Research Topics
Genomes and GenesSpecies | Xiao Jun HuangSummaryCountry: China Publications
| Collaborators
|
Detail Information
Publications
The superiority of haploidentical related stem cell transplantation over chemotherapy alone as postremission treatment for patients with intermediate- or high-risk acute myeloid leukemia in first complete remissionXiao Jun Huang
Beijing Key Laboratory of Hematopoletic Stem Cell Transplantation, Peking University People s Hospital and Peking University Institute of Hematology, Beijing, China
Blood 119:5584-90. 2012..Our results suggest that HRD-HSCT is superior to chemotherapy alone as postremission treatment for AML...
Multicenter, randomized, open-label study comparing the efficacy and safety of micafungin versus itraconazole for prophylaxis of invasive fungal infections in patients undergoing hematopoietic stem cell transplantXiaojun Huang
Peking University People s Hospital, Beijing, China
Biol Blood Marrow Transplant 18:1509-16. 2012..00, chi-square test). Micafungin was as effective as itraconazole in preventing invasive fungal infections in patients with neutropenia. In comparison to itraconazole, treatment tolerance was much better with micafungin...
Allogeneic hematopoietic stem cell transplantation in China: where we are and where to goMeng Lv
Peking University People s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No 11 Xizhimen South Street, Beijng 100044, China
J Hematol Oncol 5:10. 2012..This review will describe the current situation and provide a prospective of these unique aspects of Allo-HSCT in China...
A multicenter, open-label study of posaconazole oral suspension in the treatment of invasive fungal infections in patients refractory to or intolerant of first-line therapyXiaojun Huang
Peking University People s Hospital, Peking University Institute of Hematology, Beijing, China
Future Microbiol 7:201-9. 2012..Although initial studies have described its use in treating various fungal infections, its efficacy and safety in patients with invasive fungal infections remains to be further confirmed...
Low-dose methotrexate for the treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantationX J Huang
Institute of Hematology, Peking University, People Hospital, Beijing, China
Bone Marrow Transplant 36:343-8. 2005..6% in liver, 75% in mouth and 100% in the eye, among all enrolled patients. Side effects were minor. Short-term, low-dose MTX is a tolerable and an effective regimen for patients with aGVHD, cGVHD or post-DLI GVHD after allo-HSCT...
Treating donor mice with rhIL-11 and rhG-CSF promotes transplant-tolerance and preserves the effects of GVL after allogeneic bone marrow transplantationXiao Jun Huang
Peking University People s Hospital and Peking University Institute of Hematology, no 11, XiZhiMen South Street, Beijing 100044, China
Leuk Res 33:123-8. 2009..The 30 d leukemia-free survival improved significantly in F (70%) compared to C (0%), D (40%), and E (20%) (P<0.01). Thus, treating donor mice with rhIL-11 and rhG-CSF promoted transplant-tolerance and recipient survival...
HLA-mismatched/haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for chronic myeloid leukemia: improved outcomes in patients in accelerated phase and blast crisis phaseHuang Xiao-Jun
Peking University Institute of Hematology, People s Hospital, Beijing, China
Ann Med 40:444-55. 2008..Recently, we developed an effective method for haploidentical allo-HSCT achieving comparable outcomes to HLA-identical transplantation...
Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignanciesX J Huang
Peking University Institute of Hematology, People s Hospital, Beijing, PRC
Bone Marrow Transplant 38:291-7. 2006..0017). The results require confirmation and show that G-BM combined with PBSC from haploidentical family donors, without in vitro TCD, may be used as a good source of stem cells for allo-HSCT...
[A novel approach to HLA-mismatched transplantation]Xiao Jun Huang
Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Beijing Da Xue Xue Bao 36:229-33. 2004..To investigate the new methods of human leukocyte antigen (HLA) mismatched transplantation in patients with hematologic malignancies...
Modified donor lymphocyte infusion (DLI) for the prophylaxis of leukemia relapse after hematopoietic stem cell transplantation in patients with advanced leukemia--feasibility and safety studyXiao Jun Huang
Peking University Institute of Hematology, People s Hospital, Beijing, 100044, People s Republic of China
J Clin Immunol 28:390-7. 2008..We retrospectively evaluated the feasibility and safety of a modified prophylactic donor lymphocytes infusion (DLI) approach in advanced leukemia...
Modified donor lymphocyte infusion after HLA-mismatched/haploidentical T cell-replete hematopoietic stem cell transplantation for prophylaxis of relapse of leukemia in patients with advanced leukemiaXiao Jun Huang
Institute of Hematology, People s Hospital, Peking University, No 11 Xizhimen South Street, 100044 Beijing, People s Republic of China
J Clin Immunol 28:276-83. 2008..3 +/- 9.6% at 3 years. Chronic GVHD was associated with a lower relapse rate and higher probability of LFS. Prophylactic-modified DLI is feasible in patients with advanced leukemia to prevent relapse after HLA-mismatched HCT...
