Y Chen

Summary

Affiliation: Fujian Medical University
Country: China

Publications

  1. ncbi request reprint A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin
    Y Chen
    Department of Physiology, Georgetown University, Washington, DC 20016, USA
    J Mol Neurosci 17:59-70. 2001
  2. ncbi request reprint Latent TGF-beta binding proteins
    V Todorovic
    Department of Cell Biology, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Int J Biochem Cell Biol 37:38-41. 2005
  3. ncbi request reprint Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells
    R Yang
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Gene Ther 13:1714-23. 2006
  4. ncbi request reprint Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    U Senftleben
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 293:1495-9. 2001
  5. ncbi request reprint Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA
    L Zhu
    Division of Immunology, Beckman Institute of the City of Hope, Duarte, California 91010, USA
    Biochemistry 40:9142-50. 2001
  6. ncbi request reprint CpG DNA induces cyclooxygenase-2 expression and prostaglandin production
    Y Chen
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int Immunol 13:1013-20. 2001
  7. ncbi request reprint The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70
    Z Zhang
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Biol Chem 276:38231-6. 2001
  8. ncbi request reprint A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube
    J Briscoe
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Institute, Columbia University, 701 West 168th Street, 10032, New York, NY, USA
    Mol Cell 7:1279-91. 2001
  9. pmc Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity
    W Han
    Laboratory of Medical Immunology, School of Basic Medical Science, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Biochem J 357:127-35. 2001
  10. ncbi request reprint Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin
    I S Vizirianakis
    Department of Stomatology, University of California at San Francisco, 94143 0512, USA
    Arch Biochem Biophys 385:108-16. 2001

Collaborators

Detail Information

Publications62

  1. ncbi request reprint A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin
    Y Chen
    Department of Physiology, Georgetown University, Washington, DC 20016, USA
    J Mol Neurosci 17:59-70. 2001
    ....
  2. ncbi request reprint Latent TGF-beta binding proteins
    V Todorovic
    Department of Cell Biology, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Int J Biochem Cell Biol 37:38-41. 2005
    ..The latent TGF-beta binding protein is covalently bound to the propeptide. These binding proteins may perform at least two functions: structural, as components of the matrix, and regulatory, as modulators of TGF-beta availability...
  3. ncbi request reprint Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells
    R Yang
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Gene Ther 13:1714-23. 2006
    ..Infusion of SWNTs+ carrying SOCS1siRNA reduced SOCS1 expression and retarded the growth of established B16 tumor in mice, indicating the possibility of in vivo immunotherapeutics using SWNTs-based siRNA transfer system...
  4. ncbi request reprint Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    U Senftleben
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 293:1495-9. 2001
    ..IKKalpha is therefore a pivotal component of a second NF-kappaB activation pathway based on regulated NF-kappaB2 processing rather than IkappaB degradation...
  5. ncbi request reprint Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA
    L Zhu
    Division of Immunology, Beckman Institute of the City of Hope, Duarte, California 91010, USA
    Biochemistry 40:9142-50. 2001
    ....
  6. ncbi request reprint CpG DNA induces cyclooxygenase-2 expression and prostaglandin production
    Y Chen
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Int Immunol 13:1013-20. 2001
    ..Taken together, these data indicate that DNA containing CpG motifs is a potent inducer of COX-2 and PGE (2) production. CpG-induced PG may subsequently down-regulate the immune and inflammatory responses elicited by the CpG DNA...
  7. ncbi request reprint The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70
    Z Zhang
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Biol Chem 276:38231-6. 2001
    ..The C-terminal DNA-binding domain of Ku70 contains a helix-extended strand-helix motif, which occurs in other nucleic acid-binding proteins and may represent a common nucleic acid binding motif...
  8. ncbi request reprint A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube
    J Briscoe
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Institute, Columbia University, 701 West 168th Street, 10032, New York, NY, USA
    Mol Cell 7:1279-91. 2001
    ..mPtc1(Deltaloop2) expression also caused the abnormal spread of Shh to more dorsal cells, indicating that Shh in the neural tube, like Hh in Drosophila, induces a feedback mechanism that limits its range of action...
