Lei Li

Summary

Affiliation: Institute of Zoology
Country: China

Publications

  1. pmc A subcortical maternal complex essential for preimplantation mouse embryogenesis
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 15:416-25. 2008
  2. pmc The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA
    Juke Wang
    State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China
    PLoS ONE 7:e30209. 2012
  3. pmc The maternal to zygotic transition in mammals
    Lei Li
    Division of Molecular Embryonic Development, State Key Laboratory of Reproductive Biology, Institute of Zoology Chinese Academy of Sciences, Beijing 100101, PR China
    Mol Aspects Med 34:919-38. 2013
  4. pmc Maternal control of early mouse development
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:859-70. 2010
  5. pmc A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network
    Zhijiang Yan
    Laboratory of Genetics, National Institute of Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 47:61-75. 2012
  6. pmc Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells
    Shao Yang Ji
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e53140. 2013
  7. pmc Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives
    Lei Li
    State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, China, Center for Diagnostics and Therapeutics and Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States, and Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States
    Org Lett 15:5528-30. 2013
  8. doi request reprint Notch signaling is involved in ovarian follicle development by regulating granulosa cell proliferation
    Chun Ping Zhang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Endocrinology 152:2437-47. 2011
  9. doi request reprint Wnt/β-catenin signaling regulates follicular development by modulating the expression of Foxo3a signaling components
    Lei Li
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
    Mol Cell Endocrinol 382:915-25. 2014
  10. ncbi request reprint Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos
    Mami Ohsugi
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:259-69. 2008