Maintaining hyporesponsiveness and polarization potential of T cells after in vitro mixture of G-CSF mobilized peripheral blood grafts and G-CSF primed bone marrow grafts in different proportionsXiao Jun Huang
Peking University Institute of Hematology, People s Hospital, 42 Bei Li Shi Lu Beijing, 100044, China
Transpl Immunol 17:193-7. 2007..The immunological characteristics of T cells in G-BM and G-PB mixed in vitro in different proportions were investigated...
Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantationXiao Jun Huang
Institute of Hematology, People s Hospital, Peking University, Beijing, China
Haematologica 92:414-7. 2007..GVHD prophylaxis reduced the incidence of acute GVHD. Our primary data showed that G-CSF-primed DLI with GVHD prophylaxis was a potentially effective therapeutic option for patients who relapsed after haploidentical HSCT...
Individualized intervention guided by BCR-ABL transcript levels after HLA-identical sibling donor transplantation improves HSCT outcomes for patients with chronic myeloid leukemiaXiao Jun Huang
Peking University People s Hospital, Peking University Hematology Institute, Beijing, People s Republic of China
Biol Blood Marrow Transplant 17:649-56. 2011..Individualized intervention based on the post-HSCT BCR-ABL transcript level can decrease relapse and increase LFS of patients with CML after HLA-identical sibling HSCT...
Unmanipulated HLA-mismatched/haploidentical blood and marrow hematopoietic stem cell transplantationXiao Jun Huang
Peking University People s Hospital, Peking University Institute of Hematology, Beijing, People s Republic of China
Biol Blood Marrow Transplant 17:197-204. 2011....
A novel approach to human leukocyte antigen-mismatched transplantation in patients with malignant hematological diseaseXiao Jun Huang
Peking University Institute of Hematology, People s Hospital, Beijing 100044, China
Chin Med J (Engl) 117:1778-85. 2004..We developed a new technique for HLA mismatched allogeneic HSCT using G-CSF primed bone marrow plus G-CSF-mobilized peripheral blood stem cells without ex vivo T cell depletion...
Treatment of acute leukemia with unmanipulated HLA-mismatched/haploidentical blood and bone marrow transplantationXiao Jun Huang
Institute of Hematology, Peking University, Beijing, People s Republic of China
Biol Blood Marrow Transplant 15:257-65. 2009..001, relative risk [RR], 95% confidence interval [CI]: 2.94[1.535-5.631]) and the occurrence of aGVHD of grades 3 and 4 (P= .004). HLA-mismatched/haploidentical HSCT was feasible with unmanipulated blood and bone marrow harvest...
Current status of haploidentical stem cell transplantation for leukemiaXiao Jun Huang
Institute of Hematology, People s Hospital, Peking University, no 11, Xi Zhi Men South Street, Beijing, 10044, PR China
J Hematol Oncol 1:27. 2008....
[The therapeutic effects of FLAG regime for refractory and relapsing acute leukemia]Xiao Jun Huang
Institute of Hematology and People Hospital, Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 42:417-9. 2003..To investigate the therapeutic effects of FLAG regimen for refractory and relapsing acute leukemia...
Immune-related late-onset hemorrhagic cystitis post allogeneic hematopoietic stem cell transplantationXiao Jun Huang
Institute of Hematology, Peking University People s Hospital, Beijing, China
Chin Med J (Engl) 121:1766-9. 2008..The aim of this study was to analyze the alloimmune aetiology in the pathogenesis of LOHC post allogeneic hematopoietic stem cell transplantation (HSCT)...
Combined transplantation of G-CSF primed allogeneic bone marrow cells and peripheral blood stem cells in treatment of severe aplastic anemiaXiao-jun Huang
Peking University Institute of Hematology, People's Hospital, Beijing 100044, China
Chin Med J (Engl) 117:604-7. 2004
Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effectX J Huang
Peking University People s Hospital, Peking University Institute of Hematology, Beijing, People s Republic of China
Bone Marrow Transplant 44:309-16. 2009..Using immunosuppressive agents for 2-4 weeks may reduce DLI-associated acute GVHD without influencing relapse and survival after G-CSF-primed DLI...
Partially matched related donor transplantation can achieve outcomes comparable with unrelated donor transplantation for patients with hematologic malignanciesHuang Xiao-Jun
Peking University People s Hospital, Institute of Hematology, Beijing 100044, China
Clin Cancer Res 15:4777-83. 2009....
In vivo induction of T-cell hyporesponsiveness and alteration of immunological cells of bone marrow grafts using granulocyte colony-stimulating factorHuang Xiao Jun
Peking University, Institute of Hematology, People s Hospital, 42 Bei Li Shi Lu Beijing 100044, PR of China
Haematologica 89:1517-24. 2004..This study evaluated the function of T cells and the quantities of immunological cells of G-BM...
