Wei Li

Summary

Affiliation: Institute of Genetics and Developmental Biology
Country: China

Publications

  1. ncbi request reprint Mutational data integration in gene-oriented files of the Hermansky-Pudlak Syndrome database
    Wei Li
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Hum Mutat 27:402-7. 2006
  2. pmc Overexpression of xCT induces up-regulation of 14-3-3beta in Kaposi's sarcoma
    Yan Zeng
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Biosci Rep 30:277-83. 2010
  3. pmc Impaired long-term potentiation and long-term memory deficits in xCT-deficient sut mice
    Yan Li
    Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China
    Biosci Rep 32:315-21. 2012
  4. pmc PediDraw: a web-based tool for drawing a pedigree in genetic counseling
    Min He
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
    BMC Med Genet 8:31. 2007
  5. ncbi request reprint The BLOC interactomes form a network in endosomal transport
    Wei Li
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 34:669-82. 2007
  6. doi request reprint Efficient delivery of antitumor drug to the nuclei of tumor cells by amphiphilic biodegradable poly(L-aspartic acid-co-lactic acid)/DPPE co-polymer nanoparticles
    Siyuan Han
    CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Small 8:1596-606. 2012
  7. ncbi request reprint Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in China
    Xiao Ling Liu
    Chinese Academy of Medical Sciences, Beijing, China
    Med Sci Monit 16:CR458-63. 2010
  8. doi request reprint Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression
    Guoxin Feng
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Development 140:3838-47. 2013
  9. pmc Apoptotic regulators promote cytokinetic midbody degradation in C. elegans
    Yongping Chai
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Biol 199:1047-55. 2012
  10. doi request reprint A proneural gene controls C. elegans neuroblast asymmetric division and migration
    Zhiwen Zhu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    FEBS Lett 588:1136-43. 2014

Collaborators

  • Qi Zhou
  • Hao Wu
  • Yang Wang
  • Xin He
  • Chunying Chen
  • Li Li
  • Yuliang Zhao
  • Hongwu Liang
  • Liu Wang
  • Tao Chen
  • Yongping Chai
  • Guofeng Shen
  • Lei Liu
  • Yan Li
  • Guangshuo Ou
  • Guoxin Feng
  • Zhe Zhang
  • Xiao yang Zhao
  • Yong zhen Zhang
  • Ying Liu
  • Bo Hu
  • Min He
  • Tao Xu
  • Xu Hu
  • Lin Yang
  • Zhiwen Zhu
  • Xiangming Wang
  • Jin Guo
  • Yihong Yang
  • Ligeng Xu
  • Liming Wang
  • Ling Yang
  • Weixiao Liu
  • Peishan Yi
  • Jia Qi Chen
  • Xiao Yong Man
  • Min Zheng
  • Ze Cheng
  • Yi Jun Wu
  • Hui Li
  • Bin Wang
  • Huizhong Shen
  • Bo Xu
  • Rong Wang
  • Shu Tao
  • Zhiqiang Zhou
  • Fengmao Liu
  • Jia Xiang Chen
  • Yan Wu
  • Juan Li
  • Zhong Ze Fang
  • Fang Jiao
  • Tingting Lu
  • Xuehui Huang
  • Jian yang Guo
  • Zhi yong Zhou
  • Guang Bo Ge
  • Xiao Ling Liu
  • Yan Yan Zhang
  • Qing Zhang
  • Chao Liu
  • Yanmei Jiao
  • Yongliang Shang
  • Tao Wang
  • Feng Jin
  • Shan Liang
  • Tong Zhang
  • Jia Luo
  • Lisheng Liu
  • Pan Wang
  • Xiaoru Cheng
  • Ai Hua Wei
  • Ping Xie
  • Yu Jie Liang
  • Peng Ye Wang
  • Lilla Landeck
  • Dong Tian
  • Sui Qing Cai
  • Ye Huang
  • Yanyan Zhang
  • Haifeng Wan
  • Lihong Qiu
  • Jing Qiu
  • Qing Xu
  • Richard T Swank
  • Xiang Gao
  • Edward K Novak
  • Ding Xin Long
  • Chao Sheng
  • Shaomin Zhang

Detail Information

Publications191 found, 100 shown here

  1. ncbi request reprint Mutational data integration in gene-oriented files of the Hermansky-Pudlak Syndrome database
    Wei Li
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Hum Mutat 27:402-7. 2006
    ..All the mutations in these genes are integrated in the GOFs. We expect that these very informative and peerreviewed GOFs will be shortcuts to utilize the webbased information for the emerging interdisciplinary studies of HPS...