  9. pmc Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity
    W Han
    Laboratory of Medical Immunology, School of Basic Medical Science, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Biochem J 357:127-35. 2001
    ..These results suggest that CKLF1 might have important roles in inflammation and in the regeneration of skeletal muscle...
  10. ncbi request reprint Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin
    I S Vizirianakis
    Department of Stomatology, University of California at San Francisco, 94143 0512, USA
    Arch Biochem Biophys 385:108-16. 2001
    ....
  11. pmc Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
    O Monni
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:5711-6. 2001
    ..In summary, comprehensive analysis of the 17q23 amplicon revealed a limited number of highly expressed genes that may contribute to the more aggressive clinical course observed in breast cancer patients with 17q23-amplified tumors...
  12. ncbi request reprint RGD-Tachyplesin inhibits tumor growth
    Y Chen
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical School, Washington, DC 20007, USA
    Cancer Res 61:2434-8. 2001
    ..The in vivo studies indicated that the RGD-tachyplesin could inhibit the growth of tumors on the chorioallantoic membranes of chicken embryos and in syngenic mice...
  13. ncbi request reprint Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene
    Y Chen
    Division of Rheumatology, Department of Medicine, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Immunol 166:4163-9. 2001
    ..This finding raises significant caution with regard to the potential use of therapeutic approaches based on immune deviation toward type 2 responses...
  14. ncbi request reprint Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos
    Y Chen
    Georg August Universitat Gottingen, Institut fur Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D 37073, Gottingen, Germany
    Mech Dev 101:91-103. 2001
    ....
  15. ncbi request reprint Differentiation of brain angiotensin type 1a and 1b receptor mRNAs: A specific effect of dehydration
    Y Chen
    Department of Pharmacology and Toxicology, Wright State University School of Medicine, Dayton, Ohio, USA
    Hypertension 37:692-7. 2001
    ..This verifies the role of AT(1a) receptors in volume regulation but raises a question concerning the physiological role of the AT(1b) subtype...
  16. ncbi request reprint Transcriptional state and chromatin structure of the murine entactin and laminin gamma1 genes
    Y Chen
    Department of Biochemistry and Molecular Biology, Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL 60064, USA
    J Cell Biochem 82:225-33. 2001
    ..The induction to high levels appears to involve additional sites and possibly the production of new and/or the modification of existing trans-acting factors...
  17. ncbi request reprint Characterization of the DNA-binding property of Smad5
    W Li
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biochem Biophys Res Commun 286:1163-9. 2001
    ....
  18. ncbi request reprint Role of vicinal cysteine pairs in metalloid sensing by the ArsD As(III)-responsive repressor
    S Li
    Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, 540 E. Canfield Ave, Detroit, MI 48201, USA
    Mol Microbiol 41:687-96. 2001
    ..The data are consistent with a model in which Cys-12-Cys-13 and Cys-112-Cys-113 form independent As(III) binding sites, both of which are required for in vivo ArsD function...
  19. ncbi request reprint Mycophenolic acid upregulates B7-DC expression on dendritic cells, which is associated with impaired allostimulatory capacity of dendritic cells
    L Geng
    Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Transplant Proc 38:1622-4. 2006
    ..Thus, we suggest that MPA upregulates B7-DC expression during DC maturation induced by LPS in vitro, an effect that may be responsible for MPA-mediated inhibitory effects on the allostimulatory capacity of DC...
  20. pmc Ensembl 2006
    E Birney
    European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 34:D556-61. 2006
    ....
  21. ncbi request reprint Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart
    Y Chen
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Inflamm Res 54:338-43. 2005
    ....
  22. ncbi request reprint Assignment of suppressor of cytokine signalling-2 (SOCS2) to porcine chromosome 5 with radiation hybrids
    E Piper
    Centre for Advanced Technologies in Animal Genetics and Reproduction, University of Sydney, Sydney, Australia
    Cytogenet Genome Res 111:96. 2005
  23. pmc Analysis of missense variation in human BRCA1 in the context of interspecific sequence variation
    V Abkevich
    Myriad Genetics, Inc, Salt Lake City, UT, 84108, USA
    J Med Genet 41:492-507. 2004
    ..Before this study, only 21 of these missense changes were classified as deleterious or suspected deleterious and 14 as neutral or of little clinical significance...
