Jiejie Xu

Summary

Affiliation: Fudan University
Country: China

Publications

  1. Xiong Y, Liu L, Xia Y, Qi Y, Chen Y, Chen L, et al. Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma. Cancer Immunol Immunother. 2019;68:731-741 pubmed publisher
    ..HIF-2α contributed to evasion of anti-tumor immunity via SCF secretion and subsequent recruitment of mast cells in ccRCC patients. ..
  2. Jiang Q, Fu Q, Chang Y, Liu Z, Zhang J, Xu L, et al. CD19+ tumor-infiltrating B-cells prime CD4+ T-cell immunity and predict platinum-based chemotherapy efficacy in muscle-invasive bladder cancer. Cancer Immunol Immunother. 2019;68:45-56 pubmed publisher
    ..CD19+ TIB serve as antigen-presenting cells (APCs) to activate CD4+ TIT in the tumor environment of MIBC. ..
  3. Fu Q, Xu L, Wang Y, Jiang Q, Liu Z, Zhang J, et al. Tumor-associated Macrophage-derived Interleukin-23 Interlinks Kidney Cancer Glutamine Addiction with Immune Evasion. Eur Urol. 2019;75:752-763 pubmed publisher
    ..IL-23 should thus be considered a therapeutic target in ccRCC, either alone or in combination with immune checkpoint inhibitors. ..
  4. Xu L, Chang Y, An H, Zhu Y, Yang Y, Xu J. High APOBEC3B expression is a predictor of recurrence in patients with low-risk clear cell renal cell carcinoma. Urol Oncol. 2015;33:340.e1-8 pubmed publisher
    ..High APOBEC3B expression is an independent predictor of recurrence in patients with ccRCC, and the prognostic value is most prominent in those with low-risk disease. ..
  5. Zhang H, Wang X, Shen Z, Xu J, Qin J, Sun Y. Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection. Gastric Cancer. 2015;18:740-50 pubmed publisher
    ..Tipping TAMs to an antitumoral phenotype might be a promising therapeutic target for postoperative treatment. ..
  6. Chen X, Liu L, Wang J, Lin Z, Xiong Y, Qu Y, et al. CXCR1 expression predicts benefit from tyrosine kinase inhibitors therapy in patients with metastatic renal cell carcinoma. Urol Oncol. 2018;36:242.e15-242.e21 pubmed publisher
    ..The mechanism may be attributed to the enriched pathways of hypoxia and angiogenesis in CXCR1 positive patients. CXCR1 may be a potential therapeutic target for mRCC, but further studies are required. ..
  7. Liu Y, Liu H, Liu W, Zhang W, An H, Xu J. β1,6-N-acetylglucosaminyltransferase V predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection. World J Urol. 2015;33:1791-9 pubmed publisher
    ..MGAT5 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with ccRCC after nephrectomy. ..
  8. Xu L, Zhu Y, An H, Liu Y, Lin Z, Wang G, et al. Clinical significance of tumor-derived IL-1β and IL-18 in localized renal cell carcinoma: Associations with recurrence and survival. Urol Oncol. 2015;33:68.e9-16 pubmed publisher
    ..The combined high expression of IL-1β and IL-18 is an independent predictor for poor prognosis in patients with localized ccRCC, and the prognostic value is more pronounced in patients with low-risk disease. ..
  9. request reprint
    Liu H, Wu Q, Liu W, Liu Y, Fu Q, Zhang W, et al. ST6Gal-I predicts postoperative clinical outcome for patients with localized clear-cell renal cell carcinoma. Asian Pac J Cancer Prev. 2014;15:10217-23 pubmed
    ..High ST6Gal-I expression is a potential independent adverse predictor of survival and recurrence in ccRCC patients, and the prognostic value is most prominent in those with low and intermediate-risk disease defined by the UISS score. ..

More Information

Publications50

  1. An H, Zhu Y, Xu L, Chen L, Lin Z, Xu J. Notch1 predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection. Urology. 2015;85:483.e9-483.e14 pubmed publisher
    ..Notch1 activation is a potential independent adverse prognostic biomarker for recurrence and survival of patients with ccRCC after nephrectomy. ..
