Lu Gan

Summary

Country: China

Publications

  1. ncbi request reprint In vitro cartilage tissue formation by Co-culture of primary and passaged chondrocytes
    Lu Gan
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Tissue Eng 13:831-42. 2007
  2. ncbi request reprint A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells
    Lu Gan
    Institute of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    Eur J Pharmacol 471:217-22. 2003
  3. ncbi request reprint Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum
    Lu Gan
    Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Int Immunopharmacol 4:563-9. 2004
  4. ncbi request reprint Membrane-associated cytotoxicity induced by realgar in promyelocytic leukemia HL-60 cells
    Han qing Ye
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    J Ethnopharmacol 103:366-71. 2006
  5. doi request reprint Cellular uptake and intracellular trafficking of PEG-b-PLA polymeric micelles
    Zhen Zhang
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Biomaterials 33:7233-40. 2012
  6. doi request reprint Biphasic effects of H(2)O(2) on BK(Ca) channels
    Bo Liu
    Huazhong University of Science and Technology, Wuhan, PR China
    Free Radic Res 44:1004-12. 2010
  7. ncbi request reprint Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells
    Lu Gan
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    J Cell Biochem 96:653-64. 2005
  8. doi request reprint Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles
    Ling Xiao
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Biomaterials 32:5148-57. 2011
  9. doi request reprint Selective killing of hepatocellular carcinoma HepG2 cells by three-dimensional nanographene nanoparticles based on triptycene
    Xiaoqin Xiong
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Nanoscale 7:5217-29. 2015
  10. doi request reprint Hydrophilicity/Hydrophobicity reversable and redox-sensitive nanogels for anticancer drug delivery
    Hao Yang
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology and School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
    Mol Pharm 12:1636-47. 2015

