Wei Li

Summary

Affiliation: Institute of Genetics and Developmental Biology
Country: China

Publications

  1. ncbi request reprint Mutational data integration in gene-oriented files of the Hermansky-Pudlak Syndrome database
    Wei Li
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Hum Mutat 27:402-7. 2006
  2. pmc PediDraw: a web-based tool for drawing a pedigree in genetic counseling
    Min He
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
    BMC Med Genet 8:31. 2007
  3. ncbi request reprint The BLOC interactomes form a network in endosomal transport
    Wei Li
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 34:669-82. 2007
  4. doi request reprint Efficient delivery of antitumor drug to the nuclei of tumor cells by amphiphilic biodegradable poly(L-aspartic acid-co-lactic acid)/DPPE co-polymer nanoparticles
    Siyuan Han
    CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Small 8:1596-606. 2012
  5. ncbi request reprint Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in China
    Xiao Ling Liu
    Chinese Academy of Medical Sciences, Beijing, China
    Med Sci Monit 16:CR458-63. 2010
  6. pmc Apoptotic regulators promote cytokinetic midbody degradation in C. elegans
    Yongping Chai
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Biol 199:1047-55. 2012
  7. pmc The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles
    Qing Yang
    State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Traffic 13:1160-9. 2012
  8. doi request reprint Body mass index and hypertension among Chinese governmental and institutional employees in Beijing
    Tao Chen
    Department of Biostatistics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Angiology 63:337-42. 2012
  9. doi request reprint Regulation of thyroid hormone related genes mRNA expression by exogenous T₃ in larvae and adult Chinese rare minnow (Gobiocypris rarus)
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Shuangqin Rd 18, Haidian District, PO Box 2871, Beijing 100085, China
    Environ Toxicol Pharmacol 31:189-97. 2011
  10. ncbi request reprint Conditional targeted genome editing using somatically expressed TALENs in C. elegans
    Ze Cheng
    1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China 2 School of Life Sciences, Peking University, Beijing, China 3
    Nat Biotechnol . 2013

Collaborators

  • Chunying Chen
  • Li Li
  • Xin He
  • Yuliang Zhao
  • Lei Liu
  • Qi Zhou
  • Tao Chen
  • Min He
  • Ling Yang
  • Hongwu Liang
  • Guoxin Feng
  • Yongping Chai
  • Yong zhen Zhang
  • Xiangming Wang
  • Yihong Yang
  • Guangshuo Ou
  • Liu Wang
  • Ying Liu
  • Bo Hu
  • Tao Xu
  • Ze Cheng
  • Zhiqiang Zhou
  • Fengmao Liu
  • Yan Wu
  • Juan Li
  • Jia Xiang Chen
  • Xiao yang Zhao
  • Zhe Zhang
  • Fang Jiao
  • Zhong Ze Fang
  • Jian yang Guo
  • Zhi yong Zhou
  • Xiao Ling Liu
  • Yan Yan Zhang
  • Yan Li
  • Guang Bo Ge
  • Liming Wang
  • Qing Zhang
  • Zhiwen Zhu
  • Peishan Yi
  • Lihong Qiu
  • Jin Guo
  • Jing Qiu
  • Edward K Novak
  • Qing Xu
  • Chao Sheng
  • Richard T Swank
  • Jin Song Peng
  • Wen Ping Guo
  • Jianguo Xu
  • Ligeng Xu
  • Ming Hui Li
  • Yang Wang
  • Qiangzheng Sun
  • Yong An Dai
  • Xin Cheng Qin
  • Shaomin Zhang
  • Menno D de Jong
  • Xiao Ping Chen
  • Dong Jin
  • Bin Yu
  • Dun Jin Zhou
  • Wen Wang
  • Jun Hua Tian
  • Yanwen Xiong
  • Yong Wen He
  • Junnan Ding
  • Siyuan Han
  • Yan Wang
  • Guofeng Shen
  • Qing Yang
  • Pei pei Dong
  • Aihua Wei
  • Yanyan Cui
  • Jing Chen
  • Tingting Lu
  • Xuehui Huang
  • Li Ming Wang
  • Xiao Li Guo
  • Sreenivasulu Chintala
  • Zhiheng Liu
  • Jiang Wei Zhang
  • Fanli Zhou
  • Xiaobo Wan
  • Yan Xia Li
  • Ai Hua Wei
  • Hong Yan Zhang
  • Dong Tian
  • Ping Xie
  • Peng Ye Wang

Detail Information

Publications150 found, 100 shown here

  1. ncbi request reprint Mutational data integration in gene-oriented files of the Hermansky-Pudlak Syndrome database
    Wei Li
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Hum Mutat 27:402-7. 2006
    ..All the mutations in these genes are integrated in the GOFs. We expect that these very informative and peerreviewed GOFs will be shortcuts to utilize the webbased information for the emerging interdisciplinary studies of HPS...
