Research Topics
Genomes and Genes
| Wei LiSummaryAffiliation: Institute of Genetics and Developmental Biology Country: China Publications
| Collaborators
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Detail Information
Publications
Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cellsSreenivasulu Chintala
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Proc Natl Acad Sci U S A 102:10964-9. 2005..Thus, we have found that the Slc7a11 gene controls the production of pheomelanin pigment directly. Cells from sut mice provide a model for oxidative stress-related diseases and their therapies...
Mutational data integration in gene-oriented files of the Hermansky-Pudlak Syndrome databaseWei Li
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Hum Mutat 27:402-7. 2006..All the mutations in these genes are integrated in the GOFs. We expect that these very informative and peerreviewed GOFs will be shortcuts to utilize the webbased information for the emerging interdisciplinary studies of HPS...- PediDraw: a web-based tool for drawing a pedigree in genetic counselingMin He
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
BMC Med Genet 8:31. 2007..This limits the usage of a pedigree as demanded in remote diagnosis or online counseling from the counselees to send an electronic pedigree... - The BLOC interactomes form a network in endosomal transportWei Li
Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
J Genet Genomics 34:669-82. 2007..The disruption of this network may lead to abnormal trafficking or defective organellar development as described in patients with Hermansky-Pudlak syndrome... 
Efficient delivery of antitumor drug to the nuclei of tumor cells by amphiphilic biodegradable poly(L-aspartic acid-co-lactic acid)/DPPE co-polymer nanoparticlesSiyuan Han
CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Small 8:1596-606. 2012..These results demonstrate the feasibility of the application of the amphiphilic polyaspartic acid derivative, poly(AA-co-LA)/DPPE, as a nanocarrier for cell nuclear delivery of potent antitumor drugs...- Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in ChinaXiao Ling Liu
Chinese Academy of Medical Sciences, Beijing, China
Med Sci Monit 16:CR458-63. 2010..In this study we analyzed the Pro12Ala (C>G) polymorphism in exon 2 and the 161C>T polymorphism in exon 6 of peroxisome proliferator-activated receptor gamma gene (PPARγ) in a Tibetan population and a Han population... - Apoptotic regulators promote cytokinetic midbody degradation in C. elegansYongping Chai
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
J Cell Biol 199:1047-55. 2012..Thus, our findings uncover a novel function of cell death genes in midbody internalization and degradation after cell division... - The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organellesQing Yang
State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
Traffic 13:1160-9. 2012..Mild defects in the melanosomes of the retinal pigment epithelia and in the platelet dense granules of the Kxd1-KO mouse were observed, mimicking a mouse model of mild Hermansky-Pudlak syndrome that affects the biogenesis of LROs... - Body mass index and hypertension among Chinese governmental and institutional employees in BeijingTao Chen
Department of Biostatistics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Angiology 63:337-42. 2012..Concordant relationships were revealed in all evaluated subgroups, even among those without traditional cardiovascular risk factors... - Regulation of thyroid hormone related genes mRNA expression by exogenous T₃ in larvae and adult Chinese rare minnow (Gobiocypris rarus)Wei Li
State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Shuangqin Rd 18, Haidian District, PO Box 2871, Beijing 100085, China
Environ Toxicol Pharmacol 31:189-97. 2011..The down-regulation of gene mRNA expression could serve as a compensatory mechanism for the activation of thyroid system... - Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatmentLigeng Xu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China
Nano Lett 12:2003-12. 2012..These findings have shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems... - Stereoselective dissipation of epoxiconazole in grape (Vitis vinifera cv. Kyoho) and soil under field conditionsHongwu Liang
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Chemosphere 87:982-7. 2012..The results for stereoselective dissipations can be applied for food and environmental assessments of chiral pesticides... - The decline and residues of hexaconazole in tomato and soilHongwu Liang
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
Environ Monit Assess 184:1573-9. 2012..a.i./hm(2) for three or four times were all below 0.1 mg/kg. This work would be the guidance of establishing the maximum residue limit of hexaconazole in tomato in China... - Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticlesQing Xu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Biomaterials 33:1627-39. 2012..Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy... - Screening level of PAHs in sediment core from Lake Hongfeng, Southwest ChinaJian yang Guo
