Yi Xun Liu


Affiliation: Institute of Zoology
Country: China


  1. Liu Y. Temperature control of spermatogenesis and prospect of male contraception. Front Biosci (Schol Ed). 2010;2:730-55 pubmed
    ..These findings have provided an important theoretical basis for designing combined male contraceptives. This present review summarized progress on the mechanism of heat-induced germ cell apoptosis. ..
  2. Liu Y, Zhang Y, Li Y, Liu X, Wang X, Zhang C, et al. Regulation of follicular development and differentiation by intra-ovarian factors and endocrine hormones. Front Biosci (Landmark Ed). 2019;24:983-993 pubmed
    ..The selection of dominant follicles is driven by a series of proliferation and apoptotic events. Together, the available data suggests that follicular development is regulated both by systemic and local factors. ..
  3. Tang J, Chen D, Deng S, Li J, Li Y, Fu Z, et al. CRISPR/Cas9-mediated genome editing induces gene knockdown by altering the pre-mRNA splicing in mice. BMC Biotechnol. 2018;18:61 pubmed publisher
    ..Although alternative splicing was an unexpected outcome, this finding could be developed as a technology to generate gene knockdown models or to investigate pre-mRNA splicing. ..
  4. Batool A, Wang Y, Hao X, Chen S, Liu Y. A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth. Cell Death Dis. 2018;9:962 pubmed publisher
    ..These findings uncover the anticancer effect of miR-125b via mediating tumor-stroma crosstalk in xenograft models of TGCTs and raise the possibility of targeting miR-125b as miRNA therapeutics. ..
  5. Sun T, Zhang Y, Li H, Liu X, Yi D, Tian L, et al. Sperm DNA fragmentation index, as measured by sperm chromatin dispersion, might not predict assisted reproductive outcome. Taiwan J Obstet Gynecol. 2018;57:493-498 pubmed publisher
  6. Li J, Tang J, Cheng J, Hu B, Wang Y, Aalia B, et al. Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I. J Cell Biol. 2018;217:3901-3911 pubmed publisher
    ..These results have revealed a hidden compensatory mechanism between Cyclin B1 and Cyclin B2 in regulating MPF and oocyte meiotic resumption. ..
  7. Chen S, Liu Y. Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling. Reproduction. 2015;149:R159-67 pubmed publisher
  8. Chen S, Liu Y. Testis Cord Maintenance in Mouse Embryos: Genes and Signaling. Biol Reprod. 2016;94:42 pubmed publisher
    ..Further efforts and new genetic models are needed to unveil the gene networks and underlying mechanisms regulating testis cord integrity and morphology after sex determination. ..
  9. Wen Q, Cheng C, Liu Y. Development, function and fate of fetal Leydig cells. Semin Cell Dev Biol. 2016;59:89-98 pubmed publisher
    ..In this review, we evaluate the latest findings regarding the development, function and fate of FLCs during fetal and adult testis development. ..

More Information


  1. Liu Y. Advanced studies on ovary physiology in China in the past 30 years. Sheng Li Xue Bao. 2016;68:366-84 pubmed
  2. Yu K, Deng S, Sun T, Li Y, Liu Y. Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review. Molecules. 2018;23: pubmed publisher
    ..However, the melatonin-induced regulation of steroid hormones may differ among species, and the literature data indicate that melatonin has important effects on steroidogenesis and male reproduction. ..
  3. Cheng J, Liu Y. Age-Related Loss of Cohesion: Causes and Effects. Int J Mol Sci. 2017;18: pubmed publisher
    ..The time of cohesion cleavage plays an important role in correct chromosome segregation. This review focuses specifically on the causes and effects of age-related cohesion deterioration in female meiosis. ..
  4. Li X, Zhang Y, Wang X, Jin C, Wang Y, Sun T, et al. Regulation of blood-testis barrier assembly in vivo by germ cells. FASEB J. 2017;: pubmed publisher
    ..Li, X.-Y., Zhang, Y., Wang, X.-X., Jin, C., Wang, Y.-Q., Sun, T.-C., Li, J., Tang, J.-X., Batool, A., Deng, S.-L., Chen, S.-R., Cheng, C. Y., Liu, Y.-X. Regulation of blood-testis barrier assembly in vivo by germ cells...
  5. Cheng J, Tang J, Li J, Wang Y, Wang X, Zhang Y, et al. Role of WNT signaling in epididymal sperm maturation. J Assist Reprod Genet. 2018;35:229-236 pubmed publisher
  6. Deng S, Wang Z, Jin C, Kang X, Batool A, Zhang Y, et al. Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells. Theriogenology. 2018;106:170-177 pubmed publisher
  7. Deng S, Sun T, Yu K, Wang Z, Zhang B, Zhang Y, et al. Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen. Free Radic Biol Med. 2017;113:347-354 pubmed publisher
  8. Liu Y. Plasminogen activator/plasminogen activator inhibitors in ovarian physiology. Front Biosci. 2004;9:3356-73 pubmed
    ..Thus, the next challenge is to identify the interrelationship between multiple paracrine and autocrine factors and the PA system, and to know how they regulate the protease and the protease inhibitor in the ovary. ..
  9. Wen Q, Zheng Q, Li X, Hu Z, Gao F, Cheng C, et al. Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis. Am J Physiol Endocrinol Metab. 2014;307:E1131-43 pubmed publisher
    ..In summary, FLC-like cells in mutant testes are putative FLCs that remain mitotically active in adult mice, illustrating that Wt1 dictates the fate of FLC and ALC during postnatal testis development. ..
  10. Hao J, Chen M, Ji S, Wang X, Wang Y, Huang X, et al. Equatorin is not essential for acrosome biogenesis but is required for the acrosome reaction. Biochem Biophys Res Commun. 2014;444:537-42 pubmed publisher
    ..Eqtn is involved in the fusion of the outer acrosomal membrane and the sperm plasma membrane during the acrosome reaction, most likely via an interaction with the SNARE complex. ..
  11. Li L, Ji S, Yang J, Li X, Zhang J, Zhang Y, et al. Wnt/?-catenin signaling regulates follicular development by modulating the expression of Foxo3a signaling components. Mol Cell Endocrinol. 2014;382:915-25 pubmed publisher
    ..These findings provide evidence that Wnt signaling might negatively regulate follicular development potentially through Foxo3a signaling components. ..
  12. Liu Y, Gao F, Wei P, Chen X, Gao H, Zou R, et al. Involvement of molecules related to angiogenesis, proteolysis and apoptosis in implantation in rhesus monkey and mouse. Contraception. 2005;71:249-62 pubmed
    ..Furthermore, the combined use of these compounds produced an obvious additive effect on inhibiting implantation. This finding suggested this may be a good approach for developing an anti-implantation agent. ..