Shi Lin Chen

Summary

Affiliation: Institute of Medicinal Plant Development
Country: China

Publications

  1. ncbi request reprint [Suitability evaluation of Panax quinquefolium's producing area based on TCMGIS- I]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:741-5. 2008
  2. pmc Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species
    Shilin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    PLoS ONE 5:e8613. 2010
  3. pmc De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis
    Chao Sun
    Institute of Medicinal Plant Development IMPLAD, Chinese Academy of Medical Sciences, Haidian District, Beijing, China
    BMC Genomics 11:262. 2010
  4. pmc Genome sequence of the model medicinal mushroom Ganoderma lucidum
    Shilin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Nat Commun 3:913. 2012
  5. pmc The short ITS2 sequence serves as an efficient taxonomic sequence tag in comparison with the full-length ITS
    Jianping Han
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Biomed Res Int 2013:741476. 2013
  6. pmc Extensive pyrosequencing reveals frequent intra-genomic variations of internal transcribed spacer regions of nuclear ribosomal DNA
    Jingyuan Song
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    PLoS ONE 7:e43971. 2012
  7. ncbi request reprint [New technologies used for Panax genus research]
    Shi Lin Chen
    National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 38:633-9. 2013
  8. ncbi request reprint [Principles for molecular identification of traditional Chinese materia medica using DNA barcoding]
    Shi Lin Chen
    The National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 38:141-8. 2013
  9. pmc Transcriptome analysis reveals ginsenosides biosynthetic genes, microRNAs and simple sequence repeats in Panax ginseng C. A. Meyer
    Chunfang Li
    Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Plant Development, Beijing, China
    BMC Genomics 14:245. 2013
  10. ncbi request reprint [Genomics and synthetic biology of traditional Chinese medicine]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 47:1070-8. 2012

Collaborators

Detail Information

Publications84

  1. ncbi request reprint [Suitability evaluation of Panax quinquefolium's producing area based on TCMGIS- I]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:741-5. 2008
    ..To supply the scientific data for the choice of medicinal plants' producing area through analyzing the suitable area for Panax quinquefolium' growth...
  2. pmc Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species
    Shilin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    PLoS ONE 5:e8613. 2010
    ..The group admits that the two-locus barcode is far from perfect due to the low identification rate, and the search is not over...
  3. pmc De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis
    Chao Sun
    Institute of Medicinal Plant Development IMPLAD, Chinese Academy of Medical Sciences, Haidian District, Beijing, China
    BMC Genomics 11:262. 2010
    ..Its major bioactive constituents are the triterpene saponins known as ginsenosides. However, little is known about ginsenoside biosynthesis in American ginseng, especially the late steps of the pathway...
  4. pmc Genome sequence of the model medicinal mushroom Ganoderma lucidum
    Shilin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Nat Commun 3:913. 2012
    ..The elucidation of the G. lucidum genome makes this organism a potential model system for the study of secondary metabolic pathways and their regulation in medicinal fungi...
  5. pmc The short ITS2 sequence serves as an efficient taxonomic sequence tag in comparison with the full-length ITS
    Jianping Han
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Biomed Res Int 2013:741476. 2013
    ..Our results supported the hypothesis that ITS2 can be used as a minibarcode to effectively identify species in a wide variety of specimens and medicinal materials...
  6. pmc Extensive pyrosequencing reveals frequent intra-genomic variations of internal transcribed spacer regions of nuclear ribosomal DNA
    Jingyuan Song
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    PLoS ONE 7:e43971. 2012
    ..However, the existence of its multiple copies has complicated such usage and a detailed characterization of intra-genomic variations is critical to address such concerns...
  7. ncbi request reprint [New technologies used for Panax genus research]
    Shi Lin Chen
    National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 38:633-9. 2013
    ..In summary, the application of the new technologies lay the foundation for clarifying the molecular mechanisms of ginsenoside biosynthesis and enforcing the in vitro synthesis of important natural products and new drugs in future...
  8. ncbi request reprint [Principles for molecular identification of traditional Chinese materia medica using DNA barcoding]
    Shi Lin Chen
    The National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 38:141-8. 2013
    ..This article introduced the principle of molecular identification of CMM using DNA barcoding and its drafting instructions. Furthermore, its application perspective was discussed...