Immunomodulatory strategies for relapse after haploidentical hematopoietic stem cell transplantation in hematologic malignancy patientsXiao Jun Huang
Peking University People s Hospital, Peking University Institute of Hematology, No 11 Xizhimen South Street, Beijing, China
Best Pract Res Clin Haematol 24:351-8. 2011..Further elucidation of the underlying mechanisms that govern leukemia stem cell escape from immunosurveillance after haploidentical HSCT may broaden our understanding and lead to therapies that control relapse...
Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantationDao Pei Lu
Peking University Institute of Hematology, 11 Xizhimen South Street, Beijing 100044, China
Blood 107:3065-73. 2006..In summary, HCT performed with related HLA-mismatched donors is a feasible approach with acceptable outcomes...
Superior graft-versus-leukemia effect associated with transplantation of haploidentical compared with HLA-identical sibling donor grafts for high-risk acute leukemia: an historic comparisonYu Wang
Peking University People s Hospital, Institute of Hematology, Beijing, People s Republic of China
Biol Blood Marrow Transplant 17:821-30. 2011..048) patients. Our comparisons suggest that HID transplants can achieve a stronger graft-versus-leukemia (GVL) effect than ISD for high-risk acute leukemia patients...
Prognosis after unmanipulated HLA-haploidentical blood and marrow transplantation is correlated to the numbers of KIR ligands in recipientsXiang Yu Zhao
Peking University Institute of Hematology, Peking University People s Hospital, Beijing, China
Eur J Haematol 78:338-46. 2007....
The impact of CD34+ cell dose on platelet engraftment in pediatric patients following unmanipulated haploidentical blood and marrow transplantationYing Jun Chang
Peking University People s Hospital, Peking University Institute of Hematology, Beijing, China
Pediatr Blood Cancer 53:1100-6. 2009..The aim of this study was to investigate the effects of donor and recipient characteristics on hematopoietic recovery in pediatric patients following unmanipulated haploidentical transplantation...
[Allogeneic hematopoietic stem cell transplantation for high-risk acute leukemia]Yu Wang
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 46:903-6. 2007..To retrospectively analyze the results of a consecutive series of 90 refractory/relapsed acute leukemia (AL) patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) in our center...
The impact of graft composition on clinical outcomes in pediatric patients undergoing unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantationDai Hong Liu
Peking University People s Hospital, Peking University Institute of Hematology, Beijing, China
Pediatr Blood Cancer 57:135-41. 2011..Therefore, the impact of graft composition on transplant outcomes was evaluated...
Clinical impact of absolute lymphocyte count on day 30 after unmanipulated haploidentical blood and marrow transplantation for pediatric patients with hematological malignanciesYing Jun Chang
Peking University People s Hospital, Peking University Institute of Hematology, Beijing, China
Am J Hematol 86:227-30. 2011..166; 95%CI 0.037-0.750; P = 0.020). Our results suggest that a higher ALC-30 ≥ 300 cells/μL) could be a useful and simple tool to predict pediatric patients with a superior outcome after unmanipulated haploidentical transplantation...
Prevention of relapse using DLI can increase survival following HLA-identical transplantation in patients with advanced-stage acute leukemia: a multi-center studyYu Wang
Peking University People s Hospital, Institute of Hematology, Beijing, China
Clin Transplant 26:635-43. 2012..001). Our comparisons suggest that the prophylactic use of DLI can significantly increase survival of patients with advanced-stage, acute leukemia who receive HLA-identical sibling HSCT...
The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplantationMing Rui Huo
Peking University People s Hospital, Peking Peking University Institute of Hematology, Beijing, China
Clin Transplant 26:284-91. 2012..Our results suggest that prospective matching of patients and donors for HLA-B antigen in the unshared HLA haplotype is warranted for HLA-mismatched/haploidentical transplantation...
Administration of imatinib after allogeneic hematopoietic stem cell transplantation may improve disease-free survival for patients with Philadelphia chromosome-positive acute lymphobla stic leukemiaHuan Chen
Peking University People s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, PR China
J Hematol Oncol 5:29. 2012....
Characteristics and influencing factors of CD19+ B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantationMin Xie
Peking University People s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No 11 Xizhimen South Street, Beijing, China
Int J Hematol 96:109-21. 2012..More HLA-mismatched loci may initiate a stronger humoral response toward alloantigens >180 days after HSCT, which may be beneficial for the eradication of minimal residual disease and protection from infection...
