Research Topics
Genomes and Genes | Zhi Qi ZhaoSummaryAffiliation: Fudan University Country: China Publications
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Publications
Effects of aquaporin 4 deficiency on the expression of spinal PKCα, PKCγ and c-Fos in naloxone-precipitated morphine withdrawal miceMeng ling Chen
School of Bioscience and Food Engineering, Changshu Institute of Technology, Changshu 215500, China
Sheng Li Xue Bao 64:365-71. 2012..01). These data suggest that AQP4 deficiency-attenuated morphine withdrawal responses may be partially attributed to the changes in the spinal expression of PKCα, PKCγ or c-Fos...
Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic painZhi Jun Zhang
Institute of Nautical Medicine, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, 226001, China
J Neuroinflammation 9:136. 2012..The present study was undertaken to test the hypothesis that chemokine C-C motif ligand 2 (CCL2)-chemokine C-C motif receptor 2 (CCR2) signaling in the trigeminal nucleus is involved in the maintenance of trigeminal neuropathic pain...- Prevention of paclitaxel-induced allodynia by minocycline: Effect on loss of peripheral nerve fibers and infiltration of macrophages in ratsCui Cui Liu
Department of Physiology and Pain Research Center, Zhongshan Medical School, Sun Yat Sen University, 74 Zhongshan Rd, 2, Guangzhou, 510080, PR China
Mol Pain 6:76. 2010..Recently, Cata et al also reported that minocycline inhibited allodynia induced by low-dose paclitaxel (2 mg/kg) in rats, but the mechanism is still unclear... 
Neural mechanism underlying acupuncture analgesiaZhi Qi Zhao
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
Prog Neurobiol 85:355-75. 2008..PTX-sesntive Gi/o protein- and MAP kinase-mediated signal pathways as well as the downstream events NF-kappaB, c-fos and c-jun play important roles in EA analgesia...- Ligustrazine inhibits high voltage-gated Ca(2+) and TTX-resistant Na(+) channels of primary sensory neuron and thermal nociception in the rat: a study on peripheral mechanismBi Hua Bie
Institute of Neurobiology, Fu Dan University, Shanghai 200031, China Institute of Shanghai Physiology, Chinese Academy of Sciences, Shanghai 200031, China E mail
Neurosci Bull 22:79-84. 2006..49 mmol/L. Conclusion The results suggested that ligustrazine could elevate the threshold of thermal nociception through inhibiting the high-voltage gated calcium current and TTX-resistant sodium current of DRG neuron in the rat... - Involvement of ryanodine receptors in tetanic sciatic stimulation-induced long-term potentiation of spinal dorsal horn and persistent pain in ratsNing Lu
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
J Neurosci Res 90:1096-104. 2012..The results suggest that RyRs are involved in synaptic plasticity of the spinal pain pathway and may be a novel target for treating pain. © 2012 Wiley Periodicals, Inc... - Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesiaHua Zhang
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
J Neurosci 27:12067-77. 2007..These results reveal a novel mechanism of NK-1 in primary sensory neurons via a possible autocrine and paracrine action of SP. Activation of NK-1 in these neurons induces heat hyperalgesia via PKCepsilon-mediated potentiation of TRPV1... - State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injuryYu Zhou
Institute of Neurobiology, Fu Dan University, Shanghai, China
J Neurochem 85:571-80. 2003..Inflammatory mediator-induced activation of PKCepsilon and subsequent sensitization of VR1 to noxious stimuli by PKCepsilon may be involved in nociceptor sensitization... - Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?Wen hua Ren
Institutes of Brain Science, Institute of Neurobiology corrected Fudan University, Shanghai, China
J Neurochem 96:1636-47. 2006..Thus a new and promising strategy for the prevention of chronic pain-induced emotional disturbance might be raised... - The sensitization of peripheral C-fibers to lysophosphatidic acid in bone cancer painJun Zhao
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
Life Sci 87:120-5. 2010..Lysophosphatidic acid (LPA) is released from injured tissue and cancer cells and is involved in the induction of neuropathic pain. The present study explores whether LPA plays a role in the development of osteocarcinoma-induced pain... - Involvement of spinal microglial P2X7 receptor in generation of tolerance to morphine analgesia in ratsDong Zhou
Unit of Pain Research, Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
J Neurosci 30:8042-7. 2010..Once morphine analgesic tolerance is established, it was no longer affected by intrathecal BBG. Together, our results suggest that spinal P2X(7)R is involved in the induction but not maintenance of morphine tolerance... - Age-related alterations in responses of the nucleus basalis magnocellularis neurons to frontal cortex stimulation in ratsYu Qiu Zhang
Institute of Neurobiology, Fudan University, Shanghai, 200433, China
Neurosci Lett 330:285-9. 2002..The mean peak-firing rate of exciting phase was gradually reduced with aging. These findings indicate that there might be some functional changes in the nbM neurons with aging... - Estrogen facilitates spinal cord synaptic transmission via membrane-bound estrogen receptors: implications for pain hypersensitivityYan Zhang
