Wenhong Zhang

Summary

Affiliation: Fudan University
Country: China

Publications

  1. Cui P, Niu H, Shi W, Zhang S, Zhang H, Margolick J, et al. Disruption of Membrane by Colistin Kills Uropathogenic Escherichia coli Persisters and Enhances Killing of Other Antibiotics. Antimicrob Agents Chemother. 2016;60:6867-6871 pubmed publisher
    ..Our findings suggest that targeting bacterial membranes is a valuable approach to eradicating persisters and should have implications for more effective treatment of persistent bacterial infections. ..
  2. Niu H, Cui P, Shi W, Zhang S, Feng J, Wang Y, et al. Identification of Anti-Persister Activity against Uropathogenic Escherichia coli from a Clinical Drug Library. Antibiotics (Basel). 2015;4:179-87 pubmed publisher
    ..coli persisters in 3 days in vitro while the current UTI antibiotics failed to do so. Our findings may have implications for the development of a more effective treatment for UTIs. ..
  3. Niu H, Cui P, Yee R, Shi W, Zhang S, Feng J, et al. A Clinical Drug Library Screen Identifies Tosufloxacin as Being Highly Active against Staphylococcus aureus Persisters. Antibiotics (Basel). 2015;4:329-36 pubmed publisher
    ..Further studies are needed to evaluate tosufloxacin in animal models and to explain its unique activity against bacterial persisters. Our findings may have implications for improved treatment of persistent bacterial infections. ..
  4. Chen J, Ruan Q, Shen Y, Wang S, Shao L, Zhang W. Assessing and screening for T-cell epitopes from Mycobacterium tuberculosis RD2 proteins for the diagnosis of active tuberculosis. Braz J Infect Dis. 2018;: pubmed publisher
    ..TB assay were 76% and 75%, respectively. In conclusion, these results suggest that the six epitopes from the RD2 of M. tuberculosis have potential diagnostic value in TB. ..
  5. Sun F, Li Y, Chen Y, Guan W, Jiang X, Wang X, et al. Introducing Molecular Testing of Pyrazinamide Susceptibility Improves MDR-TB Treatment Outcomes: A Prospective Cohort Study. Eur Respir J. 2018;: pubmed publisher
    ..In the cohort introducing PZA for patients with PZA susceptible MDR-TB, the current regimen may be shortened to 12 months with comparable success rates to the WHO recommended shorter regimen. ..
  6. Zhu Y, Ai J, Xu B, Cui P, Cheng Q, Wu H, et al. Rapid and precise diagnosis of disseminated T.marneffei infection assisted by high-throughput sequencing of multifarious specimens in a HIV-negative patient: a case report. BMC Infect Dis. 2018;18:379 pubmed publisher
    ..marneffei infection provides a new perspective in the clinical approach to the systematic fungi infections and highlights the potential of this technique in rapid etiological diagnosis. ..
  7. Wang S, Wu J, Chen J, Gao Y, Zhang S, Zhou Z, et al. Evaluation of Mycobacterium tuberculosis-specific antibody responses for the discrimination of active and latent tuberculosis infection. Int J Infect Dis. 2018;70:1-9 pubmed publisher
    ..A combination of Anda-TB and the TB Complex test demonstrated high diagnostic potential in discriminating ATB from LTBI and may be an additional diagnostic tool in the diagnosis of M. tuberculosis infection. ..
  8. Li G, Yu Y, Chen S, Fan P, Shao L, Chen J, et al. Sequential combination therapy with pegylated interferon leads to loss of hepatitis B surface antigen and hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive chronic hepatitis B patients receiving long-term entecavir treatment. Antimicrob Agents Chemother. 2015;59:4121-8 pubmed publisher
    ..Sequential combination therapy can be guided by baseline HBsAg/HBeAg levels and on-treatment HBsAg dynamics. ..
  9. Wang F, Shao L, Fan X, Shen Y, Diao N, Jin J, et al. Evolution and transmission patterns of extensively drug-resistant tuberculosis in China. Antimicrob Agents Chemother. 2015;59:818-25 pubmed publisher
    ..The XDR-TB epidemic in China is mainly caused by a high degree of clonal transmission, but evolution from MDR to XDR and even superinfection with a new XDR strain can also occur. ..

