Xun Huang

Summary

Affiliation: Institute of Genetics and Developmental Biology
Country: China

Publications

  1. pmc Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation
    Yuan Tian
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 7:e1001364. 2011
  2. pmc Rab32 is important for autophagy and lipid storage in Drosophila
    Chao Wang
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e32086. 2012
  3. ncbi request reprint New players in the regulation of ecdysone biosynthesis
    Xun Huang
    Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    J Genet Genomics 35:1-10. 2008
  4. doi request reprint The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis
    Chao Wang
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Biol 351:146-55. 2011
  5. pmc Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila
    Zhiguo Ma
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Genetics 190:1299-308. 2012
  6. doi request reprint OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila
    Zhiguo Ma
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Development 137:3775-84. 2010
  7. pmc Midlife gene expressions identify modulators of aging through dietary interventions
    Bing Zhou
    Chinese Academy of Sciences Key Laboratory for Computational Biology, Chinese Academy of Sciences Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 109:E1201-9. 2012
  8. ncbi request reprint Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization
    Junfeng Bi
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Sci 125:3568-77. 2012
  9. doi request reprint Lipid metabolism and Drosophila sperm development
    Chao Wang
    State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Sci China Life Sci 55:35-40. 2012
  10. ncbi request reprint br regulates the expression of the ecdysone biosynthesis gene npc1
    Yanhui Xiang
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Biol 344:800-8. 2010

Collaborators

Detail Information

Publications20

  1. pmc Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation
    Yuan Tian
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 7:e1001364. 2011
    ..In summary, we have demonstrated a tissue-autonomous role of dSeipin in ectopic lipid storage in lipodystrophy...
  2. pmc Rab32 is important for autophagy and lipid storage in Drosophila
    Chao Wang
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e32086. 2012
    ..Loss-of-function mutants of several components in the autophagy pathway result in similar effects on lipid storage. These results highlight the potential functions of Rabs in regulating lipid metabolism...
  3. ncbi request reprint New players in the regulation of ecdysone biosynthesis
    Xun Huang
    Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    J Genet Genomics 35:1-10. 2008
    ..Here we summarized recent findings in the regulation of ecdysone biosynthesis from the aspects of cell signaling, key biosynthetic enzymes and substrate cholesterol trafficking...
  4. doi request reprint The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis
    Chao Wang
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Biol 351:146-55. 2011
    ..Together, our study reveals a sterol-dependent, ecdysone-independent mechanism of NPC1 function in Drosophila spermatogenesis...
  5. pmc Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila
    Zhiguo Ma
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Genetics 190:1299-308. 2012
    ....
  6. doi request reprint OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila
    Zhiguo Ma
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Development 137:3775-84. 2010
    ..Thus, we have identified an OSBP- and FAN-mediated sterol requirement in Drosophila spermatogenesis...
  7. pmc Midlife gene expressions identify modulators of aging through dietary interventions
    Bing Zhou
    Chinese Academy of Sciences Key Laboratory for Computational Biology, Chinese Academy of Sciences Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 109:E1201-9. 2012
    ....
  8. ncbi request reprint Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization
    Junfeng Bi
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Sci 125:3568-77. 2012
    ..Our study highlights the complex roles of Drosophila perilipin proteins and the evolutionarily conserved regulation of HSL translocation by perilipins...
  9. doi request reprint Lipid metabolism and Drosophila sperm development
    Chao Wang
    State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Sci China Life Sci 55:35-40. 2012
    ..In this mini-review, we summarized recent findings supporting a tight link between lipids metabolism and Drosophila sperm development...
  10. ncbi request reprint br regulates the expression of the ecdysone biosynthesis gene npc1
    Yanhui Xiang
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Biol 344:800-8. 2010
    ..These results imply that ecdysone could potentially act through its early response gene br to achieve positive feedback regulation of ecdysone biosynthesis during development...
  11. doi request reprint Case studies of ends-out gene targeting in Drosophila
    Haiyang Chen
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Genesis 47:305-8. 2009
    ..This technique provided successful and efficient gene replacement, greatly facilitating the gene knockout procedure...
  12. doi request reprint Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism
    Haiyang Chen
    Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Hum Mol Genet 19:494-505. 2010
    ..Together our study reveals an indispensable function of pex genes during spermatogenesis and provides a causative link between the phenotypic severity of pex mutants and VLCFA levels...
  13. pmc Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans
    Jingyan Zhang
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 9:e1003618. 2013
    ..Our study reveals a Wnt-dependent fine-tuning mechanism that is crucial for mutual target cell identification during the formation of gap junction connections. ..
  14. ncbi request reprint A lipid droplet-associated GFP reporter-based screen identifies new fat storage regulators in C. elegans
    Zhenglong Liu
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China University of the Chinese Academy of Sciences, Beijing 100049, China
    J Genet Genomics 41:305-13. 2014
    ..elegans. Our results indicate that PLIN1::GFP labels lipid droplets and can be used as a fat storage indicator in live worms. Through an RNAi screen, we further identified several previously uncharacterized new fat storage regulators. ..
  15. pmc Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets
    Peng Zhang
    Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    Mol Cell Proteomics 11:317-28. 2012
    ..elegans LDs, indicating that it can be used as a LD marker protein in C. elegans. These results will facilitate further mechanistic studies of LDs in this powerful genetic system, C. elegans...
  16. ncbi request reprint Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA
    Junfeng Bi
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100049, China
    Cell Metab 19:861-71. 2014
    ..Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis. ..
  17. doi request reprint Lipid metabolism in Drosophila: development and disease
    Zhonghua Liu
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Acta Biochim Biophys Sin (Shanghai) 45:44-50. 2013
    ..Some recent progresses of lipid metabolic regulation during Drosophila development and in Drosophila models of human diseases will be discussed in this review...
  18. doi request reprint TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance
    Song Song
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 38:1-11. 2011
    ..Over-expression of the Netrin/UNC-6 receptor Frazzled suppresses the guidance defects in trim-9 mutants. Our study reveals an evolutionarily conserved function of TRIM-9 in the UNC-40/Frazzled-mediated UNC-6/Netrin attraction pathway...
  19. pmc CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway
    Yuan Liu
    State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    PLoS Genet 10:e1004172. 2014
    ..We also revealed that a DAG-to-PE route mediated by the choline/ethanolamine phosphotransferase Bbc may contribute to the growth of fat cells in CdsA RNAi. ..