Kelvin Chan

Summary

Affiliation: Hong Kong Baptist University
Country: China

Publications

  1. pmc Development and validation of the Chinese Quality of Life Instrument
    Kwok fai Leung
    Department of Occupational Therapy, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China
    Health Qual Life Outcomes 3:26. 2005
  2. ncbi request reprint Some aspects of toxic contaminants in herbal medicines
    K Chan
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, PR China
    Chemosphere 52:1361-71. 2003
  3. ncbi request reprint Chinese medicinal materials and their interface with Western medical concepts
    Kelvin Chan
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, PR China
    J Ethnopharmacol 96:1-18. 2005
  4. doi request reprint A unique issue in the standardization of Chinese materia medica: processing
    Zhongzhen Zhao
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
    Planta Med 76:1975-86. 2010
  5. ncbi request reprint Systematic evaluation of organochlorine pesticide residues in Chinese materia medica
    Kelvin Sze Yin Leung
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
    Phytother Res 19:514-8. 2005
  6. ncbi request reprint Application of atmospheric pressure chemical ionisation mass spectrometry in the identification and differentiation of Panax species
    Kelvin Sze Yin Leung
    Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, PR China
    Phytochem Anal 18:146-50. 2007
  7. ncbi request reprint Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensis
    Guang Hua Lu
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Chromatogr A 1068:209-19. 2005
  8. ncbi request reprint Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry
    Guang Hua Lu
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Chromatogr A 1046:101-7. 2004
  9. ncbi request reprint Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro
    Patrick Y K Yue
    Hung Lai Ching Laboratory of Biomedical Science, Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong
    Angiogenesis 8:205-16. 2005
  10. ncbi request reprint Identification and determination of the major constituents in traditional Chinese medicinal plant Polygonum multiflorum thunb by HPLC coupled with PAD and ESI/MS
    Tao Yi
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong Special Administrative Region, People s Republic of China
    Phytochem Anal 18:181-7. 2007

Collaborators

  • Zhongzhen Zhao
  • Zhi Hong Jiang
  • Alan Bensoussan
  • Li zhu Lin
  • Ge Lin
  • Z Cai
  • Hong Qi Zhang
  • Pei shan Xie
  • Guang Hua Lu
  • Li Zhao
  • Tao Yi
  • Kelvin Sze Yin Leung
  • Zhong Qiu Liu
  • Hua Yu
  • Kelvin Leung
  • Chi Leung Chan
  • Yuan Ping Pang
  • Li Zhang
  • Wen Ming Li
  • Yi Tao Wang
  • Yi Fan Han
  • Liang Liu
  • Hua Zhou
  • Hong Xi Xu
  • Yuen Fan Wong
  • Yi Zeng Liang
  • Liang Cui
  • Kelvin K W Kan
  • Jason M K Ho
  • Zhe Ming Gu
  • Thomas P Cheung
  • Patrick Y K Yue
  • Kwok fai Leung
  • Shi Lin Hu
  • Zonghua Song
  • Zuo Zhong
  • Ze Ming Gu
  • Wan Chan
  • Paul R Carlier
  • Jian Lin Wu
  • Zhong Zuo
  • Man Chun Cheung
  • Mary J Munroe
  • Bobby W H Cheng
  • Kelvin S Y Leung
  • Charlie Xue
  • Chun G Li
  • T P D Fan
  • Ricky N S Wong
  • H W Yeung
  • Zhao Xiang Bian
  • N K Mak
  • L Liu
  • Ying Xie
  • Daisy Y L Wong
  • Xiong Cai
  • Ji qian Fang
  • M C Fung
  • H W Leung
  • W Y Ha
  • Feng bin Liu
  • Jiqian Fang
  • Kwokfai Leung
  • Fengbin Liu
  • Quan Xi Mei
  • Xu Luo
  • Kaishun Bi