  2. pmc Overexpression of xCT induces up-regulation of 14-3-3beta in Kaposi's sarcoma
    Yan Zeng
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Biosci Rep 30:277-83. 2010
    ..These results suggest that 14-3-3beta is a downstream effector of xCT in KS to mediate the cell proliferation...
  3. pmc Impaired long-term potentiation and long-term memory deficits in xCT-deficient sut mice
    Yan Li
    Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China
    Biosci Rep 32:315-21. 2012
    ..Supplementation of extracellular glutamate did not reverse the reduction in LTP. Taken together, our results suggest that xCT plays a role in the modulation of hippocampal long-term plasticity...
  4. pmc PediDraw: a web-based tool for drawing a pedigree in genetic counseling
    Min He
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
    BMC Med Genet 8:31. 2007
    ..This limits the usage of a pedigree as demanded in remote diagnosis or online counseling from the counselees to send an electronic pedigree...
  5. ncbi request reprint The BLOC interactomes form a network in endosomal transport
    Wei Li
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 34:669-82. 2007
    ..The disruption of this network may lead to abnormal trafficking or defective organellar development as described in patients with Hermansky-Pudlak syndrome...
  6. doi request reprint Efficient delivery of antitumor drug to the nuclei of tumor cells by amphiphilic biodegradable poly(L-aspartic acid-co-lactic acid)/DPPE co-polymer nanoparticles
    Siyuan Han
    CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Small 8:1596-606. 2012
    ..These results demonstrate the feasibility of the application of the amphiphilic polyaspartic acid derivative, poly(AA-co-LA)/DPPE, as a nanocarrier for cell nuclear delivery of potent antitumor drugs...
  7. ncbi request reprint Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in China
    Xiao Ling Liu
    Chinese Academy of Medical Sciences, Beijing, China
    Med Sci Monit 16:CR458-63. 2010
    ..In this study we analyzed the Pro12Ala (C>G) polymorphism in exon 2 and the 161C>T polymorphism in exon 6 of peroxisome proliferator-activated receptor gamma gene (PPARγ) in a Tibetan population and a Han population...
  8. doi request reprint Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression
    Guoxin Feng
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Development 140:3838-47. 2013
    ..We have thus identified TFs that function at distinct developmental stages to ensure appropriate neuroblast lineage progression and suggest that their vertebrate homologs might similarly regulate neural development. ..
  9. pmc Apoptotic regulators promote cytokinetic midbody degradation in C. elegans
    Yongping Chai
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Biol 199:1047-55. 2012
    ..Thus, our findings uncover a novel function of cell death genes in midbody internalization and degradation after cell division...
  10. doi request reprint A proneural gene controls C. elegans neuroblast asymmetric division and migration
    Zhiwen Zhu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    FEBS Lett 588:1136-43. 2014
    ..Our studies thus uncovered previously unknown functions of a proneural gene in neuroblast development. ..
  11. doi request reprint Conditional targeted genome editing using somatically expressed TALENs in C. elegans
    Ze Cheng
    1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China 2 School of Life Sciences, Peking University, Beijing, China 3
    Nat Biotechnol 31:934-7. 2013
    ..Our results show that TALENs expressed in the somatic cells of model organisms provide a versatile tool for functional genomics. ..
  12. doi request reprint Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3β
    Jia Qi Chen
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Cell Biochem Biophys 66:523-8. 2013
    ..The ERK1/2 and GSK-3β signaling pathways may play positive roles in regulating epidermal differentiation as observed in psoriasis...
  13. pmc The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles
    Qing Yang
    State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Traffic 13:1160-9. 2012
    ..Mild defects in the melanosomes of the retinal pigment epithelia and in the platelet dense granules of the Kxd1-KO mouse were observed, mimicking a mouse model of mild Hermansky-Pudlak syndrome that affects the biogenesis of LROs...
  14. doi request reprint VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway
    Wei Li
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China
    Mol Biol Rep 39:8687-94. 2012
    ..Taken together, human ORS cells express functional VEGF receptor-2 and exogenous VEGF(165) upregulates expression of VEGFR-2 and stimulates proliferation of ORS cells via VEGFR-2 mediated ERK signaling pathway...
  15. doi request reprint Exome sequencing identifies SLC24A5 as a candidate gene for nonsyndromic oculocutaneous albinism
    Ai Hua Wei
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    J Invest Dermatol 133:1834-40. 2013
    ..Our results suggest that SLC24A5 is a previously unreported nonsyndromic OCA candidate gene and that the SLC24A5 transporter is transported into mature melanosomes by HPS protein complexes...