  24. ncbi request reprint Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus
    F R Tang
    Epilepsy Research Laboratory, National Neuroscience Institute, Singapore
    Hippocampus 14:87-98. 2004
    ....
  25. ncbi request reprint Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration
    Y Chen
    Division of Biological Sciences, University of Missouri Colombia, Colombia, Missouri 65211, USA
    Dev Dyn 229:541-54. 2004
    ..Collectively, these results demonstrate that c-merlin is developmentally regulated in migrating and differentiating myogenic cells, where it functions as a negative regulator of both muscle growth and motility...
  26. pmc Orally administered RDP58 reduces the severity of dextran sodium sulphate induced colitis
    R Boismenu
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann Rheum Dis 61:ii19-24. 2002
    ..These findings indicate that RDP58 represents a new, orally available agent potentially useful in the treatment of inflammatory bowel disease...
  27. ncbi request reprint Functional regulatory regions of human transcription factor MEF2C
    C G Janson
    Yale University School of Medicine, Department of Neurology, New Haven, CT 06510, USA
    Brain Res Mol Brain Res 97:70-82. 2001
    ..This structural information may be useful for elucidating the mechanisms of MEF2C in interacting with other factors to regulate target genes...
  28. ncbi request reprint Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor
    Q Dan
    Diagnostic and Molecular Medicine Health Care Group, Veterans Affairs Medical Center, University of California, 5901 E. 7th Street, Long Beach, CA 90822, USA
    Mol Ther 4:427-37. 2001
    ..Our work suggests that mM-CSF transduced hepatoma cells could be used as a tumor vaccine to stimulate immune responses against hepatocellular carcinoma...
  29. ncbi request reprint Urokinase-type plasminogen activator up-regulates its own expression by endothelial cells and monocytes via the u-PAR pathway
    C Li
    Institute of Molecular Medicine, Nanjing University, Nanjing 10008, China
    Thromb Res 103:221-32. 2001
    ..The possibilities that the results were related to displacement of receptor-bound u-PA or the blocking of u-PA incorporation into the cells were excluded. A modest up-regulation of u-PAR was also associated with this phenomenon...
  30. ncbi request reprint Apolipoprotein E inhibits serum-stimulated cell proliferation and enhances serum-independent cell proliferation
    Y Y Ho
    Institute of Human Nutrition and the Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Biol Chem 276:43455-62. 2001
    ..We conclude that apoE does not simply inhibit cell proliferation; rather, the presence of apoE alters the response to and requirement for serum mitogens...
  31. ncbi request reprint The human estrogen receptor alpha dimer binds a single SRC-1 coactivator molecule with an affinity dictated by agonist structure
    E Margeat
    Centre de Biochimie Structurale, INSERM U414 CNRS UMR 5048 - UM1, Montpellier, France
    J Mol Biol 306:433-42. 2001
    ..Distinct anisotropy values for the ERalpha-SRC-1 complexes with different agonists suggest distinct conformations of the complexes depending upon agonist structure...
  32. ncbi request reprint Roles of TNF-related apoptosis-inducing ligand in experimental autoimmune encephalomyelitis
    B Hilliard
    Department of Molecular and Cellular Engineering, Institute for Human Gene Therapy, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 166:1314-9. 2001
    ..Based on these observations, we conclude that unlike TNF, which promotes autoimmune inflammation, TRAIL inhibits autoimmune encephalomyelitis and prevents activation of autoreactive T cells...
  33. pmc The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
    P L Chen
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Proc Natl Acad Sci U S A 95:5287-92. 1998
    ..These results suggest that the interaction between the BRC repeats of BRCA2 and RAD51 is critical for cellular response to DNA damage caused by MMS...
  34. pmc Structural and functional characterization of recombinant human cellular retinaldehyde-binding protein
    J W Crabb
    Adirondack Biomedical Research Institute, Lake Placid, New York 12946, USA
    Protein Sci 7:746-57. 1998
    ..These recombinant preparations provide valid models for human CRALBP structure-function studies...