  2. pmc PediDraw: a web-based tool for drawing a pedigree in genetic counseling
    Min He
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
    BMC Med Genet 8:31. 2007
    ..This limits the usage of a pedigree as demanded in remote diagnosis or online counseling from the counselees to send an electronic pedigree...
  3. ncbi request reprint The BLOC interactomes form a network in endosomal transport
    Wei Li
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 34:669-82. 2007
    ..The disruption of this network may lead to abnormal trafficking or defective organellar development as described in patients with Hermansky-Pudlak syndrome...
  4. doi request reprint Efficient delivery of antitumor drug to the nuclei of tumor cells by amphiphilic biodegradable poly(L-aspartic acid-co-lactic acid)/DPPE co-polymer nanoparticles
    Siyuan Han
    CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Small 8:1596-606. 2012
    ..These results demonstrate the feasibility of the application of the amphiphilic polyaspartic acid derivative, poly(AA-co-LA)/DPPE, as a nanocarrier for cell nuclear delivery of potent antitumor drugs...
  5. ncbi request reprint Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in China
    Xiao Ling Liu
    Chinese Academy of Medical Sciences, Beijing, China
    Med Sci Monit 16:CR458-63. 2010
    ..In this study we analyzed the Pro12Ala (C>G) polymorphism in exon 2 and the 161C>T polymorphism in exon 6 of peroxisome proliferator-activated receptor gamma gene (PPARγ) in a Tibetan population and a Han population...
  6. pmc Apoptotic regulators promote cytokinetic midbody degradation in C. elegans
    Yongping Chai
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Biol 199:1047-55. 2012
    ..Thus, our findings uncover a novel function of cell death genes in midbody internalization and degradation after cell division...
  7. pmc The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles
    Qing Yang
    State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Traffic 13:1160-9. 2012
    ..Mild defects in the melanosomes of the retinal pigment epithelia and in the platelet dense granules of the Kxd1-KO mouse were observed, mimicking a mouse model of mild Hermansky-Pudlak syndrome that affects the biogenesis of LROs...
  8. doi request reprint Body mass index and hypertension among Chinese governmental and institutional employees in Beijing
    Tao Chen
    Department of Biostatistics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Angiology 63:337-42. 2012
    ..Concordant relationships were revealed in all evaluated subgroups, even among those without traditional cardiovascular risk factors...
  9. doi request reprint Regulation of thyroid hormone related genes mRNA expression by exogenous T₃ in larvae and adult Chinese rare minnow (Gobiocypris rarus)
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Shuangqin Rd 18, Haidian District, PO Box 2871, Beijing 100085, China
    Environ Toxicol Pharmacol 31:189-97. 2011
    ..The down-regulation of gene mRNA expression could serve as a compensatory mechanism for the activation of thyroid system...
  10. ncbi request reprint Conditional targeted genome editing using somatically expressed TALENs in C. elegans
    Ze Cheng
    1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China 2 School of Life Sciences, Peking University, Beijing, China 3
    Nat Biotechnol . 2013
    ..Our results show that TALENs expressed in the somatic cells of model organisms provide a versatile tool for functional genomics...
  11. doi request reprint Exome sequencing identifies SLC24A5 as a candidate gene for nonsyndromic oculocutaneous albinism
    Ai Hua Wei
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    J Invest Dermatol 133:1834-40. 2013
    ..Our results suggest that SLC24A5 is a previously unreported nonsyndromic OCA candidate gene and that the SLC24A5 transporter is transported into mature melanosomes by HPS protein complexes...
  12. doi request reprint Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression
    Guoxin Feng
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Development 140:3838-47. 2013
    ..We have thus identified TFs that function at distinct developmental stages to ensure appropriate neuroblast lineage progression and suggest that their vertebrate homologs might similarly regulate neural development. ..
  13. doi request reprint Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment
    Ligeng Xu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China
    Nano Lett 12:2003-12. 2012
    ..These findings have shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems...
  14. doi request reprint Stereoselective dissipation of epoxiconazole in grape (Vitis vinifera cv. Kyoho) and soil under field conditions
    Hongwu Liang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Chemosphere 87:982-7. 2012
    ..The results for stereoselective dissipations can be applied for food and environmental assessments of chiral pesticides...