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
J Biol Chem 287:33268-81. 2012..Finally, HFS increases E2 release in spinal cord slices, which can be prevented by aromatase inhibitor androstatrienedione, suggesting activity-dependent local synthesis and release of endogenous E2... - New evidence for the involvement of spinal fractalkine receptor in pain facilitation and spinal glial activation in rat model of monoarthritisShan Sun
Institutes of Brain Science, Institute of Neurobiology, Fudan University, 138 Yixueyuan, Shanghai 200032, China
Pain 129:64-75. 2007..These data provided new evidence for the contribution of endogenous fractalkine to the initiation and early maintenance of inflammatory pain facilitation via activating spinal microglia... - Inhibitory effect of intrathecal meptazinol on carrageenan-induced thermal hyperalgesia in ratsHua Zhang
Institute of Neurobiology, Fudan University, Shanghai, 200433, China
Neurosci Lett 356:9-12. 2004..These observations suggested that mu opioid receptor rather than muscarinic acetylcholine receptor may be involved in the anti-hyperalgesia of meptazinol in the spinal cord... - Kynurenic acid enhances electroacupuncture analgesia in normal and carrageenan-injected ratsYu Qiu Zhang
Institute of Neurobiology, Fudan University, 220 Han Dan Road, 200433, Shanghai, China
Brain Res 966:300-7. 2003..t. injection of KYNA or EA alone. These results demonstrated that EAA receptor(s) antagonist could enhance EA-induced anti-nociception and anti-hyperalgesia... - Involvement of microglia and interleukin-18 in the induction of long-term potentiation of spinal nociceptive responses induced by tetanic sciatic stimulationYu Xia Chu
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
Neurosci Bull 28:49-60. 2012..The present study aimed to investigate the potential roles of spinal microglia and downstream molecules in the induction of spinal long-term potentiation (LTP) and mechanical allodynia by tetanic stimulation of the sciatic nerve (TSS)... - Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responsesYu Xia Chu
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
Brain Behav Immun 24:1176-89. 2010..These results suggest that microglial P2X7Rs and its downstream signaling pathways play a pivotal role in the induction of spinal LTP and persistent pain induced by TSS... - Expression of 5-HT1A receptor mRNA in rat lumbar spinal dorsal horn neurons after peripheral inflammationYu Qiu Zhang
Institute of Neurobiology, Fudan University, 220 Han Dan Road, 200433, Shanghai, People s Republic of China
Pain 98:287-95. 2002..These findings suggested that following peripheral inflammation, the synthesis of 5-HT(1A) receptor was increased in the lumbar spinal dorsal horn neurons, especially in spinal GABA and ENK neurons... - Antinociceptive effects of meptazinol and its isomers on carrageenan-induced thermal hyperalgesia in ratsPei Fen Wang
Institute of Neurobiology, Fudan University, Shanghai 200433, China
Sheng Li Xue Bao 56:295-300. 2004..The effects are mainly mediated by mu opioid receptors. This study provides an important clue for extending clinical utilization of meptazinol and its isomers... - Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat modelKai Zheng Duan
Fudan University, Shanghai, China
Pain 153:562-74. 2012..Targeting A-type K(+) channels in primary sensory neurons may provide a novel mechanism-based therapeutic strategy for bone cancer pain... - Role of P2X7 receptor-mediated IL-18/IL-18R signaling in morphine tolerance: multiple glial-neuronal dialogues in the rat spinal cordMeng ling Chen
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
J Pain 13:945-58. 2012..This article may represent potential new therapeutic targets for preventing morphine analgesic tolerance in clinical management of chronic pain... - Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction of long-term potentiation in ratsHong Cao
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
Neurosci Bull 25:301-8. 2009.... - Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective painHong Cao
Institutes of Neurobiology, Institute of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China
Neurosci Bull 28:77-87. 2012..The present study investigated the contributions of the NMDAR glycine site and GluN2B subunit to the activation of ERK and CREB both in vitro and in vivo in rat rACC... - Spinal somatostatin SSTR2A receptors are preferentially up-regulated and involved in thermonociception but not mechanonociceptionPing Song
Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, Peoples Republic of China
Exp Neurol 178:280-7. 2002..The results also suggest that somatostatin has an excitatory role in spinal nociceptive processing and that there are differential receptor responses to different types of noxious stimuli... - NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male ratsTing Ting Li
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Pain 146:183-93. 2009..Thus, a new strategy targeted at NMDA NR2A or NR2B subunit might be raised for the prevention of pain-related emotional disturbance... - Synergetic analgesia of propentofylline and electroacupuncture by interrupting spinal glial function in ratsLing Li Liang
Institute of Neurobiology, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
