Joshua K Ko


Affiliation: Hong Kong Baptist University
Country: China


  1. request reprint
    Ko J, Leung W, Ho W, Chiu P. Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. Eur J Pharmacol. 2007;559:1-13 pubmed
    ..These findings exemplify the potential of herbal terpenoids, particularly PAB, in modulating colon cancer carcinogenesis through known molecular targets and precise mechanism of action. ..
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    Ko J, Auyeung K. Inflammatory bowel disease: etiology, pathogenesis and current therapy. Curr Pharm Des. 2014;20:1082-96 pubmed
    ..Indeed, more experimental and clinical studies are needed to confirm the relevance of these therapies. ..
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    Ko J, Auyeung K. Identification of functional peptides from natural and synthetic products on their anticancer activities by tumor targeting. Curr Med Chem. 2014;21:2346-56 pubmed
    ..This review compiles the use of effective tumor-targeting peptides including novel CPPs that represents new therapeutic strategies for the treatment of cancers. ..
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    Ko J, Auyeung K. Target-oriented mechanisms of novel herbal therapeutics in the chemotherapy of gastrointestinal cancer and inflammation. Curr Pharm Des. 2013;19:48-66 pubmed
  5. Wang Y, Auyeung K, Zhang X, Ko J. Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression. BMC Complement Altern Med. 2014;14:401 pubmed publisher
    ..Combination of calpain inhibitors and AST could exhibit a more pronounced pro-apoptotic effect. These results help to envisage a new therapeutic approach in colon cancer by targeting calpain and GRP. ..
  6. Ko J, Lam F, Cheung A. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World J Gastroenterol. 2005;11:5787-94 pubmed
    ..To investigate the protective effects of Astragalus membranaceus (Am) against hapten-induced colitis in male Sprague-Dawley rats as well as its underlying mechanism...
  7. Ko J, Chik C. The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines. Cytokine. 2009;47:85-90 pubmed publisher
    ..This study provides important new insights that may contribute to further development of Am as a novel therapeutic agent for treating colitis diseases...