  15. doi request reprint The decline and residues of hexaconazole in tomato and soil
    Hongwu Liang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Environ Monit Assess 184:1573-9. 2012
    ..a.i./hm(2) for three or four times were all below 0.1 mg/kg. This work would be the guidance of establishing the maximum residue limit of hexaconazole in tomato in China...
  16. doi request reprint Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles
    Qing Xu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Biomaterials 33:1627-39. 2012
    ..Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy...
  17. pmc Screening level of PAHs in sediment core from Lake Hongfeng, Southwest China
    Jian yang Guo
    State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China
    Arch Environ Contam Toxicol 60:590-6. 2011
    ..Because only one core was analyzed in this study, more work is needed to confirm the sources and toxicity of PAHs in Lake Hongfeng...
  18. doi request reprint Genome-wide association studies of 14 agronomic traits in rice landraces
    Xuehui Huang
    National Center for Gene Research, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Genet 42:961-7. 2010
    ....
  19. doi request reprint Regulation of iodothyronine deiodinases and sodium iodide symporter mRNA expression by perchlorate in larvae and adult Chinese rare minnow (Gobiocypris rarus)
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
    Mar Pollut Bull 63:350-5. 2011
    ..The larval fish development could be affected by perchlorate at environmentally relevant concentrations...
  20. doi request reprint Prognostic value of coronary CT angiography and calcium score for major adverse cardiac events in outpatients
    Zhi Hui Hou
    Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    JACC Cardiovasc Imaging 5:990-9. 2012
    ..This study sought to evaluate the prognostic value of coronary artery calcium score (CACS) and coronary computed tomography angiography (CTA) for major adverse cardiac events (MACE)...
  21. doi request reprint Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions
    Qi Gu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Protein Cell 3:71-9. 2012
    ..Thus the rapid conversion established a naïve pluripotency in human ESCs like mouse ESCs, and provided a new model to study the regulation of pluripotency...
  22. pmc Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
    Chao Sheng
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Res 22:208-18. 2012
    ..In addition, iNSCs can survive and generate synapses following transplantation into the dentate gyrus. Generation of iNSCs may have important implications for disease modeling and regenerative medicine...
  23. doi request reprint Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy
    Yan Wu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Nanomedicine 7:945-54. 2011
    ..These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery of antitumor drugs...
  24. doi request reprint Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of daphnetin
    Si Cheng Liang
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China
    Drug Metab Dispos 38:973-80. 2010
    ..In conclusion, the UGT conjugation pathways of daphnetin were fully elucidated and its C-8 phenol group was more selectively catalyzed by UGTs than by the C-7 phenol...
  25. doi request reprint Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib
    Pei pei Dong
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China
    Acta Pharmacol Sin 32:399-407. 2011
    ....
  26. doi request reprint A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling
    Xiaobo Wan
    Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    J Med Chem 56:2619-29. 2013
    ....
  27. doi request reprint Stereoselective transformation of triadimefon to metabolite triadimenol in wheat and soil under field conditions
    Hongwu Liang
    Institute of Quality Standards and Testing Technology for Agro Products, Chinese Academy of Agricultural Sciences, Key Laboratory of Agrifood Quality and Safety, Ministry of Agriculture, Beijing 100081, China State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    J Hazard Mater 260:929-36. 2013
    ....
  28. doi request reprint Live imaging of cellular dynamics during Caenorhabditis elegans postembryonic development
    Yongping Chai
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Nat Protoc 7:2090-102. 2012
    ..Other applications are also possible. The protocol can be completed within 3 h and may provide insights into understanding postembryonic development...
  29. ncbi request reprint Mice overexpression of human augmenter of liver regeneration (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing, China
    Endocr J 59:989-99. 2012
    ..Present findings in the mouse may be of interest to human male fertility...
  30. pmc Emissions of PAHs from indoor crop residue burning in a typical rural stove: emission factors, size distributions, and gas-particle partitioning
    Guofeng Shen
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China
    Environ Sci Technol 45:1206-12. 2011
    ..5, and the mass percentage of PAHs in fine particles increased as the molecular weight increased. For freshly emitted PAHs, absorption into organic carbon, rather than adsorption, dominated the gas-particle partitioning...
  31. ncbi request reprint Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China
    Yong zhen Zhang
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Zhonghua Liu Xing Bing Xue Za Zhi 32:209-20. 2011
    ..From April to July in 2009 and 2010, unexplained severe hemorrhagic fever-like illnesses occurred in farmers from the Huaiyangshan mountains range...