  2. Liu H, Wu Q, Liu Y, Liu W, Zhang W, Pan D, et al. Prognostic significance of β1,6-N-acetylglucosaminyltransferase V expression in patients with hepatocellular carcinoma. Jpn J Clin Oncol. 2015;45:844-53 pubmed publisher
    ..Mgat5 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with hepatocellular carcinoma after hepatectomy. ..
  3. An H, Xu L, Chang Y, Zhu Y, Yang Y, Chen L, et al. CXC chemokine receptor 2 is associated with postoperative recurrence and survival of patients with non-metastatic clear-cell renal cell carcinoma. Eur J Cancer. 2015;51:1953-61 pubmed publisher
    ..CXCR2 is a potential independent adverse prognostic biomarker for recurrence and survival of patients with non-metastatic ccRCC after nephrectomy. ..
  4. Liu W, Liu Y, Liu H, Zhang W, An H, Xu J. Snail predicts recurrence and survival of patients with localized clear cell renal cell carcinoma after surgical resection. Urol Oncol. 2015;33:69.e1-10 pubmed publisher
    ..Nuclear Snail expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with localized ccRCC after nephrectomy. ..
  5. Chang Y, Fu Q, Xu L, Zhou L, Liu Z, Yang Y, et al. Prognostic value of preoperative lymphocyte to monocyte ratio in patients with nonmetastatic clear cell renal cell carcinoma. Tumour Biol. 2016;37:4613-20 pubmed publisher
  6. Wang J, Liu L, Qu Y, Xi W, Xia Y, Bai Q, et al. Prognostic Value of SETD2 Expression in Patients with Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors. J Urol. 2016;196:1363-1370 pubmed publisher
    ..However, it remains to be seen whether this is generalizable to other ethnicities and prospective external validation is required. ..
  7. Yang Y, Zhai C, Chang Y, Zhou L, Shi T, Tan C, et al. High expression of chemokine CCL2 is associated with recurrence after surgery in clear-cell renal cell carcinoma. Urol Oncol. 2016;34:238.e19-26 pubmed publisher
    ..High chemokine CCL2 expression is an independent predictor of recurrence in ccRCC patients. Evaluation of CCL2 could help guide postsurgical management for ccRCC patients. ..
  8. Fu H, Zhu Y, Wang Y, Liu Z, Zhang J, Xie H, et al. Identification and Validation of Stromal Immunotype Predict Survival and Benefit from Adjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer. Clin Cancer Res. 2018;24:3069-3078 pubmed publisher
    ..Furthermore, the immunotypes might be a practical predictive tool to identify pT3+pT4 patients who would benefit from ACT. Clin Cancer Res; 24(13); 3069-78. ©2018 AACR. ..
  9. Yang L, Liu Y, An H, Chang Y, Zhang W, Zhu Y, et al. High Expression of Colony-Stimulating Factor 1 Receptor Associates with Unfavorable Cancer-Specific Survival of Patients with Clear Cell Renal Cell Carcinoma. Ann Surg Oncol. 2016;23:1044-52 pubmed publisher
    ..An efficient prognostic nomogram was constructed on the basis of the independent prognostic factors. High CSF-1R expression is a potential independent adverse prognostic factor for CSS in patients with ccRCC. ..
  10. Liu H, Shen Z, Wang X, Zhang H, Qin J, Qin X, et al. Increased expression of C-C motif ligand 2 associates with poor prognosis in patients with gastric cancer after gastrectomy. Tumour Biol. 2016;37:3285-93 pubmed publisher
    ..CCL2, an identified potential independent adverse prognosticator, could be integrated with TNM staging system to improve the predictive accuracy for overall survival in gastric cancer patients especially with advanced stages. ..
  11. An H, Zhu Y, Xie H, Liu Y, Liu W, Fu Q, et al. Increased expression of interleukin-8 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma. Tumour Biol. 2016;37:4523-9 pubmed publisher
    ..Increased expression of IL-8 is a potential independent adverse prognostic biomarker for CSS and RFS in patients with ccRCC after nephrectomy. ..