Platelet engraftment in patients with hematologic malignancies following unmanipulated haploidentical blood and marrow transplantation: effects of CD34+ cell dose and disease statusYing Jun Chang
Peking University Institute of Hematology, Peking University People s Hospital, Beijing, China
Biol Blood Marrow Transplant 15:632-8. 2009..Our results suggest that low numbers of CD34(+) cells in allografts and advanced-stage disease may be critical factors associated with delayed platelet engraftment after unmanipulated haploidentical transplantation...
Influence of lymphocyte recovery on outcome of haploidentical transplantation for hematologic malignanciesYing Jun Chang
Peking University People s Hospital, Peking University Institute of Hematology, No 11 Xizhimen South Street, Beijing, China
Medicine (Baltimore) 88:322-30. 2009..211; 95% CI, 0.097-0.457; p < 0.0001). Our results suggest that the recovery of ALC-30 might have an influence on transplant outcomes following unmanipulated HLA-mismatched/haploidentical transplantation...
[Randomized clinical study for two types of recombinant human granulocyte colony-stimulating factor mobilizing peripheral blood and bone marrow stem cells in patients receiving allogeneic hematopoietic stem cell transplantation]Xiao hui Zhang
Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Zhonghua Yi Xue Za Zhi 89:2116-9. 2009....
First-line therapy for chronic graft-versus-host disease that includes low-dose methotrexate is associated with a high response rateYu Wang
Peking University People s Hospital, Institute of Hematology, Beijing, People s Republic of China
Biol Blood Marrow Transplant 15:505-11. 2009....
[Factors influencing engraftment in hematological patients after human leukocyte antigen matched sibling allogeneic blood and marrow transplantation]Ying Jun Chang
Peking University People s Hospital and Peking University Institute of Hematology, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 48:647-50. 2009..To investigate the factors influencing engraftment in patients with hematological diseases after human leukocyte antigen matched sibling allogeneic blood and marrow transplantation...
Modified conditioning regimen busulfan-cyclophosphamide followed by allogeneic stem cell transplantation in patients with multiple myelomaXiao hui Zhang
Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Chin Med J (Engl) 120:463-8. 2007..In this study the toxicity and efficacy of modified myeloablative conditioning regimen followed by allogeneic stem cell transplantation was investigated in patients with multiple myeloma...
[Analysis of etiology of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation]Dai Hong Liu
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Yi Xue Za Zhi 87:124-7. 2007..To analyze the etiology and clinical features of late onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (HSCT)...
Reconstitution of natural killer cell receptor repertoires after unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation: analyses of CD94:NKG2A and killer immunoglobulin-like receptor expression and their associations with clinical oXiang Yu Zhao
Institute of Hematology, Peking University People s Hospital, Peking University, Beijing, People s Republic of China
Biol Blood Marrow Transplant 13:734-44. 2007..Furthermore, high levels of CD94 expression in donors or in recipients by day 60 might be a good predictor for poor prognosis...
Immune reconstitution following unmanipulated HLA-mismatched/haploidentical transplantation compared with HLA-identical sibling transplantationYing Jun Chang
Peking University People s Hospital and Institute of Hematology, Beijing 100044, China
J Clin Immunol 32:268-80. 2012..Our results suggest that the clinical outcomes were not compromised by the early delayed immune reconstitution following haploidentical transplantation...
Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantationChen hua Yan
Peking University People s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, Peoples Republic of China
Blood 119:3256-62. 2012..006, OR = 0.436, respectively). These data suggest that risk stratification-directed interventions with modified DLI in patients with standard-risk acute leukemia who are MRD(+) after transplantation may improve transplantation outcomes...
Positive results of serum galactomannan assays and pulmonary computed tomography predict the higher response rate of empirical antifungal therapy in patients undergoing allogeneic hematopoietic stem cell transplantationYu Ji
Institute of Hematology, Peking University, Beijing, People s Republic of China
Biol Blood Marrow Transplant 17:759-64. 2011..Thus, we concluded that serum GM assays and pulmonary CT scan could find out patients who really need empirical antifungal therapy, which resulted in improving the efficiency of the treatment...
IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantationXiang Yu Zhao
Peking University People s Hospital and Peking University Institute of Haematology, Beijing, PR China
Eur J Immunol 41:514-26. 2011..Our results suggested that IL-17-producing T cells contributed to aGVHD. The application of G-CSF in vivo aided in reducing the occurrence of aGVHD through a decrease in IL-17 secretion by T cells...
[Donor peripheral stem cells infusion for the treatment of failure of platelet recovery after allogeneic hematopoietic stem cell transplantation]Yao Chen
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Yi Xue Za Zhi 87:964-6. 2007..To study the safety and effect of G-CSF mobilized donor hematopoietic stem cells infusion (GPBSCI) as the therapy for the failure of platelet recovery after allogeneic hematopoietic stem cell transplantation...