State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China
Arch Environ Contam Toxicol 60:590-6. 2011..Because only one core was analyzed in this study, more work is needed to confirm the sources and toxicity of PAHs in Lake Hongfeng... - Genome-wide association studies of 14 agronomic traits in rice landracesXuehui Huang
National Center for Gene Research, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Nat Genet 42:961-7. 2010.... - Regulation of iodothyronine deiodinases and sodium iodide symporter mRNA expression by perchlorate in larvae and adult Chinese rare minnow (Gobiocypris rarus)Wei Li
State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
Mar Pollut Bull 63:350-5. 2011..The larval fish development could be affected by perchlorate at environmentally relevant concentrations... - Prognostic value of coronary CT angiography and calcium score for major adverse cardiac events in outpatientsZhi Hui Hou
Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
JACC Cardiovasc Imaging 5:990-9. 2012..This study sought to evaluate the prognostic value of coronary artery calcium score (CACS) and coronary computed tomography angiography (CTA) for major adverse cardiac events (MACE)... - Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditionsQi Gu
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Protein Cell 3:71-9. 2012..Thus the rapid conversion established a naïve pluripotency in human ESCs like mouse ESCs, and provided a new model to study the regulation of pluripotency... - Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factorsChao Sheng
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Cell Res 22:208-18. 2012..In addition, iNSCs can survive and generate synapses following transplantation into the dentate gyrus. Generation of iNSCs may have important implications for disease modeling and regenerative medicine... - Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapyYan Wu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Nanomedicine 7:945-54. 2011..FROM THE CLINICAL EDITOR: In this paper, the development of novel amphiphilic copolymer nanoparticles is discussed with the goal of establishing high encapsulation efficiency for chemotherapy drugs... - Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinibPei pei Dong
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China
Acta Pharmacol Sin 32:399-407. 2011.... - Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of daphnetinSi Cheng Liang
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China
Drug Metab Dispos 38:973-80. 2010..In conclusion, the UGT conjugation pathways of daphnetin were fully elucidated and its C-8 phenol group was more selectively catalyzed by UGTs than by the C-7 phenol... - Live imaging of cellular dynamics during Caenorhabditis elegans postembryonic developmentYongping Chai
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Nat Protoc 7:2090-102. 2012..Other applications are also possible. The protocol can be completed within 3 h and may provide insights into understanding postembryonic development... - Emissions of PAHs from Indoor Crop Residue Burning in a Typical Rural Stove: Emission Factors, Size Distributions, and Gas-Particle PartitioningGuofeng Shen
Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China
Environ Sci Technol 45:1206-12. 2011..5, and the mass percentage of PAHs in fine particles increased as the molecular weight increased. For freshly emitted PAHs, absorption into organic carbon, rather than adsorption, dominated the gas-particle partitioning... - Mice overexpression of human augmenter of liver regeneration (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertilityYan Cao
Beijing Institute of Radiation Medicine, Beijing, China
Endocr J 59:989-99. 2012..Present findings in the mouse may be of interest to human male fertility... - Generation of tripotent neural progenitor cells from rat embryonic stem cellsZhenkun Wang
College of Life Science, Northeast Agricultural University of China, Harbin 150030, China
J Genet Genomics 39:643-51. 2012.... - Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, ChinaYong zhen Zhang
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Zhonghua Liu Xing Bing Xue Za Zhi 32:209-20. 2011..From April to July in 2009 and 2010, unexplained severe hemorrhagic fever-like illnesses occurred in farmers from the Huaiyangshan mountains range... - Variation in the internalization of differently sized nanoparticles induces different DNA-damaging effects on a macrophage cell lineMingyi Zhang
Lab for Bio Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Science, Beijing 10049, China
Arch Toxicol 85:1575-88. 2011..Based on these results, we assume that the damage resulted from a disruption of the balance between DNA damage and repair... - MiR-200a is involved in rat epididymal development by targeting β-catenin mRNAXiaojiang Wu