  32. doi request reprint Generation of tripotent neural progenitor cells from rat embryonic stem cells
    Zhenkun Wang
    College of Life Science, Northeast Agricultural University of China, Harbin 150030, China
    J Genet Genomics 39:643-51. 2012
    ....
  33. doi request reprint Variation in the internalization of differently sized nanoparticles induces different DNA-damaging effects on a macrophage cell line
    Mingyi Zhang
    Lab for Bio Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Science, Beijing 10049, China
    Arch Toxicol 85:1575-88. 2011
    ..Based on these results, we assume that the damage resulted from a disruption of the balance between DNA damage and repair...
  34. doi request reprint MiR-200a is involved in rat epididymal development by targeting β-catenin mRNA
    Xiaojiang Wu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Acta Biochim Biophys Sin (Shanghai) 44:233-40. 2012
    ..All these results show that miR-200a should be involved in rat epididymal development by targeting β-catenin mRNA of rat and suppressing its expression...
  35. pmc Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population
    Ying Wang
    Key laboratory of Endocrine, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    PLoS ONE 6:e26953. 2011
    ..To investigate whether the candidate genes that confer susceptibility to type 2 diabetes mellitus are also correlated with gestational diabetes mellitus (GDM) in pregnant Chinese women...
  36. doi request reprint Cycloartane triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathway
    Zhong Ze Fang
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
    Phytother Res 25:17-24. 2011
    ..These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway...
  37. ncbi request reprint Modulation of oxidative stress by functionalized fullerene materials in the lung tissues of female C57/BL mice with a metastatic Lewis lung carcinoma
    Fang Jiao
    CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety NCNST IHEP, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    J Nanosci Nanotechnol 10:8632-7. 2010
    ....
  38. pmc Mouse cloning and somatic cell reprogramming using electrofused blastomeres
    Amjad Riaz
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1st Beichen West Road, Beijing 100101, China
    Cell Res 21:770-8. 2011
    ..Our approach provides an attractive and practical alternative to therapeutic cloning using donated oocytes for the generation of patient-specific human ES cell lines...
  39. doi request reprint Dissipation and residue of dimethomorph in pepper and soil under field conditions
    Hongwu Liang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
    Ecotoxicol Environ Saf 74:1331-5. 2011
    ..These results will be helpful in setting MRL guidance for dimethomorph in pepper in China...
  40. doi request reprint MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status
    Wei Li
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
    Planta Med 77:27-31. 2011
    ....
  41. pmc Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells
    Lei Liu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China
    J Biol Chem 285:19483-90. 2010
    ..These findings also provide a step forward toward understanding the operating mechanisms during reprogramming to produce iPS cells and can potentially promote the application of iPS cells in regenerative medicine and cancer therapy...
  42. doi request reprint Temporal techniques: dynamic tracking of nanomaterials in live cells
    Wei Li
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Small 9:1585-94. 2013
    ..in live cells. The biological properties of nanoparticles in live cells are also briefly summarized according to fluorescence microscopy studies...
  43. pmc Oxaliplatin and its enantiomer induce different condensation dynamics of single DNA molecules
    Hong Yan Zhang
    Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e71556. 2013
    ..The study has strong implications for the understanding of the effect of chirality on the interaction between Pt-DACH and DNA and the kinetics of DNA condensation induced by platinum complexes. ..
  44. doi request reprint Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth
    Jia Xiang Chen
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 5 Beichenxi Road, Beijing 100101, PR China Graduate University of Chinese Academy of Sciences, Beijing 100039, PR China Medical School of Nanchang University, Nanchang 330006, PR China
    Toxicology 310:92-7. 2013
    ..Taken together, these results indicated that TOCP treatment induced autophagy in differentiated SH-SY5Y cells, which lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. ..
  45. pmc Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration
    Xiangming Wang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 110:11175-80. 2013
    ..Thus, MIG-13 links the Wnt signaling and Hox genes that guide migrations, to the actin cytoskeleton, which executes the motility response in neuronal migration. ..
  46. doi request reprint Nine-month angiographic and 2-year clinical follow-up of the NOYA biodegradable polymer sirolimus-eluting stent in the treatment of patients with de novo native coronary artery lesions: the NOYA I trial
    Bo Xu
    Fuwai Hospital, National Centre for Cardiovascular Diseases of China, Beijing, China
    EuroIntervention 8:796-802. 2012
    ....
  47. doi request reprint New insights into the functions and localization of nuclear CCT protein complex in K562 leukemia cells
    Rui Huang
    Beijing Institute of Radiation Medicine, Beijing, China
    Proteomics Clin Appl 6:467-75. 2012
    ..The purpose of this study is to explore the function of CCT in nuclear and present a strategy in clinical proteomics studies...