Imatinib mesylate versus allogeneic hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in the accelerated phaseQian Jiang
Peking University People s Hospital, Peking University Institute of Hematology, Beijing, China
Blood 117:3032-40. 2011..All trials were registered with the Chinese Clinical Trial Registry (www.chictr.org) as CHiCTR-TNC-10000955...
[The clinical analysis of nephrotic syndrome after allogeneic hematopoietic stem cell transplantation in one single center]Yao Chen
Department of Hematology, Peking University People s Hospital, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 50:572-5. 2011..To explore the incidence, diagnosis and treatment of nephrotic syndrome (NS) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in one single center...
[Abnormal expression of programmed cell death 5 gene in multiple myeloma patients]Li Bao
Peking University People Hospital, Peking University Institute of Hematology, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:634-7. 2010..47 and 1.28 +/- 1.21 respectively (p < 0.05). It is concluded that the PDCD5 protein expression levels are low in patients with MM. These findings suggest that abnormal expression of pdcd5 may be involved in the pathogenesis of MM...
[A comparative study of the curative effects of cytomegalovirus preemptive therapy in various kinds of hematopoietic stem-cell transplantation]Xiao su Zhao
Peking University Institute of Hematology and Peking University People s Hospital, Beijing, China
Zhonghua Nei Ke Za Zhi 48:476-80. 2009..Coherent preemptive therapy criterion was applied in various kinds of allogenic hematopoietic stem-cell transplant (allo-HSCT) recipients with cytomegalovirus (CMV) infection in order to evaluate its clinical value in various kinds of HSCT...
[Itraconazole for treatment of fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation]Jing Zhi Wang
Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 46:29-31. 2007..To investigate the effect of intravenous itraconazole on fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation...
Effects of the NK cell recovery on outcomes of unmanipulated haploidentical blood and marrow transplantation for patients with hematologic malignanciesYing Jun Chang
Peking University Institute of Hematology, Peking University People s Hospital, Beijing, People s Republic of China
Biol Blood Marrow Transplant 14:323-34. 2008..436; P = .059) and chronic GVHD (HR, 3.925; P = .028). Our results suggest that the recovery of NK cells is and can be used as an indicator to predicate the clinical outcomes after unmanipulated haploidentical transplantation...
[Donor lymphocyte infusion for treatment of relapse of leukemia after HLA-mismatched hematopoietic stem cell transplantation]Dai Hong Liu
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 29:78-82. 2008..To observe the efficacy and safety of donor lymphocyte infusion (DLI) for treatment of leukemia relapse after HLA-mismatched hematopoietic stem cell transplantation (HSCT)...
Hemorrhagic cystitis following hematopoietic stem cell transplantation: incidence, risk factors and association with CMV reactivation and graft-versus-host diseaseLan ping Xu
Peking University Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Chin Med J (Engl) 120:1666-71. 2007..This study determined the incidence and risk factors for HC after allo-HSCT and analyzed its association with CMV reactivation and GVHD...
Safety of recombinant human thrombopoietin in adults after related donor haploidentical haematopoietic stem cell transplantation: a pilot studyDai Hong Liu
People s Hospital Peking University, Institute of Hematology, Xicheng District, Beijing, People s Republic of China
Clin Drug Investig 31:135-41. 2011..The objective of this study was to evaluate the safety of recombinant human thrombopoietin (rhTPO) administration prior to engraftment in patients who received related donor haploidentical HSCT...
[Clinical features of cytomegalovirus pneumonia after allogeneic hematopoietic stem cell transplantation]Xiao su Zhao
Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Beijing Da Xue Xue Bao 41:548-53. 2009..To analyze the clinical features and prognosis of cytomegalovirus (CMV) pneumonia after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) under the preemptive therapy based on monitoring CMV-DNA level quantificationally...
[Transplantation of haploidentical hematopoietic stem cells from family members without in vitro T-cell depletion for treatment of hematologic malignancies in pediatric patients]Daihong Liu
Peking University People s Hospital Institute of Hematology, Peking University, Beijing 100044, China
Beijing Da Xue Xue Bao 41:291-6. 2009..To evaluate the efficacy and safety of haploidentical (from family member donors) hematopoietic stem cell transplantation (HSCT) for children with hematologic malignancies...
[Effect of different regimens on bone disease of multiple myeloma]Li Bao
Peking University People s Hospital, Peking University Institute of Hematology, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 32:221-5. 2011..To explore the difference of effects of two regimens (bortezomib and dexamethasone, BD; and thalidomide and dexamethasone, TD) on bone disease in multiple myeloma (MM)...
[The prognostic implications of secondary chromosomal aberrations in Philadelphia chromosome-positive chronic myeloid leukemia patients after imatinib mesylate treatment]Yan Zhang
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 46:648-50. 2007..To investigate the change of Philadelphia chromosome-positive clone with secondary chromosomal aberrations after imatinib mesylate (IM) treatment in patients with chronic myeloid leukemia (CML) and its relation with prognosis...
