Guang Hui Liu

Summary

Affiliation: Institute of Biophysics
Country: China

Publications

  1. pmc Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
    Guang Hui Liu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Nature 491:603-7. 2012
  2. doi request reprint iPSC technology to study human aging and aging-related disorders
    Guang Hui Liu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Curr Opin Cell Biol 24:765-74. 2012
  3. pmc Gating neural development and aging via nuclear pores
    Guang Hui Liu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Res 22:1212-4. 2012
  4. pmc Repression of classical nuclear export by S-nitrosylation of CRM1
    Peng Wang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 PR China
    J Cell Sci 122:3772-9. 2009
  5. pmc Autophagic control of cell 'stemness'
    Huize Pan
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    EMBO Mol Med 5:327-31. 2013
  6. pmc Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
    Guang Hui Liu
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 472:221-5. 2011
  7. doi request reprint Converted neural cells: induced to a cure?
    Weiqi Zhang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    Protein Cell 3:91-7. 2012
  8. pmc Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs
    Guang Hui Liu
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 8:688-94. 2011
  9. doi request reprint Mitochondrial regulation in pluripotent stem cells
    Xiuling Xu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Metab 18:325-32. 2013
  10. doi request reprint Gating pluripotency via nuclear pores
    Jiping Yang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Trends Mol Med 20:1-7. 2014

