Di Huang

Summary

Country: China

Publications

  1. pmc Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement
    Di Huang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China
    Microb Cell Fact 12:52. 2013
  2. doi Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis
    Menglei Xia
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China
    Biotechnol Bioeng 110:2717-30. 2013
  3. ncbi Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies
    Di Huang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People s Republic of China
    J Ind Microbiol Biotechnol 40:1023-37. 2013
  4. doi In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement
    Di Huang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People s Republic of China
    Appl Microbiol Biotechnol 94:637-49. 2012
  5. doi Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus
    Sumin Zhao
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People s Republic of China
    Appl Microbiol Biotechnol 97:5329-41. 2013
  6. pmc Model-Driven Redox Pathway Manipulation for Improved Isobutanol Production in Bacillus subtilis Complemented with Experimental Validation and Metabolic Profiling Analysis
    Haishan Qi
    Key Laboratory of System Bioengineering, Ministry of Education, Tianjin University, Tianjin, People s Republic of China Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People s Republic of China
    PLoS ONE 9:e93815. 2014
  7. doi Rational medium optimization based on comparative metabolic profiling analysis to improve fumaric acid production
    Guanyi Wang
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    Bioresour Technol 137:1-8. 2013
  8. pmc Rational improvement of the engineered isobutanol-producing Bacillus subtilis by elementary mode analysis
    Shanshan Li
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    Microb Cell Fact 11:101. 2012
  9. ncbi Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies
    Wenjie Du
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People s Republic of China
    J Ind Microbiol Biotechnol 41:1131-43. 2014
  10. doi Metabolic profiling of a Rhizopus oryzae fumaric acid production mutant generated by femtosecond laser irradiation
    Shouzhi Yu
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China
    Bioresour Technol 114:610-5. 2012

Collaborators

  • Xiaoqiang Jia
  • Shanshan Li
  • Jianping Wen
  • Menglei Xia
  • Haishan Qi
  • Sumin Zhao
  • Wenjie Du
  • Yunlin Chen
  • Guanyi Wang
  • Shouzhi Yu
  • Ming Huang
  • Yunli Chen

Detail Information

Publications11

  1. pmc Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement
    Di Huang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China
    Microb Cell Fact 12:52. 2013
    ..However, the production capacity of the strain is very low. Hereby, a computational guided engineering approach was proposed in order to improve the intracellular precursor and cofactor availability of FK506 in S. tsukubaensis...
  2. doi Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis
    Menglei Xia
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China
    Biotechnol Bioeng 110:2717-30. 2013
    ..The strategies developed here can easily be extended to titer improvement of other important microbial natural products and process optimization...
  3. ncbi Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies
    Di Huang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People s Republic of China
    J Ind Microbiol Biotechnol 40:1023-37. 2013
    ....
  4. doi In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement
    Di Huang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People s Republic of China
    Appl Microbiol Biotechnol 94:637-49. 2012
    ..2% higher than that of the parental strain. These results demonstrated that the metabolic network based on in silico prediction would be accurate, reasonable, and practical for target gene identification and strain improvement...
  5. doi Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus
    Sumin Zhao
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People s Republic of China
    Appl Microbiol Biotechnol 97:5329-41. 2013
    ..These results demonstrated that metabolic profiling analysis was a successful method applied in the rational guidance of the production improvement of rapamycin, as well as other industrially or clinically important compounds...
  6. pmc Model-Driven Redox Pathway Manipulation for Improved Isobutanol Production in Bacillus subtilis Complemented with Experimental Validation and Metabolic Profiling Analysis
    Haishan Qi
    Key Laboratory of System Bioengineering, Ministry of Education, Tianjin University, Tianjin, People s Republic of China Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People s Republic of China
    PLoS ONE 9:e93815. 2014
    ..These results demonstrated that model-driven complemented with metabolic profiling analysis could serve as a useful approach in the strain improvement for higher bio-productivity in further application. ..
  7. doi Rational medium optimization based on comparative metabolic profiling analysis to improve fumaric acid production
    Guanyi Wang
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    Bioresour Technol 137:1-8. 2013
    ..5 g/L) and less by-products. These results demonstrated that metabolic profiling analysis could be successfully applied to the rational guidance of medium optimization and the productivity improvement of value-added compounds...
  8. pmc Rational improvement of the engineered isobutanol-producing Bacillus subtilis by elementary mode analysis
    Shanshan Li
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    Microb Cell Fact 11:101. 2012
    ..Since elementary mode analysis (EMA) is a powerful tool for systematical analysis of metabolic network structures and cell metabolism, it might be of great importance in the rational strain improvement...
  9. ncbi Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies
    Wenjie Du
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People s Republic of China
    J Ind Microbiol Biotechnol 41:1131-43. 2014
    ..5-L bioreactor. These results demonstrated that genome shuffling and dynamic fed-batch strategies could be successfully applied to generate high-yield strains with value-added natural products during industrial microbial fermentation. ..
  10. doi Metabolic profiling of a Rhizopus oryzae fumaric acid production mutant generated by femtosecond laser irradiation
    Shouzhi Yu
    Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China
    Bioresour Technol 114:610-5. 2012
    ..33- and 7.22-fold, respectively, compared with parental strain during stationary phase. These findings provided new insights into metabolic characterization of high-yielding fumaric acid R. oryzae...
  11. doi Metabolic flux analysis and principal nodes identification for daptomycin production improvement by Streptomyces roseosporus
    Di Huang
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People s Republic of China
    Appl Biochem Biotechnol 165:1725-39. 2011
    ..Furthermore, various concentrations of the five precursors were added into the batch fermentation and led to the enhancement of daptomycin concentration and production rate...