  35. pmc Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination
    T Stams
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia 19104 6323, USA
    Protein Sci 7:556-63. 1998
    ..Binding interactions observed for brinzolamide rationalize the generally weaker affinity of inhibitors used in glaucoma therapy toward CAIV compared with CAII...
  36. ncbi request reprint Identification of pactolus, an integrin beta subunit-like cell-surface protein preferentially expressed by cells of the bone marrow
    Y Chen
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Biol Chem 273:8711-8. 1998
    ..These data suggest that Pactolus represents a gene and gene product related to those of the integrin beta subunits but whose function(s) may be quite distinct from those of the integrin beta subunits...
  37. ncbi request reprint Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    M M Ollmann
    Department of Pediatrics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 278:135-8. 1997
    ..Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling...
  38. ncbi request reprint Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
    Y Chen
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Nat Med 3:866-71. 1997
    ..Similar motifs were also identified in the envelope proteins of other flaviviridae. Developing pharmaceuticals that inhibit target cell binding may be an effective strategy for treating flavivirus infections...
  39. ncbi request reprint Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
    P L Chen
    Institute of Biotechnology, The University of Texas Health Science Center at San Antonio 78245, USA
    Genes Dev 10:2794-804. 1996
    ..Such a role contrasts with the function of Rb in arresting cell cycle progression in G1 by negative regulation of other transcription factors like E2F-1...
  40. ncbi request reprint Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal
    Y Chen
    Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, New York 14853 6301, USA
    J Biol Chem 271:20507-15. 1996
    ....
  41. ncbi request reprint Molecular cloning and functional expression of mouse connexin-30,a gap junction gene highly expressed in adult brain and skin
    E Dahl
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, 53117 Bonn, Federal Republic of Germany
    J Biol Chem 271:17903-10. 1996
    ..This suggests that the polarity of voltage gating and the cationic selectivity of connexin-30 are similar to those of its closest homologue, connexin-26...
  42. ncbi request reprint Expression of a retinoblastoma transgene results in dwarf mice
    Y J Bignon
    Center for Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio 78245
    Genes Dev 7:1654-62. 1993
    ..These studies demonstrate that the effect of RB on overall mouse development is closely dependent upon its dosage...
  43. ncbi request reprint Structure, chromosomal localization, and expression pattern of the murine Magp gene
    Y Chen
    Department of Pathology, University of Michigan, Ann Arbor 48109 0650
    J Biol Chem 268:27381-9. 1993
    ..This study presents the first comprehensive evaluation of microfibril gene expression during mammalian development...
  44. ncbi request reprint Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family
    Y Chen
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202
    FEBS Lett 347:279-83. 1994
    ..Rather, it represents a novel member of the opioid receptor gene family, not identified from previous pharmacological studies...
  45. ncbi request reprint Murine chromosomal location of the mu and kappa opioid receptor genes
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 21:659-61. 1994
    ..These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene...
  46. ncbi request reprint Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex
    Y Chen
    Molecular Medicine Unit, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 273:11887-94. 1998
    ..Thus, ubiquitin can be attached to unassembled apolipoprotein B in the Sec61 complex, and this process is affected by factors including calnexin that alter the translocation of apolipoprotein B...
  47. ncbi request reprint Complex regulation of multiple cytohesin-like genes in murine tissues and cells
    H S Kim
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    FEBS Lett 433:312-6. 1998
    ..Their broad distribution and cell and tissue specific expression patterns suggest complex regulation during development and in the adult...
  48. ncbi request reprint A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases
    Y C Yuan
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010 0269, USA
    Nat Struct Biol 5:959-64. 1998
    ..This new DNA-binding motif shares structural homology with T4 RNase H, E. coli endonuclease III and Bacillus subtilis DNA polymerase I. The structural homology suggests a mechanism for substrate recognition by these enzymes...
  49. ncbi request reprint A novel St(a) glycophorin produced via gene conversion of pseudoexon III from glycophorin E to glycophorin A gene
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10021, USA
    Hum Mutat 15:533-40. 2000
    ..Thus, the inactivation of GPA exon III by conversion of a silent GPE donor splice site portrays a new molecular mechanism for St(a) antigen expression in human erythrocytes...
