Lu Gan

Summary

Country: China

Publications

  1. ncbi In vitro cartilage tissue formation by Co-culture of primary and passaged chondrocytes
    Lu Gan
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Tissue Eng 13:831-42. 2007
  2. ncbi A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells
    Lu Gan
    Institute of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    Eur J Pharmacol 471:217-22. 2003
  3. ncbi Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum
    Lu Gan
    Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Int Immunopharmacol 4:563-9. 2004
  4. ncbi Membrane-associated cytotoxicity induced by realgar in promyelocytic leukemia HL-60 cells
    Han qing Ye
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    J Ethnopharmacol 103:366-71. 2006
  5. ncbi Biphasic effects of H(2)O(2) on BK(Ca) channels
    Bo Liu
    Huazhong University of Science and Technology, Wuhan, PR China
    Free Radic Res 44:1004-12. 2010
  6. ncbi Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles
    Ling Xiao
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Biomaterials 32:5148-57. 2011
  7. ncbi Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells
    Lu Gan
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    J Cell Biochem 96:653-64. 2005
  8. ncbi Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation
    Xiao hui Sun
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    J Pharmacol Exp Ther 323:391-7. 2007
  9. ncbi Cellular uptake and intracellular trafficking of PEG-b-PLA polymeric micelles
    Zhen Zhang
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Biomaterials 33:7233-40. 2012
  10. ncbi Chitosan as a condensing agent induces high gene transfection efficiency and low cytotoxicity of liposome
    Ruizhen Liu
    College of Life Science and Technology, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, China
    J Biosci Bioeng 111:98-103. 2011

Collaborators

  • Hui bi Xu
  • Bo Liu
  • Peng Chen
  • Zhen Zhang
  • Yi Li
  • Han qing Ye
  • Hui Li
  • Hao Yang
  • Xiangliang Yang
  • Ling Xiao
  • Ruizhen Liu
  • Changdong Wang
  • Xiao hui Sun
  • Qifa Xie
  • Xiang-Liang Yang
  • Xiao-Hui Sun
  • Fu-Liang Xiong
  • Xiaoqin Xiong
  • Xiaohui Sun
  • Yanhong Zhu
  • Huabing Chen
  • Guangxiao Yang
  • Guangyuan He
  • Xu Yan
  • Hongjuan Jin
  • Yuesheng Wang
  • Junli Chang
  • Shiyi Zhou
  • Jianxia Wang
  • Jiu-Ping Ding
  • Na Pan
  • Jiu Ping Ding
  • Xiang Liang Yang
  • Ingred Wilson
  • Liwu Li