Detail Information

Publications28

  1. pmc Development and validation of the Chinese Quality of Life Instrument
    Kwok fai Leung
    Department of Occupational Therapy, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China
    Health Qual Life Outcomes 3:26. 2005
    ....
  2. ncbi request reprint Some aspects of toxic contaminants in herbal medicines
    K Chan
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, PR China
    Chemosphere 52:1361-71. 2003
    ..The paper also summarises how modernization and progress are being carried out to get the best out of Chinese medicines for public healthcare...
  3. ncbi request reprint Chinese medicinal materials and their interface with Western medical concepts
    Kelvin Chan
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, PR China
    J Ethnopharmacol 96:1-18. 2005
    ..The impact will certainly be modernisation in every aspect of CMM to cope with the fast growing demand in quality medicines in the 21st century. Several major areas are listed for discussion...
  4. doi request reprint A unique issue in the standardization of Chinese materia medica: processing
    Zhongzhen Zhao
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
    Planta Med 76:1975-86. 2010
    ..The objective of this paper is to review the literature covering the current situation and problems of CMM processing as well as recent progress in research in this area. A summary of the most urgent work needed is proposed...
  5. ncbi request reprint Systematic evaluation of organochlorine pesticide residues in Chinese materia medica
    Kelvin Sze Yin Leung
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
    Phytother Res 19:514-8. 2005
    ..All the results will be gathered and analysed for setting up regulatory permissible limits of OCP residues in Chinese materia medica used in Hong Kong...
  6. ncbi request reprint Application of atmospheric pressure chemical ionisation mass spectrometry in the identification and differentiation of Panax species
    Kelvin Sze Yin Leung
    Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, PR China
    Phytochem Anal 18:146-50. 2007
    ..This technique provides an alternative approach to analysing high molecular weight polar compounds that typically encountered in complex matrices of Chinese medicinal materials...
  7. ncbi request reprint Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensis
    Guang Hua Lu
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Chromatogr A 1068:209-19. 2005
    ..07 +/- 2.73 (mean +/- SD, n = 10). The chemical assay of DG using total ferulic acid content would be a better choice to assess the herbal quality and was recommended...
  8. ncbi request reprint Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry
    Guang Hua Lu
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Chromatogr A 1046:101-7. 2004
    ..The overall analytical procedure is rapid and reproducible which is considered suitable for quantitative analysis of large number of samples...
  9. ncbi request reprint Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro
    Patrick Y K Yue
    Hung Lai Ching Laboratory of Biomedical Science, Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong
    Angiogenesis 8:205-16. 2005
    ..Our results suggest that Rg(1) can promote angiogenesis in multiple models, and this effect is partly due to the modulation of genes that are involved in the cytoskeletal dynamics, cell-cell adhesion and migration...
  10. ncbi request reprint Identification and determination of the major constituents in traditional Chinese medicinal plant Polygonum multiflorum thunb by HPLC coupled with PAD and ESI/MS
    Tao Yi
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong Special Administrative Region, People s Republic of China
    Phytochem Anal 18:181-7. 2007
    ..32-102.53% with RSD less than 2.35%. The overall procedure is rapid and reproducible and is considered suitable for qualitative and quantitative analysis of a large number of samples...
  11. ncbi request reprint Building a bridge for integrating Chinese medicine into conventional healthcare: observations drawn from the development of the Chinese quality of life instrument
    Li Zhao
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR
    Am J Chin Med 33:897-902. 2005
    ....
  12. doi request reprint High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen
    Liang Cui
    Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China
    Talanta 75:1002-7. 2008
    ..The in vitro and in vivo results indicate that the methylation is the main metabolic pathway of lithospermic acid B. The danshen component and its methylated metabolites were excreted to rat bile and feces...
  13. ncbi request reprint Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro
    Zhong Qiu Liu
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
    J Pharmacol Sci 99:381-91. 2005
    ..However, with respect to the in vivo influence of paeoniflorin on sinomenine, the results showed that co-administration of paeoniflorin did not affect the pharmacokinetic parameters and tissue distribution of sinomenine...
  14. ncbi request reprint Identification and comparative determination of senkyunolide A in traditional Chinese medicinal plants Ligusticum chuanxiong and Angelica sinensis by HPLC coupled with DAD and ESI-MS
    Tao Yi
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
    Chem Pharm Bull (Tokyo) 53:1480-3. 2005
    ..The analytical procedure is precise and reproducible and thus suitable for the analysis of a large number of samples...