Collaborators

Detail Information

Publications32

  1. pmc Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
    Guang Hui Liu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Nature 491:603-7. 2012
    ....
  2. doi request reprint iPSC technology to study human aging and aging-related disorders
    Guang Hui Liu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Curr Opin Cell Biol 24:765-74. 2012
    ..These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases...
  3. pmc Gating neural development and aging via nuclear pores
    Guang Hui Liu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Res 22:1212-4. 2012
    ..These findings will have far-ranging impacts on the understanding of the function of the nuclear envelope in physiological settings and in various neurological diseases...
  4. pmc Repression of classical nuclear export by S-nitrosylation of CRM1
    Peng Wang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 PR China
    J Cell Sci 122:3772-9. 2009
    ..Together, these data demonstrate that CRM1 is negatively regulated by S-nitrosylation under nitrosative stress. We speculate that this is important for promoting a cytoprotective transcriptional response to nitrosative stress...
  5. pmc Autophagic control of cell 'stemness'
    Huize Pan
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    EMBO Mol Med 5:327-31. 2013
    ..Here, we shall discuss the accumulating evidence suggesting that autophagy plays a critical role in the homeostatic control of stem cell functions during aging, tissue regeneration, and cellular reprogramming...
  6. pmc Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
    Guang Hui Liu
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 472:221-5. 2011
    ..Because progerin also accumulates during physiological ageing, our results provide an in vitro iPSC-based model to study the pathogenesis of human premature and physiological vascular ageing...
  7. doi request reprint Converted neural cells: induced to a cure?
    Weiqi Zhang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    Protein Cell 3:91-7. 2012
    ..2011; Schwartz et al., 2012). Here we will mainly discuss most recent progress on using converted functional neural cells to treat neurological diseases and highlight potential clinical challenges and future perspectives...
  8. pmc Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs
    Guang Hui Liu
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 8:688-94. 2011
    ..This type of approach could be used to generate genotype-matched cell lines for disease modeling and drug discovery and potentially also in therapeutics...
  9. doi request reprint Mitochondrial regulation in pluripotent stem cells
    Xiuling Xu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Metab 18:325-32. 2013
    ....
  10. doi request reprint Gating pluripotency via nuclear pores
    Jiping Yang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Trends Mol Med 20:1-7. 2014
    ..A thorough understanding of this process might improve our comprehension of cell pluripotency and differentiation during embryogenesis, as well as aiding the development of novel models for studying human diseases. ..
  11. pmc Thioredoxin-mediated negative autoregulation of peroxisome proliferator-activated receptor alpha transcriptional activity
    Guang Hui Liu
    Institute of Biophysics and Graduate School, Chinese Academy of Sciences, Beijing 100101, China
    Mol Biol Cell 17:1822-33. 2006
    ..Together, it is speculated that the reported negative-feedback loop may be essential for maintaining the homeostasis of PPARalpha activity...
  12. pmc Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310
    Jing Qu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing, China
    Nucleic Acids Res 35:2522-32. 2007
    ..Together, this study may provide a novel molecular mechanism, which links nitrosative stress to APE1-associated physiological and pathological processes...
  13. doi request reprint Post-translational modulation of pluripotency
    Ning Cai
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Mol Cell Biol 4:262-5. 2012
    ....
  14. pmc Lipin proteins form homo- and hetero-oligomers
    Guang Hui Liu
    Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Biochem J 432:65-76. 2010
    ..The present study provides evidence that lipin proteins function as oligomeric complexes and that the three mammalian lipin isoforms can form combinatorial units...
  15. doi request reprint Navigating the epigenetic landscape of pluripotent stem cells
    Mo Li
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 13:524-35. 2012
    ....
  16. doi request reprint Establishment of hepatic and neural differentiation platforms of Wilson's disease specific induced pluripotent stem cells
    Fei Yi
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Protein Cell 3:855-63. 2012
    ..Hence we established a platform for studying both hepatic and neural abnormalities of WD, which may provide a new tool for tissue-specific disease modeling and drug screening in the future...
  17. pmc Progress and prospects in stem cell therapy
    Xiu Ling Xu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Acta Pharmacol Sin 34:741-6. 2013
    ..In addition, we compare current gene editing technologies and discuss their potential implications in clinic application in the future...
  18. doi request reprint DNA methylome: Unveiling your biological age
    Ming Li
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    Protein Cell 4:723-5. 2013
    ....
  19. doi request reprint Concealing cellular defects in pluripotent stem cells
    Weiqi Zhang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Trends Cell Biol 23:587-92. 2013
    ....
  20. pmc "TET-on" pluripotency
    Ping Wang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Res 23:863-5. 2013
    ..Recent studies have uncovered a specific role of TET proteins in reprogramming somatic cells to induced pluripotent stem cells, a process where O-linked β-N-acetylglucosamine transferase may play a crucial role. ..
  21. doi request reprint Higher-order genomic organization in pluripotent stem cells
    Ping Wang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Protein Cell 3:483-6. 2012
    ..Recent applications of new tools for genome-wide mapping of long-range and spatial interactions have shed light onto the fundamental mechanisms of three dimensional chromatin organizations in pluripotent stem cells and their derivatives...
  22. doi request reprint Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy
    Fei Yi
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Protein Cell 3:246-50. 2012
    ..In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes...
  23. pmc The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells
    Fei Yi
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Res 23:3-5. 2013
    ..Here we aim to summarize and discuss the most recent advances in this topic and their future perspective in research and clinic...
  24. doi request reprint Regenerative medicine: transdifferentiation in vivo
    Lina Fu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Res 24:141-2. 2014
    ....
  25. pmc hESC-derived pancreatic progenitors
    Lina Sui
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Res 23:592-4. 2013
    ..Here we discuss present approaches, as well as future alternatives, in the fields of basic and clinic research on β cell differentiation, derivation and transplantation...
  26. doi request reprint NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
    Guang Hui Liu
    Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing, PR China
    Biochim Biophys Acta 1783:713-27. 2008
    ....
  27. doi request reprint Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism
    Wensu Liu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Protein Cell 4:83-5. 2013
    ..This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy...
  28. pmc Huntington's disease: dancing in a dish
    Kejing Zhang
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Res 22:1627-30. 2012
    ..Both advances are exciting, provide new resources for current and future HD research, and uncover new challenges to better understand and, most importantly, treat this devastating disease in the near future...
  29. doi request reprint Find and replace: editing human genome in pluripotent stem cells
    Huize Pan
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    Protein Cell 2:950-6. 2011
    ..2011; Liu et al., 2011b; Papapetrou et al., 2011; Sebastiano et al., 2011; Soldner et al., 2011; Zou et al., 2011a). These techniques combined with the utility of hPSCs will significantly influence the area of regenerative medicine...
  30. pmc Gametogenesis in a dish
    Ying Gu
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Res 22:1422-5. 2012
    ....
  31. pmc Nitric oxide destabilizes Pias3 and regulates sumoylation
    Jing Qu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing, China
    PLoS ONE 2:e1085. 2007
    ..This study reveals a novel crosstalk between S-nitrosation, ubiquitination, and sumoylation, which may be crucial for NO-related physiological and pathological processes...
  32. pmc Regulation of myoblast differentiation by the nuclear envelope protein NET39
    Guang Hui Liu
    Department of Cell Biology, IMM 10, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 29:5800-12. 2009
    ..Our results indicate that NET39 is part of the regulatory machinery for myogenesis and raise the possibility that it may be important for muscle homeostasis...