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Acta Biochim Biophys Sin (Shanghai) 44:233-40. 2012..All these results show that miR-200a should be involved in rat epididymal development by targeting β-catenin mRNA of rat and suppressing its expression... - Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese populationYing Wang
Key laboratory of Endocrine, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
PLoS ONE 6:e26953. 2011..To investigate whether the candidate genes that confer susceptibility to type 2 diabetes mellitus are also correlated with gestational diabetes mellitus (GDM) in pregnant Chinese women... - MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 statusWei Li
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
Planta Med 77:27-31. 2011.... - Dissipation and residue of dimethomorph in pepper and soil under field conditionsHongwu Liang
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
Ecotoxicol Environ Saf 74:1331-5. 2011..These results will be helpful in setting MRL guidance for dimethomorph in pepper in China... - Cycloartane triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathwayZhong Ze Fang
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
Phytother Res 25:17-24. 2011..These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway... - Modulation of oxidative stress by functionalized fullerene materials in the lung tissues of female C57/BL mice with a metastatic Lewis lung carcinomaFang Jiao
CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety NCNST IHEP, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
J Nanosci Nanotechnol 10:8632-7. 2010.... - Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cellsLei Liu
State Key Laboratory of Reproductive Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China
J Biol Chem 285:19483-90. 2010..These findings also provide a step forward toward understanding the operating mechanisms during reprogramming to produce iPS cells and can potentially promote the application of iPS cells in regenerative medicine and cancer therapy... - Mouse cloning and somatic cell reprogramming using electrofused blastomeresAmjad Riaz
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1st Beichen West Road, Beijing 100101, China
Cell Res 21:770-8. 2011..Our approach provides an attractive and practical alternative to therapeutic cloning using donated oocytes for the generation of patient-specific human ES cell lines... - Nine-month angiographic and 2-year clinical follow-up of the NOYA biodegradable polymer sirolimus-eluting stent in the treatment of patients with de novo native coronary artery lesions: the NOYA I trialBo Xu
Fuwai Hospital, National Centre for Cardiovascular Diseases of China, Beijing, China
EuroIntervention 8:796-802. 2012.... - New insights into the functions and localization of nuclear CCT protein complex in K562 leukemia cellsRui Huang
Beijing Institute of Radiation Medicine, Beijing, China
Proteomics Clin Appl 6:467-75. 2012..The purpose of this study is to explore the function of CCT in nuclear and present a strategy in clinical proteomics studies... - The residues and environmental risks of multiple veterinary antibiotics in animal faecesYan Xia Li
State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 100875, Beijing, China
Environ Monit Assess 185:2211-20. 2013..These medicine residues in animal faeces may potentially bring ecological risks if the animal manure is not treated effectively... - Impact of DNA twist accumulation on progressive helical wrapping of torsionally constrained DNAWei Li
Beijing National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
Phys Rev Lett 109:218102. 2012..The theoretical predictions and the experimental results are consistent with each other and their implications are discussed... - Androgenetic haploid embryonic stem cells produce live transgenic miceWei Li
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Nature 490:407-11. 2012..Our findings show the developmental pluripotency of androgenentic haploids and provide a new tool to quickly produce genetic models for recessive traits. They may also shed new light on assisted reproduction... - The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathwaysHejiang Zhou
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Biomaterials 33:6933-42. 2012..Further research is needed to systematically assess the biological responses of graphene, both to improve its safety and to contribute to the design of new biological applications... - Production of brown/yellow patches in the SLC7A11 transgenic sheep via testicular injection of transgeneXin He
State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
J Genet Genomics 39:281-5. 2012..Our studies suggest that testicular injection of transgene can be used to genetically modify sheep coat color... - Bifunctional peptides that precisely biomineralize Au clusters and specifically stain cell nucleiYaling Wang
Institute of High Energy Physics, Chinese Academy of Sciences, Yuquan Road 19B, Shi Jing Shan District, Beijing 10049, China
Chem Commun (Camb) 48:871-3. 2012..The peptide-Au clusters exhibit red emission (λ(em) = 677 nm) and specifically stain the nuclei of three cell lines... - Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64Jing Cheng
Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
Am J Hum Genet 89:56-66. 2011..Our work identifies DFNA64 as the human genetic disorder associated with SMAC/DIABLO malfunction and suggests that mutant SMAC/DIABLO(S71L) might cause mitochondrial dysfunction... - BLOS1, a putative BLOC-1 subunit, interacts with SNX1 and modulates root growth in ArabidopsisYanyan Cui
Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
J Cell Sci 123:3727-33. 2010.... - Stereoselective separation and determination of triadimefon and triadimenol in wheat, straw, and soil by liquid chromatography-tandem mass spectrometryHongwu Liang
College of Science, China Agricultural University, Beijing, P R China
J Sep Sci 35:166-73. 2012..001-0.005 mg/kg and 0.007-0.02 mg/kg, respectively. Finally, the method was successfully applied to detect TF and TN stereoisomers in wheat, straw, and soil samples from residual trials in farm... - Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-KitXiao Li Guo
Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Pigment Cell Melanoma Res 23:252-62. 2010..This expands our understanding of the intricate regulatory network governing the melanocyte development... - Analysis of two sequence variants in peroxisome proliferator activated receptor gamma gene in Tajik population at high altitudes and Han population at low altitudes in ChinaXiao Ling Liu
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Mol Biol Rep 37:179-84. 2010..0001) was significantly lower in the Tajik population than that in the Han population. Our results suggest that PPARG is a candidate gene for high-altitude adaptation in the Chinese Tajik population... - Association between 9p21.3 genomic markers and coronary artery disease in East Asians: a meta-analysis involving 9,813 cases and 10,710 controlsJin Guo
Division of Biometrics, National Center for Cardiovascular Diseases, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China
Mol Biol Rep 40:337-43. 2013..3 in China population in one study. This broad replication provides unprecedented evidence for association between genetic variants at chromosome 9p21.3 and risk of CAD in East Asians... - Smoking status on outcomes after percutaneous coronary interventionTao Chen
Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Clin Cardiol 35:570-4. 2012..The effect of smoking on prognosis among patients undergoing percutaneous coronary intervention (PCI) is controversial, and data on the importance of smoking cessation or reductions were lacking... - Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cellWei Li
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
J Cell Biol 197:27-35. 2012..Thus, autophagy genes act within the phagocyte to promote apoptotic cell degradation... - Characterization and expression analysis of hsp70 gene from Ulva prolifera J. Agardh (Chlorophycophyta, Chlorophyceae)Haining Zhang
Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China
Mar Genomics 5:53-8. 2012..The study suggested that hsp70 could be used in prediction of stress tolerance in algae and monitoring environmental changes... - Superb fluoride and arsenic removal performance of highly ordered mesoporous aluminasWei Li
Key Laboratory for Molecular Nanostructures and Nanotechnology, Institute of Chemistry, Beijing National Laboratory for Molecular Sciences BNLMS, Chinese Academy of Sciences, Beijing, PR China
J Hazard Mater 198:143-50. 2011..These materials also showed superb arsenic removal ability. 1g of mesoporous alumina was able to treat 200 kg of arsenic contaminated water with a pH value of 7, reducing the concentration of arsenate from 100 ppb to 1 ppb... - [China genetic counseling network (CGCN): a website on genetic counseling and genetic education]Min He
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Yi Chuan 29:381-4. 2007..The data warehouse of China Genetic Counseling Network (CGCN) will be a unique supplement to current status of Clinical Genetics and healthcare system in China... - The dissipation rates of trichlorfon and its degradation product dichlorvos in cabbage and soilWei Li
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
Chemosphere 82:829-33. 2011..Although trichlorfon can easily degrade into dichlorvos, which is highly toxic to humans and other animals, the observed low residual levels of dichlorvos suggest that trichlorfon is safe when applied at the recommended dosage... - Pd-catalyzed asymmetric hydrogenation of unprotected indoles activated by Brønsted acidsDuo Sheng Wang
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
J Am Chem Soc 132:8909-11. 2010..The present method provides an efficient route to enantioenriched 2-substituted and 2,3-disubstituted indolines... - A comprehensive analysis reveals mutational spectra and common alleles in Chinese patients with oculocutaneous albinismAihua Wei
Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Department of Dermatology, Xuan Wu Hospital, Capital Medical University, Beijing, China
