Research Topics
Species | Taijiao JiangSummaryAffiliation: Institute of Biophysics Country: China Publications
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Detail Information
Publications
AVID: an integrative framework for discovering functional relationships among proteinsTaijiao Jiang
Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
BMC Bioinformatics 6:136. 2005..An outstanding and important goal is to predict detailed functional annotation for all uncharacterized proteins that is reliable enough to effectively guide experiments...- NCACO-score: an effective main-chain dependent scoring function for structure modelingLiqing Tian
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
BMC Bioinformatics 12:208. 2011..Despite these efforts, development of an effective scoring function that can achieve both good accuracy and fast speed still presents a grand challenge... 
Improved side-chain modeling by coupling clash-detection guided iterative search with rotamer relaxationYang Cao
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Bioinformatics 27:785-90. 2011..However, in the tightly packed environments of protein interiors, these methods will inherently lead to atomic clashes and hinder the prediction accuracy...- Incorporation of local structural preference potential improves fold recognitionYun Hu
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
PLoS ONE 6:e17215. 2011.... - RASP: rapid modeling of protein side chain conformationsZhichao Miao
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Bioinformatics 27:3117-22. 2011..In comprehensive benchmark testings, RASP is over one order of magnitude faster (~ 40 times over CIS-RR) than the recently developed methods, while achieving comparable or even better accuracy... - A computationally guided protein-interaction screen uncovers coiled-coil interactions involved in vesicular traffickingHong Zhang
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
J Mol Biol 392:228-41. 2009..Our method provides an efficient route to discovering new coiled-coil interactions and uncovers a number of associations that may have functional significance for vesicular trafficking... - Coiled-coil networking shapes cell molecular machineryYongqiang Wang
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Mol Biol Cell 23:3911-22. 2012.... - Rapid estimation of binding activity of influenza virus hemagglutinin to human and avian receptorsYang Cao
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
PLoS ONE 6:e18664. 2011..The new computational method could provide an urgently needed tool for rapid and large-scale analysis of HA receptor specificities for global influenza surveillance... - Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendationXiangjun Du
Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Nat Commun 3:709. 2012..Furthermore, we demonstrate that the coupling of large-scale HA sequencing with PREDAC can significantly improve vaccine strain recommendation for China... - Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activityAlyssa M Larson
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Pharm Sci 101:3896-905. 2012..These observations, further explored by means of molecular modeling, reveal the previously unrecognized unpredictability of the benefits of multivalency, possibly because of poor accessibility of the viral targets to polymeric agents... - Synthetic circuits, devices and modulesHong Zhang
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Protein Cell 1:974-8. 2010..Such engineered basic building blocks largely expand the synthetic toolbox and contribute to our understanding of the underlying design principles of living cells... - Length-dependent regulation of the Kv1.2 channel activation by its C-terminusLi Li Zhao
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China
Mol Membr Biol 26:186-93. 2009..2 channel. These results imply that the dynamic interaction of the C-terminus with the S4-S5 linker from a neighboring subunit of the Kv1.2 channel provides a mechanism for its C-terminus to regulate the channel activation... - Networks of genomic co-occurrence capture characteristics of human influenza A (H3N2) evolutionXiangjun Du
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Genome Res 18:178-87. 2008..Therefore, our study demonstrates that nucleotide co-occurrence networks represent a powerful method for tracking influenza A virus evolution and that cooperative genomic interaction is a major force underlying influenza virus evolution...