  12. Wang J, Liu L, Xi W, Long Q, Wang Y, Bai Q, et al. Prognostic value of UTX expression in patients with clear cell renal cell carcinoma. Urol Oncol. 2016;34:338.e19-27 pubmed publisher
    ..824 and 0.798, respectively). UTX is a prognostic biomarker for patients with ccRCC both in OS and DFS prediction, especially significant in low-risk patients. ..
  13. Wang Z, Xu L, Chang Y, Zhou L, Fu H, Zhang W, et al. IL-33 is associated with unfavorable postoperative survival of patients with clear-cell renal cell carcinoma. Tumour Biol. 2016;37:11127-34 pubmed publisher
    ..The incorporation of IL-33 into the TNM stage and Fuhrman grade might help to refine individual risk stratification. The IL-33 expression may serve as an independent negative predictor of survival for patients with ccRCC after surgery. ..
  14. Zhou L, Chang Y, Xu L, Liu Z, Fu Q, Yang Y, et al. The Presence of Vascular Mimicry Predicts High Risk of Clear Cell Renal Cell Carcinoma after Radical Nephrectomy. J Urol. 2016;196:335-42 pubmed publisher
    ..Further external validation and functional analysis should be pursued to assess its potential prognostic and therapeutic values for clear cell renal cell carcinoma. ..
  15. Xia Y, Liu L, Xiong Y, Bai Q, Wang J, Xi W, et al. Podoplanin associates with adverse postoperative prognosis of patients with clear cell renal cell carcinoma. Cancer Sci. 2016;107:1243-9 pubmed publisher
    ..In conclusion, high tumoral podoplanin expression could independently predict an adverse clinical outcome for ccRCC patients, and it might be useful in future for clinical decision-making and therapeutic developments. ..
  16. Liu W, Yang Y, Liu Y, Liu H, Zhang W, Xu L, et al. p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma. Urol Oncol. 2015;33:205.e13-21 pubmed publisher
    ..PAK4 expression is an independent adverse prognostic biomarker for recurrence and survival among patients with low-risk ccRCC after nephrectomy. ..
  17. Xie H, Zhu Y, Zhang J, Liu Z, Fu H, Cao Y, et al. B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients. BMC Cancer. 2018;18:590 pubmed publisher
    ..Our evaluation indicated that B4GALT1 may be a possible prognosticator of MIBC, and it may be a predictive marker for the choice of ACT in pT3/4 or N+ patients. ..
  18. Liu Y, Liu H, Yang L, Wu Q, Liu W, Fu Q, et al. Loss of N-Acetylgalactosaminyltransferase-4 Orchestrates Oncogenic MicroRNA-9 in Hepatocellular Carcinoma. J Biol Chem. 2017;292:3186-3200 pubmed publisher
    ..In conclusion, this study establishes the miR-9/GALNT4 axis as a potential adverse prognostic factor and therapeutic target for HCC patients. ..
  19. Liu W, Liu Y, Liu H, Zhang W, Fu Q, Xu J, et al. Tumor Suppressive Function of p21-activated Kinase 6 in Hepatocellular Carcinoma. J Biol Chem. 2015;290:28489-501 pubmed publisher
    ..These data identified the tumor suppressive role and potential underlying mechanism of PAK6 in hepatocarcinogenesis. ..
  20. Cao Y, Liu H, Zhang H, Lin C, Li R, Zhang W, et al. Decreased expression of Siglec-8 associates with poor prognosis in patients with gastric cancer after surgical resection. Tumour Biol. 2016;37:10883-91 pubmed publisher
  21. Pan D, Xu L, Liu H, Zhang W, Zhu Y, Xu J, et al. Interleukin-11 receptor predicts post-operative clinical outcome in patients with early-stage clear-cell renal cell carcinoma. Jpn J Clin Oncol. 2015;45:202-9 pubmed publisher
  22. Yang L, Wu Q, Xu L, Zhang W, Zhu Y, Liu H, et al. Increased expression of colony stimulating factor-1 is a predictor of poor prognosis in patients with clear-cell renal cell carcinoma. BMC Cancer. 2015;15:67 pubmed publisher
    ..High CSF-1 expression is a potential adverse prognostic biomarker for recurrence and survival of ccRCC patients after nephrectomy. ..