  48. ncbi request reprint Impact of DNA twist accumulation on progressive helical wrapping of torsionally constrained DNA
    Wei Li
    Beijing National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
    Phys Rev Lett 109:218102. 2012
    ..The theoretical predictions and the experimental results are consistent with each other and their implications are discussed...
  49. doi request reprint The residues and environmental risks of multiple veterinary antibiotics in animal faeces
    Yan Xia Li
    State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 100875, Beijing, China
    Environ Monit Assess 185:2211-20. 2013
    ..These medicine residues in animal faeces may potentially bring ecological risks if the animal manure is not treated effectively...
  50. doi request reprint Androgenetic haploid embryonic stem cells produce live transgenic mice
    Wei Li
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Nature 490:407-11. 2012
    ..Our findings show the developmental pluripotency of androgenentic haploids and provide a new tool to quickly produce genetic models for recessive traits. They may also shed new light on assisted reproduction...
  51. doi request reprint Production of brown/yellow patches in the SLC7A11 transgenic sheep via testicular injection of transgene
    Xin He
    State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 39:281-5. 2012
    ..Our studies suggest that testicular injection of transgene can be used to genetically modify sheep coat color...
  52. doi request reprint The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways
    Hejiang Zhou
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Biomaterials 33:6933-42. 2012
    ..Further research is needed to systematically assess the biological responses of graphene, both to improve its safety and to contribute to the design of new biological applications...
  53. doi request reprint Bifunctional peptides that precisely biomineralize Au clusters and specifically stain cell nuclei
    Yaling Wang
    Institute of High Energy Physics, Chinese Academy of Sciences, Yuquan Road 19B, Shi Jing Shan District, Beijing 10049, China
    Chem Commun (Camb) 48:871-3. 2012
    ..The peptide-Au clusters exhibit red emission (λ(em) = 677 nm) and specifically stain the nuclei of three cell lines...
  54. pmc Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64
    Jing Cheng
    Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
    Am J Hum Genet 89:56-66. 2011
    ..Our work identifies DFNA64 as the human genetic disorder associated with SMAC/DIABLO malfunction and suggests that mutant SMAC/DIABLO(S71L) might cause mitochondrial dysfunction...
  55. doi request reprint Analysis of two sequence variants in peroxisome proliferator activated receptor gamma gene in Tajik population at high altitudes and Han population at low altitudes in China
    Xiao Ling Liu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Mol Biol Rep 37:179-84. 2010
    ..0001) was significantly lower in the Tajik population than that in the Han population. Our results suggest that PPARG is a candidate gene for high-altitude adaptation in the Chinese Tajik population...
  56. doi request reprint Stereoselective separation and determination of triadimefon and triadimenol in wheat, straw, and soil by liquid chromatography-tandem mass spectrometry
    Hongwu Liang
    College of Science, China Agricultural University, Beijing, P R China
    J Sep Sci 35:166-73. 2012
    ..001-0.005 mg/kg and 0.007-0.02 mg/kg, respectively. Finally, the method was successfully applied to detect TF and TN stereoisomers in wheat, straw, and soil samples from residual trials in farm...
  57. doi request reprint BLOS1, a putative BLOC-1 subunit, interacts with SNX1 and modulates root growth in Arabidopsis
    Yanyan Cui
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Sci 123:3727-33. 2010
    ....
  58. doi request reprint Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-Kit
    Xiao Li Guo
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Pigment Cell Melanoma Res 23:252-62. 2010
    ..This expands our understanding of the intricate regulatory network governing the melanocyte development...
  59. doi request reprint Association between 9p21.3 genomic markers and coronary artery disease in East Asians: a meta-analysis involving 9,813 cases and 10,710 controls
    Jin Guo
    Division of Biometrics, National Center for Cardiovascular Diseases, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China
    Mol Biol Rep 40:337-43. 2013
    ..3 in China population in one study. This broad replication provides unprecedented evidence for association between genetic variants at chromosome 9p21.3 and risk of CAD in East Asians...
  60. doi request reprint Smoking status on outcomes after percutaneous coronary intervention
    Tao Chen
    Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Clin Cardiol 35:570-4. 2012
    ..The effect of smoking on prognosis among patients undergoing percutaneous coronary intervention (PCI) is controversial, and data on the importance of smoking cessation or reductions were lacking...
  61. pmc Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell
    Wei Li
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Biol 197:27-35. 2012
    ..Thus, autophagy genes act within the phagocyte to promote apoptotic cell degradation...
