Huanzhang Zhu

Summary

Affiliation: Fudan University
Country: China

Publications

  1. pmc Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB
    Hao Ying
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 7:e48832. 2012
  2. pmc Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    PLoS ONE 7:e35020. 2012
  3. pmc Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells
    Xiying Qu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China andKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China
    Nucleic Acids Res 41:7771-82. 2013
  4. pmc Mutational analysis of highly conserved residues in the phage phiC31 integrase reveals key amino acids necessary for the DNA recombination
    Shaohui Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e8863. 2010
  5. pmc CCL3L1 copy number variation and susceptibility to HIV-1 infection: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e15778. 2010
  6. ncbi request reprint Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis
    Huanzhang Zhu
    State Key Laboratory of Genetic Engineering, Institute of Genetic, School of Life Sciences, Fudan University, Shanghai 200433, China
    Exp Mol Pathol 76:44-50. 2004
  7. ncbi request reprint Histone deacetylase inhibitor MC1293 induces latent HIV-1 reactivation by histone modification in vitro latency cell lines
    Xiying Qu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P R China
    Curr HIV Res 11:24-9. 2013
  8. doi request reprint Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation
    Donglin Ding
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Virology 440:182-9. 2013
  9. doi request reprint Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells
    Hao Yin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Mol Biol Rep 38:5071-8. 2011
  10. doi request reprint HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells
    Shiguan Lin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Curr HIV Res 9:202-8. 2011

Collaborators

Detail Information

Publications13

  1. pmc Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB
    Hao Ying
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 7:e48832. 2012
    ..However, little is known about the effects and action mechanism of M344 in inducing HIV expression in latently infected cells...
  2. pmc Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    PLoS ONE 7:e35020. 2012
    ..However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility...
  3. pmc Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells
    Xiying Qu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China andKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China
    Nucleic Acids Res 41:7771-82. 2013
    ....
  4. pmc Mutational analysis of highly conserved residues in the phage phiC31 integrase reveals key amino acids necessary for the DNA recombination
    Shaohui Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e8863. 2010
    ..Until now, no system mutational or biochemical studies have been carried out to assess the roles of these conserved residues in the recombination of phiC31 integrase...
  5. pmc CCL3L1 copy number variation and susceptibility to HIV-1 infection: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e15778. 2010
    ..Therefore, we performed a meta-analysis using two models to generate a more robust estimate of the association between CCL3L1 CNV and susceptibility to HIV-1 infection...
  6. ncbi request reprint Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis
    Huanzhang Zhu
    State Key Laboratory of Genetic Engineering, Institute of Genetic, School of Life Sciences, Fudan University, Shanghai 200433, China
    Exp Mol Pathol 76:44-50. 2004
    ..Taken together, our results suggest that HBx gene expression alone is not sufficient for carcinogenesis, but may act as a promoter for malignant transformation...
  7. ncbi request reprint Histone deacetylase inhibitor MC1293 induces latent HIV-1 reactivation by histone modification in vitro latency cell lines
    Xiying Qu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P R China
    Curr HIV Res 11:24-9. 2013
    ..The results suggest that the acetylation of histone plays an important role in regulating HIV-1 LTR gene expression, and MC1293 is potential drug candidate for antilatency therapies...
  8. doi request reprint Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation
    Donglin Ding
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Virology 440:182-9. 2013
    ..GLP knockdown by small interfering RNA clearly induced HIV-1 LTR expression. Results suggest that GLP may play a significant role in the maintenance of HIV-1 latency by catalyzing dimethylation of H3K9...
  9. doi request reprint Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells
    Hao Yin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Mol Biol Rep 38:5071-8. 2011
    ..Taken together, our results suggest that the histone acetylation plays an important role in regulating HIV-1 LTR gene expression, and Oxamflatin has potential as drug candidates as antilatency therapies...
  10. doi request reprint HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells
    Shiguan Lin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Curr HIV Res 9:202-8. 2011
    ..Our research reveals a potent activator for reactivating latent HIV-1 and shows promise for HIV-1 therapy...
  11. ncbi request reprint Association between polymorphism of SDF1 (CXCL12) gene and HIV-1 susceptibility: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China
    Curr HIV Res 9:112-9. 2011
    ..In conclusion, no statistically significant association between SDF1 genotype and HIV-1 susceptibility was detected in any models. Our data suggested that SDF1 genotype might have limited effect on HIV-1 susceptibility...
  12. ncbi request reprint In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus
    Lin Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    Curr HIV Res 10:572-7. 2012
    ..These data demonstrated that the envelope of CRF07_BC from China has the capability of resulting in infection to CD34+ HPCs, which may serve as a mechanism for long-term latency of HIV-1 infection in vivo...
  13. ncbi request reprint A 16bp Rep binding element is sufficient for mediating Rep-dependent integration into AAVS1
    DengMin Feng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    J Mol Biol 358:38-45. 2006
    ..These findings added new information on the mechanism of Rep-dependent AAV genome insertion at the AAVS1 site and may be helpful in developing new high efficiency vectors for site-specific transgene integration...