Zheng Guo

Summary

Affiliation: Harbin Medical University
Country: China

Publications

  1. pmc Peeling off the hidden genetic heterogeneities of cancers based on disease-relevant functional modules
    Jian Zhen Xu
    Department of Bioinformatics, Harbin Medical University, Harbin, China
    Mol Med 12:25-33. 2006
  2. pmc Pitfalls in experimental designs for characterizing the transcriptional, methylational and copy number changes of oncogenes and tumor suppressor genes
    Yuannv Zhang
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    PLoS ONE 8:e58163. 2013
  3. pmc Evaluating reproducibility of differential expression discoveries in microarray studies by considering correlated molecular changes
    Min Zhang
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    Bioinformatics 25:1662-8. 2009
  4. pmc Reproducible cancer biomarker discovery in SELDI-TOF MS using different pre-processing algorithms
    Jinfeng Zou
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu, People s Republic of China
    PLoS ONE 6:e26294. 2011
  5. pmc Functional comparison between genes dysregulated in ulcerative colitis and colorectal carcinoma
    Wenyuan Zhao
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    PLoS ONE 8:e71989. 2013
  6. pmc Reproducibility and concordance of differential DNA methylation and gene expression in cancer
    Chen Yao
    Bioinformatics Centre and Key Laboratory for NeuroInfomation of the Education Ministry of China, School of Life Science, University of Electronic Science and Technology of China, Chengdu, China
    PLoS ONE 7:e29686. 2012
  7. pmc Genes dysregulated to different extent or oppositely in estrogen receptor-positive and estrogen receptor-negative breast cancers
    Xianxiao Zhou
    Bioinformatics Centre and Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
    PLoS ONE 8:e70017. 2013
  8. pmc An integrated approach to uncover driver genes in breast cancer methylation genomes
    Xiaopei Shen
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu, China
    PLoS ONE 8:e61214. 2013
  9. pmc Distinct functional patterns of gene promoter hypomethylation and hypermethylation in cancer genomes
    Xiaopei Shen
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu, China
    PLoS ONE 7:e44822. 2012
  10. ncbi request reprint Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes
    Hongbo Shi
    College of Bioinformatics Science and Technology and State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang 150081, PR China
    BMC Syst Biol 7:101. 2013

Collaborators

Detail Information

Publications60

  1. pmc Peeling off the hidden genetic heterogeneities of cancers based on disease-relevant functional modules
    Jian Zhen Xu
    Department of Bioinformatics, Harbin Medical University, Harbin, China
    Mol Med 12:25-33. 2006
    ..The proposed modular approach is a promising computational strategy for peeling off genetic heterogeneities and understanding the modular mechanisms of human diseases such as cancers...
  2. pmc Pitfalls in experimental designs for characterizing the transcriptional, methylational and copy number changes of oncogenes and tumor suppressor genes
    Yuannv Zhang
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    PLoS ONE 8:e58163. 2013
    ....
  3. pmc Evaluating reproducibility of differential expression discoveries in microarray studies by considering correlated molecular changes
    Min Zhang
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    Bioinformatics 25:1662-8. 2009
    ..A complex disease is often characterized with many coordinated molecular changes, which should be considered when evaluating the reproducibility of discovery lists from different studies...
  4. pmc Reproducible cancer biomarker discovery in SELDI-TOF MS using different pre-processing algorithms
    Jinfeng Zou
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu, People s Republic of China
    PLoS ONE 6:e26294. 2011
    ..Specifically, a peak profile extracted from a dataset for biomarker identification depends on a data pre-processing algorithm. Until now, no widely accepted agreement has been reached...
  5. pmc Functional comparison between genes dysregulated in ulcerative colitis and colorectal carcinoma
    Wenyuan Zhao
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    PLoS ONE 8:e71989. 2013
    ..Patients with ulcerative colitis (UC) are predisposed to colitis-associated colorectal cancer (CAC). However, the transcriptional mechanism of the transformation from UC to CAC is not fully understood...
  6. pmc Reproducibility and concordance of differential DNA methylation and gene expression in cancer
    Chen Yao
    Bioinformatics Centre and Key Laboratory for NeuroInfomation of the Education Ministry of China, School of Life Science, University of Electronic Science and Technology of China, Chengdu, China
    PLoS ONE 7:e29686. 2012
    ..However, the reproducibility of differential DNA methylation discoveries for cancer and the relationship between DNA methylation and aberrant gene expression have not been systematically analysed...