  62. doi request reprint Characterization and expression analysis of hsp70 gene from Ulva prolifera J. Agardh (Chlorophycophyta, Chlorophyceae)
    Haining Zhang
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China
    Mar Genomics 5:53-8. 2012
    ..The study suggested that hsp70 could be used in prediction of stress tolerance in algae and monitoring environmental changes...
  63. doi request reprint Superb fluoride and arsenic removal performance of highly ordered mesoporous aluminas
    Wei Li
    Key Laboratory for Molecular Nanostructures and Nanotechnology, Institute of Chemistry, Beijing National Laboratory for Molecular Sciences BNLMS, Chinese Academy of Sciences, Beijing, PR China
    J Hazard Mater 198:143-50. 2011
    ..These materials also showed superb arsenic removal ability. 1g of mesoporous alumina was able to treat 200 kg of arsenic contaminated water with a pH value of 7, reducing the concentration of arsenate from 100 ppb to 1 ppb...
  64. ncbi request reprint [China genetic counseling network (CGCN): a website on genetic counseling and genetic education]
    Min He
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Yi Chuan 29:381-4. 2007
    ..The data warehouse of China Genetic Counseling Network (CGCN) will be a unique supplement to current status of Clinical Genetics and healthcare system in China...
  65. doi request reprint Pd-catalyzed asymmetric hydrogenation of unprotected indoles activated by Brønsted acids
    Duo Sheng Wang
    State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    J Am Chem Soc 132:8909-11. 2010
    ..The present method provides an efficient route to enantioenriched 2-substituted and 2,3-disubstituted indolines...
  66. pmc Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs
    DongShan Yang
    Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
    Hum Mol Genet 19:3983-94. 2010
    ..Our findings suggest that species differences determine neuropathology and underscore the importance of large mammalian animals for modeling neurological disorders...
  67. doi request reprint Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit
    Yinghui Zhang
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China
    Antioxid Redox Signal 13:999-1009. 2010
    ....
  68. doi request reprint Evaluation of trimetazidine in angina pectoris by echocardiography and radionuclide angiography: a meta-analysis of randomized, controlled trials
    Bo Hu
    Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Clin Cardiol 34:395-400. 2011
    ..The objective of this meta-analysis was to evaluate the efficacy of the metabolic agent trimetazidine (TMZ) as monotherapy in the treatment of stable angina pectoris, from echocardiography and radionuclide angiography data...
  69. doi request reprint Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy
    Liming Wang
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China
    Nano Lett 11:772-80. 2011
    ..These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy...
  70. doi request reprint A comprehensive analysis reveals mutational spectra and common alleles in Chinese patients with oculocutaneous albinism
    Aihua Wei
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Department of Dermatology, Xuan Wu Hospital, Capital Medical University, Beijing, China
    J Invest Dermatol 130:716-24. 2010
    ..6% of the mutational SLC45A2 alleles in Chinese OCA4 patients. These results provide useful information for the establishment of an optimized strategy of gene diagnosis and genetic counseling of Chinese OCA patients...
  71. ncbi request reprint Fabrication of nanostructured metal nitrides with tailored composition and morphology
    Wei Li
    Beijing National Laboratory for Molecular Sciences BNLMS and Key Laboratory for Molecular Nanostructures and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P R China
    Chem Commun (Camb) 47:3619-21. 2011
    ....
  72. doi request reprint The dissipation rates of trichlorfon and its degradation product dichlorvos in cabbage and soil
    Wei Li
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
    Chemosphere 82:829-33. 2011
    ..Although trichlorfon can easily degrade into dichlorvos, which is highly toxic to humans and other animals, the observed low residual levels of dichlorvos suggest that trichlorfon is safe when applied at the recommended dosage...
  73. pmc Occurrence and exposure to polycyclic aromatic hydrocarbons and their derivatives in a rural Chinese home through biomass fuelled cooking
    Junnan Ding
    Laboratory for Earth Surface Processes, College of Urban and Environmental Science, Peking University, Beijing, China
    Environ Pollut 169:160-6. 2012
    ..The daily mean benzo(a)pyrene equivalent exposure concentration was as high as 200 ± 160 ng/m(3) in the winter for the housewife who did the cooking compared to 59 ± 37 ng/m(3) for the control group that did not cook...
  74. ncbi request reprint Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatin
    Wei Li
    Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
    Phys Rev E Stat Nonlin Soft Matter Phys 85:021918. 2012
    ..Moreover, abrupt length changes were also observed when DNA was treated with a mixture of cisplatin and transplatin at high concentrations. A model was proposed to qualitatively explain well these results...
  75. pmc Are coiled-coils of dimeric kinesins unwound during their walking on microtubule?
