Hong Yu Zhang

Summary

Affiliation: Huazhong Agricultural University
Country: China

Publications

  1. ncbi request reprint Metabolite concentration as a criterion for antibacterial discovery
    Zhong Yi Wang
    College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P R China
    Curr Comput Aided Drug Des 9:412-6. 2013
  2. doi request reprint Structural phylogenomics uncovers the early and concurrent origins of cysteine biosynthesis and iron-sulfur proteins
    Hong Yu Zhang
    National Key Laboratory of Crop Genetic Improvement, Center for Bioinformatics, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    J Biomol Struct Dyn 30:542-5. 2012
  3. pmc DIGA--a database of improved gene annotation for phytopathogens
    Na Gao
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    BMC Genomics 11:54. 2010
  4. doi request reprint Evolutionary inspirations for drug discovery
    Hong Yu Zhang
    National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P R China
    Trends Pharmacol Sci 31:443-8. 2010
  5. pmc Chemical basis of metabolic network organization
    Qiang Zhu
    National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
    PLoS Comput Biol 7:e1002214. 2011
  6. pmc The impact of oxygen on metabolic evolution: a chemoinformatic investigation
    Ying Ying Jiang
    National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
    PLoS Comput Biol 8:e1002426. 2012
  7. doi request reprint Historical variation of structural novelty in a natural product library
    De Xin Kong
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, P R China
    Chem Biodivers 8:1968-77. 2011
  8. doi request reprint Oxidative DNA damage is important to the evolution of antibiotic resistance: evidence of mutation bias and its medicinal implications
    Zhong Yi Wang
    National Key Laboratory of Crop Genetic Improvement, Center for Bioinformatics, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, P R China
    J Biomol Struct Dyn 31:729-33. 2013
  9. doi request reprint Can medical genetics and evolutionary biology inspire drug target identification?
    Zhong Yi Wang
    National Key Laboratory of Crop Genetic Improvement, Center for Bioinformatics, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P R China
    Trends Mol Med 18:69-71. 2012
  10. doi request reprint The draft genome of sweet orange (Citrus sinensis)
    Qiang Xu
    Key Laboratory of Horticultural Plant Biology Ministry of Education, Huazhong Agricultural University, Wuhan, China
    Nat Genet 45:59-66. 2013

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Metabolite concentration as a criterion for antibacterial discovery
    Zhong Yi Wang
    College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P R China
    Curr Comput Aided Drug Des 9:412-6. 2013
    ..By the new-proposed criterion, we not only identify some promising antibacterial targets but also explain some perplexing experimental observations as well. ..
  2. doi request reprint Structural phylogenomics uncovers the early and concurrent origins of cysteine biosynthesis and iron-sulfur proteins
    Hong Yu Zhang
    National Key Laboratory of Crop Genetic Improvement, Center for Bioinformatics, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    J Biomol Struct Dyn 30:542-5. 2012
    ..It is therefore likely that Cys did not play an important role in the make up of primordial protein molecules and that Fe-S clusters were not part of active sites at the beginning of biological history...
  3. pmc DIGA--a database of improved gene annotation for phytopathogens
    Na Gao
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    BMC Genomics 11:54. 2010
    ..However, some misannotations exist in these phytopathogen genomes. Our objective is to improve these annotations and store them in a central database DIGAP...
  4. doi request reprint Evolutionary inspirations for drug discovery
    Hong Yu Zhang
    National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P R China
    Trends Pharmacol Sci 31:443-8. 2010
    ..Polyphenols have evolved a superior ability to bind various proteins, so we also argue that they are good starting points for multi-target drugs...
  5. pmc Chemical basis of metabolic network organization
    Qiang Zhu
    National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
    PLoS Comput Biol 7:e1002214. 2011
    ..This finding not only provides a chemical explanation to the preferential attachment principle for metabolic network expansion, but also has important implications for metabolic network design and metabolite concentration prediction...
  6. pmc The impact of oxygen on metabolic evolution: a chemoinformatic investigation
    Ying Ying Jiang
    National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
    PLoS Comput Biol 8:e1002426. 2012
    ..These findings enhance our understanding of the molecular link between oxygen and evolution. They also show the significance of chemoinformatics in addressing basic biological questions...
  7. doi request reprint Historical variation of structural novelty in a natural product library
    De Xin Kong
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, P R China
    Chem Biodivers 8:1968-77. 2011
    ....
  8. doi request reprint Oxidative DNA damage is important to the evolution of antibiotic resistance: evidence of mutation bias and its medicinal implications
    Zhong Yi Wang
    National Key Laboratory of Crop Genetic Improvement, Center for Bioinformatics, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, P R China
    J Biomol Struct Dyn 31:729-33. 2013
    ..Thus, we propose that consolidating the DNA repair systems of bacteria may be a viable strategy for preventing antibiotic resistance. (1)These authors contributed equally to this work. ..
  9. doi request reprint Can medical genetics and evolutionary biology inspire drug target identification?
    Zhong Yi Wang
    National Key Laboratory of Crop Genetic Improvement, Center for Bioinformatics, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, P R China
    Trends Mol Med 18:69-71. 2012
    ....
  10. doi request reprint The draft genome of sweet orange (Citrus sinensis)
    Qiang Xu
    Key Laboratory of Horticultural Plant Biology Ministry of Education, Huazhong Agricultural University, Wuhan, China
    Nat Genet 45:59-66. 2013
    ..This draft genome represents a valuable resource for understanding and improving many important citrus traits in the future...
  11. ncbi request reprint Chemoinformatics approaches for traditional Chinese medicine research and case application in anticancer drug discovery
    Xue Juan Li
    National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, PR China
    Curr Drug Discov Technol 7:22-31. 2010
    ..Recent progress on the use of chemoinformatics in TCM research will be discussed and an example of the preliminary application of chemoinformatics methods in anticancer drug design will be provided...
  12. ncbi request reprint tRNA-dependent cysteine biosynthetic pathway represents a strategy to increase cysteine contents by preventing it from thermal degradation: thermal adaptation of methanogenic archaea ancestor
    Ge Qu
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    J Biomol Struct Dyn 27:111-4. 2009
    ....