MPL W515L/K mutations in 343 Chinese adults with JAK2V617F mutation-negative chronic myeloproliferative disorders detected by a newly developed RQ-PCR based on TaqMan MGB probesGuo Rui Ruan
Peking University People s Hospital and Institute of Hematology, 11 Xi Zhi Men South Street, Beijing 100044, China
Hematol Oncol 28:33-9. 2010..It can also provide a quantitative estimate of mutant allele burden that might be useful for both patient prognosis and monitoring response to therapy...
[The efficacy and safety of mismatched hematopoietic stem cell transplantation for treatment of severe aplastic anemia]Wei Han
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 50:287-90. 2011..To study the efficacy and safety of human leukocyte antigen (HLA) mismatched hematopoietic stem cell transplantation (HSCT) on severe aplastic anemia (SAA)...
[Analysis of risk factors for the development of hemorrhagic cystitis post allogeneic hematopoietic stem cell transplantation]Hong Yu Zhang
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 28:243-6. 2007..To analyze the incidence and risk factors of hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT)...
[Quantitative analysis of dendritic cell subsets in bone marrow of patients with acute myeloid leukemia]Hai Rong Lin
Institute of Hematology, People Hospital, Peking University, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1249-54. 2009..The percentages of patients with mDC normal or mDC increase in AML-M4/5 subtypes are more than that in AML-M2/3 subtypes, while the pDC does not show difference between AML subtypes...
[Detection of common fusion transcript levels in untreated leukemia patients by real-time quantitative RT-PCR technique]Ya Zhen Qin
Institute of Hematology, People s Hospital of Peking University, Beijing 10004, China
Zhonghua Xue Ye Xue Za Zhi 28:433-7. 2007..To evaluate levels of common specific fusion transcripts M-bcr-abl, m-bcr-abl, TEL-AML1, AML1-ETO, PML-RAR alpha, CBF beta-MYH11 in untreated leukemia patients...
[The differences between recombinant human granulocyte colony-stimulating factor-primed and non-primed peripheral blood stem cell harvests]Xu Liang
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 46:566-8. 2007..To explore the differences between recombinant human granulocyte colony-stimulating factor (rhG-CSF) primed and non-primed peripheral blood stem cell harvests...
[Allogeneic stem cell transplantation for patients with Philadelphia positive leukemia resistant to imatinib]Wei Han
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Yi Xue Za Zhi 88:1974-7. 2008..To investigate the effect of allogeneic hemopoietic stem cell transplantation (HSCT) in patients with acute lymphocytic leukemia (ALL) or chronic myelocytic leukemia (CML) resistant to imatinib mesylate (IM)...
Imatinib mesylate resistance in a chronic myeloid leukemia patient with a novel e8a2 BCR-ABL transcript variantYa Zhen Qin
Peking University Institute of Hematology, Peking University People s Hospital, Beijing, People s Republic of China
Acta Haematol 120:146-9. 2008..The vast majority of chronic myeloid leukemia (CML) patients express the BCR-ABL transcript with the b2a2 (e13a2) and/or b3a2 (e14a2) junctions. However, some rare cases have atypical breakpoints...
[STI571 used in treating acute myeloid leukemia with Philadelphia chromosome]Hong Xia Shi
Institute of Hematology, People Hospital, Peking University, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:88-90. 2005..The case 2 died from interstitial pneumonia at 8 months after HSCT. In conclusion, STI571 is one of choice for the treatment of Philadelphia chromosome positive AML...
[The prevalence and risk factors of invasive fungal infection in hematopoietic stem cell transplant recipients]Lan ping Xu
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 46:486-9. 2007..To study the incidence and risk factors of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant (HSCT) recipients...
Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemiaHuan Chen
Peking University Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Chin Med J (Engl) 124:246-52. 2011..The aim of this study was to evaluate the safety and efficacy of imatinib in preventing hematological relapse when imatinib was administrated in the first 90 days after allo-HCT...
[The immunophenotypic analysis of CD7+ and (or) CD56+ acute myeloid leukemic stem cells and its applications in minimal residual disease detection]Hui Cao
People s Hospital of Peking University, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 29:23-8. 2008..To explore the immunophenotypic characteristics of CD7 and/or CD56 positive acute myeloid leukemic stem cells, and the relationship between minimal residual disease (MRD) and the leukemic stem cells (LSC)...
[The significance of serial monitoring of bcr-abl transcripts levels after allogeneic hematopoietic stem cell transplantation in screening chronic myeloid leukemia patients with low relapse]Lan ping Xu
Peking University Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 29:522-5. 2008..To explore dynamic status of bcr-abl transcript levels in chronic myeloid leukemia (CML) patients after allogeneic HSCT and to define low relapse patients who may not require further therapeutic intervention...