Collaborators

Detail Information

Publications25

  1. pmc A subcortical maternal complex essential for preimplantation mouse embryogenesis
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 15:416-25. 2008
    ..However, these embryos do not progress beyond cleavage stage development and female mice are sterile. The proteins are conserved in humans, and similar maternal effect mutations may result in recurrent embryonic loss...
  2. pmc The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA
    Juke Wang
    State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China
    PLoS ONE 7:e30209. 2012
    ..By co-incubation with the lysates of mice ovaries, FILIA and FILIA-N could sequester specific RNA components, supporting the critical roles of FILIA in regulation of RNA transcripts during mouse oogenesis and early embryogenesis...
  3. pmc The maternal to zygotic transition in mammals
    Lei Li
    Division of Molecular Embryonic Development, State Key Laboratory of Reproductive Biology, Institute of Zoology Chinese Academy of Sciences, Beijing 100101, PR China
    Mol Aspects Med 34:919-38. 2013
    ....
  4. pmc Maternal control of early mouse development
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:859-70. 2010
    ..Nevertheless, significant gaps remain in our mechanistic understanding of the networks that regulate early mammalian embryogenesis, which provide an impetus and opportunities for future investigations...
  5. pmc A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network
    Zhijiang Yan
    Laboratory of Genetics, National Institute of Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 47:61-75. 2012
    ..Thus, the RNF8-FAAP20 ubiquitin cascade is critical for recruiting FA core complex to ICLs and for normal function of the FA network...
  6. pmc Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells
    Shao Yang Ji
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e53140. 2013
    ....
  7. pmc Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives
    Lei Li
    State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, China, Center for Diagnostics and Therapeutics and Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States, and Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States
    Org Lett 15:5528-30. 2013
    ..This study represents the first facile and efficient enzymatic synthesis of GDP-sugars and derivatives starting from monosaccharides and derivatives. ..
  8. doi request reprint Notch signaling is involved in ovarian follicle development by regulating granulosa cell proliferation
    Chun Ping Zhang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Endocrinology 152:2437-47. 2011
    ..In conclusion, Notch signaling is involved in follicular development by regulating granulosa cell proliferation...
  9. doi request reprint Wnt/β-catenin signaling regulates follicular development by modulating the expression of Foxo3a signaling components
    Lei Li
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
    Mol Cell Endocrinol 382:915-25. 2014
    ..These findings provide evidence that Wnt signaling might negatively regulate follicular development potentially through Foxo3a signaling components. ..
  10. ncbi request reprint Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos
    Mami Ohsugi
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:259-69. 2008
    ..If so, the plasticity of the FILIA-MATER complex localization may reflect the regulative nature of preimplantation mouse development...
  11. doi request reprint Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction
    Wenjun Wang
    College of Pharmacy, Nankai University, Tianjin 300071, PR China
    Chem Commun (Camb) 47:11240-2. 2011
    ..This communication describes a method for enzymatic preparation of bioactive glycans, which integrated the high-efficiency of homogenous phase enzymatic reaction and fast separation of solid phase extraction...
  12. pmc The wciN gene encodes an α-1,3-galactosyltransferase involved in the biosynthesis of the capsule repeating unit of Streptococcus pneumoniae serotype 6B
    Weiqing Han
    State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
    Biochemistry 51:5804-10. 2012
    ..This work provides a chemical biology approach to characterize the activities of pneumococcal CPS GTs in vitro and will help to better understand the pneumococcal CPS biosynthetic pathway...
  13. pmc Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication
    Dongyi Xu
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    EMBO J 29:3140-55. 2010
    ..Our data suggest that Rif1 provides a new DNA-binding interface for the BLM complex to restart stalled replication forks...
  14. doi request reprint Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectoderm
    Lei Li
    College of Life Sciences, Capital Normal University, Beijing, China
    FEBS Lett 586:4100-7. 2012
    ..This regulation is independent of Cyclins and of the kinase activity of Cdk1. Our study explains how Cdk1 and Oct4 interplay to inhibit ES cell differentiation into trophectoderm and thereby maintain stemness...
  15. doi request reprint A highly efficient galactokinase from Bifidobacterium infantis with broad substrate specificity
    Lei Li
    College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Nankai District, Tianjin 300071, PR China
    Carbohydr Res 355:35-9. 2012
    ..These features make BiGalK an attractive candidate for the large scale preparation of galactose-1-phosphate and derivatives...
  16. pmc Structural insights into Paf1 complex assembly and histone binding
    Xinlei Chu
    State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin 300071, China, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and Synergetic Innovation Center of Chemical Science and Engineering, 94 Weijin Road, Tianjin 300071, China
    Nucleic Acids Res 41:10619-29. 2013
    ..Our results shed light on the PAF1C assembly process and substrate recognition during various PAF1C-coordinated histone modifications. ..
  17. ncbi request reprint Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support
    Wenjun Wang
    College of Pharmacy, Nankai University, Tianjin 300071, PR China
    Bioorg Med Chem Lett 21:5041-4. 2011
    ..0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach...
  18. pmc Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT)
    Xiaofeng Ma
    College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China
    PLoS ONE 8:e63452. 2013
    ..These findings illustrate the interaction of OGT and sugar nucleotide donor, providing insights into the OGT catalytic mechanism...
  19. doi request reprint KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8
    Yuan Yuan Su
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, and Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, and National Center of Nanoscience and Technology, Beijing, China
    J Neurosci 33:17884-96. 2013
    ..8. Therefore, our results reveal that KIF5B is required for the forward transport and axonal function of Nav1.8, suggesting a mechanism for axonal accumulation of Nav1.8 in inflammatory pain. ..
  20. doi request reprint Design and synthesis of O-GlcNAcase inhibitors via 'click chemistry' and biological evaluations
    Tiehai Li
    College of Pharmacy, Nankai University, Tianjin 300071, PR China
    Carbohydr Res 346:1083-92. 2011
    ..6 μM). Molecular docking simulations of compound 7 into CpOGA (Clostridium perfringens OGA) suggested that strong π-π stacking interaction between the compound and W490 considerably contributed to improving the inhibitory activity...
  21. doi request reprint Deoxycholic acid modified-carboxymethyl curdlan conjugate as a novel carrier of epirubicin: in vitro and in vivo studies
    Fuping Gao
    Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, PR China
    Int J Pharm 392:254-60. 2010
    ..Moreover, tumor volume reductions induced by DCMC conjugate, free EPB and EDNs were 24.3%, 58.9% and 70%, respectively, which suggested that EDNs could effectively retard the growth of the tumor...
  22. doi request reprint Development of a versatile, target-oriented tiling microarray assay for measuring allele-specific gene expression
    Hang He
    Bioinformatics Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Genomics 96:308-15. 2010
    ..Together, our work demonstrates the utility and advantages of the tiling array method in interrogating large numbers of SNPs for quantifying allele-specific gene expression...
  23. doi request reprint Inhibin A inhibits follicle-stimulating hormone (FSH) action by suppressing its receptor expression in cultured rat granulosa cells
    Cuiling Lu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China
    Mol Cell Endocrinol 298:48-56. 2009
    ..Transcriptional factor receptors, such as SF-1, AR and DAX-1 were involved in this regulation...
  24. pmc A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability
    Zhijiang Yan
    Laboratory of Genetics, National Institute of Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 37:865-78. 2010
    ..Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human...
  25. doi request reprint Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis
    Jun ling Yang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Endocrinology 151:774-82. 2010
    ..In summary, we infer that intraovarian excess androgen in PCOS might result in excess early follicles by inducing oocyte Foxo3a translocation and follicular arrest by down-regulating growth and differentiation factor-9 expression...