Detail Information

Publications18

  1. ncbi In vitro cartilage tissue formation by Co-culture of primary and passaged chondrocytes
    Lu Gan
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Tissue Eng 13:831-42. 2007
    ..Confocal microscopy showed that fluorescently labeled primary cells were distributed throughout the tissue. This coculture approach could provide a new way to solve the problem of limited cell number for cartilage tissue engineering...
  2. ncbi A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells
    Lu Gan
    Institute of Pharmacy, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    Eur J Pharmacol 471:217-22. 2003
    ..The results suggest that LBP(3p) may induce immune responses and possess potential therapeutic efficacy in cancer...
  3. ncbi Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum
    Lu Gan
    Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Int Immunopharmacol 4:563-9. 2004
    ..A total of 10 mg/kg dose is more effective than 5 and 20 mg/kg doses. This suggests that LBP3p at 10 mg/kg has a highly significant effect on tumor weight and improves the immune system...
  4. ncbi Membrane-associated cytotoxicity induced by realgar in promyelocytic leukemia HL-60 cells
    Han qing Ye
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    J Ethnopharmacol 103:366-71. 2006
    ..These results suggested that such membrane toxicity induced by realgar might play an important role in the process of apoptotic induction and could be considered as one of mechanisms underlying the cytotoxicity of realgar...
  5. ncbi Biphasic effects of H(2)O(2) on BK(Ca) channels
    Bo Liu
    Huazhong University of Science and Technology, Wuhan, PR China
    Free Radic Res 44:1004-12. 2010
    ..BK(Ca) channels and PI3K signaling pathway were involved in H(2)O(2)-induced vasodilation and H(2)O(2)-induced vasodilation by PI3K pathway was mainly due to modulation of BK(Ca) channel activity...
  6. ncbi Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles
    Ling Xiao
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Biomaterials 32:5148-57. 2011
    ..This study provides a foundation for understanding the mechanism of reversing MDR by nanoparticles better and designing more effective nano drug carriers...
  7. ncbi Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells
    Lu Gan
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    J Cell Biochem 96:653-64. 2005
    ....
  8. ncbi Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation
    Xiao hui Sun
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    J Pharmacol Exp Ther 323:391-7. 2007
    ..This is the first study demonstrating that puerarin activates BK(Ca) channels, especially BK-alpha+beta1 channels. The activation of the BK(Ca) channel probably contributes to the puerarin-mediated vasodilation action...
  9. ncbi Cellular uptake and intracellular trafficking of PEG-b-PLA polymeric micelles
    Zhen Zhang
    National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Biomaterials 33:7233-40. 2012
    ..These results suggested that dynamin- and caveolin-dependent but clathrin-independent endocytosis was involved in M-NR cellular uptake. We further found that M-NR colocalized with lysosome and microtubulin after internalization...
  10. ncbi Chitosan as a condensing agent induces high gene transfection efficiency and low cytotoxicity of liposome
    Ruizhen Liu
    College of Life Science and Technology, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, China
    J Biosci Bioeng 111:98-103. 2011
    ..The precondensation of DNA with chitosan can be a promising approach to further increase the transfection efficiency of cationic liposomes in clinical application...
  11. ncbi Resistance to docetaxel-induced apoptosis in prostate cancer cells by p38/p53/p21 signaling
    Lu Gan
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Prostate 71:1158-66. 2011
    ..However, the working mechanisms are not fully understood. We aimed to investigate the possible molecular mechanism of apoptosis induced by taxanes in prostate cancer...
  12. ncbi Puerarin protects rat pancreatic islets from damage by hydrogen peroxide
    Fu-Liang Xiong
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Eur J Pharmacol 529:1-7. 2006
    ..Puerarin may be effective in preventing islet cells from the toxic action of reactive oxygen species in diabetes...
  13. ncbi Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest
    Changdong Wang
    China UK HUST RRes Genetic Engineering and Genomics Joint Laboratory, the Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Acta Biochim Biophys Sin (Shanghai) 40:970-8. 2008
    ..These results demonstrate that NVP(1) inhibits proliferation of HepG2 through ERK signaling pathway. NVP(1) could be a potential drug for liver cancer...
  14. ncbi Enhancement of BK(Ca) channel activity induced by hydrogen peroxide: involvement of lipid phosphatase activity of PTEN
    Bo Liu
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China
    Biochim Biophys Acta 1788:2174-82. 2009
    ..These findings may elucidate a new mechanism for H(2)O(2)-induced BK(Ca) channel activation and provide some evidences for the role of PTEN on vasodilation induced by H(2)O(2)...
  15. ncbi Membrane toxicity accounts for apoptosis induced by realgar nanoparticles in promyelocytic leukemia HL-60 cells
    Han-Qing Ye
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China
    Biol Trace Elem Res 103:117-32. 2005
    ..However, raw realgar particles are not sufficient to elicit apoptosis, although they can reduce membrane fluidity in HL-60 cells...
  16. ncbi Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth
    Qifa Xie
    Laboratory of Innate Immunity and Inflammation, Department of Biological Sciences, Fralin Biotechnology Center, Virginia Tech, Blacksburg, VA 24061, United States
    Mol Immunol 44:3453-61. 2007
    ..Collectively, we demonstrate that IRAK-M is directly involved in the regulation of both innate and adaptive immune signaling processes, and deletion of IRAK-M enhances host anti-tumor immune response...
  17. ncbi Enhanced expression of dopamine D(1) and glutamate NMDA receptors in dopamine D(4) receptor knockout mice
    Lu Gan
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    J Mol Neurosci 22:167-78. 2004
    ....
  18. ncbi Large-scale purification and characterization of human parathyroid hormone-1 receptor stably expressed in HEK293S GnTI- cells
    Lu Gan
    Department of Physiology, Tufts University, School of Medicine, 136 Harrison Avenue, Boston, MA 02111-1800, USA
    Protein Expr Purif 47:296-302. 2006
    ..This work describes an approach for preparing milligram-scale quantities of receptor for elucidation of the structural biology of this seven-transmembrane GPCR...