Pin Nie


Affiliation: Institute of Hydrobiology
Country: China


  1. Xie H, Lu J, Rolhion N, Holden D, Nie P, Zhou Y, et al. Edwardsiella tarda-Induced cytotoxicity depends on its type III secretion system and flagellin. Infect Immun. 2014;82:3436-45 pubmed publisher
    ..We propose that the host controls E. tarda infection partially by detecting FliC translocated by the T3SS, whereas the bacteria downregulate the expression of FliC to evade innate immunity. ..
  2. Lu J, Wang W, Wang G, Zhang H, Zhou Y, Gao Z, et al. Edwardsiella tarda EscE (Orf13 Protein) Is a Type III Secretion System-Secreted Protein That Is Required for the Injection of Effectors, Secretion of Translocators, and Pathogenesis in Fish. Infect Immun. 2016;84:2-10 pubmed publisher
    ..tarda pathogenesis in fish. The homology of EscE within the T3SSs of other bacterial species suggests that the mechanism of secretion and translocation control used by E. tarda may be commonly used by other bacterial pathogens. ..
  3. Zhang Y, Nie P, Lin L. Complete Genome Sequence of the Fish Pathogen Flavobacterium columnare Pf1. Genome Announc. 2016;4: pubmed publisher
    ..Here, we describe the complete genome of F. columnare strain Pf1, a highly virulent strain isolated from yellow catfish (Pelteobagrus fulvidraco) in China. ..
  4. Li N, Zhu Y, LaFrentz B, Evenhuis J, Hunnicutt D, Conrad R, et al. The Type IX Secretion System Is Required for Virulence of the Fish Pathogen Flavobacterium columnare. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..columnare virulence. T9SSs are common in members of the phylum Bacteroidetes and likely contribute to the virulence of other animal and human pathogens. ..
  5. Liu L, Nie P, Yu H, Xie H. Regulation of Type III Secretion of Translocon and Effector Proteins by the EsaB/EsaL/EsaM Complex in Edwardsiella tarda. Infect Immun. 2017;85: pubmed publisher
    ..tarda during a coinfection model. These results demonstrate that EsaB/EsaL/EsaM form a ternary complex controlling the secretion of T3SS translocon and effector proteins and contributing to E. tarda pathogenesis. ..
  6. Hou J, Gan Z, Chen S, Nie P. Molecular and functional characterization of a short-type peptidoglycan recognition protein, PGRP-S in the amphibian Xenopus laevis. Dev Comp Immunol. 2019;98:13-19 pubmed publisher
    ..The present study represents the first discovery on the function of frog PGRPs, thus contributing to a better understanding of the functional evolution of PGRPs in early tetrapods. ..
  7. Huo H, Chen S, Li L, Laghari Z, Li N, Nie P. Functional characterization of interleukin (IL)-22 and its inhibitor, IL-22 binding protein (IL-22BP) in Mandarin fish, Siniperca chuatsi. Dev Comp Immunol. 2019;97:88-97 pubmed publisher
    ..In conclusion, the mandarin fish IL-22 and IL-22BP are conserved in their interaction and function with their mammalian orthologues, and these findings provide basis for future research on IL-22-IL-22BP axis in fish immunity. ..
  8. Li L, Chen S, Laghari Z, Huang B, Huo H, Li N, et al. Receptor complex and signalling pathway of the two type II IFNs, IFN-γ and IFN-γrel in mandarin fish or the so-called Chinese perch Siniperca chuatsi. Dev Comp Immunol. 2019;97:98-112 pubmed publisher
  9. Huo H, Chen S, Li L, Nie P. Functional characterization of IL-10 and its receptor subunits in a perciform fish, the mandarin fish, Siniperca chuatsi. Dev Comp Immunol. 2019;97:64-75 pubmed publisher
    ..Overall, mandarin fish IL-10 shares conserved ligand-receptor system and the prototypical inhibitory activities on pro-inflammatory cytokine expression with mammalian IL-10, implying the evolutionary conservation of this cytokine. ..