  7. pmc Genes dysregulated to different extent or oppositely in estrogen receptor-positive and estrogen receptor-negative breast cancers
    Xianxiao Zhou
    Bioinformatics Centre and Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
    PLoS ONE 8:e70017. 2013
    ....
  8. pmc An integrated approach to uncover driver genes in breast cancer methylation genomes
    Xiaopei Shen
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu, China
    PLoS ONE 8:e61214. 2013
    ..Cancer cells typically exhibit large-scale aberrant methylation of gene promoters. Some of the genes with promoter methylation alterations play "driver" roles in tumorigenesis, whereas others are only "passengers"...
  9. pmc Distinct functional patterns of gene promoter hypomethylation and hypermethylation in cancer genomes
    Xiaopei Shen
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu, China
    PLoS ONE 7:e44822. 2012
    ..Aberrant DNA methylation plays important roles in carcinogenesis. However, the functional significance of genome-wide hypermethylation and hypomethylation of gene promoters in carcinogenesis currently remain unclear...
  10. ncbi request reprint Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes
    Hongbo Shi
    College of Bioinformatics Science and Technology and State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang 150081, PR China
    BMC Syst Biol 7:101. 2013
    ..However, miRNA-disease associations identified by previous computational methods are far from completeness and more effort is needed...
  11. ncbi request reprint Edge-based scoring and searching method for identifying condition-responsive protein-protein interaction sub-network
    Zheng Guo
    Department of Bioinformatics, Bio pharmaceutical Key Laboratory of Heilongjiang Province Incubator of State Key Laboratory, Harbin Medical University, Harbin 150086, China
    Bioinformatics 23:2121-8. 2007
    ..Thus, the identification of condition-responsive PPI sub-networks is of great importance for investigating how a living cell adapts to changing environments...
  12. pmc Towards precise classification of cancers based on robust gene functional expression profiles
    Zheng Guo
    Department of Computer Science, Harbin Institute of Technology, Harbin 150001, China
    BMC Bioinformatics 6:58. 2005
    ..Therefore, there is an open space for development of the timely and relevant computational algorithms that use robust functional expression profiles towards precise classification of complex human diseases at the modular level...
  13. ncbi request reprint Gaining confidence in biological interpretation of the microarray data: the functional consistence of the significant GO categories
    Da Yang
    Department of Bioinformatics, Bio pharmaceutical Key Laboratory of Heilongjiang Province Incubator of State Key Laboratory, Harbin Medical University, Harbin 150086, China
    Bioinformatics 24:265-71. 2008
    ....
  14. doi request reprint Comparison of different normalization assumptions for analyses of DNA methylation data from the cancer genome
    Dong Wang
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    Gene 506:36-42. 2012
    ..Furthermore, we showed that some DM genes detected from different studies for a particular cancer type were significantly reproducible at the functional level...
  15. doi request reprint Extensive up-regulation of gene expression in cancer: the normalised use of microarray data
    Dong Wang
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    Mol Biosyst 8:818-27. 2012
    ....
  16. ncbi request reprint Apparently low reproducibility of true differential expression discoveries in microarray studies
    Min Zhang
    School of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China
    Bioinformatics 24:2057-63. 2008
    ..Even in technical replicate tests using identical samples, DEG detection still shows very low reproducibility. It is often believed that current small microarray studies will largely introduce false discoveries...
  17. doi request reprint Evaluating the consistency of differential expression of microRNA detected in human cancers
    Xue Gong
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China
    Mol Cancer Ther 10:752-60. 2011
    ..Thus, the detection of differentially expressed miRNAs in various experiments for a certain disease tends to be functionally reproducible and capture functionally related differential expression of miRNAs in the disease...
  18. doi request reprint Viewing cancer genes from co-evolving gene modules
    Jing Zhu
    Bioinformatics Centre and Key Laboratory for NeuroInfomation of the Education Ministry of China, School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054, China
    Bioinformatics 26:919-24. 2010
    ..Functionally related proteins encoded by genes tend to interact with each other in a modular fashion, which may affect both the mode and tempo of their evolution...
  19. pmc Extracting consistent knowledge from highly inconsistent cancer gene data sources
    Xue Gong
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China
    BMC Bioinformatics 11:76. 2010
    ..For efficient application of these abundant but diverse data sources, it is of fundamental importance to evaluate their consistency...
  20. ncbi request reprint An ensemble method for gene discovery based on DNA microarray data
    Xia Li
    Department of Computer Science, Harbin Institute of Technology, Harbin 150001, China
    Sci China C Life Sci 47:396-405. 2004
    ..We also give a numerical application for (i) and (ii) using a public microarrary data set and set aside a separate paper to address (iii)...