Neurochem Res 35:1780-6. 2010..These results indicate that propentofylline and EA induce synergetic analgesia by interrupting spinal glial function... - Effects of aquaporin 4 deficiency on morphine analgesia and chronic tolerance: a study at spinal levelMeng ling Chen
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
J Mol Neurosci 42:140-4. 2010..In conclusion, AQP4 deficiency attenuated morphine acute antinociception but did not affect chronic tolerance in tail flick test, implying a role for spinal AQP4 in morphine analgesia but not in chronic tolerance... - Inhibition of P2X receptor-mediated inward current by protein kinase C in small-diameter dorsal root ganglion neurons of adult ratsBi Hua Bie
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
Neurosci Bull 25:179-86. 2009.... - Electrophysiological and pharmacological properties of nucleus basalis magnocellularis neurons in ratsYu Qiu Zhang
Institute of Neurobiology, Fudan University, Shanghai 200433, China
Acta Pharmacol Sin 25:161-70. 2004..To investigate the primary electrophysiological and pharmacological properties of the nucleus basalis magnocellularis (nbM) neurons... - Involvement of estrogen in rapid pain modulation in the rat spinal cordYan Zhang
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
Neurochem Res 37:2697-705. 2012..These results indicate that estrogen acutely facilitates nociceptive transmission in the spinal cord via activation of membrane-bound estrogen receptors... - Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCε pathway in dorsal root ganglion neuronsHai Li Pan
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
Mol Pain 6:85. 2010..In the present study we examined whether an interaction between LPA receptor LPA(1) and TRPV1 in dorsal root ganglion (DRG) neurons contributes to the development of bone cancer pain... - Involvement of spinal somatostatin receptor SST(2A) in inflammation-induced thermal hyperalgesia: ultrastructural and behavioral studies in ratsJun Zhao
Institute of Neurobiology, Institutes of Brain Science, Fu Dan University, 138 Yixueyan Road, Shanghai 200032, People s Republic of China
Neurochem Res 33:2099-106. 2008..The up-regulation of SST(2A) receptors in the spinal cord may be one of the mechanisms underlying inflammation-induced thermal hyperalgesia... - Peripheral inflammation alters desensitization of substance P-evoked current in rat dorsal root ganglion neuronsBihua Bie
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 20032, China
Eur J Pharmacol 670:495-9. 2011..All these results indicated that tachykinin NK₁ receptor in the primary afferents might contribute to the development and maintenance of inflammatory pain... - Plasticity changes of neuronal activities in central lateral nucleus by stimulation of the anterior cingulate cortex in ratLing Zhang
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
Brain Res Bull 81:574-8. 2010..Taken together, we demonstrated descending modulation to nociceptive responses of CL neurons by direct projections from the ACC, which may underlie the neuronal mechanism of negative pain emotions... - Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective painHong Cao
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
J Neurosci 29:3307-21. 2009..All together, our results demonstrate that ERK activation in the rACC is required for the induction and expression of pain-related negative affect... - Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord sliceLong Zhen Cheng
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
Mol Pain 6:1. 2010..Ryanodine receptor (RyR) is a downstream target for NO. The present study further explored the role of RyR in synaptic plasticity of the spinal pain pathway... - Early intervention of ERK activation in the spinal cord can block initiation of peripheral nerve injury-induced neuropathic pain in ratsMei Han
Shanghai Medical College, Fudan University, Shanghai 200032, China
Sheng Li Xue Bao 63:106-14. 2011..These data suggest that activation of ERK and CREB in the spinal cord contributes to the initiation of peripheral nerve injury-induced pain hypersensitivity, and an early intervention strategy should be proposed... - PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neuronsChun Lei Cang
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, PR China
Mol Pain 5:33. 2009..Our previous results have proved the expression of SP receptor neurokinin-1 (NK-1) on DRG neurons and its interaction with transient receptor potential vanilloid 1 (TRPV1) receptor... - Knockdown of synaptic scaffolding protein Homer 1b/c attenuates secondary hyperalgesia induced by complete Freund's adjuvant in ratsYong xing Yao
Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Anesth Analg 113:1501-8. 2011..In the current study, we investigated the possible involvement of Homer 1b/c in secondary hyperalgesia induced by complete Freund's adjuvant (CFA)... - Interleukin-2 regulates membrane potentials and calcium channels via mu opioid receptors in rat dorsal root ganglion neuronsPing Song
Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Neuropharmacology 43:1324-9. 2002..The present results indicated that mu opioid receptors were involved in the regulatory effects of IL-2 on membrane potentials and calcium channels in DRG neurons, which may contribute to IL-2-induced peripheral analgesia...