Research Topics
| Kelvin ChanSummaryAffiliation: Hong Kong Baptist University Country: China Publications
| Collaborators
|
Detail Information
Publications
Development and validation of the Chinese Quality of Life InstrumentKwok fai Leung
Department of Occupational Therapy, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China
Health Qual Life Outcomes 3:26. 2005....- Some aspects of toxic contaminants in herbal medicinesK Chan
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, PR China
Chemosphere 52:1361-71. 2003..The paper also summarises how modernization and progress are being carried out to get the best out of Chinese medicines for public healthcare... - Chinese medicinal materials and their interface with Western medical conceptsKelvin Chan
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, PR China
J Ethnopharmacol 96:1-18. 2005..The impact will certainly be modernisation in every aspect of CMM to cope with the fast growing demand in quality medicines in the 21st century. Several major areas are listed for discussion... - A unique issue in the standardization of Chinese materia medica: processingZhongzhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
Planta Med 76:1975-86. 2010..The objective of this paper is to review the literature covering the current situation and problems of CMM processing as well as recent progress in research in this area. A summary of the most urgent work needed is proposed... - Systematic evaluation of organochlorine pesticide residues in Chinese materia medicaKelvin Sze Yin Leung
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
Phytother Res 19:514-8. 2005..All the results will be gathered and analysed for setting up regulatory permissible limits of OCP residues in Chinese materia medica used in Hong Kong... - Application of atmospheric pressure chemical ionisation mass spectrometry in the identification and differentiation of Panax speciesKelvin Sze Yin Leung
Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, PR China
Phytochem Anal 18:146-50. 2007..This technique provides an alternative approach to analysing high molecular weight polar compounds that typically encountered in complex matrices of Chinese medicinal materials... - Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensisGuang-Hua Lu
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Chromatogr A 1068:209-19. 2005..07 +/- 2.73 (mean +/- SD, n = 10). The chemical assay of DG using total ferulic acid content would be a better choice to assess the herbal quality and was recommended... - Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometryGuang-Hua Lu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Chromatogr A 1046:101-7. 2004..The overall analytical procedure is rapid and reproducible which is considered suitable for quantitative analysis of large number of samples... - Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitroPatrick Y K Yue
Hung Lai Ching Laboratory of Biomedical Science, Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong
Angiogenesis 8:205-16. 2005..Our results suggest that Rg(1) can promote angiogenesis in multiple models, and this effect is partly due to the modulation of genes that are involved in the cytoskeletal dynamics, cell-cell adhesion and migration... - Identification and determination of the major constituents in traditional Chinese medicinal plant Polygonum multiflorum thunb by HPLC coupled with PAD and ESI/MSTao Yi
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong Special Administrative Region, People s Republic of China
Phytochem Anal 18:181-7. 2007..32-102.53% with RSD less than 2.35%. The overall procedure is rapid and reproducible and is considered suitable for qualitative and quantitative analysis of a large number of samples... - Building a bridge for integrating Chinese medicine into conventional healthcare: observations drawn from the development of the Chinese quality of life instrumentLi Zhao
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR
Am J Chin Med 33:897-902. 2005.... - High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshenLiang Cui
Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China
Talanta 75:1002-7. 2008..The in vitro and in vivo results indicate that the methylation is the main metabolic pathway of lithospermic acid B. The danshen component and its methylated metabolites were excreted to rat bile and feces... - Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitroZhong Qiu Liu
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
J Pharmacol Sci 99:381-91. 2005..However, with respect to the in vivo influence of paeoniflorin on sinomenine, the results showed that co-administration of paeoniflorin did not affect the pharmacokinetic parameters and tissue distribution of sinomenine... - Identification and comparative determination of senkyunolide A in traditional Chinese medicinal plants Ligusticum chuanxiong and Angelica sinensis by HPLC coupled with DAD and ESI-MSTao Yi
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P. R. China