J Invest Dermatol 130:716-24. 2010..6% of the mutational SLC45A2 alleles in Chinese OCA4 patients. These results provide useful information for the establishment of an optimized strategy of gene diagnosis and genetic counseling of Chinese OCA patients... - Fabrication of nanostructured metal nitrides with tailored composition and morphologyWei Li
Beijing National Laboratory for Molecular Sciences BNLMS and Key Laboratory for Molecular Nanostructures and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P R China
Chem Commun (Camb) 47:3619-21. 2011.... - Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapyLiming Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China
Nano Lett 11:772-80. 2011..These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy... - Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigsDongShan Yang
Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
Hum Mol Genet 19:3983-94. 2010..Our findings suggest that species differences determine neuropathology and underscore the importance of large mammalian animals for modeling neurological disorders... - Evaluation of trimetazidine in angina pectoris by echocardiography and radionuclide angiography: a meta-analysis of randomized, controlled trialsBo Hu
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Clin Cardiol 34:395-400. 2011..The objective of this meta-analysis was to evaluate the efficacy of the metabolic agent trimetazidine (TMZ) as monotherapy in the treatment of stable angina pectoris, from echocardiography and radionuclide angiography data... - Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exitYinghui Zhang
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China
Antioxid Redox Signal 13:999-1009. 2010.... - Occurrence and exposure to polycyclic aromatic hydrocarbons and their derivatives in a rural Chinese home through biomass fuelled cookingJunnan Ding
Laboratory for Earth Surface Processes, College of Urban and Environmental Science, Peking University, Beijing, China
Environ Pollut 169:160-6. 2012..The daily mean benzo(a)pyrene equivalent exposure concentration was as high as 200 ± 160 ng/m(3) in the winter for the housewife who did the cooking compared to 59 ± 37 ng/m(3) for the control group that did not cook... - Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatinWei Li
Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
Phys Rev E Stat Nonlin Soft Matter Phys 85:021918. 2012..Moreover, abrupt length changes were also observed when DNA was treated with a mixture of cisplatin and transplatin at high concentrations. A model was proposed to qualitatively explain well these results... - Are coiled-coils of dimeric kinesins unwound during their walking on microtubule?Zhao Wen Duan
Key Laboratory of Soft Matter Physics and Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China
PLoS ONE 7:e36071. 2012..Thus, we concluded that the coiled-coils of kinesin-1, Ncd and Kar3/Vik1 are almost impossible to unwind during their walking on the microtubule... - [Application of zero-inflated models on regression analysis of count data: a study of sub-health symptoms]Tao Xu
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Zhonghua Liu Xing Bing Xue Za Zhi 32:187-91. 2011..ZINB seems the optimal model to study those over-dispersed count data with too many zeros... - Marital status, education, and risk of acute myocardial infarction in Mainland China: the INTER-HEART studyBo Hu
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
J Epidemiol 22:123-9. 2012..We investigated the effects of marital status and education on the risk of acute myocardial infarction (AMI) in a large-scale case-control study in China... - Identification of nucleolar and coiled-body phosphoprotein 1 (NOLC1) minimal promoter regulated by NF-κB and CREBXuesong Gao
Beijing Ditan Hospital, Peking University Health Science Center, Beijing, China
BMB Rep 44:70-5. 2011..Mutagenesis and overexpression assays revealed that NF-κB and CREB positively regulated the NOLC1 promoter. These findings may provide new insight into the mechanisms that regulate NOLC1 expression... - Investigation of binding features: effects on the interaction between CYP2A6 and inhibitorsChunzhi Ai
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
J Comput Chem 31:1822-31. 2010..In addition, the combinational use of the docking, MLP and MEP analysis is also demonstrated as a good attempt to gain an insight into the interaction between CYP2A6 and its inhibitors... - Viable fertile mice generated from fully pluripotent iPS cells derived from adult somatic cellsXiao yang Zhao
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Stem Cell Rev 6:390-7. 2010..This work provides the means for studying the mechanisms and regulation of direct reprogramming, and has encouraging implications for future clinical applications and therapeutic interventions... - Biogeochemical effects of forest vegetation on acid precipitation-related water chemistry: a case study in southwest ChinaJing Chen
State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing, 100875, China