  50. ncbi request reprint Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis
    Z Liu
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    J Biol Chem 275:25641-51. 2000
    ..These results pinpoint RhCG and Rhcg as novel polytopic membrane glycoproteins that may function as epithelial transporters maintaining normal homeostatic conditions in kidney and testis...
  51. ncbi request reprint Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains
    J Fu
    Department of Cell Biology, New York University Medical Center, New York 10016, USA
    Eur J Cell Biol 79:219-28. 2000
    ..We also show that the retention function of the transmembrane domain is strengthened by the presence of a flanking luminal region consisting of 15 amino acids...
  52. ncbi request reprint Mast cell tryptase from pig lungs triggers infection by pneumotropic Sendai and influenza A viruses. Purification and characterization
    Y Chen
    Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Japan
    Eur J Biochem 267:3189-97. 2000
    ..These results suggest that mast cell tryptase in pig lungs is the possible trigger of the pneumotropic virus infections...
  53. pmc Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p
    L Zheng
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Mol Cell Biol 20:3529-37. 2000
    ..Rb thus increased the fidelity of chromosome segregation mediated by hsHec1p in a heterologous yeast system...
  54. ncbi request reprint Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation, duplication, and posterior transformation of digit in mouse limb
    Z Zhang
    Department of Oral Biology, University of Oslo, Oslo, 0316, Norway
    Dev Biol 220:154-67. 2000
    ..In addition, BMPR-IB may represent a critical component in the Shh/FGF4 feedback loop by regulating Gremlin expression...
  55. ncbi request reprint Regulation of Smad7 promoter by direct association with Smad3 and Smad4
    R P Nagarajan
    Department of Medical Genetics, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 274:33412-8. 1999
    ..Taken together, these data provided the first evidence that Smad7 transcription is regulated by TGF-beta and activin signaling through direct binding of Smad3 and Smad4 to the Smad7 promoter...
  56. ncbi request reprint Genomic organization, chromosomal localization, and transcriptional variants of the murine Pactolus gene
    R L Margraf
    The Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, 50 N Medical Drive, Salt Lake City, Utah 84132, USA
    Mamm Genome 10:1075-81. 1999
    ..The formation of the Pactolus B and C forms is thus governed by a complex alternative splicing mechanism that is affected by the developmental status of the animal...
  57. pmc Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins
    L Zheng
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center San Antonio, San Antonio, Texas 78245, USA
    Mol Cell Biol 19:5417-28. 1999
    ..These results suggest that Hec1 proteins play a critical role in modulating chromosomal segregation, in part, through their interactions with SMC proteins...
  58. ncbi request reprint Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene
    A K Wong
    Myriad Genetics, Inc, 320 Wakara Way, Salt Lake City, Utah, 84108, USA
    Genomics 59:248-51. 1999
    ..Loss of expression of the wildtype allele in the same breast cell line supports the possibility that CDC14A may be a tumor suppressor gene that is targeted for inactivation during tumorigenesis...
  59. ncbi request reprint Characterization of early region 1 and pIX of bovine adenovirus-3
    P S Reddy
    Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada
    Virology 253:299-308. 1999
    ..To identify and characterize the proteins produced from the region, antibodies were raised in rabbits that recognized specific proteins in Western blot and immunoprecipitation assays...
  60. ncbi request reprint Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB
    H Hilbi
    Skirball Institute, Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 273:32895-900. 1998
    ..Taken together these data indicate that Shigella-induced apoptosis is distinct from other forms of apoptosis and seems uniquely dependent on Casp-1...
  61. ncbi request reprint In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
    Y Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Development 125:4943-8. 1998
    ....
  62. ncbi request reprint Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers
    P G Schlegel
    Bone Marrow Transplant Program H1353, Stanford University School of Medicine, CA 94305, USA
    J Immunol 155:3856-65. 1995
    ..Long-term engraftment of allogeneic bone marrow was documented in all transplanted mice by PCR analysis of a microsatellite region in the IL-1 beta gene...