  16. doi request reprint A randomised comparison of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: clinical and angiographic follow-up of the TARGET I trial
    Run lin Gao
    Fu Wai Hospital, National center for cardiovascular diseases of China, Beijing, China
    EuroIntervention 9:75-83. 2013
    ....
  17. doi request reprint Impaired nuclear translocation of glucocorticoid receptors: novel findings from psoriatic epidermal keratinocytes
    Xiao Yong Man
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China
    Cell Mol Life Sci 70:2205-20. 2013
    ..Therapeutic strategies designed to accumulate GR in the nucleus, such as IL-13, may be beneficial for the therapy of psoriasis...
  18. doi request reprint Effects of decabromodiphenyl ether (BDE-209) on mRNA transcription of thyroid hormone pathway and spermatogenesis associated genes in Chinese rare minnow (Gobiocypris rarus)
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, People s Republic of China
    Environ Toxicol 29:1-9. 2014
    ..Our results suggest that BDE-209 may pose threat to normal thyroid and reproductive function in fish...
  19. doi request reprint Physical activity levels, sport activities, and risk of acute myocardial infarction: results of the INTERHEART study in China
    Xiaoru Cheng
    1Division of Biometrics, National Center for Cardiovascular Diseases, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Angiology 65:113-21. 2014
    ..44 (95% CI: 1.06-1.94), for climbing and lifting was 1.00 (95% CI: 0.77-.30), and for walking was 0.90 (95%CI: 0.75-1.07). Leisure-time PA was protective for AMI risk compared to sedentary lifestyles in a population in China. ..
  20. doi request reprint Body mass index and hypertension among Chinese governmental and institutional employees in Beijing
    Tao Chen
    Department of Biostatistics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Angiology 63:337-42. 2012
    ..Concordant relationships were revealed in all evaluated subgroups, even among those without traditional cardiovascular risk factors...
  21. pmc Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration
    Xiangming Wang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 110:11175-80. 2013
    ..Thus, MIG-13 links the Wnt signaling and Hox genes that guide migrations, to the actin cytoskeleton, which executes the motility response in neuronal migration. ..
  22. doi request reprint Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa
    Wei Li
    Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Magn Reson Chem 47:902-8. 2009
    ..The (13)C NMR data and complete (1)H and (13)C NMR assignments of some known compounds are reported for the first time. In addition, the errors of (1)H and (13)C assignments reported in the literature were corrected...
  23. doi request reprint Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth
    Jia Xiang Chen
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 5 Beichenxi Road, Beijing 100101, PR China
    Toxicology 310:92-7. 2013
    ..Taken together, these results indicated that TOCP treatment induced autophagy in differentiated SH-SY5Y cells, which lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. ..
  24. doi request reprint A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet (Setaria italica)
    Guanqing Jia
    Institute of Crop Sciences, Chinese Academy of Agricultural Science, Beijing, China
    Nat Genet 45:957-61. 2013
    ..We also identified 36 selective sweeps that seem to have occurred during modern breeding. This study provides fundamental resources for genetics research and genetic improvement in foxtail millet. ..
  25. doi request reprint Regulation of thyroid hormone related genes mRNA expression by exogenous T₃ in larvae and adult Chinese rare minnow (Gobiocypris rarus)
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Shuangqin Rd 18, Haidian District, PO Box 2871, Beijing 100085, China
    Environ Toxicol Pharmacol 31:189-97. 2011
    ..The down-regulation of gene mRNA expression could serve as a compensatory mechanism for the activation of thyroid system...
  26. doi request reprint Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles
    Qing Xu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Biomaterials 33:1627-39. 2012
    ..Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy...
  27. doi request reprint Inhibition effect of enteropeptidase on RANKL-RANK signalling by cleavage of RANK
    Yunfeng Zhao
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    FEBS Lett 587:2958-64. 2013
    ..This is the first study to prove that the RANKL-RANK signalling pathway can be inhibited by cleavage of RANK instead of targeting RANKL...
  28. ncbi request reprint [Influence of cytokine combinations on proliferation and differentiation of umbilical cord blood CD34(+) cells into megakaryocytes/platelets in vitro]
    Ke Ying Zhang
    Beijing Red Cross Blood Service Center, Beijing, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:1053-7. 2011
    ....
