Affiliation: Hebei Medical University
Chen R, Zhang F, Song L, Shu Y, Lin Y, Dong L, et al
. Transcriptome profiling reveals that the SM22?-regulated molecular pathways contribute to vascular pathology. J Mol Cell Cardiol. 2014;72:263-72 pubmed publisher
..Meanwhile, rescuing SM22? expression may provide a novel therapeutic strategy for arterial diseases. ..
Lv P, Zhang F, Yin Y, Wang Y, Gao M, Xie X, et al
. SM22? inhibits lamellipodium formation and migration via Ras-Arp2/3 signaling in synthetic VSMCs. Am J Physiol Cell Physiol. 2016;311:C758-C767 pubmed publisher
..These data suggest that SM22? regulates lamellipodium formation and cell migration in a phenotype-dependent manner in VSMCs, which may be a new therapeutic target for vascular lesion formation. ..
Zhao L, Zhang F, Chen P, Xie X, Dou Y, Lin Y, et al
. Insulin-independent GLUT4 translocation in proliferative vascular smooth muscle cells involves SM22α. J Mol Med (Berl). 2017;95:181-192 pubmed publisher
..SM22α disruption enhances PDGF-BB-induced GLUT4 translocation. • Glucose level in injured vascular tissue is positively correlated with neointimal hyperplasia. ..
Shu Y, Zhang F, Bi W, Dong L, Zhang D, Chen R, et al
. SM22Î± inhibits vascular inflammation via stabilization of IÎºBÎ± in vascular smooth muscle cells. J Mol Cell Cardiol. 2015;84:191-9 pubmed publisher
..Our findings demonstrate that SM22Î± is a phosphorylation-regulated suppressor of IKK-IÎºBÎ±-NF-ÎºB signaling cascades. SM22Î± may be a novel therapeutic target for human vascular diseases and other inflammatory conditions. ..
Dong L, Li L, Song Y, Duan Z, Sun S, Lin Y, et al
. TRAF6-Mediated SM22Î± K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo. Circ Res. 2015;117:684-94 pubmed publisher
..The TRAF6-SM22Î±-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability. ..
Chen R, Kong P, Zhang F, Shu Y, Nie X, Dong L, et al
. EZH2-mediated ?-actin methylation needs lncRNA TUG1, and promotes the cortex cytoskeleton formation in VSMCs. Gene. 2017;616:52-57 pubmed publisher
..In conclusion, these findings partly suggested that EZH2-mediated methylation of ?-actin may be dependent on TUG1, and thereby promotes cortex F-actin polymerization in synthetic VSMCs. ..
Miao S, Xie X, Yin Y, Zhao L, Zhang F, Shu Y, et al
. Accumulation of Smooth Muscle 22? Protein Accelerates Senescence of Vascular Smooth Muscle Cells via Stabilization of p53 In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2017;37:1849-1859 pubmed publisher
..In conclusion, these findings suggest that the accumulation of SM22? promotes Ang II-induced senescence via the suppression of Mdm2-mediated ubiquitination and degradation of p53 in VSMCs in vitro and in vivo. ..