Chem Pharm Bull (Tokyo) 53:1480-3. 2005..The analytical procedure is precise and reproducible and thus suitable for the analysis of a large number of samples... - The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac modelKelvin Chan
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China
J Ethnopharmacol 103:425-32. 2006..The mechanism underlying the improvement of paeoniflorin's bioavailability was proposed that sinomenine could decrease the efflux transport of paeoniflorin by P-glycoprotein... - Patient-reported outcomes (PROs): an approach to evaluate treatment efficacy of Chinese medicine or integrative medicineLi Zhao
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
Chin J Integr Med 11:151-3. 2005 - [Application of factor analysis in development and validation of a new questionnaire for quality of life]Li Zhao
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University
Zhongguo Zhong Xi Yi Jie He Za Zhi 24:965-8. 2004..CONCLUSION: Factor analysis is an effective method in developing new questionnaire... - Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious ratsZhong Qiu Liu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, PR China
J Ethnopharmacol 99:61-7. 2005..01), the C(L) was decreased (P<0.01) and the V(d) was reduced (P<0.05). These results indicate that sinomenine hydrochloride at 90 mg/kg significantly improved the bioavailability of paeoniflorin in rats... - Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbsGuang-Hua Lu
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, 5 Hong Kong Baptist Road, Kowloon Tong, Hong Kong, China
J Chromatogr A 1073:383-92. 2005.... - The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitroZhong-Qiu Liu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China
Life Sci 77:3197-209. 2005..This result suggests that sinomenine might have much more potent binding ability with albumin than with alpha-1-acid-glycoprotein, resulting from its acidic property... - The isolation, identification and determination of dehydrotumulosic acid in Poria cocosZonghua Song
Shenyang Pharmaceutical University, PR China
Anal Sci 18:529-31. 2002..0 mL/min, with a UV detector setting at 242 nm and testosterone propionate used as an internal standard. This assay for dehydrotumulosic acid is simple, rapid and with good reproducibility... - Aristolochic acids detected in some raw Chinese medicinal herbs and manufactured herbal products--a consequence of inappropriate nomenclature and imprecise labelling?Thomas P Cheung
The Chinese Medicine Research Group, Division of Chinese Medicine, RMIT University, Australia
Clin Toxicol (Phila) 44:371-8. 2006..Additional measures are needed to ensure the safety of consumers of Chinese herbal medicines... - Quality control of herbal medicinesYi Zeng Liang
Research Center of Modernization of Chinese Medicines, Institute of Chemometrics and Intelligent Analytical Instruments, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China
J Chromatogr B Analyt Technol Biomed Life Sci 812:53-70. 2004..are discussed in detail with examples, which showed that the combination of chromatographic fingerprints of herbal medicines and the chemometric evaluation might be a powerful tool for quality control of herbal products... - Simultaneous qualitative and quantitative analyses of the major constituents in the rhizome of Ligusticum Chuanxiong using HPLC-DAD-MSTao Yi
West China School of Pharmacy, Sichuan University, Chengdu, PR China
Chem Pharm Bull (Tokyo) 54:255-9. 2006..The overall procedure is accurate and reproducible, which is considered suitable for the qualitative and quantitative analyses of a large number of Chuanxiong samples... - The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrineHua Yu
Institute of Chinese Medical Sciences, University of Macau, Macau SAR, PR China
J Pharm Biomed Anal 46:75-81. 2008..In summary, these physiochemical characteristics suggest that the two dimers may be promising candidates for the development of better drugs for Alzheimer's disease... - Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrineLi Zhang
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, PR China
Int J Pharm 357:85-94. 2008..In conclusion, B7T is expected to have a low oral bioavailability in vivo, which may be due to its poor intestinal permeability, significant tissue binding and hepatic hydroxylation metabolism... - Studies on the toxicity of Aristolochia manshuriensis (Guanmuton)Shi Lin Hu
Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China
Toxicology 198:195-201. 2004..2) To investigate the possibility of reducing toxicity of the herb combined with Rhizoma Coptidis (Huanglian)... - Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat bloodHua Yu
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, PR China
J Pharm Biomed Anal 44:1133-8. 2007..6 and 42.3 ng/ml, respectively. Furthermore, it was successfully applied for the pharmacokinetic measurement of B7T in rat with a single intravenous administration at 0.3mg/kg...