  29. doi request reprint NOx removal in chemical absorption-biological reduction integrated system: process rate and rate-limiting step
    Yin Feng Xia
    Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Institute of Industrial Ecology and Environment, Department of Chemical and Biological Engineering, Zhejiang University, Yuquan Campus, Hangzhou 310027, China Institute of Environmental Engineering, Zhejiang University, Zijingang Campus, Hangzhou 310058, China
    Bioresour Technol 149:184-90. 2013
    ..Moreover, it indicated that increasing the concentration of total iron appropriately could enhance the bioreduction of Fe(III)EDTA...
  30. pmc Evaluating total lymphocyte count as a surrogate marker for CD4 cell count in the management of HIV-infected patients in resource-limited settings: a study from China
    Jieqing Chen
    School of Biomedical Engineering, Capital Medical University, Beijing, China
    PLoS ONE 8:e69704. 2013
    ..To evaluate the correlation of total lymphocyte count (TLC) and CD4 cell count and the suitability of TLC as a surrogate marker for CD4 cell count of HIV-infected patients in China...
  31. pmc Generation of transgenic rats through induced pluripotent stem cells
    Ming Gui Jiang
    From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 288:27150-8. 2013
    ..riPSCs can be used as a novel tool in genetic and genomic studies of the rat. ..
  32. doi request reprint Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment
    Ligeng Xu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China
    Nano Lett 12:2003-12. 2012
    ..These findings have shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems...
  33. doi request reprint Stereoselective dissipation of epoxiconazole in grape (Vitis vinifera cv. Kyoho) and soil under field conditions
    Hongwu Liang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Chemosphere 87:982-7. 2012
    ..The results for stereoselective dissipations can be applied for food and environmental assessments of chiral pesticides...
  34. doi request reprint The decline and residues of hexaconazole in tomato and soil
    Hongwu Liang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Environ Monit Assess 184:1573-9. 2012
    ..a.i./hm(2) for three or four times were all below 0.1 mg/kg. This work would be the guidance of establishing the maximum residue limit of hexaconazole in tomato in China...
  35. doi request reprint Genome-wide association studies of 14 agronomic traits in rice landraces
    Xuehui Huang
    National Center for Gene Research, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Genet 42:961-7. 2010
    ....
  36. pmc Screening level of PAHs in sediment core from Lake Hongfeng, Southwest China
    Jian yang Guo
    State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China
    Arch Environ Contam Toxicol 60:590-6. 2011
    ..Because only one core was analyzed in this study, more work is needed to confirm the sources and toxicity of PAHs in Lake Hongfeng...
  37. pmc Ube2g2-gp78-mediated HERP polyubiquitylation is involved in ER stress recovery
    Long Yan
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Sci 127:1417-27. 2014
    ..Together, these results establish the ubiquitin-proteasome-mediated degradation of HERP as a novel mechanism that fine-tunes the stress tolerance capacity of the cell. ..
  38. doi request reprint Longitudinal changes in total, 2-LTR circular, and integrated HIV-1 DNA during the first year of HIV-1 infection in CD4Low and CD4High patient groups with HIV-1 subtype AE
    Haihong Zhang
    1 Infection Department, Beijing You An Hospital, Capital Medical University, Beijing, China
    Viral Immunol 27:478-82. 2014
    ..Disease progression may be related to the body's ability to control HIV-1 DNA during early HIV-1 infection...
  39. ncbi request reprint Generalized pure cutaneous Rosai-Dorfman disease: a link between inflammation and cancer not associated with mitochondrial DNA and SLC29A3 gene mutation?
    Min Zheng
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
    Discov Med 16:193-200. 2013
    ....
  40. doi request reprint Impact of renal dysfunction on long-term survival after isolated coronary artery bypass surgery
    Ye Lin
    Department of Cardiovascular Surgery and Research Center for Cardiovascular Regenerative Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
    Ann Thorac Surg 87:1079-84. 2009
    ..This study compared the predictive effectiveness of the Cockcroft-Gault formula, the MDRD equation, and serum creatinine level for in-hospital and long-term mortality...
  41. doi request reprint Comparative analysis of gene expression profiles between cortex and thalamus in Chinese fatal familial insomnia patients
    Chan Tian
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Chang Bai Rd 155, Beijing, 102206, People s Republic of China
    Mol Neurobiol 48:36-48. 2013
    ..This study aims to describe the global expression profiles in various brain regions of FFI while proposing useful clues for understanding the pathogenesis of FFI and selecting potential biomarkers for diagnostic and therapeutic tools...
  42. doi request reprint Vinclozolin affects the interrenal system of the rare minnow (Gobiocypris rarus)
    Lihua Yang
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
    Aquat Toxicol 104:153-9. 2011
    ..These results provide additional data about the modes of toxicological action of vinclozolin...