  21. doi request reprint Systematic interpretation of comutated genes in large-scale cancer mutation profiles
    Yunyan Gu
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    Mol Cancer Ther 9:2186-95. 2010
    ..All together, our results would provide a channel to detangle the complex collaboration of the molecular processes underlying cancer mechanism...
  22. doi request reprint Evaluation of cDNA microarray data by multiple clones mapping to the same transcript
    Dong Wang
    School of Life Science and Bioinformatics Centre, University of Electronic Science and Technology of China, Chengdu, 610054, People s Republic of China
    OMICS 13:493-9. 2009
    ..Therefore, although cDNA microarray data are of low consistency, applications based on DEGs selections could still reach correct biological results, especially at the functional modules level...
  23. doi request reprint Extracting a few functionally reproducible biomarkers to build robust subnetwork-based classifiers for the diagnosis of cancer
    Lin Zhang
    Bioinformatics Centre, Key Laboratory for NeuroInformation of Ministry of Education and School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China
    Gene 526:232-8. 2013
    ..Consequently, we were able to build robust subnetwork-based classifiers for cancer diagnosis. ..
  24. doi request reprint Rank-based predictors for response and prognosis of neoadjuvant taxane-anthracycline-based chemotherapy in breast cancer
    Lin Zhang
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu, 610054, China
    Breast Cancer Res Treat 139:361-9. 2013
    ..In conclusion, the rank-based predictors for response and prognosis can accurately and robustly predict patients with improved prognosis who might benefit from neoadjuvant taxane and anthracycline-based chemotherapy...
  25. doi request reprint Finding co-mutated genes and candidate cancer genes in cancer genomes by stratified false discovery rate control
    Jing Wang
    Bioinformatics Centre and Key Laboratory for NeuroInfomation of the Education Ministry of China, School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054, China
    Mol Biosyst 7:1158-66. 2011
    ....
  26. doi request reprint Functional modules with disease discrimination abilities for various cancers
    Chen Yao
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054, China
    Sci China Life Sci 54:189-93. 2011
    ....
  27. ncbi request reprint A novel model-free approach for reconstruction of time-delayed gene regulatory networks
    Wei Jiang
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, China
    Sci China C Life Sci 49:190-200. 2006
    ..We have applied this novel method to the publicly available data for budding yeast cell cycling. The numerical results demonstrate that most of the identified time-delayed gene regulations have current biological knowledge supports...
  28. doi request reprint Extensive increase of microarray signals in cancers calls for novel normalization assumptions
    Dong Wang
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu, China
    Comput Biol Chem 35:126-30. 2011
    ..The LVS algorithm might perform relatively well due to that it relies less on the above-mentioned assumption. Also, our results indicate that genes may be widely up-regulated in most human cancer...
  29. doi request reprint Network analysis of genomic alteration profiles reveals co-altered functional modules and driver genes for glioblastoma
    Yunyan Gu
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China
    Mol Biosyst 9:467-77. 2013
    ....
  30. doi request reprint GO-function: deriving biologically relevant functions from statistically significant functions
    Jing Wang
    Bioinformatics Centre, Key Laboratory for NeuroInformation of Ministry of Education and School of Life Science and Technology, University of Electronic Science and Technology of China
    Brief Bioinform 13:216-27. 2012
    ..Our analysis showed that GO-function can identify disease-related terms that are more statistically and biologically meaningful than those found by the other four algorithms...
  31. pmc Discovery of Time-Delayed Gene Regulatory Networks based on temporal gene expression profiling
    Xia Li
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, PR China
    BMC Bioinformatics 7:26. 2006
    ..The vast amount of large-scale and genome-wide time-resolved data is becoming increasing available, which provides the golden opportunity to unravel the challenging reverse-engineering problem of time-delayed gene regulatory networks...
  32. ncbi request reprint Widely predicting specific protein functions based on protein-protein interaction data and gene expression profile
    Lei Gao
    Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China
    Sci China C Life Sci 50:125-34. 2007
    ..Based on the GO database published in December 2004, we predict some proteins whose functions were unknown at that time, and some of the predictions have been confirmed by the new SGD annotation data published in April, 2006...
  33. pmc Separate enrichment analysis of pathways for up- and downregulated genes
    Guini Hong
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054, People s Republic of China
    J R Soc Interface 11:20130950. 2014
    ..In conclusion, analysing up- and downregulated genes separately is more powerful than analysing all of the DE genes together. ..
