Bao guo Xiao


Affiliation: Fudan University
Country: China


  1. Xin Y, Yu J, Yang X, Liu C, Li Y, Feng L, et al. FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity. Biosci Rep. 2015;35: pubmed publisher
    ..Thus, FSD-C10 may be a safer and more promising novel ROCK inhibitor than Fasudil for the treatment of several neurological disorders. ..
  2. Yu W, Wang Q, Chen S, Cao L, Tang J, Ma C, et al. The therapeutic potential of ginkgolide K in experimental autoimmune encephalomyelitis via peripheral immunomodulation. Int Immunopharmacol. 2019;70:284-294 pubmed publisher
    ..Our results provide the possibility that GK may be a promising naturally small molecule compound for the future treatment of MS. ..
  3. Wang J, Sui R, Miao Q, Wang Q, Song L, Yu J, et al. Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model. Clin Immunol. 2019;201:35-47 pubmed publisher
    ..These results provide potent evidence for the therapeutic effects of HF in CPZ-induced demyelination. ..
  4. Sui R, Miao Q, Wang J, Wang Q, Song L, Yu J, et al. Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination. Int Immunopharmacol. 2019;66:69-81 pubmed publisher
    ..These results identify a potent therapeutic efficiency for Bilobalide and highlight clear pleiotropic effects of the compound beyond specific autoantibody and inflammatory microenvironment in CPZ-mediated demyelination. ..
  5. Zhao Y, Zhang Q, Xi J, Li Y, Ma C, Xiao B. Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson's disease. J Neurol Sci. 2015;353:28-37 pubmed publisher
    ..However, a lot of investigations are warranted to further elucidate the crosstalk among Fasudil, oxidative stress, inflammatory response, GDNF and ROCK/NF-kB/Nrf2 pathways in the therapeutic potential of PD. ..
  6. Lou Z, Yu W, Chen J, Li L, Jiang L, Xiao B, et al. Neuroprotective Effect Is Driven Through the Upregulation of CB1 Receptor in Experimental Autoimmune Encephalomyelitis. J Mol Neurosci. 2016;58:193-200 pubmed publisher
    ..Its complexity remains to be carefully considered and further studied in further investigation. ..
  7. Lou Z, Cheng J, Wang X, Zhao Y, Gan J, Zhou G, et al. The inhibition of CB1 receptor accelerates the onset and development of EAE possibly by regulating microglia/macrophages polarization. J Neuroimmunol. 2018;317:37-44 pubmed publisher
    ..Therefore, CB1R may be a promising target for the treatment of MS/EAE, but its complexity remains to be carefully considered and studied in further clinical application. ..
  8. Tang J, Yu W, Chen S, Gao Z, Xiao B. Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse. Neurochem Res. 2018;43:985-994 pubmed publisher
    ..In all, our results suggest that M1 polarization and ER stress play a vital role in MDD pathogenesis. ..
  9. Li Y, Yu J, Xin Y, Feng L, Chai Z, Liu J, et al. Protective effect of a novel Rho kinase inhibitor WAR-5 in experimental autoimmune encephalomyelitis by modulating inflammatory response and neurotrophic factors. Exp Mol Pathol. 2015;99:220-8 pubmed publisher
    ..Taken together, WAR-5 exhibits therapeutic potential in EAE by more selectively inhibits ROCK II, with a greater safety than Fasudil, and is worthy of further clinical study to clarify its clinical value. ..

More Information


  1. Liu F, Yang Y, Wu J, Li S, Tang Y, Zhao J, et al. Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway. Brain Res. 2016;1632:9-18 pubmed publisher
    ..Taken together, fasudil might be able to provide a novel and promising strategy for PD treatment by enhancing α-syn clearance and activating the JNK 1/Bcl-2/beclin 1 pathway. ..
  2. Ding J, Wang J, Li Q, Yu J, Ma C, Wang X, et al. Neuroprotection and CD131/GDNF/AKT Pathway of Carbamylated Erythropoietin in Hypoxic Neurons. Mol Neurobiol. 2017;54:5051-5060 pubmed publisher
    ..Addition of GDNF to cultured neurons increased phosphorylation of AKT. CEPO protects neurons possible through the CD131/GDNF/AKT pathway. ..
  3. request reprint
    Yu J, Li Y, Song G, Yu J, Liu C, Liu J, et al. Synergistic and Superimposed Effect of Bone Marrow-Derived Mesenchymal Stem Cells Combined with Fasudil in Experimental Autoimmune Encephalomyelitis. J Mol Neurosci. 2016;60:486-497 pubmed
    ..However, a lot of investigation is warranted to further elucidate the cross talk of MSCs and Fasudil in the therapeutic potential of EAE/multiple sclerosis. ..
  4. Li Y, Yu J, Xi J, Yu W, Liu J, Wang Q, et al. Fasudil Enhances Therapeutic Efficacy of Neural Stem Cells in the Mouse Model of MPTP-Induced Parkinson's Disease. Mol Neurobiol. 2017;54:5400-5413 pubmed publisher
    ..Our study demonstrates that intranasal administration of NSCs, followed by fasudil administration, is a promising cell-based therapy for neuronal lesions. ..
  5. Chen C, Yu J, Zhang Q, Zhao Y, Liu C, Li Y, et al. Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis. Neuromolecular Med. 2015;17:454-65 pubmed publisher
    ..Our results indicate that axonal loss in MS may be related to increased ROCK activity. Fasudil could promote synaptogenesis and thus may contribute to preventing irreversible neurological disability associated with MS. ..
  6. Yu W, Chen S, Cao L, Tang J, Xiao W, Xiao B. Ginkgolide K promotes the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells. Cell Biol Toxicol. 2018;34:291-303 pubmed publisher
    ..Although our results show a potentially new therapeutic candidate for PD, the details of this mechanism need to be further identified. ..