  9. pmc Transcriptome analysis reveals ginsenosides biosynthetic genes, microRNAs and simple sequence repeats in Panax ginseng C. A. Meyer
    Chunfang Li
    Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Plant Development, Beijing, China
    BMC Genomics 14:245. 2013
    ..The global expressed sequence tags from P. ginseng tissues, especially those isolated from stems, leaves and flowers, are still limited, hindering in-depth study of P. ginseng...
  10. ncbi request reprint [Genomics and synthetic biology of traditional Chinese medicine]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 47:1070-8. 2012
    ....
  11. pmc Comprehensive transcriptome analysis reveals novel genes involved in cardiac glycoside biosynthesis and mlncRNAs associated with secondary metabolism and stress response in Digitalis purpurea
    Bin Wu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, NO, 151, Malianwa North Road, Haidian District, Beijing 100193, China
    BMC Genomics 13:15. 2012
    ..Digitalis purpurea is an important ornamental and medicinal plant. There is considerable interest in exploring its transcriptome...
  12. pmc Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling
    Chang Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science, 151 Malianwa North Road, Beijing, 100193, PR China
    BMC Complement Altern Med 12:5. 2012
    ..The current study was undertaken to investigate the molecular mechanisms of Tan IIA's apoptotic effects on leukemia cells in vitro...
  13. pmc PTIGS-IdIt, a system for species identification by DNA sequences of the psbA-trnH intergenic spacer region
    Chang Liu
    The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, P R China
    BMC Bioinformatics 12:S4. 2011
    ..Here, we compared the most commonly used alignment-based and alignment-free methods and developed a web server to allow the biologists to carry out PTIGS-based DNA barcoding analyses...
  14. ncbi request reprint [Advances of studies on new technology and method for identifying traditional Chinese medicinal materials]
    Shilin Chen
    The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Zhongguo Zhong Yao Za Zhi 37:1043-55. 2012
    ..However, the bionic identification technology is just placed in the developing stage at present...
  15. pmc Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers
    Hongmei Luo
    The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    BMC Genomics 12:S5. 2011
    ..Triterpene saponins are the bioactive constituents in P. notoginseng. However, available genomic information regarding this plant is limited. Moreover, details of triterpene saponin biosynthesis in the Panax species are largely unknown...
  16. pmc Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation
    Hongmei Luo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haidian District, Beijing, China
    BMC Plant Biol 10:209. 2010
    ..We focused on gene discovery in the areas of bioactive compound biosynthesis and transcriptional regulation as well as genetic marker detection in these species...
  17. pmc Transcriptome analysis of Bupleurum chinense focusing on genes involved in the biosynthesis of saikosaponins
    Chun Sui
    Institute of Medicinal Plant Development IMPLAD, Chinese Academy of Medical Sciences and Peking Union Medical College, NO, 151, Malianwa North Road, Haidian District, Beijing 100193, China
    BMC Genomics 12:539. 2011
    ..Consequently, this technology may help to identify the candidate genes involved in the saikosaponin biosynthetic pathway...
  18. pmc Comparative transcriptome sequencing of germline and somatic tissues of the Ascaris suum gonad
    Xuan Ma
    Noncoding RNA laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    BMC Genomics 12:481. 2011
    ..Widespread study of A. suum would be facilitated by more comprehensive genome resources and, to this end, we have produced a gonad transcriptome of A. suum...
  19. pmc Evaluating the feasibility of using candidate DNA barcodes in discriminating species of the large Asteraceae family
    Ting Gao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China
    BMC Evol Biol 10:324. 2010
    ..Studies evaluating these regions for species identification in the large plant taxon, which includes a large number of closely related species, have rarely been reported...
  20. pmc Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway
    Chang Liu
    Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
    BMC Complement Altern Med 10:79. 2010
    ....
  21. pmc Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma
    Ze Tian
    Children s Hospital Informatics Program at Harvard MIT Division of Health Sciences and Technology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    BMC Cancer 7:237. 2007
    ..It is of great interest to examine the antiproliferative activity and mechanisms of total triterpenoid glycosides of C. dahurica and therefore might eventually be useful in the prevention or treatment of Hepatoma...