  23. request reprint
    Wu S, Liu H, Zhang H, Lin C, Li R, Cao Y, et al. Galectin-8 is associated with recurrence and survival of patients with non-metastatic gastric cancer after surgery. Tumour Biol. 2016;37:12635-12642 pubmed
  24. Liu Y, Xu L, Zhu Y, Zhang W, Liu W, Liu H, et al. Galectin-8 predicts postoperative recurrence of patients with localized T1 clear cell renal cell carcinoma. Urol Oncol. 2015;33:112.e1-8 pubmed publisher
    ..Gal-8 expression is a potential independent unfavorable prognostic indicator for postoperative recurrence of patients with localized pT1 ccRCC. ..
  25. Fu H, Zhu Y, Wang Y, Liu Z, Zhang J, Wang Z, et al. Tumor Infiltrating Mast Cells (TIMs) Confers a Marked Survival Advantage in Nonmetastatic Clear-Cell Renal Cell Carcinoma. Ann Surg Oncol. 2017;24:1435-1442 pubmed publisher
    ..TIMs density is a powerful independent prognostic factor for CSS and RFS in patients with nonmetastasis (pT1-4N0M0) ccRCC. ..
  26. Xia Y, Liu L, Long Q, Bai Q, Wang J, Xu J, et al. Decreased expression of CTR2 predicts poor prognosis of patients with clear cell renal cell carcinoma. Urol Oncol. 2016;34:5.e1-9 pubmed publisher
    ..752-0.846 vs. 0.691; 95% CI: 0.637-0.745). CTR2 is a novel prognostic marker for patients with ccRCC both in OS and DFS prediction, and could be incorporated with other clinical parameters for better patient risk stratification. ..
  27. Bo X, Wang J, Suo T, Ni X, Liu H, Shen S, et al. Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients. BMC Cancer. 2018;18:313 pubmed publisher
    ..TIMs infiltration is an independent favorable prognostic factor in GBC and EBDC patients, which could better stratify patients with different prognosis and predict benefit from gemcitabine-based ACT. ..
  28. Ou C, Liu L, Wang J, Dai S, Qu Y, Xiong Y, et al. Enhancement of Siglec-8 expression predicts adverse prognosis in patients with clear cell renal cell carcinoma. Urol Oncol. 2017;35:607.e1-607.e8 pubmed publisher
    ..Our study has found that the elevated expression level of Siglec-8 was correlated with poor prognosis of patients with ccRCC. Siglec-8, incorporation with other clinical parameters, could perform better in prediction of patients? OS. ..
  29. Wei Y, Lin C, Li H, Xu Z, Wang J, Li R, et al. CXCL13 expression is prognostic and predictive for postoperative adjuvant chemotherapy benefit in patients with gastric cancer. Cancer Immunol Immunother. 2018;67:261-269 pubmed publisher
    ..In addition, CXCL13 expression may serve as a predictive biomarker of response to postoperative adjuvant chemotherapy in these patients. ..
  30. request reprint
    NguyenHoang S, Liu Y, Xu L, Chang Y, Zhou L, Liu Z, et al. High mucin-7 expression is an independent predictor of adverse clinical outcomes in patients with clear-cell renal cell carcinoma. Tumour Biol. 2016;37:15193-15201 pubmed
    ..027). A nomogram integrating Mucin-7 expression and other independent prognosticators was constructed. In summary, the high Mucin-7 expression is a potential prognosticator of adverse clinical outcome in ccRCC patients after surgery. ..
  31. Wu Q, Liu H, Liu Y, Liu W, Pan D, Zhang W, et al. Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity. J Biol Chem. 2015;290:1170-85 pubmed publisher
    ..In summary, our results reveal a novel Hnf4α/miR-122/GALNT10 regulatory pathway that facilitates EGF miR-122 activation and hepatoma growth in HBV-associated hepatocarcinogenesis. ..
