Feng Liu


Affiliation: Institute of Zoology
Country: China


  1. Liu Z, Tu H, Kang Y, Xue Y, Ma D, Zhao C, et al. Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nat Commun. 2019;10:1839 pubmed publisher
    ..Altogether, our findings reveal a pivotal role of endothelial primary cilia in HSPC development, and may shed lights into in vitro directed differentiation of HSPCs. ..
  2. Zhang Y, Liu F. Multidimensional Single-Cell Analyses in Organ Development and Maintenance. Trends Cell Biol. 2019;: pubmed publisher
  3. Tu H, Qin X, Liu Z, Song Z, Hu H, Zhang Y, et al. Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. Nat Commun. 2018;9:5277 pubmed publisher
    ..Thus, our study establishes FSD1 as a MT aster anchorage protein and reveals an important function of MT asters anchored by FSD1 in TZ assembly during ciliogenesis. ..
  4. Zhang Y, Gao S, Xia J, Liu F. Hematopoietic Hierarchy - An Updated Roadmap. Trends Cell Biol. 2018;28:976-986 pubmed publisher
    ..Here, we review recent advances in the hematopoiesis field and provide an updated view to incorporate these new findings as well as to reflect on the complexity of HSCs and their derivatives in development and adulthood. ..
  5. Gao S, Liu F. Fetal liver: an ideal niche for hematopoietic stem cell expansion. Sci China Life Sci. 2018;61:885-892 pubmed publisher
    ..Based on these studies, we hypothesize a strategy to obtain a large number of functional HSCs via 3D reconstruction of FL organoid ex vivo for clinical treatment in the future. ..
  6. Ma D, Liu F. Genome Editing and Its Applications in Model Organisms. Genomics Proteomics Bioinformatics. 2015;13:336-44 pubmed publisher
  7. Wang H, Li Y, Wang S, Zhang Q, Zheng J, Yang Y, et al. Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish. Biochem Biophys Res Commun. 2015;460:923-30 pubmed publisher
    ..Taken together, we found that FOXO3 plays an important role in erythroid differentiation in both human TF-1 cells and zebrafish, but the mechanism underlying this regulation still remains unclear. ..
  8. Wei Y, Xu J, Zhang W, Wen Z, Liu F. RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development. 2016;143:2103-10 pubmed publisher
  9. Lv J, Wang L, Gao Y, Ding Y, Liu F. 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017;214:529-545 pubmed publisher
    ..Collectively, our results reveal an unexpected role of 5-HT in HSPC development and suggest that 5-HT signaling may be a potential therapeutic target for promoting HSPC survival. ..

More Information


  1. He Q, Gao S, Lv J, Li W, Liu F. BLOS2 maintains hematopoietic stem cells in the fetal liver via repressing Notch signaling. Exp Hematol. 2017;51:1-6.e2 pubmed publisher
    ..These findings reveal that balanced control of Notch signaling by BLOS2 is required for HSC homeostasis during FL hematopoiesis. ..
  2. Yan H, Zhang C, Wang Z, Tu T, Duan H, Luo Y, et al. CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis. Sci Rep. 2017;7:7442 pubmed publisher
    ..Altogether, our data reveals a critical role of CD146 to mediate VEGF-C signaling pathway in lymphangiogenesis. ..
  3. Wang L, Liu Z, Lin H, Ma D, Tao Q, Liu F. Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 2017;36:2987-2997 pubmed publisher
    ..1 regulates collective DFC migration through cadherin 1 (Cdh1). Taken together, our data uncover dynamic DNA methylation as an epigenetic mechanism to control LR determination during early embryogenesis in vertebrates. ..
  4. Xue Y, Gao S, Liu F. Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation. Dev Biol. 2015;403:115-27 pubmed publisher
  5. Wang S, He Q, Ma D, Xue Y, Liu F. Irf4 Regulates the Choice between T Lymphoid-Primed Progenitor and Myeloid Lineage Fates during Embryogenesis. Dev Cell. 2015;34:621-31 pubmed publisher
    ..1 expression to prevent an alternate fate. Our findings provide insight into the fate determination mechanism of T lymphoid-primed progenitors. ..
  6. Xue Y, Lv J, Zhang C, Wang L, Ma D, Liu F. The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b. Dev Cell. 2017;42:349-362.e4 pubmed publisher
    ..Together, we identify the Klf6a-Ccl25b/Ccr7 axis in controlling the complex HSPC-CHT niche interaction, which may be applicable to in vitro expansion or engraftment of HSPCs after transplantation. ..
  7. Lv J, Liu F. Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis. J Vis Exp. 2017;: pubmed publisher
    ..This series of experiments would be helpful in defining the underlying mechanisms essential for HSC development in mammals. ..