  22. pmc Generation and analysis of expressed sequence tags from a cDNA library of the fruiting body of Ganoderma lucidum
    Hongmei Luo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, 151 Malianwa North Road, Haidian District, Beijing 100193, PR China
    Chin Med 5:9. 2010
    ..CONCLUSION: The present study demonstrates a successful application of EST analysis in the discovery of transcripts involved in the secondary metabolite biosynthesis and the developmental regulation of G. lucidum...
  23. pmc Mapping the potential distribution of high artemisinin-yielding Artemisia annua L. (Qinghao) in China with a geographic information system
    Linfang Huang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Chin Med 5:18. 2010
    ..Artemisia annua L. is an important source for artemisinin, a potent drug for treating malaria. This study aims to map and predict the potential geographic distribution of A. annua L. in China...
  24. pmc TCMGIS-II based prediction of medicinal plant distribution for conservation planning: a case study of Rheum tanguticum
    Hua Yu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Chin Med 5:31. 2010
    ..To provide reliable references for conservation planning and regional management, this study focuses on large-scale distribution prediction of Rheum tanguticum Maxim. ex Balf (Dahuang)...
  25. doi request reprint An introduction to the medicinal plant genome project
    Shilin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Front Med 5:178-84. 2011
    ..This study places the study on traditional Chinese medicine into the frontier field of life science...
  26. ncbi request reprint [Strategies of the study on herb genome program]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 45:807-12. 2010
    ..HerbGP shall also have significant impacts on the R&D of natural medicines and the development of medicinal farming by analysis of secondary metabolic pathways and selection of cultivars with good agricultural traits...
  27. doi request reprint 454 EST analysis detects genes putatively involved in ginsenoside biosynthesis in Panax ginseng
    S Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Haidian, Beijing 100193, China
    Plant Cell Rep 30:1593-601. 2011
    ..These 454 ESTs will provide the foundation for further functional genomic research into the traditional herb P. ginseng or its closely related species...
  28. pmc Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport
    Yongzhen Sun
    The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    BMC Genomics 12:533. 2011
    ..Despite its importance, little is known about the transcriptome of C. acuminata and the mechanism of CPT biosynthesis, as only few nucleotide sequences are included in the GenBank database...
  29. ncbi request reprint [Suitability evaluation of Cistanche desertiola based on TCMGIS-I]
    Jun Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Chinese Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 32:1396-401. 2007
    ..To analyze the appropriate producing area of Cistanche desertiola...
  30. ncbi request reprint Xanthones from the roots of Polygala caudata and their antioxidation and vasodilatation activities in vitro
    Li Lin Lin
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China
    Planta Med 71:372-5. 2005
    ..4% at 10 microg/mL, 41.2% and 47.8% at 2 microg/mL, respectively. In the vasodilatation assay, compounds 4 - 7 exhibited relaxing activity on the contractions evoked by KCl in Wistar rat thoracic aorta rings in a dose-dependent manner...
  31. ncbi request reprint [Cloning and expression analysis of a key device of HMGR gene involved in ginsenoside biosynthesis of Panax ginseng via synthetic biology approach]
    Hong Mei Luo
    National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 48:219-27. 2013
    ..The result will provide a foundation for exploring the molecular function of PgHMGR2 involved in ginsenoside biosynthesis based on synthetic biology approach in P. ginseng plants...
  32. ncbi request reprint Identification of Cistanche species (Orobanchaceae) based on sequences of the plastid psbA-trnH intergenic region
    Jian Ping Han
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 45:126-30. 2010
    ..066% to 1.224%. Our results suggest that the psbA-trnH intergenic spacer region represent a barcode that can be used to identify Cistanche species and other morphologically undistinguishable species...
  33. ncbi request reprint [Analysis of expressed sequence tags (EST) from Panax quinquefolium root]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094, China
    Yao Xue Xue Bao 43:657-63. 2008
    ..quinquefolium and it can be applied to the molecular modification of the ginsenosides biosynthetic pathway ultimately for improving the quality of American ginseng germplasm...