[Analysis of characteristics of 72 cases of t(8;21) acute myeloid leukemia]Yue yun Lai
Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
Beijing Da Xue Xue Bao 37:245-8. 2005..To investigate the laboratorial and clinical characteristics of t(8;21) AML, and to compare the differences between patients with additional chromosomal abnormalities and those without additional aberrations...
[A clinical study of allo-hematopoietic stem cell transplantation in HBsAg positive leukemia]Yao Chen
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 47:316-9. 2008..To explore the incidence and risk factors of hepatic events and overall survival among HBsAg positive leukemia patients after allo-hematopoietic stem cell transplantation (allo-HSCT)...
[Relationship between copies of cytomegalovirus in plasma and cytomegalovirus disease after allogeneic hematopoietic stem cell transplantation]Yu Hong Chen
Hematology Institute, Peking University People s Hospital, Beijing 100044, China
Zhonghua Yi Xue Za Zhi 89:1540-3. 2009..To evaluate the clinical significance of using real-time quantitative polymerase chain reaction (RQ-PCR) in monitoring cytomegalovirus infection in allogenic hemopoietic stem-cell transplant (allo-HSCT) recipients...
[Pharmacokinetics of antithymocyte globulin in recipients under-going HLA partially matched hematopoietic stem cell transplantation]Xiao hui Zhang
Institute of Hematology and People Hospital, Peking University, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:152-5. 2007..There is no racial difference in the pharmacokinetics of ATG...
[Mycophenolate mofetil in treatment of graft-versus-host disease after allogeneic hematopoietic cell transplantation: analysis of 44 cases]Huan Chen
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Yi Xue Za Zhi 88:2127-30. 2008....
High CD4/CD8 ratio in allografts predicts adverse outcomes in unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation for chronic myeloid leukemiaLan ping Xu
Peking University Institute of Hematology, Peking University People s Hospital, No 11 Xizhimen, South Street, Beijing, 100044, China
Ann Hematol 88:1015-24. 2009..No other clinical parameter was influenced by graft composition. Our results suggest that a high CD4/CD8 ratio in allografts may predict adverse survival in patients with CML undergoing haplo-mismatched HSCT...
[Comparative analysis of naive and memory CD4(+) and CD8(+) T-cell subsets in rhG-CSF mobilized peripheral blood and steady-state bone marrow]Ming Rui Huo
Institute of Hematology and People Hospital, Peking University, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:605-9. 2008....
[Investigation of plasmacytoid dendritic cell reconstitution and its relationship with cGVHD and relapse after haploidentical hematopoietic stem cell transplantation]Ji Ying Wu
Institute of Hematology and People Hospital, Peking University, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:342-7. 2007....
[Application of ricin-immunotoxin mediated T cell depletion to allogeneic hematopoietic stem cell transplantation]Yue yun Lai
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 12:270-3. 2004....
Expression of CD62L on donor CD4(+) T cells in allografts: correlation with graft-versus-host disease after unmanipulated allogeneic blood and marrow transplantationYing Jun Chang
Peking University Institute of Hematology, Peking University People s Hospital, Beijing 100044, China
J Clin Immunol 29:696-704. 2009..The aim of this study was to investigate the association of donor CD4(+) T cells expressing CD62L with transplant outcomes...
Expression profiles of adhesion molecules on naïve T cells in bone marrow grafts of healthy donors treated with granulocyte colony-stimulating factorYing Jun Chang
Peking University Institute of Hematology, Peking University People s Hospital, Beijing, China
Transpl Immunol 21:228-33. 2009..The aim of this study was to investigate the profiles of adhesion molecule expression on naïve T cells in bone marrow grafts of healthy donors treated with G-CSF...
[PRAME mRNA expression in newly diagnosed acute myeloid leukemia patients and its application to monitoring minimal residual disease]Ya Zhen Qin
Institute of Hematology, People s Hospital of Peking University, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 29:441-5. 2008..To investigate the expression level of preferentially expressed antigen of melanoma (PRAME) mRNA in newly diagnosed acute myeloid leukemia (AML) patients and evaluate its usefulness for detecting minimal residual disease (MRD)...
[Immune tolerance induced by cytokines in allogeneic hematopoietic stem cell transplantation]Ying Jun Chang
Peking University People s Hospital and Peking University Institute of Hematology, Beijing 100044, China
Beijing Da Xue Xue Bao 41:208-11. 2009..Further studies on the mechanism of the separation of GVL and GVHD are warranted...
[Influence factors of reconstitution of killer cell immunoglobulin-like receptor on NK cells following non-T-cell-depleted haploidentical hematopoietic stem cell transplantation]Xiang Yu Zhao
Peking University Institute of Hematology, People s Hospital, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 28:103-6. 2007..To explore the influence factors of reconstitution of killer cell immunoglobulin-like receptor (KIR) on NK cells in the early stage after non-T cells depletion (non-TCD) HLA-mismatched hematopoietic stem cell transplantation (HSCT)...