  43. doi request reprint Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine
    Ligeng Xu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No 11 Beiyitiao, Zhongguancun, Beijing, 100190, China
    Adv Mater 25:5928-36. 2013
    ..The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways. ..
  44. doi request reprint Smoking status on outcomes after percutaneous coronary intervention
    Tao Chen
    Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Clin Cardiol 35:570-4. 2012
    ..The effect of smoking on prognosis among patients undergoing percutaneous coronary intervention (PCI) is controversial, and data on the importance of smoking cessation or reductions were lacking...
  45. doi request reprint Combined subchronic toxicity of dichlorvos with malathion or pirimicarb in mice liver and serum: a metabonomic study
    Pan Wang
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 5 Beichenxi Road, Beijing 100101, PR China
    Food Chem Toxicol 70:222-30. 2014
    ..This study also showed that metabonomics is of potential use in food toxicity study. ..
  46. doi request reprint The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways
    Hejiang Zhou
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Biomaterials 33:6933-42. 2012
    ..Further research is needed to systematically assess the biological responses of graphene, both to improve its safety and to contribute to the design of new biological applications...
  47. doi request reprint Genetic modification and screening in rat using haploid embryonic stem cells
    Wei Li
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China Key Laboratory of Translational Stem Cell Research, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Cell Stem Cell 14:404-14. 2014
    ..Overall, RahESCs represent a practical tool for functional genetic studies and production of transgenic lines in rat. ..
  48. pmc Emission characteristics for polycyclic aromatic hydrocarbons from solid fuels burned in domestic stoves in rural China
    Guofeng Shen
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China
    Environ Sci Technol 47:14485-94. 2013
    ..For source diagnosis, high molecular weight isomers are more informative than low molecular weight ones and multiple ratios could be used together whenever possible. ..
  49. doi request reprint Regulation of iodothyronine deiodinases and sodium iodide symporter mRNA expression by perchlorate in larvae and adult Chinese rare minnow (Gobiocypris rarus)
    Wei Li
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
    Mar Pollut Bull 63:350-5. 2011
    ..The larval fish development could be affected by perchlorate at environmentally relevant concentrations...
  50. doi request reprint No difference in clinical outcomes after total knee arthroplasty between patellar eversion and non-eversion
    Zhiwei Jia
    Department of Orthopaedics, Navy General Hospital, No 6, Fucheng Road, Beijing, 100048, China
    Knee Surg Sports Traumatol Arthrosc 24:141-7. 2016
    ..However, whether patellar eversion impairs clinical outcomes remains controversial. We conducted a systematic review of randomized controlled trials (RCTs) to provide current understanding on this topic...
  51. pmc Validation and Assessment of Three Methods to Estimate 24-h Urinary Sodium Excretion from Spot Urine Samples in Chinese Adults
    Yaguang Peng
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 11:e0149655. 2016
    ..A more accurate method is needed to estimate the 24-h urinary sodium excretion from spot urine for assessment of dietary sodium intake in China. ..
  52. pmc Emissions of PAHs from indoor crop residue burning in a typical rural stove: emission factors, size distributions, and gas-particle partitioning
    Guofeng Shen
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China
    Environ Sci Technol 45:1206-12. 2011
    ..5, and the mass percentage of PAHs in fine particles increased as the molecular weight increased. For freshly emitted PAHs, absorption into organic carbon, rather than adsorption, dominated the gas-particle partitioning...
  53. doi request reprint Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions
    Qi Gu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Protein Cell 3:71-9. 2012
    ..Thus the rapid conversion established a naïve pluripotency in human ESCs like mouse ESCs, and provided a new model to study the regulation of pluripotency...
  54. pmc Age-dependent effect of high cholesterol diets on anxiety-like behavior in elevated plus maze test in rats
    Xu Hu
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Behav Brain Funct 10:30. 2014
    ....
  55. doi request reprint Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of daphnetin
    Si Cheng Liang
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China
    Drug Metab Dispos 38:973-80. 2010
    ..In conclusion, the UGT conjugation pathways of daphnetin were fully elucidated and its C-8 phenol group was more selectively catalyzed by UGTs than by the C-7 phenol...
  56. doi request reprint Mapping intracellular diffusion distribution using single quantum dot tracking: compartmentalized diffusion defined by endoplasmic reticulum
    Hui Li
    Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
    J Am Chem Soc 137:436-44. 2015
    ..These results shed new light on the diffusive movements of macromolecules in the cell, and the mapping of intracellular diffusion distribution may be used to develop strategies for nanoparticle-based drug deliveries and therapeutics. ..
  57. pmc gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains
    Weixiao Liu
    The State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Sci Rep 4:7138. 2014
    ....