  32. Xi W, Wang J, Liu L, Xiong Y, Qu Y, Lin Z, et al. Evaluation of Tumor Pseudocapsule Status and its Prognostic Significance in Renal Cell Carcinoma. J Urol. 2018;199:915-920 pubmed publisher
    ..Lack of a pseudocapsule certainly had a remarkably adverse impact on the patient outcome. Accessibility in use and cost makes pseudocapsule status a potential cost-effective parameter in clinical practice. ..
  33. Zhang J, Zhu Y, Wang Y, Fu Q, Xie H, Liu Z, et al. Prognostic and Predictive Value of O6-methylguanine Methyltransferase for Chemotherapy in Patients with Muscle-Invasive Bladder Cancer. Ann Surg Oncol. 2018;25:342-348 pubmed publisher
    ..MGMT expression may be a potential predictor for administration of adjuvant chemotherapy. ..
  34. Wang J, Liu L, Qu Y, Xi W, Xia Y, Bai Q, et al. HLA class I expression predicts prognosis and therapeutic benefits from tyrosine kinase inhibitors in metastatic renal-cell carcinoma patients. Cancer Immunol Immunother. 2018;67:79-87 pubmed publisher
    ..Its predictive value was restricted in CTL high-density tumors. However, further external validations and functional investigations are still required. ..
  35. Chang Y, Zhou L, Xu L, Fu Q, Yang Y, Lin Z, et al. High expression of CXC chemokine receptor 6 associates with poor prognosis in patients with clear cell renal cell carcinoma. Urol Oncol. 2017;35:675.e17-675.e24 pubmed publisher
    ..The expression of CXCR6 in tumor tissue may serve as a potential prognostic biomarker to refine clinical prognosis prediction combined with traditional clinical and pathological analysis for patients with ccRCC after surgery. ..
  36. Liu Y, Liu Z, Fu Q, Wang Z, Fu H, Liu W, et al. Galectin-9 as a prognostic and predictive biomarker in bladder urothelial carcinoma. Urol Oncol. 2017;35:349-355 pubmed publisher
    ..014). Expression of galectin-9 is an independent prognostic factor for RFS and CSS in patients with UCB. Evaluation of galectin-9 expression may predict the benefit from adjuvant chemotherapy. ..
  37. Wang Z, Liu H, Shen Z, Wang X, Zhang H, Qin J, et al. The prognostic value of CXC-chemokine receptor 2 (CXCR2) in gastric cancer patients. BMC Cancer. 2015;15:766 pubmed publisher
    ..Intratumoral CXCR2 expression is a novel independent predictor for survival in gastric cancer patients. CXCR2 might be a promising therapeutic target of postoperative adjuvant treatment. ..
  38. Long Q, Liu L, Xia Y, Bai Q, Wang J, Xu J, et al. High peritumoral Bmi-1 expression is an independent prognosticator of poor prognosis in renal cell carcinoma. Tumour Biol. 2015;36:8007-14 pubmed publisher
    ..High peritumoral Bmi-1 expression can serve as an independent prognostic biomarker and could be a novel therapeutic target for renal cell carcinoma (RCC). ..
  39. Xiong Y, Liu L, Xia Y, Wang J, Xi W, Bai Q, et al. Low CCL17 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma. BMC Cancer. 2017;17:117 pubmed publisher
    ..Established nomograms based on this information could help predict ccRCC patients' OS and RFS. ..
  40. Xia Y, Liu L, Xiong Y, Bai Q, Wang J, Xi W, et al. Prognostic value of CC-chemokine receptor seven expression in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitor. BMC Cancer. 2017;17:70 pubmed publisher
    ..Further external validations and basic researches were needed to confirm these results. ..
  41. Bai Q, Liu L, Xia Y, Long Q, Wang J, Xu J, et al. Prognostic significance of ST3GAL-1 expression in patients with clear cell renal cell carcinoma. BMC Cancer. 2015;15:880 pubmed publisher
    ..ST3GAL-1 is an independent adverse prognostic factor for recurrence and survival of patients with ccRCC. ..