Yuan Fang Ma
Affiliation: Henan University
Wang W, Zhang Y, Lv M, Feng J, Peng H, Geng J, et al
. Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3. J Ovarian Res. 2014;7:103 pubmed publisher
..In similar cases, not only acquired but also de novo, good curative effect might be achieved using combined antibody therapy strategies. ..
Liu F, Si Y, Liu G, Li S, Zhang J, Ma Y. The tetravalent anti-DR5 antibody without cross-linking direct induces apoptosis of cancer cells. Biomed Pharmacother. 2015;70:41-5 pubmed publisher
..Thus, the tetravalent anti-DR5 antibody will be a new kind of candidate for potential cancer therapeutics. ..
Liu D, Deng Q, Sun L, Wang T, Yang Z, Chen H, et al
. A Her2-let-7-Î²2-AR circuit affects prognosis in patients with Her2-positive breast cancer. BMC Cancer. 2015;15:832 pubmed publisher
..Our data suggest that Î²2-AR may be a new useful biomarker for predicting prognosis in Her2-positive breast cancer and may also be a promising selective therapeutic target for the aggressive subtype of breast cancer. ..
Deng Q, Chen H, Liu Y, Xiao F, Guo L, Liu D, et al
. Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model. Brain Behav Immun. 2016;57:243-254 pubmed publisher
..The findings also suggest a potential application of neuroprotective agents to prevent relapsing immune activation in the treatment of IBD. ..
Chai L, Wu S, Liu G, Wang Z, Tian W, Ma Y. OCILRP2 signaling synergizes with LPS to induce the maturation and differentiation of murine dendritic cells. Biochem Biophys Res Commun. 2014;446:836-42 pubmed publisher
..Additionally, we show that OCILRP2-Fc may cause the aforementioned effects through inhibiting NF-?B activation. Therefore, OCILRP2 is a new regulator of DC maturation and differentiation following TLR4 activation. ..
Huang H, Song Y, Wu Y, Guo N, Ma Y, Qian L. Erbin loss promotes cancer cell proliferation through feedback activation of Akt-Skp2-p27 signaling. Biochem Biophys Res Commun. 2015;463:370-6 pubmed publisher
..Thus, our finding illustrates a novel negative feedback loop between Erbin and Akt-Skp2 signaling. It suggests disrupted Erbin links polarity loss, hyperproliferation and tumorigenesis. ..
Wang Y, Jiang Y, Zhou J, Song W, Li J, Wang M, et al
. Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response. Tumour Biol. 2016;37:15265-15274 pubmed
..Downregulation of TIPE2 by NS5A is associated with genomic DNA instability and HCV-induced HCC development. Thus, TIPE2 may be a new therapeutic target for the treatment of HCV-associated HCC. ..
Jiang Y, Chen X, Fan M, Li H, Zhu W, Chen X, et al
. TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-?B pathway. Mol Immunol. 2017;82:123-136 pubmed publisher
..Thus, our research present that TRAIL affects functional activities of macrophages during I/R injury, which may be a potential therapeutic target for ischemic heart disease. ..
Liu R, Sun D, Jiao Y, Wang P, Zhang J, Wang M, et al
. Macrophage migration inhibitory factor promotes tumor aggressiveness of esophageal squamous cell carcinoma via activation of Akt and inactivation of GSK3Î². Cancer Lett. 2018;412:289-296 pubmed publisher
..Collectively, our results provided mechanistic insights into the tumor-promoting role of MIF in ESCC, and suggested that MIF represents a potential therapeutic target for treatment of ESCC. ..