  58. doi request reprint Prognostic value of coronary CT angiography and calcium score for major adverse cardiac events in outpatients
    Zhi Hui Hou
    Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    JACC Cardiovasc Imaging 5:990-9. 2012
    ..This study sought to evaluate the prognostic value of coronary artery calcium score (CACS) and coronary computed tomography angiography (CTA) for major adverse cardiac events (MACE)...
  59. doi request reprint Nine-month angiographic and 2-year clinical follow-up of the NOYA biodegradable polymer sirolimus-eluting stent in the treatment of patients with de novo native coronary artery lesions: the NOYA I trial
    Bo Xu
    Fuwai Hospital, National Centre for Cardiovascular Diseases of China, Beijing, China
    EuroIntervention 8:796-802. 2012
    ....
  60. doi request reprint Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate
    Jiang Wei Zhang
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Drug Metab Dispos 36:2292-8. 2008
    ..In conclusion, CYP3A4 was the major P450 isoform involved in MPA hydroxylation, with 6beta, 2beta, and 1beta being the possible hydroxylation sites. Minipig and rat could be the surrogate models for man in MPA pharmacokinetic studies...
  61. doi request reprint Direct measurement of sequential folding pathway and energy landscape of human telomeric G-quadruplex structures
    Wei Li
    Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
    J Am Chem Soc 135:6423-6. 2013
    ..The energy landscape derived from the probability distribution shows clearly that the G-quadruplex goes through an intermediate when it is unfolded, and vice versa...
  62. pmc Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
    Chao Sheng
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Res 22:208-18. 2012
    ..In addition, iNSCs can survive and generate synapses following transplantation into the dentate gyrus. Generation of iNSCs may have important implications for disease modeling and regenerative medicine...
  63. doi request reprint Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy
    Yan Wu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Nanomedicine 7:945-54. 2011
    ..These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery of antitumor drugs...
  64. pmc Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib
    Pei pei Dong
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China
    Acta Pharmacol Sin 32:399-407. 2011
    ....
  65. doi request reprint Association study of the miRNA-binding site polymorphisms of CDKN2A/B genes with gestational diabetes mellitus susceptibility
    Xiaojing Wang
    Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuai Fu Yuan No 1, Dongcheng District, Beijing, 100730, China
    Acta Diabetol 52:951-8. 2015
    ..The aim of the study was to first investigate the associations between miR-binding SNPs of CDKN2A/B, GDM susceptibility, and quantitative metabolism traits...
  66. pmc Autophagy is required for ectoplasmic specialization assembly in sertoli cells
    Chao Liu
    a State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Autophagy . 2016
    ..Altogether, our works reveal that the degradation of PDLIM1 by autophagy in Sertoli cells is important for the proper assembly of the ES, and these findings define a novel role for autophagy in Sertoli cell-germ cell communication...
  67. doi request reprint Antibiotic-induced imbalances in gut microbiota aggravates cholesterol accumulation and liver injuries in rats fed a high-cholesterol diet
    Xu Hu
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China
    Appl Microbiol Biotechnol 99:9111-22. 2015
    ..Modulation of gut microbiota could be a novel target for preventing cholesterol-related metabolic disorders. ..
  68. doi request reprint MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status
    Wei Li
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
    Planta Med 77:27-31. 2011
    ....
  69. doi request reprint Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat
    Jia Luo
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China
    Sci China Life Sci 57:327-35. 2014
    ..These results indicate that probiotic L. helveticus strain NS8 is beneficial for the treatment of cognitive decline and anxiety-like behavior in HA rats. ..
  70. doi request reprint Short communication: Longitudinal changes in peripheral blood NK cells during the first year of HIV-1 Infection in CD4Low and CD4High patient groups
    Yanmei Jiao
    1 Center for Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing, China
    AIDS Res Hum Retroviruses 31:229-36. 2015
    ..We concluded, therefore, that robust NK functioning cells that are present during an acute HIV-1 infection might be beneficial in controlling HIV-1 disease progression...
  71. ncbi request reprint Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China
    Yong zhen Zhang
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Zhonghua Liu Xing Bing Xue Za Zhi 32:209-20. 2011
    ..From April to July in 2009 and 2010, unexplained severe hemorrhagic fever-like illnesses occurred in farmers from the Huaiyangshan mountains range...
