Affiliation: Institute of Zoology
Zhang W, Cheng Y, Li Y, Chen Z, Jin P, Chen D. A feed-forward mechanism involving Drosophila fragile X mental retardation protein triggers a replication stress-induced DNA damage response. Hum Mol Genet. 2014;23:5188-96 pubmed publisher
Huang H, Li Y, Szulwach K, Zhang G, Jin P, Chen D. AGO3 Slicer activity regulates mitochondria-nuage localization of Armitage and piRNA amplification. J Cell Biol. 2014;206:217-30 pubmed publisher
..Collectively, our findings uncover a new mechanism that couples mitochondria with nuage to regulate secondary piRNA amplification. ..
Ji S, Li C, Hu L, Liu K, Mei J, Luo Y, et al
. Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A. Proc Natl Acad Sci U S A. 2017;114:6316-6321 pubmed publisher
Ji S, Luo Y, Cai Q, Cao Z, Zhao Y, Mei J, et al
. LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan. Mol Cell. 2019;74:363-377.e5 pubmed publisher
..Thus, regulated biomolecular condensates may represent a mechanism that controls dynamic enzymatic activities and related biological processes. ..
Cheng Y, Wang Z, Tan W, Wang X, Li Y, Bai B, et al
. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nat Neurosci. 2018;21:1689-1703 pubmed publisher
..Collectively, our results suggest that MIR137 plays essential roles in postnatal neurodevelopment and that dysregulation of miR-137 potentially contributes to neuropsychiatric disorders in humans. ..
Cheng Y, Chen D. Fruit fly research in China. J Genet Genomics. 2018;45:583-592 pubmed publisher
..Here, we review some of the recent fruit fly studies in China, and mainly focus on those studies in the fields of stem cell biology, cancer therapy and regeneration medicine, neurological disorders and epigenetics. ..
Zhang G, Huang H, Liu D, Cheng Y, Liu X, Zhang W, et al
. N6-methyladenine DNA modification in Drosophila. Cell. 2015;161:893-906 pubmed publisher
..Collectively, we uncover a DNA modification in Drosophila and describe a potential role of the DMAD-6mA regulatory axis in controlling development in higher eukaryotes. ..