Lei Zhou

Summary

Affiliation: Huazhong Agricultural University
Country: China

Publications

  1. ncbi Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
    Hepatology 57:1384-93. 2013
  2. ncbi Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, People s Republic of China
    J Nat Med 65:50-6. 2011
  3. ncbi C/EBPα promotes transcription of the porcine perilipin5 gene
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan City, Hubei Province 430070, PR China
    Mol Cell Endocrinol 364:28-35. 2012
  4. ncbi Molecular cloning and characterization of the anti-obesity gene adipose in pig
    Yanling Wu
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China
    Gene 509:110-9. 2012
  5. ncbi Clenbuterol inhibits SREBP-1c expression by activating CREB1
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P R China
    J Biochem Mol Biol 40:525-31. 2007
  6. ncbi Molecular characterization, expression and chromosomal localization of porcine PNPLA3 and PNPLA4
    Zhilong Chen
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People s Republic of China
    Biotechnol Lett 33:1327-37. 2011
  7. ncbi Cloning, expression pattern, chromosomal localization, and evolution analysis of Porcine gnaq, gna11, and gna14
    Huaping Chen
    Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Huazhong Agricultural University, Wuhan, 430070, People s Republic of China
    Biochem Genet 46:398-405. 2008
  8. ncbi Resistin overexpression impaired glucose tolerance in hepatocytes
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China
    Eur Cytokine Netw 17:189-95. 2006
  9. ncbi Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway
    Jian Zhang
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    Inflammation 33:25-33. 2010
  10. ncbi Gene organization, alternate splicing and expression pattern of porcine visfatin gene
    Huaping Chen
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China
    Domest Anim Endocrinol 32:235-45. 2007

Collaborators

Detail Information

Publications13

  1. ncbi Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
    Hepatology 57:1384-93. 2013
    ..This reveals a novel pathway for mitochondrial regulation, and suggests that the maintenance of normal mitochondrial content could be a new strategy for treatment of obesity-associated diseases. (HEPATOLOGY 2013)...
  2. ncbi Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, People s Republic of China
    J Nat Med 65:50-6. 2011
    ..It is said that GBE treatment could avoid drug-induced obesity. Our data suggest that GBE has the potential to prevent insulin resistance and is a promising anti-diabetic drug...
  3. ncbi C/EBPα promotes transcription of the porcine perilipin5 gene
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan City, Hubei Province 430070, PR China
    Mol Cell Endocrinol 364:28-35. 2012
    ..Taken together, our results indicate that C/EBPα is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPα expression...
  4. ncbi Molecular cloning and characterization of the anti-obesity gene adipose in pig
    Yanling Wu
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China
    Gene 509:110-9. 2012
    ..Taken together, our results would be helpful for further study of Adp regulation in the process of fat accumulation...
  5. ncbi Clenbuterol inhibits SREBP-1c expression by activating CREB1
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P R China
    J Biochem Mol Biol 40:525-31. 2007
    ..However, our results showed that clenbuterol or CREB1 overexpression suppressed PPARs transcription in 293T and L-02 cells, which suggested that they impair SREBP-1c expression in other ways...
  6. ncbi Molecular characterization, expression and chromosomal localization of porcine PNPLA3 and PNPLA4
    Zhilong Chen
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People s Republic of China
    Biotechnol Lett 33:1327-37. 2011
    ..Porcine PNPLA3 and PNPLA4 were assigned respectively to chromosome 5p11-p15 and Xp24...
  7. ncbi Cloning, expression pattern, chromosomal localization, and evolution analysis of Porcine gnaq, gna11, and gna14
    Huaping Chen
    Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Huazhong Agricultural University, Wuhan, 430070, People s Republic of China
    Biochem Genet 46:398-405. 2008
    ..This is the first report of molecular cloning and characterization of porcine Gnaq, Gna11, and Gna14, which will be helpful for further understanding of the physiological role of Gq class genes in pigs...
  8. ncbi Resistin overexpression impaired glucose tolerance in hepatocytes
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China
    Eur Cytokine Netw 17:189-95. 2006
    ..Moreover, resistin lowered mRNA levels of IRS-2 while stimulating SOCS-3 expression, which suggests it impairs glucose tolerance by blocking the insulin signal transduction pathway...
  9. ncbi Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway
    Jian Zhang
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    Inflammation 33:25-33. 2010
    ..These results suggest that resistin enhances COX-2 expression in mouse macrophage cells in a TAK1-IKK-NF-kappaB-dependent manner and therefore plays a critical role in inflammatory processes...
  10. ncbi Gene organization, alternate splicing and expression pattern of porcine visfatin gene
    Huaping Chen
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China
    Domest Anim Endocrinol 32:235-45. 2007
    ..The discovery of the three variants of visfatin in porcine would be useful to the further investigation of the function of the visfatin gene...
  11. ncbi Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes
    Lei Zhou
    College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
    FEBS Lett 581:4303-8. 2007
    ..CM with resistin addition induced stronger insulin resistance than CM alone pointing to a specific role of resistin in the initiation of hepatic insulin resistance in humans...
  12. ncbi A nodule-specific plant cysteine proteinase, AsNODF32, is involved in nodule senescence and nitrogen fixation activity of the green manure legume Astragalus sinicus
    Yixing Li
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China
    New Phytol 180:185-92. 2008
    ..Interestingly, nodules enlarged in length were also observed on Asnodf32-silenced hairy roots. The results reported here indicate that Asnodf32 plays an important role in the regulation of root nodule senescence...
  13. ncbi Transcriptional regulation of the resistin gene
    Lei Zhou
    State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan City, Hubei Province 430070, China
    Domest Anim Endocrinol 30:98-107. 2006
    ..Moreover, while C/EBPalpha was necessary for resistin expression, we found that up-regulating C/EBPalpha levels alone was not sufficient to induce a similar level of resistin in preadipocytes to that in adipocytes...