  72. doi request reprint Bispecific anti-CD3 x anti-HER2 antibody mediates T cell cytolytic activity to HER2-positive colorectal cancer in vitro and in vivo
    Huamin Han
    CAS Key Laboratory of Pathogenic Microbiology and Immunology CASPMI, Centre for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P R China
    Int J Oncol 45:2446-54. 2014
    ..The HER2Bi-armed ATCs with anti-tumor effects may provide a promising immunotherapy for colorectal carcinoma in the future...
  73. doi request reprint Generation of Mammalian offspring by haploid embryonic stem cells microinjection
    Ling Shuai
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Curr Protoc Stem Cell Biol 31:1A.6.1-15. 2014
    ..This unit will be interesting to researchers who focus on recessive screens and transgenic animal model production with haploid stem cells...
  74. doi request reprint Cycloartane triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathway
    Zhong Ze Fang
    Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
    Phytother Res 25:17-24. 2011
    ..These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway...
  75. pmc Field measurement of emission factors of PM, EC, OC, parent, nitro-, and oxy- polycyclic aromatic hydrocarbons for residential briquette, coal cake, and wood in rural Shanxi, China
    Guofeng Shen
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China
    Environ Sci Technol 47:2998-3005. 2013
    ..Most EFs measured in the field were higher than those measured in stove combustions under laboratory conditions...
  76. doi request reprint A metabonomic investigation of the effects of 60 days exposure of rats to two types of pyrethroid insecticides
    Yu Jie Liang
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
    Chem Biol Interact 206:302-8. 2013
    ..This approach may lead to the discovery of novel biomarkers of pyrethroids toxicity and thereby provide new insights into the toxicological mechanisms of pesticides pyrethroids...
  77. doi request reprint A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling
    Xiaobo Wan
    Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    J Med Chem 56:2619-29. 2013
    ....
  78. pmc Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons
    Zhe Zhang
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China Graduate School of Chinese Academy of Sciences, Beijing, China
    PLoS Genet 10:e1004124. 2014
    ..Our results suggest that the SLC35D3 gene, close to the D6S1009 locus, is a candidate gene for MetS, which is involved in metabolic control in the central nervous system by regulating dopamine signaling. ..
  79. pmc Oxaliplatin and its enantiomer induce different condensation dynamics of single DNA molecules
    Hong Yan Zhang
    Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e71556. 2013
    ..The study has strong implications for the understanding of the effect of chirality on the interaction between Pt-DACH and DNA and the kinetics of DNA condensation induced by platinum complexes. ..
  80. doi request reprint Temporal techniques: dynamic tracking of nanomaterials in live cells
    Wei Li
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Small 9:1585-94. 2013
    ..in live cells. The biological properties of nanoparticles in live cells are also briefly summarized according to fluorescence microscopy studies...
  81. pmc H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin
    Ping Chen
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Genes Dev 27:2109-24. 2013
    ..Our results provide key insights into the mechanism of how histone variants H3.3 and H2A.Z function together to regulate gene transcription via the modulation of chromatin dynamics over the enhancer and promoter regions. ..
  82. doi request reprint Stereoselective transformation of triadimefon to metabolite triadimenol in wheat and soil under field conditions
    Hongwu Liang
    Institute of Quality Standards and Testing Technology for Agro Products, Chinese Academy of Agricultural Sciences, Key Laboratory of Agrifood Quality and Safety, Ministry of Agriculture, Beijing 100081, China
    J Hazard Mater 260:929-36. 2013
    ....
  83. doi request reprint Live imaging of cellular dynamics during Caenorhabditis elegans postembryonic development
    Yongping Chai
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Nat Protoc 7:2090-102. 2012
    ..Other applications are also possible. The protocol can be completed within 3 h and may provide insights into understanding postembryonic development...
  84. ncbi request reprint Mice overexpression of human augmenter of liver regeneration (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing, China
    Endocr J 59:989-99. 2012
    ..Present findings in the mouse may be of interest to human male fertility...
  85. doi request reprint Generation of tripotent neural progenitor cells from rat embryonic stem cells
    Zhenkun Wang
    College of Life Science, Northeast Agricultural University of China, Harbin 150030, China
    J Genet Genomics 39:643-51. 2012
    ....
  86. doi request reprint Variation in the internalization of differently sized nanoparticles induces different DNA-damaging effects on a macrophage cell line
    Mingyi Zhang
    Lab for Bio Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Science, Beijing 10049, China
    Arch Toxicol 85:1575-88. 2011
    ..Based on these results, we assume that the damage resulted from a disruption of the balance between DNA damage and repair...
  87. doi request reprint MiR-200a is involved in rat epididymal development by targeting β-catenin mRNA
    Xiaojiang Wu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Acta Biochim Biophys Sin (Shanghai) 44:233-40. 2012
    ..All these results show that miR-200a should be involved in rat epididymal development by targeting β-catenin mRNA of rat and suppressing its expression...