More Information


  1. Gan Z, Yang Y, Chen S, Hou J, Laghari Z, Huang B, et al. Unique Composition of Intronless and Intron-Containing Type I IFNs in the Tibetan Frog Nanorana parkeri Provides New Evidence To Support Independent Retroposition Hypothesis for Type I IFN Genes in Amphibians. J Immunol. 2018;201:3329-3342 pubmed publisher
  2. Huang W, Wang Z, Liang Y, Nie P, Huang B. Characterization of MyD88 in Japanese eel, Anguilla japonica. Fish Shellfish Immunol. 2018;81:374-382 pubmed publisher
    ..Taken together, sequence characterization, gene expression and cellular distribution data obtained in this study suggest that AjMyD88, similar to its mammalian ortholog, plays an important role in eel immune response against bacteria. ..
  3. Lu X, Chen Y, Cui Z, Zhang X, Lu L, Li S, et al. Characterization of grass carp CD40 and CD154 genes and the association between their polymorphisms and resistance to grass carp reovirus. Fish Shellfish Immunol. 2018;81:304-308 pubmed publisher
    ..These results indicated that CD40 and CD154 play important roles in the responses to GCRV in grass carp. The SNP markers in the CD40 associated with the resistance to GCRV may facilitate the disease-resistant breeding of grass carp. ..
  4. Huang B, Jia Q, Liang Y, Huang W, Nie P. Interferon regulatory factor 10 (IRF10): Cloning in orange spotted grouper, Epinephelus coioides, and evolutionary analysis in vertebrates. Fish Shellfish Immunol. 2015;46:669-77 pubmed publisher
  5. Fan Y, Chang M, Ma J, LaPatra S, Hu Y, Huang L, et al. Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus. Vet Res. 2015;46:136 pubmed publisher
    ..The results reported herein provided significant and new EST information that could contribute greatly in investigations into the molecular functions of immune genes in the Chinese giant salamander. ..
  6. Li N, Qin T, Zhang X, Huang B, Liu Z, Xie H, et al. Gene deletion strategy to examine the involvement of the two chondroitin lyases in Flavobacterium columnare virulence. Appl Environ Microbiol. 2015;81:7394-402 pubmed publisher
    ..The gene deletion method developed in this study may be employed to investigate the virulence factors of this bacterium and may have wide application in many other members of the phylum Bacteroidetes. ..
  7. Gan Z, Wang B, Tang J, Lu Y, Jian J, Wu Z, et al. Molecular characterization and expression of CD2 in Nile tilapia (Oreochromis niloticus) in response to Streptococcus agalactiae stimulus. Fish Shellfish Immunol. 2016;50:101-8 pubmed publisher
    ..This is the first report on the expression of CD2 induced by bacteria vaccination in teleosts. These findings indicated that On-CD2 may play an important role in the immune response to intracellular bacteria in Nile tilapia. ..
  8. Chen S, Zhang X, Li L, Ruan B, Huang B, Huang W, et al. Evolution of IFN-? in tetrapod vertebrates and its functional characterization in green anole lizard (Anolis carolinensis). Dev Comp Immunol. 2016;61:208-24 pubmed publisher
  9. Fu J, Chen S, Zou P, Huang B, Guo Z, Zeng L, et al. IFN-? in turtle: conservation in sequence and signalling and role in inhibiting iridovirus replication in Chinese soft-shelled turtle Pelodiscus sinensis. Dev Comp Immunol. 2014;43:87-95 pubmed publisher
    ..However, the mechanism involved in the antiviral activity may require further investigation. ..
  10. Huang W, Zhu M, Chen S, Wang Z, Liang Y, Huang B, et al. Molecular cloning and expression analysis of a fish specific interferon regulatory factor, IRF11, in orange spotted grouper, Epinephelus coioides. Fish Shellfish Immunol. 2017;60:368-379 pubmed publisher
  11. Gan Z, Chen S, Hou J, Huo H, Zhang X, Ruan B, et al. Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae. Fish Shellfish Immunol. 2016;54:1-10 pubmed publisher
    ..agalactiae. These findings indicated that On-PGRP-SC2 may play important roles in the immune response to S. agalactiae in Nile tilapia. ..
  12. Xu Q, Chang M, Sun R, Xiao F, Nie P. The first non-mammalian CXCR5 in a teleost fish: molecular cloning and expression analysis in grass carp (Ctenopharyngodon idella). BMC Immunol. 2010;11:25 pubmed publisher
  13. Huang B, Qi Z, Xu Z, Nie P. Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution. BMC Immunol. 2010;11:22 pubmed publisher
    ..However, the ten IRF family members in vertebrates and those IRF-like genes in non-vertebrate deuterostomes were quite different in those analyzed characters, as they might have undergone different patterns of evolution. ..
  14. Zhang Y, Zhao L, Chen W, Huang Y, Yang L, Sarathbabu V, et al. Complete genome sequence analysis of the fish pathogen Flavobacterium columnare provides insights into antibiotic resistance and pathogenicity related genes. Microb Pathog. 2017;111:203-211 pubmed publisher
    ..The predicted antibiotic resistance and pathogenicity related genes will shed a new light on the development of more efficient preventional strategies against the infection of F. columnare, which is a major worldwide fish pathogen. ..
  15. Laghari Z, Li L, Chen S, Huo H, Huang B, Zhou Y, et al. Composition and transcription of all interferon regulatory factors (IRFs), IRF1‒11 in a perciform fish, the mandarin fish, Siniperca chuatsi. Dev Comp Immunol. 2018;81:127-140 pubmed publisher
    ..It is considered that the present study provides the first detailed analysis on all IRF members in an aquaculture species of fish, and can be served as the base for further investigation on the role of IRFs in teleost fish. ..
  16. Zou P, Nie P. Zebrafish as a Model for the Study of Host-Virus Interactions. Methods Mol Biol. 2017;1656:57-78 pubmed publisher
    ..These protocols should provide efficient and typical means to address host-virus interactions in a more general biological sense. ..
  17. Ruan B, Chen S, Hou J, Huang B, Laghari Z, Li L, et al. Two type II IFN members, IFN-? and IFN-? related (rel), regulate differentially IRF1 and IRF11 in zebrafish. Fish Shellfish Immunol. 2017;65:103-110 pubmed publisher
  18. Gan Z, Chen S, Huang B, Hou J, Nie P. Intronless and intron-containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates. Dev Comp Immunol. 2017;67:166-176 pubmed publisher
    ..This study thus contributes to a better understanding of the origin and evolution of type I IFNs in vertebrates, and of the occurrence of intronless I IFNs in higher vertebrates. ..
  19. Zou P, Chang M, Li Y, Huan Zhang S, Fu J, Chen S, et al. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish Shellfish Immunol. 2015;43:13-24 pubmed publisher