Li Li


Affiliation: Huazhong Agricultural University
Country: China


  1. Lin W, Guo H, Wang L, Zhang D, Wu X, Li L, et al. Nitrite Enhances MC-LR-Induced Changes on Splenic Oxidation Resistance and Innate Immunity in Male Zebrafish. Toxins (Basel). 2018;10: pubmed publisher
    ..Our results clearly demonstrate that nitrite and MC-LR exert synergistic suppressive effects on fish innate immunity via interfering antioxidant responses, and their joint toxicity should not be underestimated in eutrophic lakes. ..
  2. Lin W, Guo H, Li Y, Wang L, Zhang D, Hou J, et al. Single and combined exposure of microcystin-LR and nitrite results in reproductive endocrine disruption via hypothalamic-pituitary-gonadal-liver axis. Chemosphere. 2018;211:1137-1146 pubmed publisher
  3. Hou J, Su Y, Lin W, Guo H, Li L, Anderson D, et al. Estrogenic potency of MC-LR is induced via stimulating steroidogenesis: In vitro and in vivo evidence. Environ Pollut. 2018;240:615-622 pubmed publisher
  4. Lin W, Hou J, Guo H, Li L, Wang L, Zhang D, et al. The synergistic effects of waterborne microcystin-LR and nitrite on hepatic pathological damage, lipid peroxidation and antioxidant responses of male zebrafish. Environ Pollut. 2018;235:197-206 pubmed publisher
  5. Li L, Xie P, Guo L. Antioxidant response in liver of the phytoplanktivorous bighead carp (Aristichthys nobilis) intraperitoneally-injected with extracted microcystins. Fish Physiol Biochem. 2010;36:165-72 pubmed publisher
  6. Hou J, Li L, Xue T, Long M, Su Y, Wu N. Damage and recovery of the ovary in female zebrafish i.p.-injected with MC-LR. Aquat Toxicol. 2014;155:110-8 pubmed publisher
    ..Although the negative effects of MC-LR can be overcome by ovarian antioxidant system in this study, the potential reproductive risks of MC-LR should not be neglected because of its wide occurrence. ..
  7. Hou J, Li L, Xue T, Long M, Su Y, Wu N. Hepatic positive and negative antioxidant responses in zebrafish after intraperitoneal administration of toxic microcystin-LR. Chemosphere. 2015;120:729-36 pubmed publisher
    ..These results illustrated that antioxidant status played an important role in zebrafish protection against MC-LR-caused oxidative stress through regulating antioxidant enzyme gene expression and activities. ..
  8. Hou J, Li L, Wu N, Su Y, Lin W, Li G, et al. Reproduction impairment and endocrine disruption in female zebrafish after long-term exposure to MC-LR: A life cycle assessment. Environ Pollut. 2016;208:477-85 pubmed publisher
  9. Su Y, Li L, Hou J, Wu N, Lin W, Li G. Life-cycle exposure to microcystin-LR interferes with the reproductive endocrine system of male zebrafish. Aquat Toxicol. 2016;175:205-12 pubmed publisher

More Information


  1. Hou J, Su Y, Lin W, Guo H, Xie P, Chen J, et al. Microcystin-LR retards gonadal maturation through disrupting the growth hormone/insulin-like growth factors system in zebrafish. Ecotoxicol Environ Saf. 2017;139:27-35 pubmed publisher
    ..Our results provide evidence that MC-LR at environmentally relevant concentrations is able to induce impairments on fish gonadal development. ..
  2. Lin W, Hou J, Guo H, Qiu Y, Li L, Li D, et al. Dualistic immunomodulation of sub-chronic microcystin-LR exposure on the innate-immune defense system in male zebrafish. Chemosphere. 2017;183:315-322 pubmed publisher
  3. Long M, Lin W, Hou J, Guo H, Li L, Li D, et al. Dietary supplementation with selenium yeast and tea polyphenols improve growth performance and nitrite tolerance of Wuchang bream (Megalobrama amblycephala). Fish Shellfish Immunol. 2017;68:74-83 pubmed publisher
    ..In conclusion, a basal diet supplemented with the combination of 0.50 mg/kg selenium yeast and 50 mg/kg tea polyphenols could effectively improve growth performance and nitrite resistance in Wuchang bream. ..