  88. pmc Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population
    Ying Wang
    Key laboratory of Endocrine, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    PLoS ONE 6:e26953. 2011
    ..To investigate whether the candidate genes that confer susceptibility to type 2 diabetes mellitus are also correlated with gestational diabetes mellitus (GDM) in pregnant Chinese women...
  89. pmc Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells
    Lei Liu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China
    J Biol Chem 285:19483-90. 2010
    ..These findings also provide a step forward toward understanding the operating mechanisms during reprogramming to produce iPS cells and can potentially promote the application of iPS cells in regenerative medicine and cancer therapy...
  90. doi request reprint Dissipation and residue of dimethomorph in pepper and soil under field conditions
    Hongwu Liang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
    Ecotoxicol Environ Saf 74:1331-5. 2011
    ..These results will be helpful in setting MRL guidance for dimethomorph in pepper in China...
  91. pmc Mouse cloning and somatic cell reprogramming using electrofused blastomeres
    Amjad Riaz
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1st Beichen West Road, Beijing 100101, China
    Cell Res 21:770-8. 2011
    ..Our approach provides an attractive and practical alternative to therapeutic cloning using donated oocytes for the generation of patient-specific human ES cell lines...
  92. ncbi request reprint Modulation of oxidative stress by functionalized fullerene materials in the lung tissues of female C57/BL mice with a metastatic Lewis lung carcinoma
    Fang Jiao
    CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety NCNST IHEP, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    J Nanosci Nanotechnol 10:8632-7. 2010
    ....
  93. ncbi request reprint Impact of DNA twist accumulation on progressive helical wrapping of torsionally constrained DNA
    Wei Li
    Beijing National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
    Phys Rev Lett 109:218102. 2012
    ..The theoretical predictions and the experimental results are consistent with each other and their implications are discussed...
  94. doi request reprint The residues and environmental risks of multiple veterinary antibiotics in animal faeces
    Yan Xia Li
    State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, 100875, Beijing, China
    Environ Monit Assess 185:2211-20. 2013
    ..These medicine residues in animal faeces may potentially bring ecological risks if the animal manure is not treated effectively...
  95. doi request reprint New insights into the functions and localization of nuclear CCT protein complex in K562 leukemia cells
    Rui Huang
    Beijing Institute of Radiation Medicine, Beijing, China
    Proteomics Clin Appl 6:467-75. 2012
    ..The purpose of this study is to explore the function of CCT in nuclear and present a strategy in clinical proteomics studies...
  96. doi request reprint Androgenetic haploid embryonic stem cells produce live transgenic mice
    Wei Li
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Nature 490:407-11. 2012
    ..Our findings show the developmental pluripotency of androgenentic haploids and provide a new tool to quickly produce genetic models for recessive traits. They may also shed new light on assisted reproduction...
  97. doi request reprint Production of brown/yellow patches in the SLC7A11 transgenic sheep via testicular injection of transgene
    Xin He
    State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 39:281-5. 2012
    ..Our studies suggest that testicular injection of transgene can be used to genetically modify sheep coat color...
  98. doi request reprint Bifunctional peptides that precisely biomineralize Au clusters and specifically stain cell nuclei
    Yaling Wang
    Institute of High Energy Physics, Chinese Academy of Sciences, Yuquan Road 19B, Shi Jing Shan District, Beijing 10049, China
    Chem Commun (Camb) 48:871-3. 2012
    ..The peptide-Au clusters exhibit red emission (λ(em) = 677 nm) and specifically stain the nuclei of three cell lines...
  99. pmc Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64
    Jing Cheng
    Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
    Am J Hum Genet 89:56-66. 2011
    ..Our work identifies DFNA64 as the human genetic disorder associated with SMAC/DIABLO malfunction and suggests that mutant SMAC/DIABLO(S71L) might cause mitochondrial dysfunction...
  100. doi request reprint Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-Kit
    Xiao Li Guo
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Pigment Cell Melanoma Res 23:252-62. 2010
    ..This expands our understanding of the intricate regulatory network governing the melanocyte development...
  101. doi request reprint Analysis of two sequence variants in peroxisome proliferator activated receptor gamma gene in Tajik population at high altitudes and Han population at low altitudes in China
    Xiao Ling Liu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Mol Biol Rep 37:179-84. 2010
    ..0001) was significantly lower in the Tajik population than that in the Han population. Our results suggest that PPARG is a candidate gene for high-altitude adaptation in the Chinese Tajik population...