Zhi Li Huang

Summary

Country: China

Publications

  1. ncbi request reprint The role of adenosine in the regulation of sleep
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Top Med Chem 11:1047-57. 2011
  2. ncbi request reprint Sleep regulation in adenosine A2A receptor-deficient mice
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    Neurology 61:S94-6. 2003
  3. ncbi request reprint Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 23:5975-83. 2003
  4. pmc Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:17949-54. 2006
  5. ncbi request reprint Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
  6. pmc Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92. 2006
  7. doi request reprint Drug delivery through a chronically implanted stomach catheter improves efficiency of evaluating wake-promoting components
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    J Neurosci Methods 175:58-63. 2008
  8. pmc Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Neurosci 31:10067-75. 2011
  9. ncbi request reprint Prostaglandins and adenosine in the regulation of sleep and wakefulness
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Opin Pharmacol 7:33-8. 2007
  10. ncbi request reprint Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka, Japan
    Drug News Perspect 17:105-9. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint The role of adenosine in the regulation of sleep
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Top Med Chem 11:1047-57. 2011
    ..The potential therapeutic applications of agonists and antagonists of these receptors in sleep disorders are briefly discussed...
  2. ncbi request reprint Sleep regulation in adenosine A2A receptor-deficient mice
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    Neurology 61:S94-6. 2003
  3. ncbi request reprint Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 23:5975-83. 2003
    ..Furthermore, EP4 agonist perfusion into the TMN induced wakefulness. These findings indicate that PGE2 induces wakefulness through activation of the histaminergic system via EP4 receptors...
  4. pmc Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:17949-54. 2006
    ..These results clearly show that the lipocalin-type PGDS/PGD2/DP1R system plays pivotal roles in the regulation of physiological sleep...
  5. ncbi request reprint Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
    ..Thus, caffeine-induced wakefulness depends on adenosine A2A receptors...
  6. pmc Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92. 2006
    ....
  7. doi request reprint Drug delivery through a chronically implanted stomach catheter improves efficiency of evaluating wake-promoting components
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    J Neurosci Methods 175:58-63. 2008
    ..These results indicate that oral administration through a chronic stomach catheter is a useful way for evaluating wake-promoting components...
  8. pmc Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Neurosci 31:10067-75. 2011
    ..Our observations suggest that caffeine promotes arousal by activating pathways that traditionally have been associated with motivational and motor responses in the brain...
  9. ncbi request reprint Prostaglandins and adenosine in the regulation of sleep and wakefulness
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Opin Pharmacol 7:33-8. 2007
    ....
  10. ncbi request reprint Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka, Japan
    Drug News Perspect 17:105-9. 2004
    ..The results reported herein may provide new insights into the molecular mechanisms of sleep-wake regulation and may lead to the development of new anti-sleep drugs as well as new hypnotic agents...
  11. doi request reprint How do the basal ganglia regulate sleep-wake behavior?
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Trends Neurosci 35:723-32. 2012
    ..Furthermore, we propose a model whereby adenosine and dopamine receptors in the nucleus accumbens (NAc) are involved in the integration of behavioral processes and the induction of wakefulness through cortical activation...
  12. pmc Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep
    Yo Oishi
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 105:19992-7. 2008
    ..These results indicate that endogenous adenosine in the TMN suppresses the histaminergic system via A(1)R to promote NREM sleep...
  13. doi request reprint Crocin promotes non-rapid eye movement sleep in mice
    Mika Masaki
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka, Japan
    Mol Nutr Food Res 56:304-8. 2012
    ..These compounds did not change the amount of REM sleep or show any adverse effects, such as rebound insomnia, after the induction of sleep...
  14. ncbi request reprint Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep
    Tetsuya Okada
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Biochem Biophys Res Commun 312:29-34. 2003
    ..These results demonstrate that the leptomeninges control the extracellular level of adenosine in the subarachnoid space by their high 5(')-nucleotidase and ADA activities and regulate non-rapid eye movement sleep...
  15. pmc Role of the basal ganglia in the control of sleep and wakefulness
    Michael Lazarus
    International Institute for Integrative Sleep Medicine WPI IIIS, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan Electronic address
    Curr Opin Neurobiol 23:780-5. 2013
    ....
  16. doi request reprint Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Neurosci 28:8462-9. 2008
    ..However, pretreatment of D(2)R KO mice with D(1)R antagonist completely abolished arousal effects of modafinil. These findings strongly indicate that dopaminergic D(1)R and D(2)R are essential for the wakefulness induced by modafinil...
  17. pmc Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid
    Takahisa Kanekiyo
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 104:6412-7. 2007
    ..Our findings may provide a diagnostic and therapeutic approach for AD...
  18. doi request reprint Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats
    Yi Qun Wang
    Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai, China
    J Neurochem 120:314-24. 2012
    ....