Research Topics
Genomes and Genes | Xun HuangSummaryAffiliation: Institute of Genetics and Developmental Biology Country: China Publications
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Detail Information
Publications
New players in the regulation of ecdysone biosynthesisXun Huang
Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
J Genet Genomics 35:1-10. 2008..Here we summarized recent findings in the regulation of ecdysone biosynthesis from the aspects of cell signaling, key biosynthetic enzymes and substrate cholesterol trafficking...
Rab32 is important for autophagy and lipid storage in DrosophilaChao Wang
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
PLoS ONE 7:e32086. 2012..Loss-of-function mutants of several components in the autophagy pathway result in similar effects on lipid storage. These results highlight the potential functions of Rabs in regulating lipid metabolism...
Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of DrosophilaZhiguo Ma
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Genetics 190:1299-308. 2012....
Opposite and redundant roles of the two Drosophila perilipins in lipid mobilizationJunfeng Bi
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
J Cell Sci 125:3568-77. 2012..Our study highlights the complex roles of Drosophila perilipin proteins and the evolutionarily conserved regulation of HSL translocation by perilipins...
Lipid metabolism and Drosophila sperm developmentChao Wang
State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Sci China Life Sci 55:35-40. 2012..In this mini-review, we summarized recent findings supporting a tight link between lipids metabolism and Drosophila sperm development...
Proteomic study and marker protein identification of Caenorhabditis elegans lipid dropletsPeng Zhang
Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
Mol Cell Proteomics 11:317-28. 2012..elegans LDs, indicating that it can be used as a LD marker protein in C. elegans. These results will facilitate further mechanistic studies of LDs in this powerful genetic system, C. elegans...
Midlife gene expressions identify modulators of aging through dietary interventionsBing Zhou
Chinese Academy of Sciences Key Laboratory for Computational Biology, Chinese Academy of Sciences Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Proc Natl Acad Sci U S A 109:E1201-9. 2012....
Lipid metabolism in Drosophila: development and diseaseZhonghua Liu
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Acta Biochim Biophys Sin (Shanghai) 45:44-50. 2013..Some recent progresses of lipid metabolic regulation during Drosophila development and in Drosophila models of human diseases will be discussed in this review...
Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formationYuan Tian
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
PLoS Genet 7:e1001364. 2011..In summary, we have demonstrated a tissue-autonomous role of dSeipin in ectopic lipid storage in lipodystrophy...
The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesisChao Wang
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Dev Biol 351:146-55. 2011..Together, our study reveals a sterol-dependent, ecdysone-independent mechanism of NPC1 function in Drosophila spermatogenesis...