J Environ Monit 12:1799-806. 2010..The most appropriate forest vegetation for water conservation and remediation of acid precipitation in this region was explored for the sake of ecosystem management, ecological restoration and economic development... - Function annotation of the rice transcriptome at single-nucleotide resolution by RNA-seqTingting Lu
National Center for Gene Research and Institute of Plant Physiology and Ecology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200233, China
Genome Res 20:1238-49. 2010..The ratio of SNPs with nonsynonymous/synonymous mutations was nearly 1:1.06. In total, we interrogated and compared transcriptomes of the two rice subspecies to reveal the overall transcriptional landscape at maximal resolution... - Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populationsYang Li
Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China
Hum Mol Genet 18:4897-904. 2009..Thus, we demonstrate that, unlike FOXO3A, FOXO1A is more closely associated with human female longevity, suggesting that the genetic contribution to longevity trait may be affected by genders... - Preliminary strategic environmental assessment of the Great Western Development Strategy: safeguarding ecological security for a new western ChinaWei Li
State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, No 19, Xin Jie Kou Wai St, Haidian District, Beijing, 100875, China
Environ Manage 49:483-501. 2012.... - The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in ChinaYong zhen Zhang
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China
J Virol 86:2864-8. 2012..HYSV RNA was found in human and both tick species, with greater prevalence in H. longicornis and lesser prevalence in R. microplus. Phylogenetic analyses indicate that HYSV is a novel species of the genus Phlebovirus... - Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcomeYong zhen Zhang
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Clin Infect Dis 54:527-33. 2012.... - The degradation of 1,2,4-trichlorobenzene using synthesized Co3O4 and the hypothesized mechanismShijing Lin
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, Beijing 100085, China
J Hazard Mater 192:1697-704. 2011..The superoxide anions caused ring-cracking oxidation of 1,2,4-TrCB, possibly producing some low-molecular-weight products, thus explaining a mass imbalance in the chlorine atoms and total organic carbon... - Vinclozolin affects the interrenal system of the rare minnow (Gobiocypris rarus)Lihua Yang
State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
Aquat Toxicol 104:153-9. 2011..These results provide additional data about the modes of toxicological action of vinclozolin... - PPI finder: a mining tool for human protein-protein interactionsMin He
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
PLoS ONE 4:e4554. 2009..However, the predicted PPIs from these methods are rarely evaluated by known PPI databases and co-occurred terms in Gene Ontology (GO) database... - The environmental fate of different forms of ZJ0702 in open rape field and MRL calculationLi Li
Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Beijing 100101, PR China
Toxicol Mech Methods 21:37-40. 2011..The low final residue levels of ZJ0702 in rapeseed and soil indicated that this new pesticide was environmentally safe. It was recommended that MRL for ZJ0702 in rapeseed be 1 mg/kg in China... - Hydrophilic TiO2 porous spheres anchored on hydrophobic polypropylene membrane for wettability induced high photodegrading activitiesFang Niu
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P R China
Nanoscale 2:1480-4. 2010..In photodegrading reactions, the resulting TiO(2)/PP composite film exhibits a 10 times higher activity in flow-type setup than the same TiO(2) catalyst in a traditional batch-type setup... - Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetateJiang Wei Zhang
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
Drug Metab Dispos 36:2292-8. 2008..In conclusion, CYP3A4 was the major P450 isoform involved in MPA hydroxylation, with 6beta, 2beta, and 1beta being the possible hydroxylation sites. Minipig and rat could be the surrogate models for man in MPA pharmacokinetic studies... - Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophreniaYa Qin Feng
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Schizophr Res 106:218-28. 2008..Our results suggest that the destabilization of snapin in sdy mice may lead to abnormal neurotransmission and therefore abnormal behaviors. This further defines the sdy mutant as a potential model in schizophrenia research... - [Observation and analysis on water-soluble inorganic chemical compositions of atmospheric aerosol in Gongga Mountain]Ya Nan Zhao
Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China
Huan Jing Ke Xue 30:9-13. 2009..87 and 0.84 in PM2.5 and PM10. The concentration ratio of SO4(2-) and NH4+ is approximate to 1:2 in PM10, main existence form of SO4(2-) and NH4+ (NH4)2SO4 at Gongga Mountain... - [Formation and function of Weibel-Palade bodies]Zhe Zhang