[Effect of bone marrow graft collection on composition of peripheral blood stem cell grafts from healthy donors after recombinant human granulocyte colony-stimulating factor application in vivo for mobilization]Ying Jun Chang
People s Hospital and Institute of Hematology, Peking University, Bejing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:610-3. 2008....
[Chimeric anti-CD25 monoclonal antibody for treating acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation]Jing Zhi Wang
Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 47:923-5. 2008..To investigate the efficacy of chimeric anti-CD(25) monoclonal antibody (basiliximab) on acute graft-versus-host disease (GVHD) in patients following allogeneic hematopoietic stem cell transplantation...
[Reconstitution dynamics of plasmacytoid and myeloid dendritic cell precursors after allogeneic HLA mismatched/ haploidentical hematopoietic stem cell transplantation]Ji Ying Wu
Institute of Hematology and People s Hospital, Peking University, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 28:73-7. 2007..To explore the characteristics and significance of reconstitution of peripheral blood dendritic cells (DCs) after HLA haploidentical hematopoietic stem cell transplantation (HSCT)...
[The prognostic analysis of KIR ligand mismatch in HLA-mismatched hematopoietic stem cell transplantation]Xiang Yu Zhao
Institute of Hematology, People s Hospital of Peking University, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 29:316-20. 2008..To evaluate the prognostic implication of the killer-immunoglobulin like receptor (KIR) ligand mismatch in HLA mismatched hematopoietic stem cell transplantation (HSCT)...
[The significance of dynamic detection of WT1 expression on patients of hematologic malignancy following allogeneic hematopoietic stem cell transplantation]Song Jin
Institute of Hematology, People s Hospital of Peking University, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 47:578-81. 2008....
[The efficacy of imatinib mesylate for 124 patients with chronic myeloid leukemia in accelerated and blastic phase]Qian Jiang
Peking University, Institute of Hematology, People s Hospital, Beijing, China
Zhonghua Xue Ye Xue Za Zhi 28:721-6. 2007..To evaluate the efficacy and safety of imatinib mesylate (imatinib) for patients with Philadelphia chromosome-positive (Ph+ ) chronic myeloid leukemia (CML) in accelerated and blastic phase...
[CD34 cells and T cell subsets in recombinant human granulocyte colony-stimulating factor primed bone marrow grafts from donors with different characteristics]Ying Jun Chang
Peking University Institute of Hematology and Peking University People s Hospital, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 29:512-6. 2008..To investigate the cell composition in granulocyte colony-stimulating factor One (rhG-CSF) primed bone marrow grafts (G-BM) from donors with different characteristics...
[The value of serum galactomannan detection for diagnosis of invasive aspergillosis in hematopoietic stem cell transplant recipients]Yu Ji
Institute of Hematology and People s Hospital, Peking University, Beijing 100044, China
Zhonghua Xue Ye Xue Za Zhi 28:83-6. 2007..To evaluate the value of serum galactomannan (GM) detection for diagnosis of invasive aspergillosis (IA) in hematopoietic stem cell transplant recipients...
A novel triple-regulated oncolytic adenovirus carrying PDCD5 gene exerts potent antitumor efficacy on common human leukemic cell linesMin Xie
Peking University People s Hospital and Institute of Hematology, Beijing, China
Apoptosis 14:1086-94. 2009..We concluded that the triple-regulated SG611-PDCD5, as a more potent and safer antitumor therapeutic, could provide a new strategy for leukemia biotherapy...
[A clinical study of lymphoproliferative disorders following allogeneic hematopoietic stem cell transplantation]Lan ping Xu
Institute of Hematology, People s Hospital, Peking University, Beijing, China
Zhonghua Nei Ke Za Zhi 46:996-9. 2007..To study the risk factors and clinical characteristics of post transplantation lymphoproliferative disorders (PTLD) after hematopoietic stem cell transplantation (HSCT)...
[Valganciclovir for treatment of cytomegalovirus viremia in patients following allogeneic hematopoietic stem cell transplantation]Yu Wang
Institute of Hematology, People s Hospital of Peking University, Beijing100044, China
Zhonghua Yi Xue Za Zhi 88:3265-7. 2008..To investigate the efficacy and safety of valganciclovir in treatment of cytomegalovirus viremia in patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT)...
[Secondary prophylaxis of invasive fungal infection in haematopoietic stem cell recipients]Lan ping Xu
Peking University Institute of Hematology, Beijing 100044, China
Zhonghua Nei Ke Za Zhi 48:853-6. 2009..To investigate the efficacy and safety of secondary anti-fungal prophylaxis (SAP) in haematopoietic stem cell recipients who had a history of antecedent invasive fungal infection (IFI)...