  34. ncbi request reprint A relative ordering-based predictor for tamoxifen-treated estrogen receptor-positive breast cancer patients: multi-laboratory cohort validation
    Xianxiao Zhou
    Bioinformatics Centre, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
    Breast Cancer Res Treat 142:505-14. 2013
    ..In summary, the proposed predictor can accurately and robustly predict tamoxifen sensitivity of ER-positive breast cancer patients and identified patients with a high probability of 10-year RFS following tamoxifen monotherapy...
  35. pmc GO-2D: identifying 2-dimensional cellular-localized functional modules in Gene Ontology
    Jing Zhu
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, China
    BMC Genomics 8:30. 2007
    ..Based on Gene Ontology, a large number of automatic tools have been developed for the functional analysis and biological interpretation of the high-throughput microarray data...
  36. ncbi request reprint Revealing weak differential gene expressions and their reproducible functions associated with breast cancer metastasis
    Jinfeng Zou
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054, China
    Comput Biol Chem 39:1-5. 2012
    ....
  37. pmc Revealing and avoiding bias in semantic similarity scores for protein pairs
    Jing Wang
    Bioinformatics Centre, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China
    BMC Bioinformatics 11:290. 2010
    ..Thus, it is necessary to evaluate the effects of the bias on semantic similarity scores between proteins and then find a method to avoid them...
  38. ncbi request reprint A robust hybrid between genetic algorithm and support vector machine for extracting an optimal feature gene subset
    Li Li
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, People s Republic of China
    Genomics 85:16-23. 2005
    ....
  39. ncbi request reprint Globally predicting protein functions based on co-expressed protein-protein interaction networks and ontology taxonomy similarities
    Mingzhu Zhu
    Department of Bioinformatics, Harbin Medical University, Harbin, 150086, China
    Gene 391:113-9. 2007
    ....
  40. doi request reprint Identifying cancer genes from cancer mutation profiles by cancer functions
    Yanhui Li
    Bioinformatics Centre, School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054, China
    Sci China C Life Sci 51:569-74. 2008
    ..Finally, with precision 0.42, we suggest a list of 46 kinase genes as candidate cancer genes which are annotated to cancer functions and carry at least 3 non-silent mutations...
  41. ncbi request reprint Broadly predicting specific gene functions with expression similarity and taxonomy similarity
    Hui Yu
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, China
    Gene 352:75-81. 2005
    ....
  42. pmc Multi-level reproducibility of signature hubs in human interactome for breast cancer metastasis
    Chen Yao
    Bioinformatics Centre and Key Laboratory for NeuroInfomation of the Education Ministry of China, School of Life Science, University of Electronic Science and Technology of China, Chengdu, 610054, China
    BMC Syst Biol 4:151. 2010
    ..However, for a cancer, such disease signatures identified from different studies have little overlap...
  43. doi request reprint Analysis of pathway mutation profiles highlights collaboration between cancer-associated superpathways
    Yunyan Gu
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, People s Republic of China
    Hum Mutat 32:1028-35. 2011
    ..Together, our results provide guidelines to distill the pathway collaboration in carcinogenesis from the complexity of cancer somatic mutation profiles...
  44. ncbi request reprint [Finding finer functions for proteins related to breast cancer based on protein interaction network]
    Jing Wang
    Department of Bioinformatics, Pharmacology and Bio pharmaceutical Key Laboratory of Heilongjiang Province and State, Harbin Medi cal University, Harbin 150086, China
    Yi Chuan 29:1061-6. 2007
    ..The predicted finer functions are highly valuable for guiding the follow-up wet-lab re-search to study the molecular mechanism of breast cancer...
  45. ncbi request reprint [Association analysis of gene expression and gene function]
    Na Xu
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 24:385-8. 2007
    ..2) The mRNA expression level is consistent with the intensity of functional relationships between genes. So it can be concluded that the function of genes involved in any pathway is correlated with the mRNA expression level of genes...
  46. ncbi request reprint [Identifying candidate cancer genes based on co-evolving gene modules]
    Jing Zhu
    School of Life Science and Bioinformatics Centre, University of Electronic Science and Technology of China, Chengdu 610054, China
    Yi Chuan 32:694-700. 2010
    ..Thus, the candidate cancer genes with low mutation frequencies can be found by our method...
  47. pmc Deconvolution of the gene expression profiles of valuable banked blood specimens for studying the prognostic values of altered peripheral immune cell proportions in cancer patients
    Lishuang Qi
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    PLoS ONE 9:e100934. 2014
    ..The aim of this study was to demonstrate the feasibility of deconvolving blood-based gene expression profiles (GEPs) to estimate the proportions of immune cells and determine their prognostic values for cancer patients...