  34. ncbi request reprint [Development of the devices for synthetic biology of triterpene saponins at an early stage: cloning and expression profiling of squalene epoxidase genes in panax notoginseng]
    Yun Yun Niu
    National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 48:211-8. 2013
    ..It was strongly suggested that PnSEs play different roles in secondary metabolite biosynthesis in P. notoginseng. PnSE1 might be involved in triterpenoid biosynthesis and PnSE2 might be involved in phytosterol biosynthesis...
  35. pmc EST analysis reveals putative genes involved in glycyrrhizin biosynthesis
    Ying Li
    Institute of Medicinal Plant Development IMPLAD, Chinese Academy of Medical Sciences and Peking Union Medical College, NO, 151, Malianwa North Road, Haidian District, Beijing 100193, China
    BMC Genomics 11:268. 2010
    ..uralensis, is currently unclear. Identification of candidate genes involved in the glycyrrhizin biosynthetic pathway will significantly contribute to the understanding of the biosynthetic and medicinal chemistry of this compound...
  36. ncbi request reprint [Establishment of the national macro-management system on Chinese medicinal resource--base of the modernization for Chinese medicine]
    Pei Gen Xiao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, WHO Collaborating Center for Traditional Medicine, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 28:4-6. 2003
    ..To establish a national management system on the utilization and protection, reserves and wastes of Chinese medicinal resources, and provide a scientific basis for the national administering authorities for the macro-management...
  37. ncbi request reprint [Studies on the resources survey methods of Panax notogingseng based on remote sensing]
    Ying qun Zhou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Chinese Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 30:1902-5. 2005
    ..To explore the survey methods for the cultivated medicinal plant resources such as Panax notogingseng based on remote sensing...
  38. ncbi request reprint [Study on the plant community of Fritillaria cirrhosa]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094
    Zhongguo Zhong Yao Za Zhi 28:398-402. 2003
    ..To provide scientific basis for natural cultivation of Fritillaria cirrhosa...
  39. ncbi request reprint Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats
    Li Ping Yan
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Life Sci 79:324-30. 2006
    ..Whether puerarin targets directly on cholesterol homeostasis or both cholesterol homeostasis and endothelial function remains to be determined...
  40. doi request reprint Molecular identification of Corni Fructus and its adulterants by ITS/ITS2 sequences
    Dian Yun Hou
    Institute of Medicinal Plant Development IMPLAD, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Chin J Nat Med 11:121-7. 2013
    ..The DNA barcoding method was used to accurately and rapidly identify Corni Fructus and its adulterants...
  41. ncbi request reprint Species identification of medicinal pteridophytes by a DNA barcode marker, the chloroplast psbA-trnH intergenic region
    Xin Ye Ma
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, PR China
    Biol Pharm Bull 33:1919-24. 2010
    ..Thus, the psbA-trnH intergenic region is a suitable DNA marker for species identification in medicinal pteridophytes...
  42. ncbi request reprint [Stability and accuracy of the identification of Notopterygii Rhizoma et Radix using the ITS/ITS2 barcodes]
    Tian yi Xin
    National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 47:1098-105. 2012
    ....
  43. ncbi request reprint New lignans and cytotoxic constituents from Schisandra propinqua
    Li Jia Xu
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P R China
    Planta Med 72:169-74. 2006
    ..Cell cycle analysis and Hoechst 33 258 staining assay suggested that one possible mechanism of cytotoxic activity by 2 might be related to the induction of apoptosis...
  44. ncbi request reprint [Cloning and bioinformatic analysis of PqERF1 gene in Panax quinquefolius]
    Yong zhen Sun
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 46:1008-14. 2011
    ..quinquefolius...
  45. ncbi request reprint [Rapid and undamaged determination of C. deserticola by Fourier-transform infrared spectroscopy and clustering analysis]
    Rong Xu
    Endangered TCM Propagation and Breeding National Engineering Laboratory, The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Guang Pu Xue Yu Guang Pu Fen Xi 29:1860-3. 2009
    ..On the whole, combined with clustering analysis, FTIR provides a effective way to evaluate the origin of the Chinese medicines rapidly and undamagedly...
