046-53. 2012
    ..Their structures were determined by spectroscopic and chemical methods. In the preliminary assay, compounds 2 and 5-8 reduced dl-galactosamine (GalN)-induced hepatocyte (WB-F344 cells) damage with 37-41% inhibitions at 10 μM...
  13. ncbi Minor constituents from the tubers of Gymnadenia conopsea
    Jia Chen Zi
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Asian Nat Prod Res 12:477-84. 2010
    ....
  14. ncbi 6,7-di-O-glucopyranosyl-esculetin protects SH-SY5Y cells from dopamine-induced cytotoxicity
    Da Long Zhao
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine affiliated Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Eur J Pharmacol 580:329-38. 2008
    ..These data indicate that 6,7-di-O-glucopyranosyl-esculetin may provide a useful therapeutic strategy for the treatment of progressive neurodegenerative diseases such as Parkinson's disease...
  15. ncbi Anthraquinones from the roots of Knoxia valerianoides
    Feng Zhao
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
    J Asian Nat Prod Res 13:1023-9. 2011
    ..Compounds 4 and 5 showed moderate activity against nitrogen oxide production in macrophages induced by lipopolysaccharide, at 10(- 5) M, with inhibition ratios of 50.4 ± 3.6 and 41.7 ± 2.1%, respectively...
  16. ncbi [Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity]
    Sheng Lin
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Zhongguo Zhong Yao Za Zhi 33:1708-10. 2008
    ..To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity...
  17. ncbi Terpenoids from the tuber of Cremastra appendiculata
    Shuai Li
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Asian Nat Prod Res 10:685-91. 2008
    ..Compound 3 showed in vitro-selective cytotoxicity against human breast cancer cell lines (MCF-7) with an IC50 of 3.18 microM, but 1 and 2 were inactive (IC50>10 microg/ml)...
  18. ncbi Minor new constituents from Heteroplexis micocephala
    Xiao Na Fan
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education of PRC, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 45:82-6. 2010
    ..Their structures were elucidated with spectroscopic data analysis including 2D NMR experiments...
  19. ncbi Phenolic glucosides from Alangium plantanifolium
    Jian Gong Shi
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
    J Asian Nat Prod Res 4:47-51. 2002
    ..The structure of 1 was elucidated to be 1-O-[2-(1-hydroxy-6-oxocyclohex-2-ene-1-carboxymethyl)-phenyl]-4,6-O-[(S)-,4,4',5,5' 6,6'-hexahydroxydiphenoyl]-beta-D-glucopyranose...