  15. ncbi request reprint The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model
    Kelvin Chan
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China
    J Ethnopharmacol 103:425-32. 2006
    ..The mechanism underlying the improvement of paeoniflorin's bioavailability was proposed that sinomenine could decrease the efflux transport of paeoniflorin by P-glycoprotein...
  16. ncbi request reprint Patient-reported outcomes (PROs): an approach to evaluate treatment efficacy of Chinese medicine or integrative medicine
    Li Zhao
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
    Chin J Integr Med 11:151-3. 2005
  17. ncbi request reprint [Application of factor analysis in development and validation of a new questionnaire for quality of life]
    Li Zhao
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University
    Zhongguo Zhong Xi Yi Jie He Za Zhi 24:965-8. 2004
    ..To explore the application of factor analysis in creating a new health-related questionnaire for evaluating quality of life, the Chinese for Quality of Life Instrument (ChQOL)...
  18. ncbi request reprint Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats
    Zhong Qiu Liu
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, PR China
    J Ethnopharmacol 99:61-7. 2005
    ..01), the C(L) was decreased (P<0.01) and the V(d) was reduced (P<0.05). These results indicate that sinomenine hydrochloride at 90 mg/kg significantly improved the bioavailability of paeoniflorin in rats...
  19. ncbi request reprint Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs
    Guang Hua Lu
    Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, 5 Hong Kong Baptist Road, Kowloon Tong, Hong Kong, China
    J Chromatogr A 1073:383-92. 2005
    ....
  20. ncbi request reprint The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitro
    Zhong Qiu Liu
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China
    Life Sci 77:3197-209. 2005
    ..This result suggests that sinomenine might have much more potent binding ability with albumin than with alpha-1-acid-glycoprotein, resulting from its acidic property...
  21. ncbi request reprint The isolation, identification and determination of dehydrotumulosic acid in Poria cocos
    Zonghua Song
    Shenyang Pharmaceutical University, PR China
    Anal Sci 18:529-31. 2002
    ..0 mL/min, with a UV detector setting at 242 nm and testosterone propionate used as an internal standard. This assay for dehydrotumulosic acid is simple, rapid and with good reproducibility...
  22. ncbi request reprint Aristolochic acids detected in some raw Chinese medicinal herbs and manufactured herbal products--a consequence of inappropriate nomenclature and imprecise labelling?
    Thomas P Cheung
    The Chinese Medicine Research Group, Division of Chinese Medicine, RMIT University, Australia
    Clin Toxicol (Phila) 44:371-8. 2006
    ..There is a lack of systematic information about the aristolochic acid content of Aristolochia species and related genera, including those in Chinese materia medica that are used in the treatment of overweight individuals...
  23. ncbi request reprint Quality control of herbal medicines
    Yi Zeng Liang
    Research Center of Modernization of Chinese Medicines, Institute of Chemometrics and Intelligent Analytical Instruments, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 812:53-70. 2004
    ..are discussed in detail with examples, which showed that the combination of chromatographic fingerprints of herbal medicines and the chemometric evaluation might be a powerful tool for quality control of herbal products...
  24. ncbi request reprint Simultaneous qualitative and quantitative analyses of the major constituents in the rhizome of Ligusticum Chuanxiong using HPLC-DAD-MS
    Tao Yi
    West China School of Pharmacy, Sichuan University, Chengdu, PR China
    Chem Pharm Bull (Tokyo) 54:255-9. 2006
    ..The overall procedure is accurate and reproducible, which is considered suitable for the qualitative and quantitative analyses of a large number of Chuanxiong samples...
  25. ncbi request reprint The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine
    Hua Yu
    Institute of Chinese Medical Sciences, University of Macau, Macau SAR, PR China
    J Pharm Biomed Anal 46:75-81. 2008
    ..In summary, these physiochemical characteristics suggest that the two dimers may be promising candidates for the development of better drugs for Alzheimer's disease...
  26. doi request reprint Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine
    Li Zhang
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, PR China
    Int J Pharm 357:85-94. 2008
    ..In conclusion, B7T is expected to have a low oral bioavailability in vivo, which may be due to its poor intestinal permeability, significant tissue binding and hepatic hydroxylation metabolism...
  27. ncbi request reprint Studies on the toxicity of Aristolochia manshuriensis (Guanmuton)
    Shi Lin Hu
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China
    Toxicology 198:195-201. 2004
    ..2) To investigate the possibility of reducing toxicity of the herb combined with Rhizoma Coptidis (Huanglian)...
  28. ncbi request reprint Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood
    Hua Yu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, PR China
    J Pharm Biomed Anal 44:1133-8. 2007
    ..6 and 42.3 ng/ml, respectively. Furthermore, it was successfully applied for the pharmacokinetic measurement of B7T in rat with a single intravenous administration at 0.3mg/kg...