  46. ncbi request reprint [Full-length cDNA cloning and bioinformatics analysis of PnUGT1 gene in Panax notoginseng]
    Li Xiang
    National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 47:1085-91. 2012
    ..PnUGT1 was more abundant in P. notoginseng leaf than in flower, stem and root. Therefore, PnUGT1 gene may be involved in notoginsenoside biosynthesis...
  47. ncbi request reprint [The sustainable development framework of national Chinese medicine resources]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Chinese Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 30:1141-6. 2005
    ..It provided external scientific standard for the research of the sustainable development on Chinese medicine resources...
  48. ncbi request reprint [Survey scheme of the main Chinese medicines resources]
    Shi Lin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Chinese Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 30:1229-32, 1289. 2005
    ..This paper explains the meaning and necessity. And it also investigated the survey object, contents, new technologies and methods...
  49. ncbi request reprint [Study on producing area suitability of genuine traditional Chinese drugs]
    Feng Mei Suo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Chinese Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 30:1485-8. 2005
    ..The direction and strategy of producing area suitability of genuine traditional Chinese drugs for the future were proposed and prospected aiming to provide with scientific thoughtway and guiding later production and practice...
  50. ncbi request reprint [Transcriptome characterization for Salvia miltiorrhiza using 454 GS FLX]
    Ying Li
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 45:524-9. 2010
    ..Data presented in this study will constitute an important resource for the scientific community that is interested in the molecular genetics and functional genomics of S. miltiorrhiza...
  51. ncbi request reprint [Suitability evaluation of Cistanche tubulosa based on TCMGIS-I]
    Jun Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Chinese Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:496-501. 2008
    ..To analyze the appropriate producing area of Cistanche tubulosa by mean of TCMGIS-I...
  52. ncbi request reprint [Chinese meteria medica resources and ecological modernization]
    Yong Peng
    Institute of Modicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 32:1125-7. 2007
    ..Some appropriate measures should be implemented in order to guarantee both the Chinese materia medica resources supply and environment protection...
  53. ncbi request reprint [Construction of the coexpression vector containing key element GLCYP450 involved in Ganoderma triterpene biosynthesis and its reductase gene GLNADPH]
    Xu Guo
    National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 48:206-10. 2013
    ..This study provides a foundation for researching Ganoderma triterpene biosynthesis using the approach of synthetic biology...
  54. ncbi request reprint [Identification of Daturae flos and its adulterants based on DNA barcoding technique]
    Jian Ping Han
    The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education of PRC, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 46:1408-12. 2011
    ..Samples of Brugmansia arborea were clustered into one clade, and the other species of Datura L. formed another clade. The results showed that either ITS2 or psbA-trnH was useful to identify Daturae Flos from its adulterants...
  55. ncbi request reprint [Study on application of low altitude remote sensing to Chinese herb medicinal sustainable utilization]
    Ying qun Zhou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:977-9. 2008
    ..This paper described the technical system, equipment and image processing of low altitude remote sensing, and analyzed its future application in Chinese herb medicinal sustainable utilization...
  56. ncbi request reprint [Infrared spectroscopic study on the component and vigor analysis of Cistanche deserticola seeds]
    Rong Xu
    The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Guang Pu Xue Yu Guang Pu Fen Xi 29:97-101. 2009
    ..The results suggest that FTIR not only can be used in fast comprehensive analysis of seed components, but also can be used in the seed vigor analysis, seed longevity determination and seed quality evaluation...
  57. ncbi request reprint [Cloning and analysis of mevalonate kinase (PnMVK1) gene in Panax notoginseng]
    Xu Guo
    National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical, Beijing 100193, China
    Yao Xue Xue Bao 47:1092-7. 2012
    ..This study cloned and analyzed PnMVK1 gene from P. notoginseng for the first time. The result will provide a foundation for exploring the mechanism of terpenoid biosynthesis in P. notoginseng plants...
  58. ncbi request reprint [A review of research on sustainable use of medicinal plants cropland in China]
    Wei Wei Gao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100094, China
    Zhongguo Zhong Yao Za Zhi 31:1665-9. 2006
    ..The strengthening research fields in the further were suggested...
  59. ncbi request reprint [Conspectus of ecophysiological study on medicinal plant in wild nursery]
    Xi wen Li
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 32:1388-92. 2007
    ....
