Wei Li


Affiliation: Institute of Zoology
Country: China


  1. Yang L, Liu C, Zhao W, He C, Ding J, Dai R, et al. Impaired Autophagy in Intestinal Epithelial Cells Alters Gut Microbiota and Host Immune Responses. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..Our study suggests that Atg5 deficiency results in an imbalance of the host-microbe interaction and deterioration of the gut microenvironment. ..
  2. Wang L, Xu Z, Khawar M, Liu C, Li W. The histone codes for meiosis. Reproduction. 2017;154:R65-R79 pubmed publisher
    ..We not only systematically review the functional roles of histone codes in meiosis but also discuss future trends and perspectives in this field. ..
  3. Gu H, Shi X, Liu C, Wang C, Sui N, Zhao Y, et al. USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. Nat Commun. 2019;10:1465 pubmed publisher
    ..This work uncovers a novel crosstalk pathway between ubiquitination and autophagy through USP8-EPG5 interaction to regulate the stemness of ESCs. ..
  4. Zhu F, Liu C, Wang F, Yang X, Zhang J, Wu H, et al. Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome. Am J Hum Genet. 2018;103:188-199 pubmed publisher
    ..Thus, mutations in PMFBP1 are an important cause of infertility in men with acephalic spermatozoa syndrome. ..
  5. Liu Y, Liu C, Dong W, Li W. Physiological functions and clinical implications of the N-end rule pathway. Front Med. 2016;10:258-70 pubmed publisher
    ..This review summarized the physiological functions of the N-end rule pathway, introduced the related biological processes and diseases, with an emphasis on the inner link between this pathway and certain symptoms. ..
  6. Gao H, Liu C, Li W. Assessing Autophagy in the Leydig Cells. Methods Mol Biol. 2019;1854:71-85 pubmed publisher
    ..In this chapter, we describe the morphological, cellular, and biochemical methods to monitor autophagy in Leydig cells. ..
  7. Wang L, Tu Z, Liu C, Liu H, Kaldis P, Chen Z, et al. Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis. Cell Death Differ. 2018;25:1174-1188 pubmed publisher
    ..Together, our results reveal a novel mechanism of TRF1, Speedy A, and Cdk2 in protecting telomere from fusion in a highly crowded microenvironment during meiosis. ..
  8. Xu Z, Song Z, Li G, Tu H, Liu W, Liu Y, et al. H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation. Nucleic Acids Res. 2016;44:9681-9697 pubmed
  9. Liu C, Ma Y, Shang Y, Huo R, Li W. Post-translational regulation of the maternal-to-zygotic transition. Cell Mol Life Sci. 2018;75:1707-1722 pubmed publisher
    ..In this review, we summarize recent progress regarding the molecular mechanisms underlying post-translational regulation of maternal component degradation and ZGA during the MZT and discuss some important issues in the field. ..

More Information


  1. Gao F, Li G, Liu C, Gao H, Wang H, Liu W, et al. Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells. J Cell Biol. 2018;217:2103-2119 pubmed publisher
    ..Collectively, these results reveal that autophagy promotes cholesterol uptake into Leydig cells by eliminating NHERF2, suggesting that dysfunction of autophagy might be causal in the loss of testosterone production in some patients. ..
  2. Liu C, Khan J, Li W. Assessing Autophagy in Sertoli Cells. Methods Mol Biol. 2018;1748:113-128 pubmed publisher
  3. Zhao H, Wang Q, Liu C, Shang Y, Wen F, Wang F, et al. A Role for the Respiratory Chain in Regulating Meiosis Initiation in Saccharomyces cerevisiae. Genetics. 2018;208:1181-1194 pubmed publisher
    ..In summary, our studies unveiled the close relationship between mitochondria and sporulation, and uncover a novel meiosis initiation pathway that is regulated by the respiratory chain. ..
  4. Liu Y, Liu C, Chang Z, Wadas B, Brower C, Song Z, et al. Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway. J Biol Chem. 2016;291:7426-38 pubmed publisher
    ..These effects ofAte1ablation are inferred to be caused, at least in part, by the failure to destroy the C-terminal fragment of Rec8 in the absence of N-terminal arginylation. ..
  5. Shang Y, Yan J, Tang W, Liu C, Xiao S, Guo Y, et al. Mechanistic insights into acephalic spermatozoa syndrome-associated mutations in the human SUN5 gene. J Biol Chem. 2018;293:2395-2407 pubmed publisher
  6. Yin H, Zheng L, Liu W, Zhang D, Li W, Yuan L. Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion. Biochim Biophys Acta Mol Cell Res. 2017;1864:645-654 pubmed publisher
    ..We propose that the archetypal linker protein Rootletin maintains centrosome cohesion in part through inhibition of VHL-mediated Cep68 degradation. ..
  7. Liu C, Song Z, Wang L, Yu H, Liu W, Shang Y, et al. Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice. Development. 2017;144:441-451 pubmed publisher
    ..Taken together, these findings reveal that Sirt1 has a novel physiological function in acrosome biogenesis. ..
  8. Li S, Liu C, Gu L, Wang L, Shang Y, Liu Q, et al. Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36. Open Biol. 2016;6: pubmed publisher
    ..Altogether, this work reveals autophagy may protect cardiomyocytes from the MI/R injury through the clearance of CLP36, and these findings define a novel relationship between autophagy and the regulation of stress fibre in heart. ..
  9. Gao F, Shang Y, Liu W, Li W. The linkage specificity determination of Ube2g2-gp78 mediated polyubiquitination. Biochem Biophys Res Commun. 2016;473:1139-1143 pubmed publisher
    ..Together, our studies uncover a novel mechanism underlying the linkage specificity determination of longer polyubiquitin chains. ..