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Yi Chuan 31:882-8. 2009..The underlying mechanism of the formation of WPB remains further investigation, which will gain insights into its function. The molecular mechanism of WPB formation and its function were discussed in this review... - Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosisFang Lao
CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
ACS Nano 3:3358-68. 2009..Our results indicate that C(60)(C(COOH)(2))(2) nanoparticles possess a novel ability of selectively entering oxidation-damaged cerebral endothelial cells rather than normal endothelial cells and then protecting them from apoptosis... - Overexpression of xCT induces up-regulation of 14-3-3beta in Kaposi's sarcomaYan Zeng
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
Biosci Rep 30:277-83. 2010..These results suggest that 14-3-3beta is a downstream effector of xCT in KS to mediate the cell proliferation... - Regulation of neuropathy target esterase by the cAMP/protein kinase A signalJia Xiang Chen
Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, PR China
Pharmacol Res 62:259-64. 2010..These results are the first evidence that cAMP/PKA signals regulate NTE expression and GPC content in mammalian cells... - Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activityWei Li
State Key Laboratory of Bio organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China
Bioorg Med Chem Lett 20:3112-5. 2010..All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity... - Potent angiogenesis inhibition by the particulate form of fullerene derivativesHuan Meng
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
ACS Nano 4:2773-83. 2010..We propose that using nanoscale "particulate" itself as a new form of medicine (particulate medicine) may be superior to the traditional "molecular" form of medicine (molecular medicine) in cancer treatment... - Survey of prevalence, awareness, treatment, and control of hypertension among Chinese governmental and institutional employees in BeijingTao Xu
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Clin Cardiol 33:E66-72. 2010..Few studies have been done on the effects that awareness, treatment, and control have on hypertension among governmental and institutional employees... - Streptococcus suis outbreak investigation using multiple-locus variable tandem repeat number analysisWei Li
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Microbiol Immunol 54:380-8. 2010..The developed MLVA scheme for S. suis has greater discriminative power than PFGE. The method described here may be useful for identifying the source of S. suis infection and monitoring its spread... - [Sediment record of DDTs in sediment core from Hongfeng reservoir]Jian yang Guo
State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China
Huan Jing Ke Xue 31:1589-93. 2010..The residue levels of DDE, DDD, DDT, and DDTs in surface sediment from Hongfeng reservoir were all between ERL and ERM, suggesting potential risk could occur, and the contamination of DDT in Hongfeng reservoir deserving more concerns... - [Lysosome of Eisenia fetida as biomarker of soil pollution]Nengwen Xiao
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
Ying Yong Sheng Tai Xue Bao 17:516-9. 2006..fetida's body. NRRT could be served as a biomarker of soil pollution, and a promising tool for the early warning of potential danger... - Proteome-wide analysis of protein function composition reveals the clustering and phylogenetic properties of organismsLunjiang Ling
Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
Mol Phylogenet Evol 25:101-11. 2002..quot;.. - A hidden Markov model for analyzing ChIP-chip experiments on genome tiling arrays and its application to p53 binding sequencesWei Li
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health Boston, MA 02115, USA
Bioinformatics 21:i274-82. 2005..SUPPLEMENTARY INFORMATION: Available at the following URL http://genome.dfci.harvard.edu/~xsliu/HMMTiling/index.html... - Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse waysWei Li
Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
Mol Cell Biol 24:3295-306. 2004..We provide evidence that expression of VWM mutant eIF2B may enhance the translation of specific mRNAs. The variability of the clinical phenotype in VWM may reflect the multiple ways in which VWM mutations affect eIF2B function... - Murine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organellesWei Li
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Bioessays 26:616-28. 2004..Studies of the molecular functions of HPS proteins will reveal important details of vesicle trafficking and may lead to therapies for HPS... - Application of sparse NMR restraints to large-scale protein structure predictionWei Li
Center of Excellence in Bioinformatics, University at Buffalo, Buffalo, New York 14203, USA
Biophys J 87:1241-8. 2004..5 A with N/4 restraints. Thus, TOUCHSTONEX can be a tool for NMR-based rapid structure determination, as well as used in other experimental methods that can provide tertiary restraint information...