  60. doi request reprint Sulfur fumigation, a better or worse choice in preservation of Traditional Chinese Medicine?
    Xue Jiang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Phytomedicine 20:97-105. 2013
    ..The QOSFD is regarded as a promising preservation technique in the field of TCM, medicinal materials, agriculture, and fruit industry...
  61. doi request reprint Identification of Dendrobium species by a candidate DNA barcode sequence: the chloroplast psbA-trnH intergenic region
    Hui Yao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, PR China
    Planta Med 75:667-9. 2009
    ..5 %. Our results support the notion that the psbA-trnH intergenic spacer region could be used as a barcode to distinguish various Dendrobium species and to differentiate Dendrobium species from other adulterating species...
  62. ncbi request reprint [UPLC fingerprint for quality assessment of ginsenosides of ginseng radix et rhizoma]
    Cui ying Zhang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 45:1296-300. 2010
    ..The quality was assessed by similarity evaluation system for chromatographic fingerprint of TCM (2004B Version). The convenient and high specific method can be used to identify and evaluate the quality of the Ginseng Radix et Rhizoma...
  63. ncbi request reprint [Some key problems of quantitative estimation in multilevel remote sensing monitoring system of plant medicinal materials]
    Cai Xiang Xie
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:326-9. 2008
    ....
  64. ncbi request reprint Four new diterpenes from Aphanamixis polystachya
    Hai Feng Wu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China
    Fitoterapia 90:126-31. 2013
    ..Their structures including the absolute configuration were elucidated by spectroscopic data and CD analysis. The cytotoxicities of the isolated compounds against a panel of human cancer cell lines were evaluated. ..
  65. ncbi request reprint [Salvia miltiorrhiza as medicinal model plant]
    Jing Yuan Song
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 48:1099-106. 2013
    ..Accompanying modern investigation of life sciences, the platform for medicinal model plant, S. miltiorrhiza, will be promoted to be established. It is important to develop the ethnopharmacology and new drugs around the world...
  66. ncbi request reprint [Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro]
    Li Lin Lin
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 30:827-30. 2005
    ..To study the chemical constituents in roots of P. fallax and their anti-oxidation activities in vitro...
  67. ncbi request reprint [Review of bioactivities of natural cycloartane triterpenoids]
    Ze Tian
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Zhongguo Zhong Yao Za Zhi 31:625-9. 2006
    ..This will be benefit for the further research and development of the compounds...
  68. ncbi request reprint [Preliminary pharmaphylogenetic study on Ranunculaceae]
    Yong Peng
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing
    Zhongguo Zhong Yao Za Zhi 31:1124-8. 2006
    ..To deal with the correlation between phylogeny, chemical constituents and pharmaceutical aspects of Ranunculaceae, namely a pharmaphylogenic study of this taxon...
  69. ncbi request reprint [Classification of licorice based on inorganic elements characteristics]
    Ying qun Zhou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:1101-4. 2010
    ..In conclusion, the method we founded here turned out to be intuitive, informative, and highly accurate, and can be used to reveal the characteristic of inoganic elements in medicinal plant...
  70. ncbi request reprint [FTIR and 2D-IR spectroscopic studies on different sources of Herbra cistanche]
    Rong Xu
    The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, National Engineering Laboratory for Breedng of Endangered Medicinal Materials, Beijing 100193, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:897-900. 2010
    ..The three kinds of herbs were quite different from each other in the number and intensity of autopeaks. Therefore, FTIR macro-fingerprint method can identify different sources of Hebra cistance fast, nondestructively and effectively...
  71. ncbi request reprint [Quality variation and ecotype division of Panax quinquefolium in China]
    Lin Fang Huang
    The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 48:580-9. 2013
    ..In addition, the results demonstrate the critical need for improving quality, appropriate ecological regionalization and promoting industrialized development of P. quinquefolium L...
  72. ncbi request reprint [Simultaneous determination of peimisine and sipeimine in Fritillaria walujewii regel and Fritillaria pallidiflora Schrenk by UPLC-ELSD]
    Bao zhong Duan
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 45:1541-4. 2010
    ..The average recovery was 94.5% and 98.1% with RSD < or = 2.36%. The UPLC-ELSD method is simple, sensitive and accurate with good repeatability, which is available for quality control of F. walujewii Regel and F. pallidiflora Schrenk...
