Genomes and Genes


Wanzhu Jin


Affiliation: Institute of Zoology
Country: China


  1. Yuan X, Hu T, Zhao H, Huang Y, Ye R, Lin J, et al. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. Proc Natl Acad Sci U S A. 2016;113:2708-13 pubmed publisher
    ..These results highlight that endogenous BAT activity is closely related to the development of PCOS phenotypes and that BAT activation might be a promising therapeutic option for the treatment of PCOS. ..
  2. Yin N, Zhang H, Ye R, Dong M, Lin J, Zhou H, et al. Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. Int J Mol Sci. 2019;20: pubmed publisher
    ..Taken together, our results clearly demonstrate that as an effective BAT activator, FS may have great potential for treatment of obesity and related metabolic disorders. ..
  3. Yuan X, Wei G, You Y, Huang Y, Lee H, Dong M, et al. Rutin ameliorates obesity through brown fat activation. FASEB J. 2017;31:333-345 pubmed publisher
    ..Lin, J., Hu, T., Zhang, H., Zhang, C., Zhou, H., Ye, R., Qi, X., Zhai, B., Huang, W., Liu, S., Xie, W., Liu, Q., Liu, X., Cui, C., Li, D., Zhan, J., Cheng, J., Yuan, Z., Jin, W. Rutin ameliorates obesity through brown fat activation. ..
  4. Wu R, Sun J, Wang J, Li B, Liu Q, Ning G, et al. c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice. Diabetologia. 2017;60:900-910 pubmed publisher
    ..This suggests it may become a novel therapeutic target in the treatment of metabolic disorders. ..
  5. Hu T, Yuan X, Wei G, Luo H, Lee H, Jin W. Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice. Eur J Nutr. 2018;57:391-403 pubmed publisher
    ..These results highlight that myricetin prevents obesity and systemic insulin resistance by activating BAT and increasing adiponectin expression in BAT. ..
  6. Hu T, Yuan X, Ye R, Zhou H, Lin J, Zhang C, et al. Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. J Nutr Biochem. 2017;47:21-28 pubmed publisher