Collaborators

Detail Information

Publications27

  1. ncbi request reprint In vitro cartilage tissue formation by Co-culture of primary and passaged chondrocytes
    Lu Gan
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Tissue Eng 13:831-42. 2007
    ..Confocal microscopy showed that fluorescently labeled primary cells were distributed throughout the tissue. This coculture approach could provide a new way to solve the problem of limited cell number for cartilage tissue engineering...
  2. ncbi request reprint A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells
    Lu Gan
    Institute of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    Eur J Pharmacol 471:217-22. 2003
    ..The results suggest that LBP(3p) may induce immune responses and possess potential therapeutic efficacy in cancer...
  3. ncbi request reprint Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum
    Lu Gan
    Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Int Immunopharmacol 4:563-9. 2004
    ..A total of 10 mg/kg dose is more effective than 5 and 20 mg/kg doses. This suggests that LBP3p at 10 mg/kg has a highly significant effect on tumor weight and improves the immune system...
  4. ncbi request reprint Membrane-associated cytotoxicity induced by realgar in promyelocytic leukemia HL-60 cells
    Han qing Ye
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    J Ethnopharmacol 103:366-71. 2006
    ..These results suggested that such membrane toxicity induced by realgar might play an important role in the process of apoptotic induction and could be considered as one of mechanisms underlying the cytotoxicity of realgar...
  5. doi request reprint Cellular uptake and intracellular trafficking of PEG-b-PLA polymeric micelles
    Zhen Zhang
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Biomaterials 33:7233-40. 2012
    ..These results suggested that dynamin- and caveolin-dependent but clathrin-independent endocytosis was involved in M-NR cellular uptake. We further found that M-NR colocalized with lysosome and microtubulin after internalization...
  6. doi request reprint Biphasic effects of H(2)O(2) on BK(Ca) channels
    Bo Liu
    Huazhong University of Science and Technology, Wuhan, PR China
    Free Radic Res 44:1004-12. 2010
    ..BK(Ca) channels and PI3K signaling pathway were involved in H(2)O(2)-induced vasodilation and H(2)O(2)-induced vasodilation by PI3K pathway was mainly due to modulation of BK(Ca) channel activity...
  7. ncbi request reprint Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells
    Lu Gan
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    J Cell Biochem 96:653-64. 2005
    ....
  8. doi request reprint Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles
    Ling Xiao
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Biomaterials 32:5148-57. 2011
    ..This study provides a foundation for understanding the mechanism of reversing MDR by nanoparticles better and designing more effective nano drug carriers...
  9. doi request reprint Selective killing of hepatocellular carcinoma HepG2 cells by three-dimensional nanographene nanoparticles based on triptycene
    Xiaoqin Xiong
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Nanoscale 7:5217-29. 2015
    ..This study provides a foundation for understanding the mechanism of selective induction of apoptosis in cancer cells by NG nanoparticles and designing more effective chemotherapeutical agents. ..
  10. doi request reprint Hydrophilicity/Hydrophobicity reversable and redox-sensitive nanogels for anticancer drug delivery
    Hao Yang
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology and School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
    Mol Pharm 12:1636-47. 2015
    ....
  11. ncbi request reprint Antagonistic effect of scutellarin on the toxicity of selenium in rat livers
    Ali Abdalla Eltayeb
    Department of Chemistry, Huazhong University of Science and Technology, Wuhan, 430074, People s Republic of China
    Biol Trace Elem Res 98:253-64. 2004
    ..The groups treated with both selenium and scutellarin or only scutellarin did not show significant tissue damage. Thus, scutellarin had an antagonistic effect against the toxicity of selenium...
  12. ncbi request reprint Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation
    Xiao hui Sun
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    J Pharmacol Exp Ther 323:391-7. 2007
    ..This is the first study demonstrating that puerarin activates BK(Ca) channels, especially BK-alpha+beta1 channels. The activation of the BK(Ca) channel probably contributes to the puerarin-mediated vasodilation action...
  13. doi request reprint Thioredoxin 1 upregulates FOXO1 transcriptional activity in drug resistance in ovarian cancer cells
    Jianlin Wang
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Biochim Biophys Acta 1852:395-405. 2015
    ..These findings provided a novel mechanism on Trx1/FOXO1 signaling in drug resistance in ovarian cancer cells. ..
  14. doi request reprint Enhancement of BK(Ca) channel activity induced by hydrogen peroxide: involvement of lipid phosphatase activity of PTEN
    Bo Liu
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China
    Biochim Biophys Acta 1788:2174-82. 2009
    ..These findings may elucidate a new mechanism for H(2)O(2)-induced BK(Ca) channel activation and provide some evidences for the role of PTEN on vasodilation induced by H(2)O(2)...
  15. ncbi request reprint Puerarin protects rat pancreatic islets from damage by hydrogen peroxide
    Fu Liang Xiong
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Eur J Pharmacol 529:1-7. 2006
    ..Puerarin may be effective in preventing islet cells from the toxic action of reactive oxygen species in diabetes...
  16. ncbi request reprint Membrane toxicity accounts for apoptosis induced by realgar nanoparticles in promyelocytic leukemia HL-60 cells
    Han qing Ye
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People s Republic of China
    Biol Trace Elem Res 103:117-32. 2005
    ..However, raw realgar particles are not sufficient to elicit apoptosis, although they can reduce membrane fluidity in HL-60 cells...
  17. doi request reprint Temperature-sensitive fluorescent organic nanoparticles with aggregation-induced emission for long-term cellular tracing
    Zhen Wang
    College of Life Science and Technology, Huazhong University of Science and Technology, and National Engineering Research Center for Nanomedicine, Wuhan, Hubei 430074, China
    ACS Appl Mater Interfaces 7:3420-5. 2015
    ..These nanoparticles can be internalized readily by HeLa cells and can be used as long-term tracer in live cells to be retained for as long as seven passages. ..
  18. doi request reprint Chitosan as a condensing agent induces high gene transfection efficiency and low cytotoxicity of liposome
    Ruizhen Liu
    College of Life Science and Technology, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, China
    J Biosci Bioeng 111:98-103. 2011
    ..The precondensation of DNA with chitosan can be a promising approach to further increase the transfection efficiency of cationic liposomes in clinical application...
  19. ncbi request reprint Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest
    Changdong Wang
    China UK HUST RRes Genetic Engineering and Genomics Joint Laboratory, the Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Acta Biochim Biophys Sin (Shanghai) 40:970-8. 2008
    ..These results demonstrate that NVP(1) inhibits proliferation of HepG2 through ERK signaling pathway. NVP(1) could be a potential drug for liver cancer...
  20. doi request reprint Resistance to docetaxel-induced apoptosis in prostate cancer cells by p38/p53/p21 signaling
    Lu Gan
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Prostate 71:1158-66. 2011
    ..However, the working mechanisms are not fully understood. We aimed to investigate the possible molecular mechanism of apoptosis induced by taxanes in prostate cancer...
  21. pmc New insights into the genetic networks affecting seed fatty acid concentrations in Brassica napus
    Xiaodong Wang
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China
    BMC Plant Biol 15:91. 2015
    ..Its oil is a mixture of various fatty acids and dissection of the genetic network for fatty acids biosynthesis is of great importance for improving seed quality...
  22. doi request reprint Proteomic and comparative genomic analysis of two Brassica napus lines differing in oil content
    Lu Gan
    Institute of Resource Biology and Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    J Proteome Res 12:4965-78. 2013
    ..Finally, the function of one gene that coded storage protein was verified by using a collection of Arabidopsis lines that can conditionally express the full length cDNA from developing seeds of B. napus. ..
  23. ncbi request reprint Effects of selenium overexposure on glutathione peroxidase and thioredoxin reductase gene expressions and activities
    Lu Gan
    Department of Chemistry, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Biol Trace Elem Res 89:165-75. 2002
    ..The results suggested that Se overexposure had an adverse effect on GSH-Px and TR mRNA levels and activities, and there could be tissue differences in the regulation of selenoprotein levels...
  24. doi request reprint Three-dimensional nanographene based on triptycene: synthesis and its application in fluorescence imaging
    Chun Zhang
    College of Life Science and Technology, Huazhong University of Science and Technology, and National Engineering Research Center for Nanomedicine, Hubei, 430074, China
    Org Lett 14:5912-5. 2012
    ..With the characteristic of intrinsic fluorescence, the 3D nanographene was used as a fluorescent agent for in vitro and in vivo fluorescence imaging with good antiphotobleaching ability and little toxicity...
  25. pmc Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth
    Qifa Xie
    Laboratory of Innate Immunity and Inflammation, Department of Biological Sciences, Fralin Biotechnology Center, Virginia Tech, Blacksburg, VA 24061, United States
    Mol Immunol 44:3453-61. 2007
    ..Collectively, we demonstrate that IRAK-M is directly involved in the regulation of both innate and adaptive immune signaling processes, and deletion of IRAK-M enhances host anti-tumor immune response...
  26. ncbi request reprint Large-scale purification and characterization of human parathyroid hormone-1 receptor stably expressed in HEK293S GnTI- cells
    Lu Gan
    Department of Physiology, Tufts University, School of Medicine, 136 Harrison Avenue, Boston, MA 02111 1800, USA
    Protein Expr Purif 47:296-302. 2006
    ..This work describes an approach for preparing milligram-scale quantities of receptor for elucidation of the structural biology of this seven-transmembrane GPCR...
  27. ncbi request reprint Enhanced expression of dopamine D(1) and glutamate NMDA receptors in dopamine D(4) receptor knockout mice
    Lu Gan
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    J Mol Neurosci 22:167-78. 2004
    ....