More Information

Publications21

  1. Zhao J, Du P, Cui P, Qin Y, Hu C, Wu J, et al. LncRNA PVT1 promotes angiogenesis via activating the STAT3/VEGFA axis in gastric cancer. Oncogene. 2018;37:4094-4109 pubmed publisher
    ..Collectively, our study first elucidates the mechanism of PVT1-mediated angiogenesis via evoking the STAT3/VEGFA signalling axis, which provides promising target for developing new therapeutic strategy in gastric cancer. ..
  2. Gao Y, Zhang S, Ou Q, Shen L, Wang S, Wu J, et al. Characterization of CD4/CD8+ αβ and Vγ2Vδ2+ T cells in HIV-negative individuals with different Mycobacterium tuberculosis infection statuses. Hum Immunol. 2015;76:801-7 pubmed publisher
    ..Cellular immune responses are impaired in ATB patients. Antigen-specific CD4+ T cell may migrate from the periphery to the lesion site, where they exert anti-tuberculosis functions. ..
  3. Ruan Q, Zhang S, Ai J, Shao L, Zhang W. Screening of latent tuberculosis infection by interferon-γ release assays in rheumatic patients: a systemic review and meta-analysis. Clin Rheumatol. 2016;35:417-25 pubmed publisher
  4. Liu W, Chen J, Shen Y, Jin J, Wu J, Sun F, et al. Phenotypic and genotypic characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis clinical isolates in Hangzhou, China. Clin Microbiol Infect. 2018;24:1016.e1-1016.e5 pubmed publisher
    ..Mutations in rpsA and panD were also associated with PZA resistance in MDR isolates expressing wild-type pncA. The detection of mutations in pncA, rpsA and panD can be useful for the determination of PZA resistance. ..
  5. Ai J, Zhang S, Ruan Q, Yu Y, Zhang B, Liu Q, et al. The Risk of Tuberculosis in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor-α Antagonist: A Metaanalysis of Both Randomized Controlled Trials and Registry/Cohort Studies. J Rheumatol. 2015;42:2229-37 pubmed publisher
    ..The study also proposes the necessity of LTBI prophylaxis in patients with RA. ..
  6. Ruan Q, Zhu Y, Chen S, Zhu L, Zhang S, Zhang W. Disseminated cryptococcosis with recurrent multiple abscesses in an immunocompetent patient: a case report and literature review. BMC Infect Dis. 2017;17:369 pubmed publisher
    ..Moreover, this phenomenon could be related with low-grade virulence and relative long illness duration. ..
  7. Niu H, Yee R, Cui P, Tian L, Zhang S, Shi W, et al. Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library. Pathogens. 2017;6: pubmed publisher
    ..We ranked these new drug candidates according to their MICs against the MRSA strain USA300. Our findings may have implications for more effective treatment of MRSA infections. ..
  8. Liu Y, Ou Q, Liu Q, Gao Y, Wu J, Zhang B, et al. The expressions and roles of different forms of IL-22 in Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2017;107:95-103 pubmed publisher
    ..In conclusion, our results suggest that IL-22 has various roles in tuberculosis immune responses. In particular, membrane-bound IL-22+ T cells may play important roles in the human immune response to Mycobacterium. ..
  9. Ai J, Zhang H, Cui P, Xu B, Gao Y, Cheng Q, et al. Dynamic and direct pathogen loads surveillance to reflect disease progression and therapeutic efficacy in central nervous system infection using a novel semi-quantitive sequencing platform. J Infect. 2017;: pubmed publisher
    ..NGS may perform as a promising tool for infectious disease course surveillance through its ability of revealing the direct connection between pathogen loads and variate disease states in the future...
  10. He L, Wang X, Cui P, Jin J, Chen J, Zhang W, et al. ubiA (Rv3806c) encoding DPPR synthase involved in cell wall synthesis is associated with ethambutol resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb). 2015;95:149-54 pubmed publisher
    ..The essentiality of UbiA, its involvement in EMB resistance, and lack of human homologs make UbiA an attractive target for new drug development. ..
  11. Wang J, Yu Y, Li G, Shen C, Meng Z, Zheng J, et al. Relationship between serum HBV-RNA levels and intrahepatic viral as well as histologic activity markers in entecavir-treated patients. J Hepatol. 2017;: pubmed publisher
  12. Wu J, Wang S, Lu C, Shao L, Gao Y, Zhou Z, et al. Multiple cytokine responses in discriminating between active tuberculosis and latent tuberculosis infection. Tuberculosis (Edinb). 2017;102:68-75 pubmed publisher
    ..Cytokines such as IL-2 and IL-10 may serve as biomarkers for distinguishing ATB from LTBI and healthy control and may contribute to intervention and improvement in TB diagnosis. ..