Dayong Shi


Affiliation: Institute of Oceanology
Country: China


  1. Xu K, Guo C, Shi D, Meng J, Tian H, Guo S. Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents Through ROS-Mediated Apoptotic Pathway. Mar Drugs. 2019;17: pubmed publisher
  2. Li X, Xu Q, Li C, Luo J, Li X, Wang L, et al. Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors. Eur J Med Chem. 2019;166:178-185 pubmed publisher
    ..All these results indicate that compound 22 could serve as a qualified agent to treat type II diabetes. ..
  3. Liu H, Guo C, Guo S, Wang L, Shi D. Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells. Molecules. 2019;24: pubmed publisher
    ..Therefore, this probe has great potential application in environment and biological samples. ..
  4. Wang L, Wang S, Jiang B, Wu N, Li X, Wang B, et al. Design, synthesis and biological evaluation of novel bromophenol derivatives incorporating indolin-2-one moiety as potential anticancer agents. Mar Drugs. 2015;13:806-23 pubmed publisher
    ..The structure-activity relationships (SARs) of bromophenol derivatives had been discussed, which were useful for exploring and developing bromophenol derivatives as novel anticancer drugs. ..
  5. Wang S, Wang L, Jiang B, Wu N, Li X, Liu S, et al. Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects. Int J Mol Sci. 2015;16:13548-60 pubmed publisher
    ..These results indicate that BDDPM can be exploited as an anti-angiogenic drug, or as a lead compound for the development of novel multi-target RTKs inhibitors. ..
  6. Luo J, Wu N, Jiang B, Wang L, Wang S, Li X, et al. Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition. Mar Drugs. 2015;13:4452-69 pubmed publisher
    ..Thus, HPN can be considered to have potential for the development of anti-diabetic agent that could protect both hepatic cell mass and function. ..
  7. Li N, Wang L, Jiang B, Guo S, Li X, Chen X, et al. Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors. Bioorg Med Chem Lett. 2018;28:2131-2135 pubmed publisher
    ..The structure-activity relationships of these pyrimidinedione derivatives had been discussed, which would be useful for developing novel DPP-4 inhibitors as treating type 2 diabetes. ..
  8. Guo C, Wang L, Zhao Y, Liu H, Li X, Jiang B, et al. A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway. Mar Drugs. 2018;16: pubmed publisher
  9. request reprint
    Wang L, Jiang B, Wu N, Wang S, Shi D. Small molecules as potent protein tyrosine phosphatase 1B (PTP1B) inhibitors documented in patents from 2009 to 2013. Mini Rev Med Chem. 2015;15:104-22 pubmed
    ..This paper will provide valuable information for understanding the current anti-PTP1B investigation and developing potent PTP1B inhibitors as treating 2-DM drugs. ..

More Information


  1. Li N, Wang L, Jiang B, Li X, Guo C, Guo S, et al. Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus. Eur J Med Chem. 2018;151:145-157 pubmed publisher
    ..We also discuss strategies and structure-activity relationships for identifying potent DPP-4 inhibitors, which will provide useful information for developing potent DPP-4 drugs as type 2 diabtes treatments. ..
  2. Wu N, Liu J, Zhao X, Yan Z, Jiang B, Wang L, et al. Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumour Biol. 2015;36:9667-76 pubmed publisher
    ..This study also reveals that targeting STAT3 signal pathway is an important strategy for the treatment of human GBM. ..
  3. Wu N, Luo J, Jiang B, Wang L, Wang S, Wang C, et al. Marine bromophenol bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells via modulating β1-integrin/FAK signaling. Mar Drugs. 2015;13:1010-25 pubmed publisher
  4. Shi D, Guo S, Jiang B, Guo C, Wang T, Zhang L, et al. HPN, a synthetic analogue of bromophenol from red alga Rhodomela confervoides: synthesis and anti-diabetic effects in C57BL/KsJ-db/db mice. Mar Drugs. 2013;11:350-62 pubmed publisher
    ..HPN therefore have potential for development as treatments for Type 2 diabetes. ..
  5. Li X, Xu Q, Luo J, Wang L, Jiang B, Zhang R, et al. Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B. Eur J Med Chem. 2017;136:348-359 pubmed publisher
    ..The similarity of its action profiling with that produced by insulin suggested its potential as a new non-insulin-dependent drug candidate. ..
  6. Xu Q, Luo J, Wu N, Zhang R, Shi D. BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes. Int J Biol Macromol. 2018;106:379-386 pubmed publisher
    ..Taken together, BPN activates insulin signaling and alleviates insulin resistance and represents a potential candidate for further development as an antidiabetic agent. ..
  7. Wang L, Guo C, Li X, Wang S, Jiang B, Zhao Y, et al. Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation. Mar Drugs. 2017;15: pubmed publisher
    ..These results might be useful for bromophenol derivatives to be explored and developed as novel anticancer drugs. ..
  8. Zhang R, Yu R, Xu Q, Li X, Luo J, Jiang B, et al. Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors. Eur J Med Chem. 2017;134:24-33 pubmed publisher
    ..Molecule docking and molecular dynamics studies reveal the reason of selectivity for PTP1B over TCPTP. Moreover, the cell permeability and cellular activity of compound 10a are demonstrated respectively. ..
  9. Li X, Wang L, Shi D. The design strategy of selective PTP1B inhibitors over TCPTP. Bioorg Med Chem. 2016;24:3343-52 pubmed publisher
    ..Furthermore, the design strategy of selective PTP1B inhibitors over TCPTP is also proposed. We hope our work could provide an effective way to gain specific PTP1B inhibitors. ..
  10. Zhao Y, Guo C, Wang L, Wang S, Li X, Jiang B, et al. A novel fluorinated thiosemicarbazone derivative- 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway. Biochem Biophys Res Commun. 2017;491:65-71 pubmed publisher
    ..As a result, it is indicated that compound 1 induced apoptosis on A549 cells was realized by regulating ROS-mediated mitochondria-dependent signaling pathway. ..
  11. Zhang R, Song L, Jiang B, Wang L, Wu N, Guo S, et al. Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity. Bioorg Med Chem Lett. 2017;27:2488-2492 pubmed publisher
    ..Moreover, compound 9 blocked A549 cells at the G0/G1 phase. The cellular uptake studies suggested that ribose-modified compound 9 could be taken through GLUT1 in A549 cell line. ..