  48. doi request reprint Finding disease-specific coordinated functions by multi-function genes: insight into the coordination mechanisms in diseases
    Wencai Ma
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    Genomics 94:94-100. 2009
    ..Our approach can also provide important information for finding novel disease genes as well as their mechanisms in diseases...
  49. ncbi request reprint [Analysis of the mRNA expression similarity of genes in the same gene expression regulatory pathway]
    Chuan Xing Li
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, China
    Yi Chuan 26:929-33. 2004
    ....
  50. ncbi request reprint Learnability-based further prediction of gene functions in Gene Ontology
    Kang Tu
    Department of Bioinformatics, Harbin Medical University, Harbin 150086, People s Republic of China
    Genomics 84:922-8. 2004
    ....
  51. pmc Multivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches
    Zheng Guo
    Department of Computer Science, Harbin Institute of Technology, Harbin, China
    BMC Genet 4:S68. 2003
    ....
  52. ncbi request reprint Deciphering global signal features of high-throughput array data from cancers
    Deng Wu
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
    Mol Biosyst 10:1549-56. 2014
    ..These results force us to re-evaluate the proper use of normalization procedures under different experimental conditions and for different array platforms. ..
  53. doi request reprint Systematic analysis and prediction of longevity genes in Caenorhabditis elegans
    Yan hui Li
    University of Electronic Science and Technology of China, Chengdu 610054, China
    Mech Ageing Dev 131:700-9. 2010
    ..85. Some of the predicted genes have been validated by published articles or wet lab experiments. The contribution of each feature to the predicted results was also evaluated...
  54. ncbi request reprint Effects of replacing the unreliable cDNA microarray measurements on the disease classification based on gene expression profiles and functional modules
    Dong Wang
    Department of Bioinformatics and Bio pharmaceutical Key Laboratory of Heilongjiang Province and State, Harbin Medical University Harbin 150086, China
    Bioinformatics 22:2883-9. 2006
    ..The focus of the paper is to study the effects of different MV treatments for cDNA microarray data on disease classification analysis...
  55. ncbi request reprint [Preliminary analysis on the gene expression profiles of different types of gliomas with cDNA array]
    Rong cai Jiang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P R China
    Ai Zheng 21:1085-9. 2002
    ..The cDNA was used in order to detect the differences in gene expression profiles of different types of gliomas...
  56. ncbi request reprint Solvent-free enzymatic synthesis of 1,3-diconjugated linoleoyl glycerol optimized by response surface methodology
    Zheng Guo
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    Biotechnol Prog 20:619-22. 2004
    ..The reaction was scaled up to a production level of 100 g of 1,3-dCLG at a yield of 90.7%, indicating a promising feature of the technology in industrial applications...
  57. ncbi request reprint [Analysis of codon usage in potato and its application in the modification of t-PA gene]
    Xi Bai
    College of Life Sciences, Northeast Agricultural University, Harbin 150030, China
    Yi Chuan 26:75-83. 2004
    ..The codons of tissue plasminogen activator (t-PA) gene sequence have been reconstructed according to the results. The t-PA gene sequence containing the optimal codons of potato will be used for t-PA production by potato bioreactor...
  58. pmc Genetic linkage analysis of longitudinal hypertension phenotypes using three summary measures
    Shaoqi Rao
    Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, USA
    BMC Genet 4:S24. 2003
    ..Alternatively, we may consider using univariate transformation for linkage analysis of longitudinal repeated measures...
  59. doi request reprint Acute myocardial ischemia up-regulates nociceptin/orphanin FQ in dorsal root ganglion and spinal cord of rats
    Zheng Guo
    Department of Anesthesiology, Shanxi Medical University, 56 Xinjian Nan Road, Taiyuan 030001, Shanxi, PR China
    Neurosci Lett 433:274-8. 2008
    ..The observations indicate that cardiac noxious neural afferent drive is responsible for the up-regulation of N/OFQ in the primary afferent neurons and intrinsic spinal neurons...
  60. ncbi request reprint Structures of ionic liquids dictate the conversion and selectivity of enzymatic glycerolysis: theoretical characterization by COSMO-RS
    Biqiang Chen
    BioCentrum DTU, Technical University of Denmark, Building 222, DK 2800 Lyngby, Denmark
    Biotechnol Bioeng 99:18-29. 2008
    ..This might be of general value to help to understand the multiple solvation interaction among IL reaction systems at molecular level and promote the application of IL-mediated reactions to practical interests...