Joshua K Ko
Affiliation: Hong Kong Baptist University
Ko J, Leung W, Ho W, Chiu P. Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. Eur J Pharmacol. 2007;559:1-13 pubmed
..These findings exemplify the potential of herbal terpenoids, particularly PAB, in modulating colon cancer carcinogenesis through known molecular targets and precise mechanism of action. ..
Ko J, Auyeung K. Inflammatory bowel disease: etiology, pathogenesis and current therapy. Curr Pharm Des. 2014;20:1082-96 pubmed
..Indeed, more experimental and clinical studies are needed to confirm the relevance of these therapies. ..
Ko J, Auyeung K. Identification of functional peptides from natural and synthetic products on their anticancer activities by tumor targeting. Curr Med Chem. 2014;21:2346-56 pubmed
..This review compiles the use of effective tumor-targeting peptides including novel CPPs that represents new therapeutic strategies for the treatment of cancers. ..
Ko J, Auyeung K. Target-oriented mechanisms of novel herbal therapeutics in the chemotherapy of gastrointestinal cancer and inflammation. Curr Pharm Des. 2013;19:48-66 pubmed
Wang Y, Auyeung K, Zhang X, Ko J. Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression. BMC Complement Altern Med. 2014;14:401 pubmed publisher
..Combination of calpain inhibitors and AST could exhibit a more pronounced pro-apoptotic effect. These results help to envisage a new therapeutic approach in colon cancer by targeting calpain and GRP. ..
Ko J, Lam F, Cheung A. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World J Gastroenterol. 2005;11:5787-94 pubmed
..To investigate the protective effects of Astragalus membranaceus (Am) against hapten-induced colitis in male Sprague-Dawley rats as well as its underlying mechanism...
Ko J, Chik C. The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines. Cytokine. 2009;47:85-90 pubmed publisher
..This study provides important new insights that may contribute to further development of Am as a novel therapeutic agent for treating colitis diseases...