Guiqing Peng

Summary

Affiliation: Huazhong Agricultural University
Country: China

Publications

  1. Wang G, Liang R, Liu Z, Shen Z, Shi J, Shi Y, et al. The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in Piglets. Viruses. 2019;11: pubmed publisher
    ..Importantly, the optimized reverse genetics platform used in this study will simplify the construction of mutant infectious clones and help accelerate progress in coronavirus research. ..
  2. Zheng A, Shi Y, Shen Z, Wang G, Shi J, Xiong Q, et al. Insight into the evolution of nidovirus endoribonuclease based on the finding that nsp15 from porcine Deltacoronavirus functions as a dimer. J Biol Chem. 2018;293:12054-12067 pubmed publisher
    ..Our findings provide a theoretical basis for improving our understanding of NendoU evolution and offer useful clues for designing drugs and vaccines against nidoviruses. ..
  3. Zeng Z, Deng F, Shi K, Ye G, Wang G, Fang L, et al. Dimerization of Coronavirus nsp9 with Diverse Modes Enhances Its Nucleic Acid Binding Affinity. J Virol. 2018;92: pubmed publisher
    ..Importantly, these findings may provide a new insight for antiviral drug development. ..
  4. Wang J, Deng F, Ye G, Dong W, Zheng A, He Q, et al. Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses. Virol Sin. 2016;31:49-56 pubmed publisher
    ..CCL94 (cat kidney) cells could be infected efficiently by TGEV but not PEDV. Overall, our study provides new insights into the mechanisms of viral entry and forms a basis for antiviral drug screening. ..
  5. Shi Y, Li Y, Lei Y, Ye G, Shen Z, Sun L, et al. A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of Porcine Reproductive and Respiratory Syndrome Virus nsp11. J Virol. 2016;90:4579-4592 pubmed publisher
  6. Li Y, Dong W, Shi Y, Deng F, Chen X, Wan C, et al. Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication. Virology. 2016;488:216-24 pubmed publisher
    ..Thus, we propose that during RABV infection, P binds to L9 that translocates from the nucleus to the cytoplasm, inhibiting the initial stage of RABV transcription. ..
  7. Deng F, Ye G, Liu Q, Navid M, Zhong X, Li Y, et al. Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains. Viruses. 2016;8:55 pubmed publisher
    ..Understanding the differences in receptor binding between the prototype and the variant strains may provide insight into PEDV pathogenesis. ..
  8. Ye G, Deng F, Shen Z, Luo R, Zhao L, Xiao S, et al. Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease. Virology. 2016;494:225-35 pubmed publisher
  9. Zeng Z, Li T, Jin X, Peng F, Song N, Peng G, et al. Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016. Virol Sin. 2017;32:298-306 pubmed publisher

More Information

Publications11

  1. Shi Y, Lei Y, Ye G, Sun L, Fang L, Xiao S, et al. Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus. Vet Microbiol. 2018;213:114-122 pubmed publisher
    ..In summary, compounds 2 and 3 exhibit broad-spectrum antiviral activity and may facilitate the development of antiviral drugs against PRRSV and PEDV. ..
  2. Shen Z, Ye G, Deng F, Wang G, Cui M, Fang L, et al. Structural Basis for the Inhibition of Host Gene Expression by Porcine Epidemic Diarrhea Virus nsp1. J Virol. 2018;92: pubmed publisher
    ..Importantly, our structural data are conducive to understanding the mechanism of PEDV nsp1 inhibition of the expression of host genes and may aid in the development of a new attenuated vaccine. ..