Affiliation: Institute of Zoology
Huang B, Cheng X, Wang H, Huang W, la Ga Hu Z, Wang D, et al
. Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively. J Transl Med. 2016;14:45 pubmed publisher
Liu T, Cui Y, Zhao H, Liu H, Zhao S, Gao Y, et al
. High levels of testosterone inhibit ovarian follicle development by repressing the FSH signaling pathway. J Huazhong Univ Sci Technolog Med Sci. 2015;35:723-729 pubmed publisher
..These findings are an important step in further understanding the pathogenesis of polycystic ovary syndrome. ..
Hao J, Chen M, Ji S, Wang X, Wang Y, Huang X, et al
. Equatorin is not essential for acrosome biogenesis but is required for the acrosome reaction. Biochem Biophys Res Commun. 2014;444:537-42 pubmed publisher
..Eqtn is involved in the fusion of the outer acrosomal membrane and the sperm plasma membrane during the acrosome reaction, most likely via an interaction with the SNARE complex. ..
Zhang L, Chen M, Wen Q, Li Y, Wang Y, Wang Y, et al
. Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015;112:4003-8 pubmed publisher
..This study thus provides a novel concept for somatic cell fate determination in testis development that may also represent an etiology of male infertility in human patients. ..
Wang Y, Li Q, Liu C, Han F, Chen M, Zhang L, et al
. Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development. Biol Reprod. 2015;92:104 pubmed publisher
..Collectively, this study demonstrated that Prmt5 plays critical roles in germ cell development that are required for germ cell survival during embryonic stages. ..
Chen M, Zhang L, Cui X, Lin X, Li Y, Wang Y, et al
. Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression. Development. 2017;144:44-53 pubmed publisher
..Without Wt1, the expression of Sf1 was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells. Our study uncovers a novel mechanism of somatic cell differentiation during gonad development. ..
Li Y, Zhang L, Hu Y, Han F, Qin Y, Chen M, et al
. β-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression. J Biol Chem. 2017;292:17577-17586 pubmed publisher
..Our study provides a new mechanism for Sertoli cell lineage maintenance during gonad development. ..