Xiangmin Li

Summary

Affiliation: Huazhong Agricultural University
Country: China

Publications

  1. Qian S, Fan W, Liu T, Wu M, Zhang H, Cui X, et al. Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage. J Virol. 2017;91: pubmed publisher
    ..We also found that SVV is sensitive to IFN-β. These findings increase our understanding of the interaction between SVV and host innate immunity. ..
  2. Zhang H, Wen W, Hao G, Chen H, Qian P, Li X. A Subunit Vaccine Based on E2 Protein of Atypical Porcine Pestivirus Induces Th2-type Immune Response in Mice. Viruses. 2018;10: pubmed publisher
    ..This observation indicates that the E2 subunit vaccine induces a Th2-type immune response. Our results showed that E2 protein can be developed as a safe and effective subunit vaccine for the control of APPV infection. ..
  3. Zhang H, Wen W, Zhao Z, Wang J, Chen H, Qian P, et al. Enhanced protective immunity to CSFV E2 subunit vaccine by using IFN-γ as immunoadjuvant in weaning piglets. Vaccine. 2018;36:7353-7360 pubmed publisher
    ..Therefore, E2 + IFN-γ subunit vaccine is a promising marker vaccine candidate for the control and eradication of CSF. ..
  4. Li X, Zhu Q, Cao Q, Chen H, Qian P. Japanese encephalitis virus upregulates the expression of SOCS3 in mouse brain and Raw264.7 Cells. Viruses. 2014;6:4280-93 pubmed publisher
    ..Taken together, our data showed that JEV early infection could induce the upregulation of SOCS3 expression, both in vitro and in vivo, providing the basic theoretical foundation for future research on the invasion mechanism of JEV. ..
  5. Zhang H, Qian P, Liu L, Qian S, Chen H, Li X. Virus-like particles of chimeric recombinant porcine circovirus type 2 as antigen vehicle carrying foreign epitopes. Viruses. 2014;6:4839-55 pubmed publisher
    ..Results show that PCV2 VLPs can be used as an efficient antigen carrier for delivery of foreign epitopes, and a potential novel vaccine. ..
  6. Zhang H, Qian P, Peng B, Shi L, Chen H, Li X. A novel subunit vaccine co-expressing GM-CSF and PCV2b Cap protein enhances protective immunity against porcine circovirus type 2 in piglets. Vaccine. 2015;33:2449-56 pubmed publisher
    ..Thus, the novel Cap-GM-CSF subunit vaccine has the potential to be used as an effective and safe vaccine candidate against PCV2 infection. ..
  7. Li X, Liu R, Tang H, Jin M, Chen H, Qian P. Induction of protective immunity in swine by immunization with live attenuated recombinant pseudorabies virus expressing the capsid precursor encoding regions of foot-and-mouth disease virus. Vaccine. 2008;26:2714-22 pubmed publisher
    ..Our results showed that the recombinant PRV-P1 can induce not only humoral and cell-mediated immune responses but also partial protection against FMDV challenge, making it a good candidate for future development of the FMD vaccine. ..
  8. Qian S, Fan W, Qian P, Zhang D, Wei Y, Chen H, et al. Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. Viruses. 2015;7:1613-26 pubmed publisher
    ..Studies on applying apigein in vivo are required for drug development and further identification of potential drug targets against FDMV infection. ..
  9. Qian P, Zhi X, Wang B, Zhang H, Chen H, Li X. Construction and immune efficacy of recombinant pseudorabies virus expressing PrM-E proteins of Japanese encephalitis virus genotype І. Virol J. 2015;12:214 pubmed publisher
    ..PRV TK(-)/gE(-)/PrM-E(+) is a potential vaccine candidate against PRV and JEV GI infection in the future. ..

More Information

Publications16

  1. Zhang G, Chen X, Qian P, Chen H, Li X. Immunogenicity of a recombinant Sendai virus expressing the capsid precursor polypeptide of foot-and-mouth disease virus. Res Vet Sci. 2016;104:181-7 pubmed publisher
    ..Our results indicated that the recombinant SeV-P1 virus could be utilized as an alternative strategy to develop a new generation of safety and efficacious vaccine against FMDV infection. ..
  2. Qian S, Fan W, Qian P, Chen H, Li X. Isolation and full-genome sequencing of Seneca Valley virus in piglets from China, 2016. Virol J. 2016;13:173 pubmed
    ..Moreover, veterinarians must pay attention to this vesicular disease and reinforce biosecurity measures and prevent SVV spread. ..
  3. Fan W, Qian P, Wang D, Zhi X, Wei Y, Chen H, et al. Integrin ?v?3 promotes infection by Japanese encephalitis virus. Res Vet Sci. 2017;111:67-74 pubmed publisher
    ..Moreover, integrin ?v mediates JEV infection in viral binding stage of life cycle. Therefore, our study suggested that integrin ?v and ?3 serve as a host factor associated with JEV entry into the target cells. ..
  4. Xu J, Qian P, Wu Q, Liu S, Fan W, Zhang K, et al. Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo. Antiviral Res. 2014;109:22-9 pubmed publisher
    ..These results suggest that sIFITM3 is a promising antiviral agent and that can safeguard the host from infection with FMDV. ..
  5. Fan W, Zhang D, Qian P, Qian S, Wu M, Chen H, et al. Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism. Antiviral Res. 2016;127:32-40 pubmed publisher
    ..These results suggest that the intracellular neutralization features of FMDV contribute to the antiviral activity of sTRIM21. sTRIM21 provide another intracellular mechanism to inhibit FMDV infection in infected cells. ..
  6. Fan W, Qian S, Qian P, Li X. Antiviral activity of luteolin against Japanese encephalitis virus. Virus Res. 2016;220:112-6 pubmed publisher
    ..With a time-of-drug addition assay revealing that JEV replication was inhibited by luteolin after the entry stage. Overall, our results suggested that luteolin can be used to develop an antiviral drug against JEV. ..
  7. Zhang H, Zheng H, Qian P, Xu J, Yang X, Zhou R, et al. Induction of systemic IFITM3 expression does not effectively control foot-and-mouth disease viral infection in transgenic pigs. Vet Microbiol. 2016;191:20-6 pubmed publisher
    ..Based on these observations, we propose that a combination of interferons and vaccines be used to control FMDV infections and subsequent FMD outbreaks. ..