  73. ncbi request reprint [Study on the stigma/pollen vigor and self-compatibility of Platycodon grandiflorum]
    Jian He Wei
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Chinese Peking Union Medical College, Beijing
    Zhongguo Zhong Yao Za Zhi 31:366-8. 2006
    ..To provide the basal data for the breeding and cultivation of Platycodon grandiflorum...
  74. ncbi request reprint [Chemical constituents from stems of Schisandra propinqua]
    Li Jia Xu
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:521-3. 2008
    ..To study the chemical constituents in the stems of Schisandra propinqua and evaluate their effects on proliferation of vascular smooth muscle cells (VSMCs) in vitro by MTT assay...
  75. ncbi request reprint Ethnopharmacological investigations on Thalictrum plants in China
    Si Bao Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094, China
    J Asian Nat Prod Res 5:263-71. 2003
    ..In addition, the correlation between folk therapeutic effects and chemical constituents, and the modem pharmacological activities, are discussed as well as the prospect of isolation and development of new drugs from this genus of plants...
  76. ncbi request reprint [Review of current situations and prospects of research and development on traditional Chinese medicine cosmetics]
    Meng Zhang
    Institute of Medical Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 32:2457-60. 2007
    ..Finally, the developmental prospects of TCMC in China were discussed in two aspects of the strategy of the R&D and the problems facing when it was marketed...
  77. ncbi request reprint [Ecological evaluation of suitable area for production of Phellodendron amurense based on TCMGIS- I]
    Feng Mei Suo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Chinese Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:1536-9. 2008
    ..3 m2, the results also indicate some condign regions in Innermongolia municipality. The system is much valuable to the division of adaptive area, introduction and acclimatization of medicinal materials...
  78. ncbi request reprint [Research progress on resources in Bulbus Fritillariae Cirrhosae]
    Hui Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 33:1645-8. 2008
    ..The present problems and the future research direction on bulbus fritillariae cirrhosae were also discussed...
  79. doi request reprint JR6, a new compound isolated from Justicia procumbens, induces apoptosis in human bladder cancer EJ cells through caspase-dependent pathway
    Xiao Li He
    Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No 151 Malianwa North Road, Haidian District, Beijing, China
    J Ethnopharmacol 144:284-92. 2012
    ..Here, we identified a new compound 6'-hydroxy justicidin A (JR6) from Justicia procumbens, which showed obvious anti-cancer effects...
  80. pmc UPLC-QTOF/MS Analysis of Alkaloids in Traditional Processed Coptis chinensis Franch
    Xue Jiang
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Evid Based Complement Alternat Med 2012:942384. 2012
    ..chinensis Franch. with principal component analysis (PCA). The obvious separation in PCA confirms the traditional processing theory in TCM...
  81. doi request reprint Rapid determination of yunaconitine and related alkaloids in aconites and aconite-containing drugs by ultra high-performance liquid chromatography-tandem mass spectrometry
    Long Song
    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Biomed Chromatogr 26:1567-74. 2012
    ..This newly developed method facilitates the rapid screening of YAC and related toxic aconite alkaloids and allows YAC to be used as a chemical marker for the quality control of aconites and aconite-containing drugs...
  82. ncbi request reprint [Comparison of the contents of trace elements in the roots of four original danshen (Salvia miltiorrhiza bunge)]
    Chun E He
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:801-3. 2010
    ..The difference in the contents of trace elements has an important effect on the research into the contents of officinal ingredients and their curative effect of the roots of four kinds of original danshen germplasm...
  83. ncbi request reprint [Studies on seed quality evaluation technique and grading rules of Cistanche deserticola]
    Rong Xu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100193, China
    Zhong Yao Cai 32:475-8. 2009
    ..To establish a seed quality evaluation technique system and quality grading rules for Cistanche deserticola...
  84. doi request reprint Suppression of diet-induced hypercholesterolemia by scutellarin in rats
    Qing Li
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P R China
    Planta Med 75:1203-8. 2009
    ..However, whether scutellarin's atheroscleroprotective potential targets endothelial function directly or indirectly on its antioxidative activity remains to be determined...