    Zhao Wen Duan
    Key Laboratory of Soft Matter Physics and Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e36071. 2012
    ..Thus, we concluded that the coiled-coils of kinesin-1, Ncd and Kar3/Vik1 are almost impossible to unwind during their walking on the microtubule...
  76. ncbi request reprint [Application of zero-inflated models on regression analysis of count data: a study of sub-health symptoms]
    Tao Xu
    Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Zhonghua Liu Xing Bing Xue Za Zhi 32:187-91. 2011
    ..ZINB seems the optimal model to study those over-dispersed count data with too many zeros...
  77. ncbi request reprint Marital status, education, and risk of acute myocardial infarction in Mainland China: the INTER-HEART study
    Bo Hu
    Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    J Epidemiol 22:123-9. 2012
    ..We investigated the effects of marital status and education on the risk of acute myocardial infarction (AMI) in a large-scale case-control study in China...
  78. doi request reprint Biogeochemical effects of forest vegetation on acid precipitation-related water chemistry: a case study in southwest China
    Jing Chen
    State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing, 100875, China
    J Environ Monit 12:1799-806. 2010
    ..The most appropriate forest vegetation for water conservation and remediation of acid precipitation in this region was explored for the sake of ecosystem management, ecological restoration and economic development...
  79. doi request reprint Identification of nucleolar and coiled-body phosphoprotein 1 (NOLC1) minimal promoter regulated by NF-κB and CREB
    Xuesong Gao
    Beijing Ditan Hospital, Peking University Health Science Center, Beijing, China
    BMB Rep 44:70-5. 2011
    ..Mutagenesis and overexpression assays revealed that NF-κB and CREB positively regulated the NOLC1 promoter. These findings may provide new insight into the mechanisms that regulate NOLC1 expression...
  80. pmc Function annotation of the rice transcriptome at single-nucleotide resolution by RNA-seq
    Tingting Lu
    National Center for Gene Research and Institute of Plant Physiology and Ecology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200233, China
    Genome Res 20:1238-49. 2010
    ..The ratio of SNPs with nonsynonymous/synonymous mutations was nearly 1:1.06. In total, we interrogated and compared transcriptomes of the two rice subspecies to reveal the overall transcriptional landscape at maximal resolution...
  81. doi request reprint Viable fertile mice generated from fully pluripotent iPS cells derived from adult somatic cells
    Xiao yang Zhao
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Stem Cell Rev 6:390-7. 2010
    ..This work provides the means for studying the mechanisms and regulation of direct reprogramming, and has encouraging implications for future clinical applications and therapeutic interventions...
  82. doi request reprint Investigation of binding features: effects on the interaction between CYP2A6 and inhibitors
    Chunzhi Ai
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    J Comput Chem 31:1822-31. 2010
    ..In addition, the combinational use of the docking, MLP and MEP analysis is also demonstrated as a good attempt to gain an insight into the interaction between CYP2A6 and its inhibitors...
  83. pmc Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations
    Yang Li
    Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China
    Hum Mol Genet 18:4897-904. 2009
    ..Thus, we demonstrate that, unlike FOXO3A, FOXO1A is more closely associated with human female longevity, suggesting that the genetic contribution to longevity trait may be affected by genders...
  84. pmc Preliminary strategic environmental assessment of the Great Western Development Strategy: safeguarding ecological security for a new western China
    Wei Li
    State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, No 19, Xin Jie Kou Wai St, Haidian District, Beijing, 100875, China
    Environ Manage 49:483-501. 2012
    ....
  85. pmc The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China
    Yong zhen Zhang
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China
    J Virol 86:2864-8. 2012
    ..HYSV RNA was found in human and both tick species, with greater prevalence in H. longicornis and lesser prevalence in R. microplus. Phylogenetic analyses indicate that HYSV is a novel species of the genus Phlebovirus...
  86. doi request reprint Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome
    Yong zhen Zhang
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Clin Infect Dis 54:527-33. 2012
    ....
  87. doi request reprint The degradation of 1,2,4-trichlorobenzene using synthesized Co3O4 and the hypothesized mechanism
    Shijing Lin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, Beijing 100085, China
    J Hazard Mater 192:1697-704. 2011
    ..The superoxide anions caused ring-cracking oxidation of 1,2,4-TrCB, possibly producing some low-molecular-weight products, thus explaining a mass imbalance in the chlorine atoms and total organic carbon...
  88. doi request reprint Vinclozolin affects the interrenal system of the rare minnow (Gobiocypris rarus)
    Lihua Yang
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
    Aquat Toxicol 104:153-9. 2011
    ..These results provide additional data about the modes of toxicological action of vinclozolin...
  89. ncbi request reprint [Formation and function of Weibel-Palade bodies]
    Zhe Zhang
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Yi Chuan 31:882-8. 2009
    ..The underlying mechanism of the formation of WPB remains further investigation, which will gain insights into its function. The molecular mechanism of WPB formation and its function were discussed in this review...
  90. pmc Overexpression of xCT induces up-regulation of 14-3-3beta in Kaposi's sarcoma
    Yan Zeng
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Biosci Rep 30:277-83. 2010
    ..These results suggest that 14-3-3beta is a downstream effector of xCT in KS to mediate the cell proliferation...
  91. doi request reprint Potent angiogenesis inhibition by the particulate form of fullerene derivatives
    Huan Meng
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    ACS Nano 4:2773-83. 2010
    ..We propose that using nanoscale "particulate" itself as a new form of medicine (particulate medicine) may be superior to the traditional "molecular" form of medicine (molecular medicine) in cancer treatment...
  92. doi request reprint Survey of prevalence, awareness, treatment, and control of hypertension among Chinese governmental and institutional employees in Beijing
    Tao Xu
    Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Clin Cardiol 33:E66-72. 2010
    ..Few studies have been done on the effects that awareness, treatment, and control have on hypertension among governmental and institutional employees...
  93. doi request reprint Regulation of neuropathy target esterase by the cAMP/protein kinase A signal
    Jia Xiang Chen
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, PR China
    Pharmacol Res 62:259-64. 2010
    ..These results are the first evidence that cAMP/PKA signals regulate NTE expression and GPC content in mammalian cells...
  94. doi request reprint Streptococcus suis outbreak investigation using multiple-locus variable tandem repeat number analysis
    Wei Li
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Microbiol Immunol 54:380-8. 2010
    ..The developed MLVA scheme for S. suis has greater discriminative power than PFGE. The method described here may be useful for identifying the source of S. suis infection and monitoring its spread...
  95. pmc Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity
    Wei Li
    State Key Laboratory of Bio organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China
    Bioorg Med Chem Lett 20:3112-5. 2010
    ..All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity...
  96. ncbi request reprint [Sediment record of DDTs in sediment core from Hongfeng reservoir]
    Jian yang Guo
    State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China
    Huan Jing Ke Xue 31:1589-93. 2010
    ..The residue levels of DDE, DDD, DDT, and DDTs in surface sediment from Hongfeng reservoir were all between ERL and ERM, suggesting potential risk could occur, and the contamination of DDT in Hongfeng reservoir deserving more concerns...
  97. doi request reprint Hydrophilic TiO2 porous spheres anchored on hydrophobic polypropylene membrane for wettability induced high photodegrading activities
    Fang Niu
    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P R China
    Nanoscale 2:1480-4. 2010
    ..In photodegrading reactions, the resulting TiO(2)/PP composite film exhibits a 10 times higher activity in flow-type setup than the same TiO(2) catalyst in a traditional batch-type setup...
  98. ncbi request reprint [Observation and analysis on water-soluble inorganic chemical compositions of atmospheric aerosol in Gongga Mountain]
    Ya Nan Zhao
    Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China
    Huan Jing Ke Xue 30:9-13. 2009
    ..87 and 0.84 in PM2.5 and PM10. The concentration ratio of SO4(2-) and NH4+ is approximate to 1:2 in PM10, main existence form of SO4(2-) and NH4+ (NH4)2SO4 at Gongga Mountain...
  99. doi request reprint Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis
    Fang Lao
    CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    ACS Nano 3:3358-68. 2009
    ..Our results indicate that C(60)(C(COOH)(2))(2) nanoparticles possess a novel ability of selectively entering oxidation-damaged cerebral endothelial cells rather than normal endothelial cells and then protecting them from apoptosis...
  100. doi request reprint Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate
    Jiang Wei Zhang
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Drug Metab Dispos 36:2292-8. 2008
    ..In conclusion, CYP3A4 was the major P450 isoform involved in MPA hydroxylation, with 6beta, 2beta, and 1beta being the possible hydroxylation sites. Minipig and rat could be the surrogate models for man in MPA pharmacokinetic studies...
  101. doi request reprint The environmental fate of different forms of ZJ0702 in open rape field and MRL calculation
    Li Li
    Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Beijing 100101, PR China
    Toxicol Mech Methods 21:37-40. 2011
    ..The low final residue levels of ZJ0702 in rapeseed and soil indicated that this new pesticide was environmentally safe. It was recommended that MRL for ZJ0702 in rapeseed be 1 mg/kg in China...